Please see the Sodium ("Salt") Basics articles here (https://members.nutritiondetective.com/posts/love-your-liver-sodium-salt-basics) if you haven't already.
This is based on my client observations over time.
The people who don't salt their food never seem to improve, and seem to be some of the least resilient, most health-UNstable people that I work with.
It has come to the point where I will tell people that I CANNOT get them better if they don't salt their food.
There might be some super rare exceptions to this. Odds are, it's not you (but it could be).
Salt your food to taste with a bright white, single-ingredient salt. See the link above.
If you are used to not salting your food, start with a tiny bit, and you will likely start developing a taste for it again over time.
If you are living or working somewhere with mold, you are constantly being exposed to mycotoxins (mold toxins) in the air you are breathing. Short story, this is bad.
PRO TIP: If an area smells moldy or musty, THERE IS MOLD THERE.
PRO TIP #2: If you live in a wet/humid area, there's a very high chance of mold in your house.
PRO TIP #3: If you know a significant water leak happened, and you aren't sure if the materials damaged were professionally removed & remediated, there's probably STILL a mold problem.
No, essential oils and other stuff is not going to "fix" the problem.
If you aren't sure, you need to test your house. Do a search for "best home mold test kits" or something similar. Test it. Maybe use two different kits (they're not expensive). Maybe test again in a different ("wetter") season of the year. FIND THE PROBLEM.
Only if you can't find it in your house (or work), then MAYBE you get a blood test for mycotoxins to see if you are being exposed somewhere...but knowing you have mycotoxins in your blood doesn't help you if YOU DON'T KNOW WHERE THE MOLD IS COMING FROM TO ELIMINATE IT AT THE SOURCE.
DO NOT TRY TO "DETOX" THE MOLD OUT OF YOUR SYSTEM UNTIL THE ACTUAL MOLD ***SOURCE*** IS COMPLETELY GONE!!! I don't care what these loony practitioners tell you.
I'm not a mold expert, you're going to get the extent of my knowledge here.
Here's the gist:
This mold problem was one of the first of these I figured out. Whenever I had a client who was super-sensitive to supplements (or to everything), or was getting worse on my approaches, or was becoming more sensitive to supplements over time, there was ALMOST ALWAYS A MOLD PROBLEM.
Do not ignore this. Figure it out.
You will absolutely absorb copper from drinking water and bathing water (transdermally, that's why we use topical magnesium, right???).
How can you know if you have copper water pipes in your home? Simple. Go look at the pipes going into and out of your water heater. If they are the bronzish-orangish copper color, you have copper water pipes.
Copper in your water is bad. The simple solutions are to take actions to remove the copper from the water.
A reverse-osmosis filtration (or distiller, if you choose) system for your drinking & cooking water takes care of that side of this equation completely. Under-counter or countertop, doesn't matter, just get one.
Bathing water is a bit trickier.
Most shower filters (like Aquasana) are simple carbon filters that mainly only take out the chlorine. That's nice, but NOT ENOUGH.
These MineralStream shower filters (https://mineralstream.co/collections/mineral-collection) contain zeolite balls in their filter system, and the company tells me that they reduce copper in the water significantly (they also make the water softer, which means they take out other minerals as well).
What about whole-house filtration systems? Here's the problem. The filtration system is put in BEFORE the water heater and the copper pipes. This means the "filtered" water then goes into the water heater and copper pipes...and the "emptier" the water, the more it is likely to leach copper into the water from the pipes that it still has to pass through. Now, the water is not in the pipes that long...I don't know for sure how much of a problem this actually is. The only way to find out would be testing the hot water (tap water) BEFORE someone got the whole-house system, and then testing the hot water AFTER they got the whole-house system. If you are a science-experiment-geek type and want to do this for everyone's benefit, feel free and let me know the results.
Copper will really mess you up. Take this one seriously.
I'm going to start with the second part first. ALL fish & shellfish contains significant mercury, I don't care where it's from, I don't care wild/farmed/whatever. Minimize fish & shellfish intake to minimize eating unnecessary mercury.
On to dental fillings. If you look in your mouth and you have gray / silver / darkish-grayish-blackish fillings, you have mercury amalgam fillings. If your fillings are WHITE, then this is not a problem for you.
If you have mercury fillings, every time you chew and/or drink anything warm, you are offgassing mercury into your mouth, which is then breathed in and/or swallowed. The mouth tissues will also be absorbing it. Let me be clear: IF YOU HAVE MERCURY FILLINGS, YOU ARE MERCURY TOXIC. THE FIRST AND MOST IMPORTANT STEP IS TO STOP IN-TOXING!!! The body will do much of the detox work itself once the source is gone (is this sounding familiar yet?).
Now, I'm not a dentist or dental expert. What you choose to do with the situation after your fillings are removed is up to you. Others here on the network will have better ideas than I will, because I have never gotten any fillings in my life.
Do NOT use a "typical/conventional" dentist to remove your fillings! Use only dentists who have been trained by the International Association of Maxillofacial and Oral Toxicology (IAOMT.org (https://iaomt.org)). They will do the best job of protecting YOU from absorbing the toxic mercury that they're going to take out of your mouth.
Only do 2-3 fillings per session (if you have a lot). More than that, and you'll likely start detoxing the mercury out of your system really fast, and make yourself feel TERRIBLE. Do it in steps if you have a lot of fillings.
DO NOT EXPECT BIG HEALTH IMPROVEMENTS IF YOU ARE POISONING YOURSELF WITH MERCURY DAILY. Get this taken care of.
I refuse to make this topic complicated.
Everyone needs at least fifty (50) grams of TOTAL protein per day, minimum. If you have never totaled up your total protein in a day (ahem, *ladies* especially), you should do so. TOTAL protein includes the protein in EVERYTHING you consume (not just meat, it includes plant foods). Some of you might be quite surprised when you realize you aren't hitting this MINIMUM number. Of course, you can eat more, and that is encouraged.
People also need to eat enough Calories (aka energy). No, I don't have some complex equation for this. If you are constantly hungry for high-Calorie foods like (examples):
These are signs that your body is telling you that you are NOT eating enough TOTAL CALORIES. Many people feel "full" eating higher fiber and more nutrient-dense foods, and they stop eating before they get enough Calories in. Use these examples of cravings to help tell you that you're not eating enough (not some fancy chart or equation).
Changing your diet drastically towards LYL principles has caused enough people these issues that this article was created, so I hope it helps you avoid this same mistake!
SECTION HEADER PAGE: Love Your Liver STARTER GUIDE
NOTE: This List Is *NOT* Nuanced. For The Nuance And Specifics, Refer To The Related Articles In The Love Your Liver Program!
These Things Cause Bile-Dumping. The More Cholestatic You Are, The Less Of These You Will Tolerate Because Too Much Of Your Bile Is Refluxing Into Your BLOODSTREAM...So If You Do Too Much Of Any Of These And You Feel WORSE Afterwards, Then After You Have Recovered, Next Time Simply DO LESS. Your Tolerance Of These Things Will Grow Over Time If You Work The Program Properly. If You Push Yourself Too Hard, You Will Get WORSE For A Good Long While. DON'T DO THAT.
These Things Are Generally "Good For You", BUT ONLY If You Aren't Making Yourself Feel WORSE With Them!!! Get Your DOSE Right For Your Stage Of Recovery!
If You Are Feeling Worse As You Go Along, It Is Likely One Of The Following Is Happening:
If You Aren't Sure Which One It Is, Read The Articles More, Or Ask A Question On The Network.
Compiled by Beth Martens (https://members.nutritiondetective.com/members/28437904)
I'd like to thank Beth Martens (https://members.nutritiondetective.com/members/28437904) for making this document and sharing it with us!
The PDF is below, and it can also be downloaded from Google Drive here:
https://drive.google.com/file/d/1YLyrjzl1vW4U3a2Rkquny-LCMZkfT8Z1/view?usp=sharing
See the video we did together on it below.
[Note: Full food list available as PDF download:]
Beth_s_LYL_Low_Toxin_Food_List.pdf (https://media2-production.mightynetworks.com/asset/58b63de7-36c6-4e89-bbe8-4008f0329292/Beth_s_LYL_Low_Toxin_Food_List.pdf)
SECTION HEADER PAGE: Order of Adding Stuff & Focus Point Articles
Use the Order of Adding Stuff as a general guideline of "what to try first, and what to try next"
These Focus Point articles are meant to build on top of the Order of Adding Stuff!
*Updated August 28, 2025, added MSG*
*Updated June 27, 2023, added Phase 0*
*Originally published June 9, 2023*
NOTE: This is the FIRST article of a ENTIRE RE-WORKING of the LYL program. There will soon be a shorter, more bullet-point version of the LYL, along with the typical LOOOOONG articles & videos version of the LYL. This is a work in progress, so be patient, por favor. Gracias
This is what I am calling the "Order of Adding Stuff", and by that I mean it is a suggested order of how you *TRY OUT* adding things into your personalized approach.
If you haven't figured it out already, not everything is going to work for YOU. Sometimes we can make guesses, and most of the time you simply have to TRY IT AND SEE.
Links will be added as the revised LYL programs are re-organized.
Many of the supplements below can either be ordered from us (email Julie at admin@nutritiondetective.com for supp price list & to get your discount!) or at my Amazon list here: https://amzn.to/3SZioZY (https://amzn.to/3SZioZY)
IMPORTANT: YES, the "Order of Adding Stuff" can also be used in REVERSE ORDER...that is, if you are feeling bad or too detox-y, you can REDUCE or STOP things from the "Order of Adding Stuff" (from here on abbreviated OAS) in the reverse order, from the bottom to the top in an effort to reduce symptoms or slow detox down.
Phase 0: Hydration, Breathing, Light, Movement
Phase 1: Bowels, Biome, Bile
Fix your pooping:
Constipation, LYL-approved constipation helpers below:
Diarrhea:
Probiotics (https://members.nutritiondetective.com/posts/love-your-liver-the-program-probiotics-gut-biome) (see LYL article series):
Fiber:
Soluble - preferred by fermentative:
Insoluble - preferred by putrefactive:
Phase 2: Electrolytes
Phase 3: "Big" Minerals
Phase 4: Antidotes, B-vitamins
Phase 5: Lactoferrin (https://members.nutritiondetective.com/posts/love-your-liver-the-program-lactoferrin)
Phase 6: MMS, CDS, Sodium chlorite (https://members.nutritiondetective.com/posts/love-your-liver-the-program-information-on-chlorine-dioxide-applications-aka-sodium-chlorite-unactivated-mms-cds-mms1-etc)
Big 6 Lymph Drainage (https://www.stopchasingpain.com/the-big-6-tm/#big-6-video) - daily.
Exercise - even if it is only lightly bouncing your heels up and down in place, mild rebounding, or walking. Movement moves things, it prevents stagnation, and it increases your oxygen levels so that you can OXIDIZE toxins!
Get outside for sun and fresh air.
Any supplement mentioned below that has an (A) after it links to my LinkTree, where my ND Amazon Product List can be found (https://linktr.ee/nutritiondetective). Please do not post the direct Amazon Product List link on the network, Amazon really doesn't like that and they'll cancel my account again!
If you are constipated, make sure to do what you can to keep pooping! Natural Vitality Calm plain powder (https://linktr.ee/nutritiondetective) can help with double duty, providing magnesium for pooping and citrate for copper detox. See below for more info.
Homeopathic Detox Therapy (https://members.nutritiondetective.com/posts/love-your-liver-the-program-undoing-medsdrug-damage-done-to-your-liver-resetting-your-gut-biome-homeopathic-detox-therapy-hdt) - If you are quite sure that your female issues started after taking a medication (ie. birth control pills are common for this!) or after some other specific toxin exposure, consider this.
Probiotics (https://members.nutritiondetective.com/posts/love-your-liver-the-program-probiotics-gut-biome) - Ladies, always try lactobacillus FIRST. Read the articles here (https://members.nutritiondetective.com/posts/love-your-liver-the-program-probiotics-gut-biome) (and start with lactobacillus). Sunfiber can also help feed the good bacteria and keep you pooping.
Soluble fiber from food and/or supplements - if you think more might help, try it! That said, make sure you aren't doing too much and making things worse! Main options:
Flush niacin - Binds to copper. Please read the articles (https://members.nutritiondetective.com/posts/love-your-liver-the-program-niacin-aka-nicotinic-acid-guidelines-by-kelsey-kenney), only take a tolerated dose, and BUFFER it with one of the specifically mentioned buffers as described!
Make sure you are NOT eating these high-copper foods on a regular basis:
Charcoal applications (https://linktr.ee/nutritiondetective) over the lower abdomen can help to remove toxicity. Recipes:
Cramps/cramping, anxiety, depression - topical magnesium (over the abdomen especially) and potassium. Also see below about mineral citrates (https://linktr.ee/nutritiondetective) and cream of tartar aka potassium bitartrate (https://linktr.ee/nutritiondetective).
The Big Minerals (zinc, selenium, molybdenum) are all necessary for detoxing "vitamin" A and copper, so get the right amount without overdoing it. Testing with us is the best way to optimize these! Also, all three of these minerals are anti-yeast / anti-fungal, for those with chronic candida issues.
Our selenium product: Nutrition Detective Selenium Glycinate 150 mcg capsules
Our molybdenum products: Nutrition Detective Molybdenum Glycinate 150 mcg capsules / EIDON Ionic Minerals Molybdenum Liquid 2 oz
Our zinc products: Zinc Picolinate 15 mg 100 capsules / Zinc Picolinate 30 mg 100 capsules
Combination (selenium + molybdenum + zinc) products: Keystone Minerals 100 Capsules / Keystone Minerals PLUS Niacin 60 capsules
MMS (chlorine dioxide) (https://linktr.ee/nutritiondetective). This has helped multiple women with their BV (bacterial vaginosis) and/or candida issues. Could be used orally and/or internally/vaginally. Please see the e-books in the MMS section for more details on dosing and applications. The long-term goal is to change the terrain down there so these things can't grow. This is meant to be used short-term for a specific issue, not long-term.
Extras (as in band-aids, crutches, *not essential* yet may be helpful for SYMPTOMS) to help with hormonal and menstrual issues from copper toxicity (a major cause of women's issues):
FOR ALL OF THE BELOW: Watch my livestream about copper binders first!
https://youtube.com/live/T33iqL81j8g (https://youtube.com/live/T33iqL81j8g)
Citric acid aka Citrate - Citric acid has been shown to bind to copper. Mineral citrates like magnesium citrate and potassium citrate provide citric acid while also giving you minerals! It also helps to decalcify soft tissues and reduce/prevent kidney stones.
Tartaric acid / potassium bitartrate / cream of tartar (https://linktr.ee/nutritiondetective) - Tartaric acid has been shown to bind copper and help with an animal model of PCOS. Max of 1 tsp a day!
Folinic acid as calcium folinate. 400mcg a day is the normal dose, 800mcg per day is the max dose.
L-theanine (https://linktr.ee/nutritiondetective) - SunTheanine is one patented product, however, any L-theanine works fine. L-theanine binds to copper and makes it less toxic in the body. You can experiment with up to 1200 mg/day. Copper toxicity symptoms it might help with: anxiety, low stress tolerance, falling asleep, poor sleep quality, brain fog.
Vitamin K2 as MK-4. We use the MK-4 and K1 forms to potentially help with heavy menstrual bleeding. We don't use the MK-7 form any longer, as Kelsey Kenney educated me on how it is a p-glycoprotein inhibitor and slows cellular detox. Studies for atherosclerosis have gone as high as 60mg (60,000mcg) per day. I have people do "normal" dosing around 3-5mg per day, higher dosing is around 10mg per day, and you have the option to experiment with up to 60mg a day. Symptoms it might help with: heavy menstrual bleeding, bleeding gums, easy bruising, bleeding takes a long time to stop, sensitive teeth, osteopenia/osteoporosis.
Inositol (https://linktr.ee/nutritiondetective) - Inositol binds to copper and makes it less toxic in the body. Some people really don't tolerate it, so be aware of that and start slow!
Melatonin (https://linktr.ee/nutritiondetective) - Melatonin binds to copper and makes it less toxic in the body. Max daily dose of 3mg (much less can work, start slow!). I do not suggest MEGAdosing it, like the 20-60 mg/day crazy doses that some out there are recommending.
Megadosing vitamin C to shut down detox (WATCH VIDEO!), using non-GMO ascorbic acid (need to buffer this!) or sodium ascorbate (https://linktr.ee/nutritiondetective).
Hopefully you find something in here that helps your situation. Remember, the long-term goal is consistent DETOX and restoring NUTRITION!
SECTION HEADER PAGE: Foundational Information About Cholestasis, LIVER INJURY, And Bile
[Section intro page - contains links to the 3 lessons below]
What is cholestasis?
Chole- = related to bile
-stasis = stagnation (state of not flowing or moving)
Cholestasis is the unhealthy state of bile not moving forward properly in the bile ducts, and WORSE, going backwards or infiltrating into places it is NOT SUPPOSED TO BE.
Why do we care about cholestasis?
Because the root cause of nearly all modern chronic disease can be found within this cholestasis model. You may not believe me yet, and that's OK.
If you don't yet know who figured out the "VA toxicity AND/OR OTHER THINGS lead to --> CHOLESTASIS leads to --> bile in the blood (that contains VA and other nasties) and in other places IT DOESN'T BELONG leads to --> CHRONIC DISEASE that can show up ANYWHERE in the body that the toxic bile is touching over and over" model first, then you should look at Anthony Mawson's papers (https://pubmed.ncbi.nlm.nih.gov/?term=Mawson+AR%5BAuthor%5D&sort=date) (I have linked them all below and simplified their subjects for you) demonstrating the connections between the following diseases and VA toxicity + cholestasis...I have placed them in the order that he published them, most recent first:
COVID-19 (https://pubmed.ncbi.nlm.nih.gov/33983857/)
Vaccine-induced disease (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/33198395/)
Rubella, autism, and vaccines (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31546693/)
Gulf War Syndrome / Illness (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30609834/)
Onchocerciasis, aka "river blindness" [paper #2] (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/29317828/)
Malaria, Epstein-Barr Virus (EBV), and Burkitt's Lymphoma [paper #2 on malaria] (https://doi.org/10.1002/ijc.30885)
Malaria, Epstein-Barr Virus (EBV), and Burkitt's Lymphoma [response] (https://doi.org/10.1002/ijc.31122)
Preterm birth and poor birth outcomes (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27595011/)
Zika virus and related birth defects (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/27403405/)
Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25579087/)
Dengue fever (https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(13)00393-9)
Postpartum depression (https://pubmed.ncbi.nlm.nih.gov/23816449/)
Malaria [paper #1] (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23683366/)
Influenza, aka "the flu" (https://www.hindawi.com/journals/isrn/2013/246737/)
Glioma (brain tumor/cancer) (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22904645/)
Childhood learning disorders, hyperactivity (ADD / ADHD), and aggression (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762766/)
Low resting heart rate (bradycardia) and aggressive behavior (https://pubmed.ncbi.nlm.nih.gov/19063930/)
Bone pain, growth failure (slow/retarded growth), skin rash, asthma, autism in a child (https://pubmed.ncbi.nlm.nih.gov/18566348/)
Onchocerciasis, aka "river blindness" [paper #1] (https://pubmed.ncbi.nlm.nih.gov/12474485/)
Hepatitis B-induced liver damage (https://pubmed.ncbi.nlm.nih.gov/11520938/)
Asthma (https://www.imrpress.com/journal/FBL/6/3/10.2741/mawson)
Primary Biliary Cirrhosis (PBC) (https://pubmed.ncbi.nlm.nih.gov/10968936/), which is cholestasis by definition
Gout [paper #2] (https://pubmed.ncbi.nlm.nih.gov/2068576/)
Systemic Lupus Erythematosus (SLE) and kidney/renal disease (https://pubmed.ncbi.nlm.nih.gov/3854166/)
Gout [paper #1] (https://pubmed.ncbi.nlm.nih.gov/6144903/)
Nearly every body system is represented above, and the last paper (the first one he did, from what I can find) was written in 1984 (!!!).
Modern medicine has basically NO explanation for where chronic diseases come from. This cholestasis model easily explains everything, and many times, there is research connecting cholestasis (which can have many different names in the literature) directly to specific diseases.
Who has cholestasis?
Pretty much anyone and everyone with chronic health problems (aka chronic disease) has some degree of cholestasis. If you are here trying to get better, then you have some amount of cholestasis and this is what we are trying to focus on and fix. If you have VA toxicity, then it is the VA toxicity that caused your cholestasis, and we are trying to fix your VA toxicity and the cholestasis, because they are completely intertwined.
If your health problems showed up after a vaccine, then the vaccine started (or worsened) your cholestasis.
If your health problems showed up after a fad diet, then that fad diet started (or worsened) your cholestasis.
If your health problems showed up after taking birth control (or ANY OTHER MEDICATION or even a supplement!), then the birth control started (or worsened) your cholestasis.
If your mother was already very cholestatic when she was pregnant with you, AND/OR you had jaundice when you were born or soon after, THEN YOU HAVE HAD SOME AMOUNT OF CHOLESTASIS YOUR ENTIRE LIFE. Yes, you can be BORN with this problem, and yes, sadly, you may have given it to your children. The way to fix it is to accept what is done is done, and move on.
For a person to PROPERLY RECOVER from any type of ADDICTION (think alcohol, drugs, caffeine, even sugar)...they must FIRST admit they have the PROBLEM.
I'm telling you that if you are here, you have some amount of cholestasis aka LIVER INJURY. Your job is to accept that, internalize it, and now start thinking of your liver as an INJURED BODY PART that we are trying to REHABILITATE back to proper FUNCTION.
As we restore your liver's proper function and the BILE goes where it is supposed to--which is to go from:
Your liver to
Your bile ducts to
Your small intestine to
Your large intestine to
YOUR POOP (this is where it LEAVES YOU FOR GOOD!!!)
OR, if you do not poop it out, the bile is re-absorbed by the intestines and goes to the portal vein, straight to the liver, to be filtered out AGAIN, "recycled" and turned into more bile AGAIN, only to RESTART THE WHOLE PROCESS. This is called enterohepatic CIRCULAtion (gut-to-liver-to-gut in a CIRCULAr process).
Cholestasis means that TOXIC BILE has ESCAPED this closed loop and is wandering around your body, DAMAGING (to some extent) EVERYTHING IT TOUCHES.
How does cholestasis cause health problems?
Follow me here.
Bile is, by definition, the MOST TOXIC FLUID IN YOUR ENTIRE BODY. So, whenever you think of “toxicity” like the hippy health people talk about on the interwebz, realize that all of that toxicity is getting CONCENTRATED IN YOUR BILE. That’s how your body wants to get rid of it first. Talking about “the liver”, “toxicity”, and maybe giving minor lip service to “the bile”--without ever even mentioning cholestasis--is what everyone is doing, and that is why THEY AREN’T GETTING ANYWHERE IN TERMS OF FIXING THE LIVER!!!
This toxic bile soup basically damages EVERYTHING IT TOUCHES, and our body is constantly repairing that damage (some damage is normal, too much damage and the body can’t keep up with the repairs). It damages the liver's bile-producing cells themselves. It damages the bile ducts. It damages the epithelial cells, which includes your skin and your gut lining (think “leaky gut”). IF BILE GETS INTO YOUR BLOOD (aka cholestasis!), THEN IT DAMAGES EVERYTHING IT TOUCHES, AND THE BLOOD GOES ***EVERYWHERE*** IN YOUR BODY.
Are you fully grasping the importance of this yet? Do you see how modern medicine won’t ever be able to solve any health problems until 1) they realize that BILE IN THE BLOOD is the root of all these problems, and 2) they admit that their POISON MEDICATIONS, VACCINES, AND CHEMICALS ARE THE ***BIGGEST CONTRIBUTORS*** TO THIS PROBLEM CALLED CHOLESTASIS AKA LIVER INJURY?!?! On that note, please take some time to scroll through this studies in this Pubmed search for "Drug-Induced Liver Injury" (https://pubmed.ncbi.nlm.nih.gov/?term=drug-induced+liver+injury%5BTitle%2FAbstract%5D). Your medication history, EVERY SINGLE ONE, plays a role in how you got here.
What is in this toxic bile?
The bile contains:
Bile acids (nasty enough), different bile acid patterns/profiles have been noted in many different disease states
Vitamin A in any/all of its toxic forms
Toxic copper
Toxic iron
Any/all other toxic metals
Potentially any other fat-soluble toxin you’ve ever stored in your liver!!!
Other nasty things, I think you get the point.
How exactly does my cholestasis problem show up as different from other people's cholestasis problem?
Bile getting into your bloodstream will then cause YOU your unique disease symptoms based on these factors:
The actual toxins present in YOUR bile (includes medications and vaccines)
The weak or weakened links in your body (physical injuries, mental/emotional traumas, etc.)
Nutrient (mostly mineral) deficiencies present
Your gut biome situation
Your specific bile acid pattern/profile
Genetics
Where does the cholestasis happen, ie. how does the bile get into the blood?
Bile leaks into the bloodstream (or other places it isn't supposed to be) from one of three main places:
Through the liver itself or from the bile ducts INSIDE the liver, this is called INTRAhepatic cholestasis.
Through the bile ducts OUTSIDE the liver, this is called EXTRAhepatic cholestasis.
Through "increased intestinal permeability" aka LEAKY GUT, where the bile leaks out of the gut to the systemic bloodstream, instead of the re-absorbed bile going straight back to the liver like it is supposed to.
I (https://doi.org/10.1002/ijc.30885)t is the action of the toxic bile on the liver cells, the bile ducts (big and small), and on your gut lining that actually cause the damage and eventual leaking into places it isn't supposed to be. Remember, the form of VA known as all-trans retinoic acid (ATRA) is used as a CHEMICAL PEEL to MELT PEOPLE'S FACE SKIN OFF!!! That's just ONE of the nasty things in your bile! If it can "chemically peel" your face, what do you think it does to your INSIDES???
If thinking about bile ***ACIDS*** causing damage to the very pipes they run through, damaging those pipes and then leaking out helps you visualize it, then go with that (it's pretty much what is happening). If too much bile backpressure develops, the bile ducts can also burst, just like a water pipe in your house.
The main takeaway will always be that toxic bile is getting into places it is NOT supposed to be. Our job is to fix the problem.
How is Vitamin A toxicity related to cholestasis?
Vitamin A causes cholestasis, and Vitamin A is stored in the liver, which means it will continue to cause cholestasis until it is out of the liver. See Anthony Mawson’s papers that I linked above for more on this topic.
In general, nearly all the things that we try to reduce / minimize / avoid on this program are related to causing or worsening cholestasis. This includes vaccines, pharmaceutical drugs, excessive fats, excessive fructose, glyphosate, pesticides, many chemicals, etc. etc. etc. The full list will be covered later in the program.
When does this cholestasis problem start?
It can start in utero (in the uterus, before birth), as I mentioned above.
Jaundice is happening to “about 60 percent of newborns (https://www.ucsf.edu/news/2006/05/97848/study-shows-newborns-jaundice-no-greater-risk-developmental-problems).” Jaundice is, by definition, excess bilirubin (BILE-irubin) in the blood, that’s cholestasis! It is now said that “normal pregnancy is associated with mild sub-clinical cholestasis. (https://pubmed.ncbi.nlm.nih.gov/6872255/)” Morning sickness is cholestasis. “Acid” reflux (think bile acids) is cholestasis. Leaky gut is cholestasis. See below for the World Gastroenterology Association’s statement on diseases and cholestasis.
Think back to when your health problems became noticeable. That is when your cholestasis really got rolling...but it might have been present before that too, just not very noticeable. For some of you who have been “unwell” your entire life, then it probably started in utero. Again, yes, this can be passed down to our kids.
How can we be sure I have cholestasis?
There are lab tests and symptoms that can make cholestasis quite obvious. The main and most telling one is serum bile acids, and it has now been added to my standard blood testing. I will get to that in a future article. That is referred to as CLINICAL cholestasis (outright, obvious, shows up via lab tests and/or imaging and/or specific symptoms). However…
Most people today are dealing with SUBCLINICAL cholestasis. A problem that is enough to cause them chronic health issues, YET is not enough to show up in “common” lab tests and/or imaging and/or very specific symptoms.
To show you just HOW BAD modern medicine is at finding liver disease, did you know they use a term called “silent liver disease” for fatty liver disease? Some examples found in a Pubmed search for “silent liver disease”:
Silent non-alcoholic fatty liver disease-a clinical-histological study (https://pubmed.ncbi.nlm.nih.gov/15519647/)
Silent liver diseases in autopsies from forensic medicine of Tehran (https://pubmed.ncbi.nlm.nih.gov/17061603/)
Nonalcoholic Fatty Liver Disease: A Silent Epidemic. (https://pubmed.ncbi.nlm.nih.gov/31574071/)
[Nonalcoholic hepatic steatosis: a silent disease]. (https://pubmed.ncbi.nlm.nih.gov/30889343/)
Fatty liver disease: putting the spotlight on a silent menace for young adults. (https://pubmed.ncbi.nlm.nih.gov/31954686/)
Women and alcoholic liver disease - warning of a silent danger. (https://pubmed.ncbi.nlm.nih.gov/29443115/)
Association between non-alcoholic fatty liver disease and silent carotid plaque in Chinese aged population: a cross-sectional study (https://apm.amegroups.com/article/view/37262/29269)
Epstein-Barr virus: silent companion or causative agent of chronic liver disease? (https://pubmed.ncbi.nlm.nih.gov/20806428/)
Obesity and Pediatric Fatty Liver: The Silent Epidemic and Significant Health Problem (https://pubmed.ncbi.nlm.nih.gov/33030457/)
Clinical predictors of silent but substantial liver fibrosis in primary Sjogren's syndrome (https://pubmed.ncbi.nlm.nih.gov/26587876/)
So, something happened in my searches above for the terms “silent liver disease” that helps prove my point...which is that nearly all modern chronic disease is linked to cholestasis (cholestasis, aka bile in the blood, is the result of nearly any/all liver disease). Note that in the last 5 studies, silent liver disease (mostly fatty liver, which is late-stage cholestasis) was linked to:
Alcohol consumption
Carotid plaque, aka cardiovascular disease, aka what most people call “heart disease”
Epstein-Barr virus, said to be a potential cause of “chronic fatigue syndrome”
Pediatric obesity, aka our epidemic of overly fat children
Sjogren’s syndrome, an autoimmune condition
Are you seeing it yet? ALL DISEASE STARTS IN THE LIVER, AND IT IS VIA THE BILE IN THE BLOOD IS HOW THE DISEASE IS TRANSMITTED TO ANY/ALL PARTS OF THE BODY. This is a more solid global theoretical mechanism of chronic disease than ANYTHING that conventional or alternative medicine has ever put forth, in my humble opinion.
The definition of “subclinical” is relating to a disease which is not detectable by the usual clinical tests, and/or isn’t severe enough to present the “typical” definitive symptoms of that condition. This means that you can absolutely have a problem with it, yet your doctor CANNOT FIND ANY “EVIDENCE” OF IT. Read that last part again if you’re going to go ask your normal doctor, “Doc, do I have cholestasis?” They will likely say NO without even thinking twice about it, and they’ll be wrong (isn’t that to be expected at this point though?).
No, really. READ THE ABOVE PARAGRAPH AGAIN. Please don't come to me and say "but my normal doctor says I DON'T have cholestasis". If you are not feeling as well as you should, then I'm saying you have some degree of cholestasis that YOUR DOCTOR PROBABLY COULDN'T EVEN FIND IF HE/SHE TRIED THEIR HARDEST. They usually don't ever try that hard though...do they?
What about other liver diseases? I’m going to tell you before you read the below excerpt that EVERY LIVER DISEASE IS RELATED TO CHOLESTASIS IN SOME WAY, and they’re basically going to agree with me at the end. Fatty liver is late-stage cholestasis. Cirrhosis is late-late-stage cholestasis. With that noted, check this out:
World Gastroenterology Association - Global Burden Of Liver Disease: A True Burden on Health Sciences and Economies!! (https://web.archive.org/web/20230306052600/https://www.worldgastroenterology.org/publications/e-wgn/e-wgn-expert-point-of-view-articles-collection/global-burden-of-liver-disease-a-true-burden-on-health-sciences-and-economies)
“Chronic liver disease occurs throughout the world irrespective of age, sex, region or race. Cirrhosis is an end result of a variety of liver diseases characterized by fibrosis and architectural distortion of the liver with the formation of regenerative nodules and can have varied clinical manifestations and complications. According to WHO, about 46% of global diseases and 59% of the mortality is because of chronic diseases and almost 35 million people in the world die of chronic diseases 1. Liver disease rates are steadily increasing over the years. According to National statistics in the UK, liver diseases have been ranked as the fifth most common cause of death 2. Liver diseases are recognized as the second leading cause of mortality amongst all digestive diseases in the US 3.
Global prevalence of cirrhosis from autopsy studies ranges from 4.5% to 9.5% of the general population 5, 6, 7. [...] Prevalence of cirrhosis is likely to be underestimated as almost a third of the patients remain asymptomatic. [...] During 2001, the estimated worldwide mortality from cirrhosis was 771,000 people, ranking 14th and 10th as the leading cause of death in the world and in developed countries, respectively 8. Deaths from cirrhosis have been estimated to increase and would make it as the 12th leading cause of death in 2020 9.
Cirrhosis is well recognized and the main cause of HCC, which has an annual global incidence of over half a million, and a 5 year survival of 10%. The incidence of this cancer has been steadily rising at an alarming rate, making HCC the 5th most common cancer in men and the 7th most common cancer in women in recent estimates.
Globally, cardiovascular disease, diabetes and stroke have always stolen the limelight in chronic disease burden. ***The fact is that most of these conditions start with fatty liver*** [!!!] and obesity.”
They gave the whole game away in that last line. CHRONIC DISEASES START AS UNDETECTABLE CHOLESTASIS PROBLEMS (fatty liver is one way to say it, and is how they find it once they’re able to!). As we fix the CHOLESTATIC LIVER problem, your health issues will go away, trust me.
https://rumble.com/v27zm4c-cholestasis-original.html (https://rumble.com/v27zm4c-cholestasis-original.html)
Micronutrients in Liver Disease: Roles, Risk Factors for Deficiency, and Recommendations for Supplementation
https://aspenjournals.onlinelibrary.wiley.com/doi/10.1002/ncp.10451 (https://aspenjournals.onlinelibrary.wiley.com/doi/10.1002/ncp.10451)
Micronutrients in Liver Disease Roles Risk Factors for Deficiency and Recommendations for Supplementation.pdf (https://media2-production.mightynetworks.com/asset/27286586/Micronutrients_in_Liver_Disease_Roles_Risk_Factors_for_Deficiency_and_Recommendations_for_Supplementation.pdf)
Abstract:
Micronutrients are essential components of the diet and are required to maintain fundamental bodily functions. Liver disease has a profound effect on nutrient intake, metabolism of nutrients, and nutrition status, often resulting in some degree of malnutrition, including micronutrient deficiency. Vitamin and mineral deficiencies can impair metabolic processes at the cellular and biochemical level even before clinical and physical alterations are seen. It is essential that micronutrient status is evaluated as part of a comprehensive nutrition assessment for all patients with chronic or advanced liver disease. Early intervention to correct suspected or confirmed deficiencies may minimize symptoms and improve clinical outcomes and quality of life. In this narrative review, different types of liver disease and associated micronutrient abnormalities are outlined, and methods of micronutrient assessment and supplementation are discussed.
Conclusion:
Because the severity of liver disease correlates with the severity of micronutrient disturbances, it is especially important to evaluate for micronutrient deficiencies in those with advanced liver disease. Failure to do so poses a considerable risk to nutrition status. Timely identification and supplementation to correct micronutrient deficiency may attenuate the progression of liver disease and associated complications. Excessive, prolonged, or unmonitored supplementation of certain minerals or fat-soluble vitamins, however, may result in toxicity. More research and additional case reporting are needed to identify optimal dosing for suspected or confirmed micronutrient deficiencies in patients with advanced liver disease, but treatment is simple, cost-effective, and high yield.
I don't know much more to say on this one.
These are "big picture" things that you want to understand, so that you can use them in your own personal situations as they arise
https://rumble.com/v273lhc-approaches-for-adding-increasing-new-supplements-or-foods.html (https://rumble.com/v273lhc-approaches-for-adding-increasing-new-supplements-or-foods.html)
This may be one of the most helpful things you learn here!
https://rumble.com/v273nji-hydration-basics.html (https://rumble.com/v273nji-hydration-basics.html)
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Once one understands the systemic implications of cholestasis, AND one notices the YELLOWED SKIN side effect listed below, it is quite obvious that Rhogam causes liver injury.
Get emergency medical help if you have any of these signs of an allergic reaction: rash or hives; feeling light-headed, chest tightness, difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fever, chills, shaking, back pain, unusual weakness, red or pink urine;
pale or ***yellowed skin***, dark colored urine;
rapid breathing, rapid heart rate, confusion, feeling short of breath;
signs of kidney failure--little or no urinating, swelling, rapid weight gain; or
signs of a blood clot--sudden numbness or weakness, slurred speech, problems with vision or balance, chest pain, coughing up blood, swelling with redness and warmth in one or both legs.
Common side effects may include:
nausea, diarrhea, vomiting, stomach pain;
headache, dizziness;
drowsiness, weakness, general ill feeling;
joint or muscle pain;
flushing (warmth, redness, or tingly feeling);
mild itching or skin rash;
increased sweating; or
pain or tenderness where the medicine was injected.
This is the easiest one, so I'm starting here. Don't overthink this.
I go into a lot more details about these types in the videos in my hair & blood testing seminar and the Inner Circle and Advanced Detox program video Q&As, so if you want more info than what is here, go to those places.
I'm going to keep this very simple. Simple to self-diagnose, simple for you to address.
Simplified (TL;DR version):
OVERweight --> Reduce your dietary fat intake as much as practical.
UNDERweight --> You will need relatively more fat intake than the OVER types. You are trying to figure out the "lowest" fat intake that keeps your symptoms from worsening and also keeps you from losing weight. To put it another way: You are NOT trying to minimize your fat intake...yet, you are trying to figure out the MINIMUM amount of fat that you need to MINIMIZE SYMPTOMS while PREVENTING UNNECESSARY and UNDESIRABLE WEIGHT LOSS.
More Details:
***OVER types. If you are overweight already, or you are "normal" weight with a tendency to GAIN weight, then this is your type. Your body is good at making bodyfat and liver fat to store TOXIC BILE in, this helps to take the toxic bile OUT of your BLOODSTREAM, generally resulting in LESS SYMPTOMS but MORE STORAGE of toxic bile in that fat. You are to reduce your fat intake as much as you are able. If you are eating muscle meats, there is no concern about any "fat deficiency". This is, in my estimate, 95% of modern people (notice the obesity numbers these days?).
***UNDER types. If you are underweight, or you are "normal" weight with a tendency to LOSE weight, then this is your type. Your body is NOT good at making bodyfat and liver fat to store TOXIC BILE in, so this toxic bile tends to stay floating around IN your BLOODSTREAM, generally resulting in MORE SYMPTOMS and MORE LIVER DAMAGE, but LESS STORAGE of toxic bile. You are NOT to reduce your fat intake as much...you are to figure out what amount of fat you do best on, which will be noticeably more than the OVER type...this is NOT a free ticket to gorge on fat though! This is mainly to keep your "detox" from going TOO FAST and making you feel overly bad. The extra dietary fat is likely acting similar to the bodyfat that OVER types are able to make so easily, that you are not. I'm going to suggest you do not fight this...UNDERs who ignore this or think they know better, and don't eat enough fat will SUFFER GREATLY through this process, and LOSE TOO MUCH WEIGHT. This is, in my estimate, only about 5% of modern people.
General fat intake tips for the different types:
OVERs:
Reduce or eliminate ADDING fats/oils to things. This is the EASIEST and MOST IMPORTANT thing!
If you can add LESS fats/oils to things, do it.
If you don't have to add fats/oils to things, then don't.
If it naturally contains some fat as a WHOLE FOOD, then don't worry about it too much. That said, if you can somehow reduce the fat in that whole food, then do so.
Rinsing browned ground beef in a strainer (and then also rinsing the browning pan or Instant Pot you cooked it in) if you are putting the beef back in it later will SIGNIFICANTLY reduce the amount of fat in the finished ground beef. Shake the excess water out of the ground beef while it is in the strainer, before proceeding with your recipe. You and your family will likely not notice a difference, and may even appreciate the "less greasy" version better.
If you can pick a lower-fat whole food version of something (that isn't a lab-created FrankenFood), then do so.
Pick lower fat cuts of meat. FYI, the lower the fat is in a cut of steak, the greater the zinc content (that's a good thing) and generally the lower the fat-soluble toxin content (including VA).
Don't eat the skin on poultry (this means chicken for most).
Just stop it with the dairy already. Milk is provided to babies by their mothers to give them what they need in the fastest-growing periods of their life. If you are an adult, and you are done growing UP, what is the only other way you can grow? OUT. Dairy is designed for tissue GROWTH. The calcium, Vitamin A, and Vitamin D that you were sold on as being "good for you" was a plot by the Rockefellers (huge in the dairy industry and dairy "science", look it up!) to help you die early. JUST STOP IT.
UNDERs:
CONCEPT (again, for those in the back): You are NOT trying to minimize your fat intake...yet, you are trying to figure out the MINIMUM amount of fat that you need to MINIMIZE SYMPTOMS while PREVENTING UNNECESSARY and UNDESIRABLE WEIGHT LOSS.
Not enough fat intake = feeling bad and losing weight
Too much fat = putting the toxic bile you're trying to excrete RIGHT BACK INTO THE SYSTEM/CIRCULATION (dietary fat increases bile re-absorption and vice-versa)
You are trying to find a happy medium between the two!
No, I don't have a general grams amount of fats you should consume. You have to figure it out for yourself. Going by your symptoms and your scale weight will be your best guide. If you are having real trouble with this, you could schedule a consult with me through Julie at admin@nutritionrestored.com (https://members.nutritiondetective.commailto:admin@nutritionrestored.com) .
Whole food fats will be much preferred versus oils.
If you're going to be eating higher animal fat products to do this, then you want to do your best to make sure that the red meat is grassfed, and the poultry is NOT being fed SOY. The massive phytoestrogen content of a soy diet does affect the meat, and will affect YOU. "You aren't just what you eat, you are what you eat, ATE."
UNDERs often have copper toxicity problems deep in their liver...so be very wary of how you feel if you add too many nuts/seeds to your diet for more fat (they are very high in copper). Most higher-fat plant foods are generally quite high in copper, so getting your extra fat from muscle meat sources may be your best bet.
If you're going to add oils at all, use ones that are organic and naturally refined (NOT chemically refined).
If you're going to use butter or ghee, make sure it is from grassfed cows. I have decided that it is better to avoid the estrogenic soy fed to organic dairy cows (if one is going to eat it), even if it means more VA in the butter from grassfed (NO SOY) dairy cows.
This section will cover breathing and breathwork, which can help detox aldehydes through the breath, along with improving oxygenation and carbon dioxide exchange.
Use this link if the embedded video isn't working:
https://www.youtube.com/live/R2FWt1G0bq4 (https://www.youtube.com/live/R2FWt1G0bq4)
*Added June 27, 2023*
Link to Rome Za (https://members.nutritiondetective.com/members/9327864)'s ---> BREAKTHROUGH BREATHWORK Protocol (https://highperformanceprotocols.com/breakthrough-breathwork-online-course?am_id=garret3230)
Breathing. You do it approximately 20,000 times per day.
Every time you breathe out, you are expelling alcohols, aldehydes, and other gaseous toxins from your lungs.
This means that the BETTER you breathe--not necessarily "more" or "faster breathing" but BETTER breathing--the more alcohols & aldehydes and other gaseous toxins you will expel through the breath ALL DAY LONG...and as long as you don't get overly aggressive with the breathwork, this should NOT have any "detox" symptoms with it!
Sounds pretty cool, right?
The science geeks (of which I am proud to be one) are asking for the references now, right?
From the paper Accelerated ethanol elimination via the lungs (https://www.nature.com/articles/s41598-020-76233-9):
We hypothesized that isocapnic hyperpnea (IH), previously shown to be effective in acceleration of clearance of vapour anesthetics and carbon monoxide, would also accelerate the clearance of ethanol. In this proof-of-concept pilot study, five healthy male subjects were brought to a mildly elevated blood ethanol concentration (~ 0.1%) and ethanol clearance monitored during normal ventilation and IH on different days. IH increased elimination rate of ethanol in proportion to blood levels, increasing the elimination rate more than three-fold. Increased veno-arterial ethanol concentration differences during IH verified the efficacy of ethanol clearance via the lung. These data indicate that IH is a nonpharmacologic means to accelerate the elimination of ethanol by superimposing first order elimination kinetics on underlying zero order liver metabolism.
Now that's pretty technical talk, even for me. Here's an article about that study with a simpler explanation A potential game-changer to reverse alcohol intoxication (https://www.sciencedaily.com/releases/2020/11/201112080913.htm)
Normally, 90% of the alcohol in the human body is cleared exclusively by the liver at constant rate that can't be increased. Currently there is no other method, short of dialysis, whereby alcohol can be removed from the blood.
The principle behind UHN team's approach is simply to recruit the lungs to breathe out the alcohol. The harder the breathing, it was reasoned, the more alcohol is eliminated. The team found that indeed, hyperventilation eliminated the alcohol at least three times faster than through the liver alone.
"But you can't just hyperventilate, because in a minute or two you would become light-headed and pass out," explains Dr. Fisher, anesthesiologist and senior scientist at the Toronto General Hospital Research Institute (TGHRI).
When hyperventilating -- breathing deeper and more rapidly than normal -- the body eliminates carbon dioxide from the blood along with the alcohol. The decrease of this gas in the blood is the cause of symptoms such as light-headedness, tingling or numbness on hands and feet, and fainting.
Dr. Fisher and his team used a device that allows the patient to hyperventilate off the alcohol while returning precisely the amount of carbon dioxide to the body to keep it at normal levels in the blood -- regardless of the extent of hyperventilation.
We know that:
EthanOL ("alcohol") and retinOL (vA) are alcohols
AcetALDEHYDE and retinALDEHYDE are aldehydes
Slow aldehyde dehydrogenase (ALDH) causes aldehydes (retinaldehyde, acetaldehyde, formaldehyde, etc.) to build up in the system
In #toxicbiletheory (https://members.nutritiondetective.com/spaces/5495233/search?term=%23toxicbiletheory), slowed ALDH also goes with decreased bile production AND more cholestasis aka toxic bile leakage
If you are building up ALDEHYDES in your system, they WILL cause you symptoms and they WILL try to escape another way
This escape route is through the lungs and breath
So with that overflow escape route established, this will end up in one of two situations, which I'll show you below.
Aldehydes WILL come out your lungs...our goal is to reduce the amount of aldehydes coming IN overall, while the breathing/breathwork will help the aldehydes escape better & faster ALL DAY LONG.
Slow ALDH + too many aldehydes coming in (diet, crappy air quality, herbs/spices, essential oils, etc.) + crappy breathing EQUALS way too many aldehydes coming out of the lungs and results in LUNG DISEASES from the aldehydes damaging the lung tissue ("a poison on the way in, is a poison on the way out"):
Exhaled Aldehydes as Biomarkers for Lung Diseases: A Narrative Review (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/36014494/)
Straight-chain aliphatic aldehydes were repeatedly detected in the breath of patients suffering from lung diseases using a variety of methods, such as mass spectrometry, ion mobility spectrometry, or electro-chemical sensors. Several studies found increased concentrations of exhaled aldehydes in patients suffering from lung cancer, inflammatory and infectious lung diseases, and mechanical lung injury.
Genetically slow ALDH2 results in more lung diseases AND more esophageal cancer (because of the increased aldehydes not having a good ALDH detox pathway AND they are overwhelming the lungs + probably crappy breathing on top of it all:
Effects of the common polymorphism in the human aldehyde dehydrogenase 2 (ALDH2) gene on the lung (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28431562/)
ALDH2 polymorphism has several subtle effects on the lungs, some of which are similar to changes observed during normal aging, suggesting a "premature lung aging" effect.
Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma (https://www.researchgate.net/publication/349833576_Endogenous_aldehyde_accumulation_generates_genotoxicity_and_exhaled_biomarkers_in_esophageal_adenocarcinoma)
Thus, we present a model for increased exhaled aldehydes based on endogenous [made within the body] accumulation from reduced detoxification, which also causes therapeutically actionable genotoxicity.
What can we do to fix this issue? WE CAN LEARN HOW TO BREATHE BETTER!!!
Less toxins IN + more toxins OUT + correcting nutrient deficiencies (think oxygen and carbon dioxide here) = BETTER HEALTH
Sounds like a familiar approach, right?
I learned the basic level of breathwork teachings (https://highperformanceprotocols.com/breakthrough-breathwork-online-course?am_id=garret3230) from Rome Za (https://members.nutritiondetective.com/members/9327864) himself (I now consider him a great friend and peer) and I practice it regularly, usually in the mornings after my self-hypnosis and/or meditation tracks, or before my workout(s).
I absolutely feel that my breathing capacity has increased since working on this.
I feel like any detox-dumps resolve more quickly, and...
I'm not gonna lie--we humans are vain creatures after all--my abzzz are looking better than they ever have (Rome Za (https://members.nutritiondetective.com/members/9327864) says his breathwork can replace abdominal exercises, and I'm going to say I believe him based on my experience!)
So that's my take on the breathing/breathwork part of this detox equation. The next article in this series will be from the man Rome Za (https://members.nutritiondetective.com/members/9327864) himself!
*Added June 27, 2023*
BREAKTHROUGH BREATHWORK Protocol (https://highperformanceprotocols.com/breakthrough-breathwork-online-course?am_id=garret3230) by Rome Za (https://members.nutritiondetective.com/members/9327864) (his email is at the bottom of this article if you have questions for him)
"During my time doing survival training, the wilderness guides would refer to the rule of 3…
(of course this is an approximation)
“We can live without food for about 3 weeks… We can live without water for 3 days… We can live without air for 3 minutes…”
We can argue about the details but this ‘rule of 3’ is not far off from the biological truth…
We all know that our breath is necessary for survival…
But what the majority of people in our modern day culture don’t know is that the optimization of our breath is necessary to thrive as well!
The breath is crucial for our wellness and performance as well..
When water flows it is healthy…
When water stagnates it becomes a breeding ground for bacteria, fungi, and all types of biofilm…
The same for our breath…
When our breath flows correctly we are detoxing, energizing, and relaxing our entire biological system…
When our breath stagnates due to poor biomechanics (most people)...
Stress, dis-ease, and toxins accumulate inside of us.
In the last decade I have worked with thousands of people from high performing athletes, special forces operators and entrepreneurs all the way across the spectrum to farmers, grandmas, and kids…
What I have found is that even if people practice some sort of breathwork (very rare) they are practicing it with poor mechanics which is probably doing more harm than good long term…
Proper biomechanics of breath is the META Level of breathing that will improve your entire life…
It’s not about the 15 minutes of breathwork that you do…
It’s about re-patterning your breathing mechanics so that you are breathing like a pro 24 hours a day…
Awake or asleep…
The average person takes approximately 22,000 breaths a day…
Ideally those breaths are bio-mechanically correct..
Think about it …
When your breathing mechanics are dysfunctional you tend to operate in a primarily sympathetic state which leads to symptoms you might be familiar with…
High stress
Neck and shoulder pain and stiffness
Lower back pain and stiffness
Digestive issues
Brain fog
Lowered immunity
Sleep problems
Anxiety/depression
Low energy
Low libido
Uncontrollable cravings
And so much more...
For years I have studied the breath..
From the physical practices to the mystical and esoteric..
I have studied with countless Gurus, scientists, Grandmasters and teachers all over the world…
As well as seeing thousands of students…
And to meet someone who has functional breathing is one of the rarest gems in the world…
Luckily for you…
I have been able to distill the last 15 years of my work into easy to follow systems and exercises…
And it only takes 7 minutes a day… ---> BREAKTHROUGH BREATHWORK Protocol (https://highperformanceprotocols.com/breakthrough-breathwork-online-course?am_id=garret3230)
See you on the other side!"
Rome Za (https://members.nutritiondetective.com/members/9327864)
Email: breathe@romeza.com (https://members.nutritiondetective.commailto:breathe@romeza.com)
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I want to make this simple.
If you are someone who is EXTREMELY sensitive to EMFs, you may need to take more actions than what is detailed here. This may include, but isn't limited to: moving out of cities, living outdoors, avoiding/minimizing EMFs as much as possible, always maximizing distance between EMF sources and yourself, turning off electricity breakers, using shielding clothing & accessories, Earthing/grounding, etc. I'm sure there's a lot more I didn't mention. It also means that people who are that EMF-sensitive are VERY, VERY TOXIC. If this is you, then work on the toxicity and do what YOU need to do to feel better!
For the rest of us, the solutions I'm going to cover are so that we can continue to live & function within our modern lifestyles, because avoiding EMFs is simply not possible in the modern countries (now that StarLink is up, it's pretty unavoidable anywhere, sadly).
For those who previously heard me talk about the Vortex BioShield (https://amzn.to/3QbcHsc) company, I absolutely believe that what I have found now is far superior (this is based on having used both products).
Keep reading, and I hope you get as much relief as possible soon!
You can hear my explanation of how I believe EMFs and toxicities synergize in a bad way on many of my YouTube videos. I'm going to review it here.
I've been talking about this for years. Here's a podcast interview I did back in 2019 (paywalled, sorry): https://www.electricsense.com/healing-emf-sensitivity/ (https://www.electricsense.com/healing-emf-sensitivity/)
I am NOT going to get into major fearmongering or deep conspiracy theories about EMFs (don't think I can't, it's just NOT helpful).
EMF = Electro-Magnetic Fields or Electrical and Magnetic Fields
Definition of EMF: "Electric and magnetic fields (EMFs) are invisible areas of energy, often referred to as Radiation, that are associated with the use of electrical power and various forms of natural and man-made lighting."
Governments and industries don't want you to think man-made EMFs are bad. They are lying and gaslighting us, as usual. Here is a gaslighting info page from the NIEHS on the topic as an example: Electric & Magnetic Fields (https://www.niehs.nih.gov/health/topics/agents/emf/index.cfm)
Put simply...man-made EMFs are not good for us. Being toxic & good mineral deficient isn't good for us either.
Combine EMFs with toxicities & good mineral deficiencies = even worse health problems aka Electromagnetic HyperSensitivity (EHS).
The more toxic people are, particularly in copper, aluminum, iron, calcium, nickel, & cobalt, the more sensitive they will be to EMF. Here's how it works.
Copper accumulates in us. Copper is the most ELECTRICALLY CONDUCTIVE mineral we are exposed to in larger amounts (mg vs. mcg) and that we easily accumulate in our tissues/liver. Too much copper = we become too "electric" = messes us up.
Iron accumulates in us. Iron is the most MAGNETIC mineral we are exposed to in larger amounts (mg vs. mcg) and that we easily accumulate in our tissues/liver. Too much iron = we become too "magnetic" = messes us up.
Do you see how too much copper (electric/conductive) and/or iron (magnetic) would then set up our body's chemistry to become easily affected in a bad way by electro-magnetic fields? Hopefully you do!
Think of it this way. If twins were exposed to the same EMFs, but one twin was much more copper & iron toxic than the other, it makes sense that the more toxic one would have more health problems from the SAME EMF EXPOSURE.
I am a real life example of this. I used to be MUCH more copper and iron toxic than I am today. I used to be REALLY sensitive to EMFs. As I have detoxed over the years, I would now say I'm not "EMF sensitive" any longer! Yet...I still know that they aren't good for me and so I take actions to reduce their effects on me (more on that to come)
Expanding the minerals list a bit:
Copper & calcium & aluminum = electrical/conductive minerals that accumulate in us
Iron & nickel & cobalt = magnetic minerals that accumulate in us
We are MAINLY concerned with copper, iron, and calcium, as these are the minerals that EASILY accumulate in us in the highest amounts and take the longest to fix.
The other ones I mention--aluminum, nickel, cobalt--are concerns, yes...however, they are in much smaller amounts in the body and generally go down by doing things correctly in the Love Your Liver program.
Also, we are mainly concerned with the minerals that ACCUMULATE in us, not so much with the "electrolytes" (magnesium, potassium, sodium) that pass through us on a daily basis.
Here is what we have control over in regards to EMFs and their effects on us:
We CAN reduce or eliminate our copper, aluminum, iron, calcium, nickel, & cobalt toxicities
This is what we are doing through the LYL program
We CAN modulate aka modify the EMFs we are exposed to, so they are not as disruptive to our system
This is through the EMF Solutions products (learn more in the FAQ that follows)
We CAN reduce or even eliminate some of the EMFs we are exposed to (removing sources, turning things off, using blocking approaches)
I cover a lot of this in the EMF chapter of my book: https://amzn.to/46wUPNG (https://amzn.to/46wUPNG) (my sections on EMF and exercise are still valid)
LessEMF.com (https://lessemf.com/?affid=56) has a lot of blocking doo-hickeys for sale
GetLambs.com (https://getlambs.com/?rfsn=3974543.58d4e) has clothing interwoven with silver, that blocks EMFs
Totally blocking EMFs means that your phone, Bluetooth, wifi, and anything else that is wireless WILL NOT WORK, which is not a practical solution for many in the modern-day world
Now, for the reality. Most of us live in cities or towns and don't plan on moving off-grid to a log cabin with no electricity or internet or cell phones. What we are after then, is figuring out how we can stay where we are and make things healthier for ourselves and our families!
This is not going to be an easy-to-follow article. I just don't know how to connect all these in a linear format. So, I'll be posting the links, quotes, and my thoughts on each one.
A published paper on the potential connection between 5G and coofid:
Evidence for a connection between coronavirus disease-19 and exposure to radiofrequency radiation from wireless communications including 5G (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580522/)
Coronavirus disease (COVID-19) public health policy has focused on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and its effects on human health while environmental factors have been largely ignored. In considering the epidemiological triad (agent-host-environment) applicable to all disease, we investigated a possible environmental factor in the COVID-19 pandemic: ambient radiofrequency radiation from wireless communication systems including microwaves and millimeter waves. SARS-CoV-2, the virus that caused the COVID-19 pandemic, surfaced in Wuhan, China shortly after the implementation of city-wide (fifth generation [5G] of wireless communications radiation [WCR]), and rapidly spread globally, initially demonstrating a statistical correlation to international communities with recently established 5G networks. In this study, we examined the peer-reviewed scientific literature on the detrimental bioeffects of WCR and identified several mechanisms by which WCR may have contributed to the COVID-19 pandemic as a toxic environmental cofactor. By crossing boundaries between the disciplines of biophysics and pathophysiology, we present evidence that WCR may: (1) cause morphologic changes in erythrocytes including echinocyte and rouleaux formation that can contribute to hypercoagulation; (2) impair microcirculation and reduce erythrocyte and hemoglobin levels exacerbating hypoxia; (3) amplify immune system dysfunction, including immunosuppression, autoimmunity, and hyperinflammation; (4) increase cellular oxidative stress and the production of free radicals resulting in vascular injury and organ damage; (5) increase intracellular Ca2+ essential for viral entry, replication, and release, in addition to promoting pro-inflammatory pathways; and (6) worsen heart arrhythmias and cardiac disorders.
Note that toxic bile would cause all the things above. Note that they are talking about Ca2+ (calcium)...this plays into voltage-gated calcium channels.
I absolutely believe the two are connected. I think the "trigger" for the massive, prolonged bile dump that is coofid was EMF, a self-poisoning from stored toxicity in the liver. I also noticed the early pattern that US coofid started in the same places they were first introducing 5G networks!
Registration of reactions occurring from the emergence of a virus by using an electromagnetic charge effect (https://www.researchgate.net/publication/347407160_Registration_of_Reactions_Occurring_From_the_Emergence_of_a_Virus_by_Using_an_Electromagnetic_Charge_Effect)
Even if you have no idea what the title means, I'm focusing HARD on the last half of that title.
This method makes it possible both to control the emergence of a virus and to study it.
Emergence = The act of rising from or out of that which covers or conceals; a coming forth or into view.
Are you seeing it yet?
What frequency is 5G? (https://www.verizon.com/about/our-company/5g/what-frequency-5g)
What frequency does 5G use?
Verizon uses several spectrum bands for its 5G offerings. 5G Ultra Wideband, Verizon’s millimeter wavelength (mmWave)-based 5G, operates at frequencies of about 28 GHz and 39GHz.
Electromagnetic information delivery as a new tool in translational medicine (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211758/)
This procedure allows to an external electro-magnetic stimulus to be stored, translated and transferred by the aqueous systems to the biological target, driving selectively their endogenous activity mimicking the effect of a specific source molecule. Signals from a chemical differentiation agent such as Retinoic Acid (RA) was captured and transferred to the target culture medium of Neuroblastoma Cell Line (LAN-5) and the proliferation rate was assessed, in order to investigate cell responses to electromagnetic information system.
Our hypotheses is that an aqueous system, such one of those enfolded in livings, could play an additional role in modulating biological functions providing basis for processing, storing and retrieving information mediated by electro-magnetic signals mimicking the effect of a specific drug or driving a specific endogenous function [6 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211758/#b6),7 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211758/#b7)].
The cell treated with standard chemical Retinoic Acid solution was also used as a positive control (RA). Cell growth and mortality, analyzed by direct cell count using Trypan Blue dye exclusion assay, showed that treatment with chemical Retinoic Acid dramatically decreased LAN-5 cell growth and increased cell mortality compared to control ones (Figures 2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211758/figure/fig02/) and and4).4 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211758/figure/fig04/)). Interestingly, cells grown in presence of the electro-magnetic signal from RA (RA-ECM), showed a statistical significant decrease of cell growth, similarly to RA treatment, but no changes in cellular mortality (Figures 2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211758/figure/fig02/) and and3).3 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211758/figure/fig03/)).
They are creating the EFFECT OF RETINOIC ACID on cells with ELECTROMAGNETIC FIELDS.
Differential response of the permeability of the rat liver canalicular membrane to sucrose and mannitol following in vivo acute single and multiple exposures to microwave radiation (2.45 GHz) and radiant-energy thermal stress (https://pubmed.ncbi.nlm.nih.gov/8475254/)
"liver canalicular membrane" = bile duct membrane
2.4 GHz = typical WiFi frequency
Rats were exposed to both microwave EMF radiation OR actual heat, pay attention to how it affects BILE:
In both acute exposure protocols, a rapidly reversible increase in bile flow rate was observed.
This is BILE DUMPING from both the EMF exposure and the heating exposure.
Four exposures (30 min/day x 4 days) to either microwave radiation (80 mW/cm2) or a matched radiant-energy thermal load resulted in a significant depression in bile flow rate at normothermic temperatures.
Then the bile flow DECREASED back at normal temperatures. Where do you think the bile was probably going instead? If you answered, "leaking into the bloodstream due to the toxic bile dump creating even more leaks than before", I'd say you are probably right.
Conversely, multiple exposures produced nonreversible changes in bile flow rate and canalicular membrane permeability, with microwave exposure producing greater alterations in the function of the canalicular membrane than an equivalent radiant-energy thermal load.
We have now established that EMF can induce bile dumping and affect the "leakiness" of the bile ducts.
Athermal alterations in the structure of the canalicular membrane and ATPase activity induced by thermal levels of microwave radiation (https://pubmed.ncbi.nlm.nih.gov/8265788/)
Sprague-Dawley rats (200-250 g) were exposed 30 min/day for 4 days to thermogenic levels (rectal temperature increase of 2.2 degrees C) of microwave radiation [2.45 GHz, 80 mW/cm2, continuous-wave mode (CW)] or to a radiant heat source resulting in an equivalent increase in body temperature of 2.2 degrees C. On the fifth day after the 4 days of exposure to microwave radiation, the animals were sacrificed and their livers removed.
The canalicular membranes were isolated and evaluated for adenosinetriphosphatase (ATPase) activity, total fatty acid composition and membrane fluidity characteristics. Mg(++)-ATPase activity (Vmax) decreased by 48.5% in the group exposed to microwave radiation, with no significant change in the group exposed to radiant heat.
I'm going to ASSume that decreasing the MAGNESIUM-containing involved in ATP (cellular energy) production by nearly 50% is VERY BAD.
Assessment of function, histopathological changes, and oxidative stress in liver tissue due to ionizing and non-ionizing radiations (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442457/)
Compared to past decades, humans are exposed to rapidly increasing levels of radiofrequency electromagnetic radiations (RF-EMF). Despite numerous studies, the biological effects of human exposure to different levels of RF-EMF are not fully understood yet. This study aimed to evaluate the bioeffects of exposure to "900/1800 MHz" and “2.4 GHz" RF-EMFs, and x-rays alone as well as their potential interactions, i.e. inducing simple additive, adaptive, or synergistic effects.
Conclusion: The exposure to both ionizing and non-ionizing radiations could alter some liver function tests. A short term pre-exposure to RF-EMF before exposure to an 8 Gy challenging dose of x-rays caused the alterations in oxidative stress markers and liver function tests, which indicate that oxidative stress is possibly involved in the adaptive response.
Non-ionizing radiations are electromagnetic waves, which are not able to ionize the target but could trigger a change in the cells by thermal and non-thermal effects (5 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442457/#B5)). The frequencies between 300 MHz and 300 GHz of non-ionizing radiations, including mobile phones and Wi-Fi routers and industry, are widely used in daily work (6 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442457/#B6)).
Nevertheless, the lack of information about the exact mechanisms of RF-EMF effects is evident. Furthermore, the simple additive, adaptive, or synergistic effects of RF-EMFs with ionizing radiations are not identified in detail.
The lack of evidence about the effects of RF-EMFs on the liver and the existence of AR is apparent.
Effects of Electromagnetic Pulse on Serum Element Levels in Rat (https://link.springer.com/article/10.1007/s12011-014-9903-0)
"In this study, Sprague-Dawley rats were randomly divided into 50-kV/m EMP-exposed group (n = 10), 100-kV/m EMP-exposed group (n = 10), 200-kV/m EMP-exposed group (n = 40), and the sham-exposed group (n = 20). The macro and trace element concentrations in serum were examined at 6, 12, 24, and 48 h after EMP exposure at different electric field intensities. Compared with the sham-exposed groups, the concentration of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), selenium (Se), and manganese (Mn) in rat serum was not changed significantly within 48 h after 200 pulses of EMP exposure at electric field intensity of 50, 100, and 200 kV/m although the K level was decreased and the Ca level was increased with the electric field intensity of EMP increasing. In addition, there was a tendency that the Zn level was decreased with the time going on within 48 h after EMP exposure."
Higher calcium. Lower potassium. Lower zinc.
These are the patterns I'm fixing every day in people.
Amyotrophic lateral sclerosis (Lou Gehrig’s disease) is caused by
electric currents applied to or induced in the body: It is an iatrogenic disease of athletes caused by use of electrotherapy devices (https://drive.google.com/file/d/1L3yJy8i9pxB75ojxKIjPmNjGKe3P4BSH/view)
The theoretical paper above is why I generally don't trust almost all therapies that run currents through the body. This includes Rife and Hulda Clark's "Zapper". Our nervous system is bio-chemical-electric in nature, and running electric currents through it can possibly "wear it out", even if short-term benefits are noted. Duration Paradox, as usual.
Government Files About "Remote Mind Control" (https://vigilantcitizen.com/latestnews/government-accidentally-sends-files-on-remote-mind-control-to-journalist/)
In short, the following studies show that vA, iron, and copper are all connected to the functions of voltage-gated calcium channels (VGCCs). This means, in my humble opinion, that EMFs combined with vA toxicity, iron overload, copper toxicity, and excess calcium...can make one feel worse, deposit more of these things into tissues (see heart & iron study below), and slow detox overall.
If we can reduce EMF's impact on the VGCCs and the "subcellular chaos" it creates, we can theoretically feel better and get toxins out of our tissues and body faster!
CAUTION: Go slow with introducing the EMF Solutions products as Sara recommends. Most, if not all of us, know how bad we can feel if we speed up detox too much, too fast. I believe we are primed to detox due to our low toxin intakes, and removing EMF stress allows our body to really start cleaning house.
You don't have to listen to me, and remember, "if you're going to be dumb, you better be tough!"
"vitamin" A
vA + magnetic field are extra toxic to brain cancer cells:
Synergic effect of retinoic acid and extremely low frequency magnetic field exposure on human neuroblastoma cell line BE(2)C. (https://pubmed.ncbi.nlm.nih.gov/20564173/)
The aim of the present study was to assess whether exposure to a sinusoidal extremely low frequency magnetic field (ELF-MF; 50 Hz, 1 mT) can affect proliferation and differentiation in the human neuroblastoma cell line BE(2)C, which is representative of high risk neuroblastomas. Cells were subjected to ELF-MF exposure in the presence or absence of a neuronal differentiating agent (all-trans-retinoic acid, ATRA) for 24-72 h. In each experiment, ELF-MF-exposed samples were compared to sham-exposed samples. Cells exposed to ELF-MF combined with retinoic treatment showed a decreased cellular proliferation and an increased proportion of G(0)/G(1) phase cells compared to cells exposed to either treatment alone. Moreover, ELF-MF- and ATRA-treated cells showed more differentiated morphological traits (a higher neurite number/cell, an increased neurite length), together with a significant increase of mRNA levels of p21(WAF1/CIP1) and cdk5 genes, both involved in neuronal differentiation. In addition, the expression of cyp19 gene, which is involved both in neuronal differentiation and stress response, was evaluated; cyp19 gene expression was enhanced by ATRA treatment and significantly enhanced further by ELF-MF exposure combined with ATRA. In conclusion, our data suggest that ELF-MF exposure can strengthen ATRA effects on neuroblastoma cells.
vA and VGCCs:
Retinoic acid inhibits neuronal voltage-gated calcium channels (https://pubmed.ncbi.nlm.nih.gov/29748133/)
Retinoic acid is the active metabolite of vitamin A and regulates several important cellular processes by activating retinoic acid receptors (RAR) and retinoid X receptors (RXR). These receptors generally act as transcription factors, though non-genomic actions of both retinoic acid and the receptors have also been reported. One such nongenomic effect includes the modulation of Ca2+ levels during homeostatic synaptic plasticity in the hippocampus. Retinoic acid can thus affect Ca2+ signaling and can potentially control both synaptic plasticity and neuronal firing. However, whether retinoic acid can regulate voltage-gated Ca2+ channels (either via genomic or nongenomic actions), which are fundamental to these processes, has not yet been studied in detail. Here we demonstrate the effects of retinoic acid on the biophysical properties of voltage-gated Ca2+ channels in cultured invertebrate motorneurons. Overnight exposure to physiological concentrations of retinoic acid significantly inhibited the voltage-gated Ca2+ current (ICa) in an isomer-dependent manner. Specifically, all-trans retinoic acid (atRA), but not 9-cis RA (9cRA), depolarized the voltage of half-maximal activation of ICa. AtRA also reduced the rate of channel activation and delayed recovery from inactivation. We provide evidence that both L-type and non-L-type voltage-gated Ca2+ channels are affected by atRA, as both nifedipine-sensitive and nifedipine-resistant ICa were inhibited in these neurons. These effects of retinoic acid are thought to be at least partially mediated by the retinoid receptors, as treatment of the neurons with synthetic RAR and RXR agonists produced a similar inhibition of ICa.
Iron
In iron overload aka hemochromatosis situations, iron can pass through the VGCCs!
Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures (https://pubmed.ncbi.nlm.nih.gov/17404834/)
Recent studies suggest that iron enters cardiomyocytes via the L-type voltage-gated calcium channel (VGCC). The neuronal VGCC may also provide iron entry. As with calcium, extraneous iron is associated with the pathology and progression of neurodegenerative diseases such as Parkinson's and Alzheimer's disease. VGCCs, ubiquitously expressed, may be an important route of excessive entry for both iron and calcium, contributing to cell toxicity or death. We evaluated the uptake of (45)Ca(2+) and (55)Fe(2+) into NGF-treated rat PC12, and murine N-2alpha cells. Iron not only competed with calcium for entry into these cells, but iron uptake (similar to calcium uptake) was inhibited by nimodipine, a specific L-type VGCC blocker, and enhanced by FPL 64176, an L-VGCC activator, in a dose-dependent manner. Taken together, these data suggest that voltage-gated calcium channels are an alternate route for iron entry into neuronal cells under conditions that promote cellular iron overload toxicity.
VGCCs may be the main way iron accumulates in the heart:
Calcium channels and iron uptake into the heart (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158869/)
Iron overload can lead to iron deposits in many tissues, particularly in the heart. It has also been shown to be associated with elevated oxidative stress in tissues. Elevated cardiac iron deposits can lead to iron overload cardiomyopathy, a condition which provokes mortality due to heart failure in iron-overloaded patients. Currently, the mechanism of iron uptake into cardiomyocytes is still not clearly understood. Growing evidence suggests L-type Ca2+ channels (LTCCs) as a possible pathway for ferrous iron (Fe2+) uptake into cardiomyocytes under iron overload conditions. Nevertheless, controversy still exists since some findings on pharmacological interventions and those using different cell types do not support LTCC’s role as a portal for iron uptake in cardiac cells. Recently, T-type Ca2+ channels (TTCC) have been shown to play an important role in the diseased heart. Although TTCC and iron uptake in cardiomyocytes has not been investigated greatly, a recent finding indicated that TTCC could be an important portal in thalassemic hearts. In this review, comprehensive findings collected from previous studies as well as a discussion of the controversy regarding iron uptake mechanisms into cardiomyocytes via calcium channels are presented with the hope that understanding the cellular iron uptake mechanism in cardiomyocytes will lead to improved treatment and prevention strategies, particularly in iron-overloaded patients.
Copper
Copper seems to irreversibly inhibit VGCCs:
External copper inhibits the activity of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle (https://pubmed.ncbi.nlm.nih.gov/12647034/)
We have characterized the effect of external copper on the gating properties of the large-conductance calcium- and voltage-sensitive potassium channel from skeletal muscle, incorporated into artificial bilayers. The effect of Cu2+ was evaluated as changes in the gating kinetic properties of the channel after the addition of this ion. We found that, from concentrations of 20 microM and up, copper induced a concentration- and time-dependent decrease in channel open probability. The inhibition of channel activity by Cu2+ could not be reversed by washing or by addition of the copper chelator, bathocuproinedisulfonic acid. However, channel activity was appreciably restored by the sulfhydryl reducing agent dithiothreitol. The effect of copper was specific since other transition metal divalent cations such as Ni2+, Zn2+ or Cd2+ did not affect BK(Ca) channel activity in the same concentration range. These results suggest that external Cu2+-induced inhibition of channel activity was due to direct or indirect oxidation of key amino-acid sulfhydryl groups that might have a role in channel gating.
More connecting of copper and VDCCs (voltage-dependent):
Copper-induced intracellular calcium release requires extracellular calcium entry and activation of L-type voltage-dependent calcium channels in Ulva compressa (https://pubmed.ncbi.nlm.nih.gov/22751323/)
The marine alga Ulva compressa exposed to 10 µM copper showed a triphasic increase of intracellular calcium with maximal levels at 2, 3 and 12 h involving the activation of ryanodine-, Ins(1,4,5)P3- and NAADP-sensitive calcium channels. In order to analyze the requirement of extracellular calcium entry for intracellular calcium release as well as the activation of voltage-dependent calcium channels (VDCC) and phospholipase C, U. compressa was treated with EGTA, a non-permeable calcium chelating agent, with verapamil, nipfedipine and diltiazem, inhibitors of L-type VDCC, and with neomycin and U731222, inhibitors of phospholipase C. The release of intracellular calcium was partially inhibited with EGTA at 2 and 3 h and completely inhibited at 12 h of copper exposure and decreased with inhibitors of L-type VDCC and phospholipase C. Thus, copper-induced intracellular calcium release depends on calcium entry and activation of L-type VDCC and phospholipase C. An integrative model of copper-induced cellular responses in U. compressa is presented.
Copper toxicity may allow copper to pass through VGCCs as well!
Calcium channels and iron metabolism: A redox catastrophe in Parkinson's disease and an innovative path to novel therapies? (https://www.researchgate.net/publication/354610800_Calcium_channels_and_iron_metabolism_A_redox_catastrophe_in_Parkinson's_disease_and_an_innovative_path_to_novel_therapies)
Not only iron, but other metal ions, including redox-active copper as copper (II) (ionic radius: 0.87 Å) [39], may potentially be transported by calcium channels, which could aggravate redox stress that is known to exist in nigral neurons [4]. Furthermore, it is established that copper ions ligate with α-synuclein fibrils and remain redox-active [41]. This factor is significant, as α-synuclein aggregation is a major triad hallmark of PD, along with mitochondrial dysfunction and iron accumulation [12, 42].
[updated 3/24/2025]
FAQ Table of Contents
[brackets & italics are added by Dr. Smith]
What is an EMF and how do they affect us?
[PLEASE READ this first one, and pay attention to "subatomic chaos" and "Voltage-Gated Calcium Channels", as this relates to the next article!]
What is a Voltage-Gated Calcium Channel aka VGCC?
Introduction to EMF Solutions
What makes EMF Solutions products different from other products on the market?
What’s in EMF Solutions products, and why doesn’t my Gauss meter or Radiofrequency meter show fewer EMFs after installation?
What items are in these products? Is it Shungite?
Should I still use a Gauss meter, Radiofrequency meter, or EMI Dirty Electricity meter if EMF Solutions products don’t block EMFs?
Is it mandatory to purchase these meters to know what I need from EMF Solutions?
Introduction to Sara Viau
***How do I purchase EMF Solutions products using the DRSMITH discount code? [READ CAREFULLY!]***
Do EMF Solutions products cause detox? What should I start with if I’m sensitive to new health protocols?
What if I don't have a detox? Does that mean the products aren't working?
What if I am on a strict budget?
How do EMF Solutions products work once they are installed?
Where can I find research proving the effectiveness of EMF Solutions products?
What is an EMF and how do they affect us?
Electromagnetic Frequency (EMF) waves are produced by the motion of electrically charged particles, also known as photons. These quantum energy particles travel at the speed of light in a wave form. These waves are also referred to as “Electromagnetic Radiation” (EMR) because they radiate from electrically charged particles.
According to Cory Hillis, President of EMF Solutions, electromagnetic fields (EMFs) generate a secondary form of energy referred to as "subatomic chaos," also known as Quantum Chaos.
EMF Solutions emphasizes the research of biochemist Dr. Martin Pall PhD, who uncovered a connection between EMFs and their effects on the human body. In 2013, Dr. Pall discovered that one of the primary non-thermal effects of EMFs is the activation of Voltage-Gated Calcium Channels (VGCCs) in the cell membranes. When these channels are activated by EMFs, they produce large amounts of intracellular calcium (Ca2+), which leads to the creation of free radicals and oxidative stress.
References:
Kaplan, Suleyman and Devra Davis. Controversies on Electromagnetic Fields in Neurobiology of Organisms. (https://www.sciencedirect.com/journal/journal-of-chemical-neuroanatomy/vol/75/part/PB) Journal of Chemical Neuroanatomy, Special Issue 75.B (2016): 41-140.
Pall, Martin L. Electromagnetic fields act via activation of voltage‐gated calcium channels to produce beneficial or adverse effects. (https://pmc.ncbi.nlm.nih.gov/articles/PMC3780531/) Journal of cellular and molecular medicine 17.8 (2013): 958-965.
What is a VGCCs
VGCCs, or Voltage-Gated Calcium Channels, are a type of ion channel found in the cell membranes of many types of cells, including nerve, muscle, and endocrine cells. They open in response to changes in the electrical voltage across the cell membrane, allowing calcium ions (Ca²⁺) to enter the cell.
Calcium plays a critical role in various cellular functions, including muscle contraction, neurotransmitter release in nerve cells, and hormone secretion in endocrine cells. In particular, VGCCs are crucial in transmitting electrical signals within cells and between different parts of the body.
VGCCs are also important in the context of EMF (electromagnetic fields) exposure, as some studies suggest that EMFs may activate these channels, leading to an influx of calcium ions into cells, which could contribute to oxidative stress and other biological effects. This is particularly relevant for those concerned with the health impact of EMF exposure.
Where is the research that supports this?
Research suggesting that EMFs (Electromagnetic Fields) can affect VGCCs (Voltage-Gated Calcium Channels) comes primarily from studies in the field of bioelectromagnetics, which explores how electromagnetic fields influence biological systems. Here are some key pieces of evidence and notable researchers who have explored this connection:
1. Dr. Martin Pall’s Work:
Dr. Martin Pall, Professor Emeritus of Biochemistry and Basic Medical Sciences at Washington State University, is one of the primary researchers in this area. In his 2013 paper titled “Electromagnetic Fields Act Via Activation of Voltage-Gated Calcium Channels to Produce Beneficial or Adverse Effects” (https://pmc.ncbi.nlm.nih.gov/articles/PMC3780531/), Pall hypothesizes that EMFs exert their biological effects primarily through the activation of VGCCs in cell membranes. The hypothesis is that EMFs cause these channels to open, allowing an excess influx of calcium ions (Ca²⁺) into the cells. This excess calcium can then lead to various downstream effects, such as oxidative stress, inflammation, and cell damage.
Reference:
Pall, M. L. (2013). Electromagnetic fields act via activation of voltage-gated calcium channels to produce beneficial or adverse effects. (https://pmc.ncbi.nlm.nih.gov/articles/PMC3780531/) Journal of Cellular and Molecular Medicine, 17(8), 958–965.
2. Studies on Calcium Ion Flux:
Other studies have shown a correlation between EMF exposure and changes in calcium ion flux in cells. This includes experiments where low-frequency and radiofrequency electromagnetic fields appear to affect the behavior of VGCCs in nerve and muscle cells.
• One of these studies observed that millimeter-wave exposure increased calcium ion concentrations in cells, which further supports the VGCC activation mechanism (Schwarz et al., 2008).
3. Oxidative Stress and EMF:
Research has also linked EMF exposure to increased oxidative stress, often citing the role of VGCCs in this process. Studies have found that the excessive calcium influx caused by VGCC activation can increase the production of reactive oxygen species (ROS), which may lead to cellular damage and contribute to various health problems.
Reference:
Yakymenko, I., et al. (2015). Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation. (https://pubmed.ncbi.nlm.nih.gov/26151230/) Electromagnetic Biology and Medicine, 34(3), 186-202.
These studies and papers form the foundation for the argument that EMF exposure can interact with VGCCs, potentially leading to harmful biological effects. However, it’s important to note that while this hypothesis has gained some traction, the exact mechanisms by which EMFs might influence VGCCs remain a subject of ongoing research and debate within the scientific community.
Introduction to EMF Solutions
EMF Solutions was founded in 2015 by Cory Hillis, who serves as the principal inventor and lead designer. His passion for helping others stems from his personal experience with EMF remediation and its impact on his health.
What makes EMF Solutions products different from other products on the market?
EMF Solutions’ products are unique in that they remediate a broad spectrum of EMFs, including Electric Fields, Magnetic Fields, Dirty Electricity, and Radio-Frequency (Bluetooth, WiFi, and Cellular Networks 3G, 4G, 5G). Many other brands address only a few of these.
EMF Solutions uses natural, earth-based materials to produce a strong paramagnetic field, which restructures the chaotic energy EMFs create.
They ensure product safety by testing all batches with a Geiger counter, ensuring no increase in Geiger counter CPMs.
Unlike many other products, EMF Solutions do not block or shield EMFs, which can be ineffective or unsafe. Instead, their products neutralize EMFs without disrupting device functionality.
EMF Solutions products are self-sustaining, requiring no replacement, charging, or regular maintenance.
Their products are tested by an independent lab and proven 99.9% effective.
What’s in EMF Solutions products, and why doesn’t my Gauss meter or Radiofrequency meter show fewer EMFs after installation?
EMF Solutions products use a proprietary blend of paramagnetic earth minerals that emit a strong, coherent frequency to neutralize chaotic manmade EMFs. Since these products don’t block or absorb EMFs, your electronics will continue to function normally. However, traditional meters like Gauss or Radiofrequency meters won’t show a decrease in EMF levels because the product neutralizes rather than blocks EMFs.
What items are in these products? Is it Shungite?
The blend is proprietary and consists of three paramagnetic, earth-based materials, one of which is exceptionally rare. While policy prohibits confirming or denying the specific materials used, I can share that they work by generating a paramagnetic field through their combined interaction. Rather than interfering with each other, these materials enhance one another’s effects. Each component is tested to ensure longevity, sustaining its paramagnetic field for longer than a human lifespan. Additionally, all products have been tested with a Geiger counter and do not emit radiation.
Should I still use a Gauss meter, Radiofrequency meter, or EMI Dirty Electricity meter if EMF Solutions products don’t block EMFs?
Yes! These meters help establish a baseline of EMF levels for educational purposes and assist EMF Solutions Specialist, Sara Viau, in identifying the highest priority areas for remediation. While the meters won’t detect changes, understanding where EMFs are concentrated helps guide the installation process.
Is it mandatory to purchase these meters to know what I need from EMF Solutions?
No. Sara Viau can provide a complimentary assessment of your EMF remediation needs without requiring the purchase of these meters. Simply contact Sara by phone or email for guidance.
Introduction to Sara Viau
Sara Viau is a Double Board Certified Holistic Health Practitioner, Certified EMF Specialist, and an Independent Certified Representative of EMF Solutions. She has been affiliated with the company since March 2020 and offers consultations to clients worldwide. To schedule a complimentary phone or zoom assessment with Sara Viau call 772-333-9046 or email mindbodybalancefl@gmail.com (https://members.nutritiondetective.commailto:mindbodybalancefl@gmail.com).
Do EMF Solutions products cause detox? What should I start with if I’m sensitive to new health protocols?
[From Dr. Smith: I'm suggesting that LYL people PLAN on feeling a detox response! We are ready and primed for detox! Expect it and go SLOWLY as described!]
About 20% of people who remediate EMFs may experience a detox response, with those suffering from autoimmune issues having a higher likelihood of detoxing. Detox symptoms can vary from mild to severe, depending on the individual. To minimize detox effects, it's recommended to start with the Home Bundle (for homes larger than 1,000 sq. ft.) or Condo Bundle (for smaller spaces), and gradually add other products over time. If you experience a detox after EMF remediation contact Sara Viau for support and guidance.
What if I don't have a detox? Does that mean the products aren't working?
Not everyone will go through a noticeable “detox” phase when using EMF Solutions products, and that’s not a bad thing. It may simply mean your body is already in a more regulated, balanced state and doesn’t need to do a big purge.
You might have already cleared enough stress and interference from your system that now, instead of reacting or detoxing, your body is ready to receive and integrate at a deeper level.
This is often the shift from survival mode to restoration mode, where instead of the body focusing on flushing out toxins, it’s now able to prioritize nutrient absorption, cellular repair, hormone balance, and more efficient energy use. It’s like your system is finally calm enough to receive the good things you’re giving it: supplements, quality food, hydration, rest, and healing frequencies.
So if you’re not detoxing, it doesn’t mean the products aren’t working, it may mean they’ve already helped you reach a more efficient state. You’re not in cleanup mode anymore, you’re in upgrade mode.
What if I am on a strict budget?
Contact Sara Viau, who will help prioritize which products are most important for your immediate needs. She can also guide you on integrating EMF Solutions into your daily routine at a pace that works for you.
How do EMF Solutions products work once they are installed?
The magnetic and electric fields from Alternating Current (AC) enhance the harmonizing paramagnetic field generated by EMF Solutions products. This amplified paramagnetic field neutralizes subatomic chaos, delivering protection throughout your home. The harmonizing paramagnetic field generated from the EMF Solutions products (Room Harmonizer, Home Harmonizer, or Booster Box) attracts into the metal components of the electric panel, meter, or circuit like a magnet attracting a piece of metal.
All EMF Solutions products use the same three proprietary earth based materials. Items like the Device Chip (most commonly used for routers, wifi boosters and extenders, air purifiers, and grounding mats), Laptop Chips (also used for tablets), Cell Chip, iCell Chip (for iPhone 12,13, and 14), and the Car Harmonizer automatically attract into the EMF energy (electric field, magnetic field, and/or radiofrequency) created by the device/technology it is installed on.
The EMF Solutions harmonizing paramagnetic items worn on your person such as the EMF Band (for children), EMF Band XL (for adults), the Personal Card (for kids), Personal Card XL (for adults), Personal Card XXL (for adults and those who are sensitive to EMFs) automatically attract to surrounding or nearby EMF energy that is affecting the human biofield and body systems.
Where can I find research proving the effectiveness of EMF Solutions products?
Live Blood Dark-Field Microscopy tests demonstrate the positive effects of EMF Solutions products on human cells. The study, conducted by Dr. Mazvita Maziveyi (“Dr. Vita”), showed that EMF Solutions products help normalize calcium levels in human cells, addressing the harmful effects of EMFs at the cellular level. For more detailed research, please refer to the attachments below or Dr. Vita's publications on her ResearchGate profile.
Dr “Vita” (or Dr Mazivita Maziveyi) headed the Independent Lab Study showing EMF Solutions' products working to normalize EMF-caused changes within human cells in 2021. In two separate studies she measured Calcium levels in thousands of cells and got the highest statistical results possible. Here's some info about the head researcher’s experience and credentials:
Dr Vita has 17 Publications and a ton of (680) citations (citations means other scientists are quoting or referring to your work).
Dr Vita specializes in human cell and cancer studies.
Her profile as a researcher is impressive. The link below will take you to her profile.
https://www.researchgate.net/profile/Mazvita-Maziveyi (https://www.researchgate.net/profile/Mazvita-Maziveyi)
Here is a study/publication she accomplished (on Pubmed/NCBI):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564663/ (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564663/)
Watch interviews of Cory Hillis linked below to learn more about EMF Solutions, the dangers of EMFs, and what can be done to fix this major environmental stressor! Cory Hillis has been invited to speak with Del Matthew Bigtree, Joni from Daystar network’s Joni Table Talk, Critically Thinking with the 5 Docs, Dr. Lee Merritt, and Dr. Carrie Madej. Here are all the wonderful interviews! These can be shared with others if you find that to be resourceful. Enjoy!
https://youtu.be/5uLiLQYm71s (https://youtu.be/5uLiLQYm71s)
https://youtu.be/gL-OGq5KQVY (https://youtu.be/gL-OGq5KQVY)
https://www.bitchute.com/video/TTT18yG9cvq8/ (https://www.bitchute.com/video/TTT18yG9cvq8/)
https://www.brighteon.com/7c5dd4a2-7607-44ad-aabf-d980284a9a4b (https://www.brighteon.com/7c5dd4a2-7607-44ad-aabf-d980284a9a4b)
https://rumble.com/v2f035k-re-upload-critically-thinking-with-dr.-t-and-dr.-p-episode-137-5-docs-mar-2.html (https://rumble.com/v2f035k-re-upload-critically-thinking-with-dr.-t-and-dr.-p-episode-137-5-docs-mar-2.html)
NOTE: This is all done through Sara Viau's business. If you mess up these simple instructions (using the discount code DRSMITH only on the store at mindbodybalancefl.com (https://members.nutritiondetective.com//mindbodybalancefl.com)), don't come back complaining!
A) Schedule a complimentary phone or zoom assessment with Sara Viau and tell her that you were referred by Dr. Smith. Call 772-333-9046 or email mindbodybalancefl@gmail.com (https://members.nutritiondetective.commailto:mindbodybalancefl@gmail.com).
To locate EMF Solutions products, select “More” then “Shop EMF Remediation.” You may also use the following direct link: https://www.mindbodybalancefl.com/store/c2/EMF_Remediation.html (https://www.mindbodybalancefl.com/store/c2/EMF_Remediation.html)
Do EMF Solutions products cause a detox? What EMF Solutions products should I start with if I am sensitive to new health and wellness protocols and products?
[From Dr. Smith: I'm suggesting that LYL people PLAN on feeling a detox response! We are ready and primed for detox! Expect it and go SLOWLY as described!]
NOTE: To reduce the chances of a strong detox response, it is best to start with the Home Bundle (living spaces over 1,000 sq. ft.) or Condo Bundle (living spaces under 1,000 sq. ft.) and wait a few weeks to a month to purchase other items like the EMF Band XL, Personal Card, Cell Chip (or iCell Chip), Car Harmonizer, Laptop/Tablet Chips, additional Device Chips, additional Better ZZZs, or add-on products like the Booster Box or Room Harmonizer.
What if I am on a strict budget?
Contact Sara Viau and she will help you prioritize what EMF Solutions products are most important to start with. With the help and guidance of Sara Viau, you can learn how to slowly integrate EMF Solutions products into your daily routine over time.
Please read *all* of these articles very carefully.
Never forget: "If you're going to be dumb, you better be tough."
Many of you are long-time LYL members and have heard me talk about B-vitamins, antidotes, detox bottlenecks, slowed-down ALDH, etc. You may have even heard me previously (not even that long ago!) talk about the so-called "vitamin B3", aka Niacin, in a fairly negative way. Well, as I have done before with very important things like toxic vitamin D supplements and toxic "vitamin" A...I have now changed my stance 180 degrees on the compound known as NICOTINIC ACID, often referred to as "niacin", along with a lot of other related compounds (most of which are not helpful). Via a rapid education by Kelsey J (https://members.nutritiondetective.com/members/17025514) (thank you many times over Kelsey!), I understand this topic much more deeply now and I believe that this compound (the CORRECT form of it) is a KEY part to UNLOCKING DETOX BOTTLENECKS and making this whole recovery process FASTER!
How did Kelsey convince me of this radical change? I'll first say that I didn't really have a strong anti-Niacin stance, and I had hunches that I didn't know enough about it to pass final judgment, so I was ripe for the re-education if it was going to help us like Kelsey suggested it would. She was determined (aka stubborn, a quality I admire) to show me what she knew about this compound that others SEVERELY MISUNDERSTOOD.
[On a historical note, it was Matt Stone (https://members.nutritiondetective.com/members/2544775) bringing Grant Genereux's work to my attention several times (once on FaceBook, once on his blog) that got me to look at "vitamin" A toxicity deeper, so this determination tactic has been beneficial before!]
Kelsey shared with me the research on Niacin (we'll refer to it as NA for nicotinic acid, aka flush niacin, aka nicotinate, NOTHING ELSE IS TO BE USED) on Parkinson's disease in the hopes that it would help my mother. I decided we had nothing to lose by trying it, and my intuition told me that I could trust Kelsey and that maybe there was something I had missed (NOTE: It has been helping my mom!!!). I did remember that there is a HUGE controversy in the health world over "niacin"...some people think it will fix everything, others think it is liver-toxic. Well, Kelsey cleared that up for me, and she'll do that for you too in the other articles she's graciously written for us!
As I'm about to show you, I realized that I had been moving towards NA as an important part of the LYL, I had simply been doing it INDIRECTLY! Here is a short version of my Niacin re-education...there is more detail on these in Kelsey's following articles.
Kelsey explained to me that nicotinic acid was actually an AMINO ACID that we derive from tryptophan. It is NOT a B-vitamin in structure, do NOT call it a B-vitamin around the LYL. This takes it OUT of the category of B-vitamins and puts it with the essential amino acids (because if pellagra is the deficiency disease of niacin, and niacin is an amino acid, then NIACIN = ESSENTIAL), in my professional opinion! She showed me the structure of it compared with other amino acids. It checked out. I realized that we emphasize getting plenty of animal protein here, and animal protein is the highest source of tryptophan in our diets. Connection between LYL and NA #1.
She explained to me that the picolinate (aka picolinic acid) in the zinc picolinate we LOVE so much is also a downstream product of tryptophan metabolism. Connection between LYL and NA #2.
She showed me how NICOTINATE appears to be a co-factor for LACTOFERRIN. This was a "holy crap!" moment for me. If the body was deficient in NA, how could it possibly make enough of its own lactoferrin? Simple answer: it can't! Kelsey theorizes that the gentler processing of our ND Lactoferrin keeps the nicotinate bound to the LF…while the other harsher whey-based processes may wash it off. Hey, it’s possible! Connection between LYL and NA #3.
She showed me how NAD+ (a critical coenzyme present in every living cell that is involved in many metabolic processes associated with cellular energy production), which is ***made most efficiently from NA*** was REQUIRED to RUN ALDH! Considering this is the most critical detox bottleneck, opening this up would be HUGE! Connection between LYL and NA #4.
She explained to me how the mainstream "niacin" (used to fortify foods, and what is put in B-complexes and multivitamins) is actually niacinAMIDE (aka nicotinAMIDE), and that ***people get problems from having TOO MUCH niacinAMIDE and NOT ENOUGH NA***. Too much niacinAMIDE will SLOW DOWN the body's ability to make NA and therefore NAD+!!! So "they're" giving people the WRONG FORM that is actually making them SICKER? That fits "their" genocidal patterns and made sense to me! Connection between LYL and NA #5.
She showed me research that NA appears to reverse/counteract vA toxicity in several ways (see below). Connection between LYL and NA #6.
She showed me research that NA increased bile production. Connection between LYL and NA #7.
She showed me research on how supplemental NA seemed to help or reverse nearly every major disease that we've associated with vA toxicity. Connection between LYL and NA #8.
She showed me research on how supplemental NA rapidly helped to fix "leaky gut" and reduce malondialdehyde! (https://pubmed.ncbi.nlm.nih.gov/16713031/) Connection between LYL and NA #9.
She showed me research on how we are dependent on bifidobacteria (bifidus) to take excess niacinamide and turn it back into nicotinate. So gut dysbiosis affects NAD+, and the causes of this are related to toxic bile, other toxins, mineral deficiencies, antibiotics (including certain herbs), antiparasitic & pesticide residues in our foods, and unnaturally low-carb and/or low fiber diets and/or low iron diets...to give a brief and incomplete list. Connection between LYL and NA #10.
She showed me research that the "Niacin flush" was NOT a histamine reaction, and how NA actually helped reduce mast cell-mediated allergic reactions! (https://www.biorxiv.org/content/10.1101/2023.02.19.529168v1) Connection between LYL and NA #11 follows off of this one, keep reading...
What is the "Niacin flush" if it isn't histamine then? This next THEORY is my own--Kelsey told me she agrees with it (whew! 😅 )--it all makes sense to me and relates to the "Niacin flush" in very important ways. Follow me here, as best you can.
FIRST, in an acute mega-overdose of vA (called acute hypervitaminosis A in the research), the following symptoms typically happen (there are others but they are not important in this example):
"Flushing"
Skin redness
Skin warmth/heat
Pruritis aka itching
Dry skin, also referred to as peeling or desquamation
This is from an excess of vA overflowing the liver's ability to store it, so it is stored in the SKIN and SUBCUTANEOUS FAT, and eventually SLOWLY detoxing and moving towards the liver for either further storage or excretion. This is a PAINFUL PROCESS and lasts days to WEEKS.
NEXT, in a sunburn, where toxic vA in the SKIN and SUBCUTANEOUS FAT is massively oxidized (aka "detoxed", and in the biotransformation process is made MORE TOXIC before it is sent to the liver), the following symptoms typically happen:
Skin redness
Skin warmth/heat
Pruritis aka itching
Dry skin, also referred to as peeling or desquamation
This is also a SLOW & PAINFUL PROCESS and lasts days to WEEKS. Tell me you see the similarities, yes?
Both of the above are reflective of an excess of toxic vA in the skin & subcutaneous fat, SLOWLY going through a PAINFUL detox process. That's what major detox looks like! Can you say "bottlenecks"? I sure can!
Now, remember my saying, "It's a POISON on the way IN, and it's a POISON on the way OUT!" This is really important to understand so we can tie this theory together!
FINALLY, the "Niacin flush"...a reaction caused by taking an AMINO ACID that is known to both accelerate vA detox pathways AND PROTECT the body against vA toxicity damage (see below for more on this). What are the SHORT-TERM (max 2 hours, usually much shorter) symptoms of the "Niacin flush"?:
"Flushing"
Skin redness
Skin warmth/heat
Pruritis aka itching
For some people, in the beginning, there may be a bit of dry skin
This will pass, and some extra hydration may help minimize it. Your skin WILL improve, trust me!
HOPEFULLY you are putting this together! I believe (theorize) that the "flush" is actually an ACCELERATED DETOX PROCESS of vA in the SKIN and SUBCUTANEOUS FAT, taking vA through it's different forms ("detoxing" it) and moving people through detox symptoms similar to both a vA overdose and/or a sunburn, BUT in a QUICK (and only mildly uncomfortable) way! Poison on the way IN, looking like poison on the way OUT!
Let's connect these in the same vein, just a bit more obviously:
vA toxicity causes increased light sensitivity (easy sunburning, eyes get very light sensitive)
See my older article on this here: Sun allergy and sun poisoning are signs of Poison/"Vitamin A" toxicity (and major detox/dumping into the system) (https://nutritionrestored.com/blog-forum/topic/sun-allergy-and-sun-poisoning-are-signs-of-poison-vitamin-a-toxicity-and-major-detox-dumping-into-the-system/)
Two major pellagra (Niacin deficiency disease) symptoms (https://en.wikipedia.org/wiki/Pellagra#Signs_and_symptoms) are (yes, I used Wikipedia links, deal with it 😝 ):
Sensitivity to sunlight (https://en.wikipedia.org/wiki/Photodermatitis) aka photodermatitis
"Photodermatitis, sometimes referred to as sun poisoning or photoallergy, is a form of allergic contact dermatitis in which the allergen [toxic vA] must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous."
Wow, niacin deficiency causes sun sensitive skin reactions to a sunlight-activated allergen (TOXIC vA) that are like ECZEMA, you don't say?!?!
Dermatitis (a characteristic "broad collar" rash known as casal collar (https://en.wikipedia.org/wiki/Casal_collar))
"The Casal collar or Casal necklace is a medical sign in which there is a redness and darkening of the skin around the neck, seen in people with pellagra. It becomes prominent following exposure to sun, and can be itchy with a burning feeling and pain. It can blister and weep, and turn into thick dark skin, with a coppery hue."
Sun-sensitive, redness, itchy, burning feeling, and pain. Sounds familiar! A coppery hue, you say?!?! That shouldn't sound too weird to us here, right?
Supplementing NA helps protect skin cells against sun (UV) damage IN VITRO:
Niacin protects against UVB radiation-induced apoptosis in cultured human skin keratinocytes (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577345/)
"Niacin pretreatment protects against UV-induced cell death and apoptosis in keratinocytes [primary type of skin cells] (HaCaT cells) by enhancing AKT/mTOR and S6 activation."
Supplementing NA helps protect skin cells against sun (UV) damage IN VIVO:
A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in ***photodamaged skin*** (https://pubmed.ncbi.nlm.nih.gov/17518989/)
"The results indicate that MN enhances epidermal differentiation and barrier function in skin, suggesting that this method of nicotinic acid delivery may prove useful in limiting progression of actinic skin damage and possibly in treating other conditions involving skin barrier impairment."
What if we had research showing that Niacin reduces retinol-binding protein aka RBP (a stand-in measure for "blood vA", lowers LIVER vA, and also prevents damage from topical retinoic acid? This should all start making sense now:
Novel Pleiotropic Effects of Niacin (https://etd.auburn.edu/bitstream/handle/10415/3200/Dissertation_Desiree%20Wanders.pdf?sequence=2)
"Conclusions: Since niacin was able to reduce serum RBP4 in wild-type and GPR109A null mice, but niacin had no effect on RBP4 gene or protein expression in the liver or fat of any mice, niacin most likely reduces serum RBP4 concentrations in mice in a receptor-independent manner, possibly through increased clearance."
[faster vA detox is implied here]
Inadequate Niacin Intake Disrupts Growth and Retinol Homeostasis Resulting in Higher Liver and Lower Serum Retinol Concentrations in Male Rats (https://pubmed.ncbi.nlm.nih.gov/37354977/)
"Conclusions: Optimal niacin intake is associated with lower liver VA [vitamin A] and higher serum retinol and plasma PLP concentrations."
[NOTE: Zinc does this same pattern!]
Effect of myristyl ***nicotinate*** on retinoic acid therapy for facial photodamage (https://pubmed.ncbi.nlm.nih.gov/17927576/)
"...a double-blind, placebo-controlled pilot study examined the combined use of retinoic acid with myristyl nicotinate (MN), a lipophilic derivative of niacin that enhances skin barrier function, in female subjects with mild to moderate facial photodamage. [...] These results show that prior and concurrent use of MN can mitigate barrier impairment and improve the tolerability of retinoic acid therapy..."
And lastly, it is extremely well-demonstrated that NA reduces LDL & VLDL cholesterol (the "bad" and "very bad" ones, respectively) and lowers triglycerides...
Did you know that LDL (bad) and VLDL (very bad) cholesterol CONTAIN vA?:
HEPATIC METABOLISM OF RETINOIDS AND DISEASE ASSOCIATIONS (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488285/)
"In the fasting circulation, over 95% of retinoid is present as retinol bound to RBP (i.e., as retinol-RBP). The remainder is found as retinyl ester in lipoproteins of hepatic origin, very low density lipoprotein and low density lipoprotein (VLDL and LDL)."
Did you know that high triglycerides are basically a dead giveaway for vA toxicity?
My old article on this: Your high triglycerides are just Poison/"Vitamin A" toxicity (https://nutritionrestored.com/blog-forum/topic/your-high-triglycerides-are-just-poison-vitamin-a-toxicity/)
So...if vA toxicity is involved in high LDL, VLDL, and triglycerides...and NA is known to lower LDL, VLDL, and triglycerides...need I say more?
After all that...I want to say that NA is NOT the "one magick pill" that fixes everything! Kelsey has done lots of NA and it helped her in many ways, AND she is making FURTHER improvements by doing the LYL and working on correcting mineral deficiencies via blood & hair testing consultation with me. This is ONE MORE MAJOR PIECE to the puzzle we are fixing, and it wouldn't be a "puzzle" if there was only one piece!
I believe this is a HUGE piece, and I was not meant to find it too early in this journey (or else I wouldn't have continued finding pieces out of necessity).
PLEASE read ALL of the articles following, MORE THAN ONCE!
Thank you again to Kelsey for your determination. I believe anyone and everyone here can benefit, even from small doses of NA.
Now go read the other articles!
What is Niacin?
Let us begin with a non-exhaustive, research-backed list of what NA can do relative to what we are all trying to do here:
Activate about 400 known detoxification enzymes[1] including our favorite families of enzymes like ADH, ALDH, RALDH {retinaldehyde dehydrogenase)...opening up the bottlenecks that our accumulated toxicity and deficiency has induced so that we can put those toxins through the full detox pathway and get them OUT.
Provide the building block for more ATP (energy) synthesis.
Building block for more DNA synthesis, protection and repair.
Increase bile production and excretion for more rapid detoxification via the poop.
Stimulate the so-called “tight junctions” in the intestine, liver, brain etc that literally “knit” cells together in an orderly sheet. And more intact barriers means LESS LEAKS OF BILE ACIDS AND OTHER CRAP INTO BLOOD and LIVER AND BRAIN!)
Important nutrient for the immune system, your mobile toxin cleanup crew.
Stimulate the expression and function of toxin transport channels on the cell membranes, one of those being p-glycoprotein family, and other organic acid transporters/bilirubin transporters, bile acid transporters, etc..
Enhance nutrient absorption and energy utilization from your food while keep anti-nutrients inside the intestines so you need less food/supplements
*There are many, many reasons to believe that flush niacin reduces cravings for all kinds of toxins you may have a hard time letting go of, making it easier to stick to your Love Your Liver diet and toxin-avoidance guidelines.
At higher doses such as 500mg to 1000mg it will lower LDL cholesterol (which vitamin A is bound to and you can poop out a lot more vitamin A this way) and increase HDL which is known as the “good cholesterol”
Is a chelator for metals and prefers the heavier ones much in the way that charcoal or zeolite will bind tighter to them than beneficial minerals.
Maybe you already knew about Niacin aka vitamin B3, maybe you didn't. Bet you want to know more now, right?!?!
Did you know there are two very different molecules that are accepted by “authorities” to be considered “niacin”?
One of these (niacinamide aka nicotinamide) is considered an “essential medicine” by the World Health Organization (we don't trust them at all, do we?!?!)and there sure are a lot of unhealthy things listed there, including retinol, uggh.1 (https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/)
The other, niacin aka nicotinic acid aka NA, is actually a “conditionally essential/conditionally indispensable”, non-proteogenic (not used to make proteins) amino acid2 (https://medlineplus.gov/ency/article/002222.htm) made in the body from tryptophan3 (https://www.amazon.com/Niacin-Andrew-W-Saul-PhD/dp/1684429021)
Times of illness and stress? Like...that’s every day now, amirite?
From: Niacin: The Real Story by Dr. Abram Hoffer et. al3 (https://www.amazon.com/Niacin-Andrew-W-Saul-PhD/dp/1684429021):
NA is made via the Tryptophan (amino acid) metabolic pathway (pictured below) primarily in the liver at a rate of only 1-2% efficiency4 (https://journals.sagepub.com/doi/10.4137/IJTR.S11588) (yes, our already overburdened livers have to do this too!) The Quinolinic acid pictured at the bottom left turns into nicotinic acid which is then made into NAD+. And notice that there's Picolinic acid on the right like what's used in Dr. Smith's Zinc Drops and Keystone Minerals.
(5)
NA is structurally an amino acid...
just like the amino acids Histidine, Proline, and Tryptophan on the chart below:
And just like other questionable government-mandated fortification programs such as “vitamin A”, “vitamin D”, etc., many government agencies recommend or require “niacin” be added to foods, pet foods, livestock feed, refined grains, etc. These same agencies make no distinction between the two. The form used to fortify foods and included in most multivitamins/b-complexes is niacinamide, NOT nicotinic acid! This is a BIG PROBLEM.
A typical processed and fortified food product:
Only one of these two compounds considered niacin by the “authorities” is required for ACTUAL good health. Nicotinic acid, the true niacin and the one we will be addressing to improve our health-and again-is NOT really a B vitamin at all, but an AMINO ACID! This article will guide you on how to take and get the most benefit out of this crucial amino acid, malevolently misnamed and grouped into the “vitamins” to avoid confusion among the masses. Our goal here is to help you understand more about this misunderstood amino acid, so you can use it in the best way(s) possible to help regain and improve your health.
What Happens when you take Niacin?
In your body, it’s actually nicotinate that does all the good stuff we’re looking for. It binds the receptors and is the ideal substrate for making NAD+, a basic building block of life. How do we get from nicotinic acid to nicotinate then?
When you consume nicotinic acid, the hydrogen atoms on the molecules of nicotinic acid disassociate (break off) from a majority of the nicotinic acid in the aqueous (wet) environment of your stomach. The hydrogen associates with water molecules in your tummy making H30+ (hydronium). The more H30+ in a solution, the more acidic (lower pH) that solution is considered (in this case, the stomach contents)..
This is nothing to worry about, as your stomach is designed for very acidic conditions (1-2 pH) and nicotinic acid with a pH of about 3 is not a big deal. We take in acidic foods and drinks all the time. However, there may be excess acidity introduced to the body when using large (over 500-1000 mg, or 0.5-1 gram) doses of nicotinic acid on a regular basis. We’ll get more into how to address that issue later in this article, it’s easy to fix.
The nicotinate molecule has many different receptors and channels (structures inside and outside the cell that bind molecules and do or cause various actions to happen as a result) and one of the most important receptors related to our efforts to become healthier is called GPR109A (for you research geeks out there). Furthermore, one of the most important roles of nicotinate is providing the most usable raw material to create NAD+ (a building block of life and energy metabolism) in every single cell in your body. We want to ensure that GPR109A and other nicotinate receptors and channels have the best possible chance of being bound by/taking in nicotinate and perform the important functions associated with it.
(1)B3 Utilizing Proteins Excel. https://docs.google.com/spreadsheets/d/1ryMDA6e5ugeYg1KHbou5aThm2fV8btOY/edit?usp=drive_link&ouid=101312185800432673420&rtpof=true&sd=true (https://docs.google.com/spreadsheets/d/1ryMDA6e5ugeYg1KHbou5aThm2fV8btOY/edit?usp=drive_link&ouid=101312185800432673420&rtpof=true&sd=true)
(2) Office of Dietary Supplements - Niacin. https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/ (accessed 2023-11-04). (https://ods.od.nih.gov/factsheets/Niacin-HealthProfessional/)
(3) Amino acids: MedlinePlus Medical Encyclopedia. https://medlineplus.gov/ency/article/002222.htm (accessed 2023-11-05). (https://medlineplus.gov/ency/article/002222)
(4) Saul, A. W.; Hoffer, A.; Foster, H. D.; Penberthy, W. T. Niacin: The Real Story, Third edition.; Turner Publishing Company: Nashville, Tennessee, 2023. (https://www.amazon.com/Niacin-Andrew-W-Saul-PhD/dp/1684429021)
(5) Fukuwatari, T.; Shibata, K. Nutritional Aspect of Tryptophan Metabolism. Int. J. Tryptophan Res. IJTR 2013, 6 (Suppl 1), 3–8. https://doi.org/10.4137/IJTR.S11588. (https://doi.org/10.4137/IJTR.S11588)
(6) File:Tryptophan metabolism.svg - Wikipedia. https://commons.wikimedia.org/wiki/File:Tryptophan_metabolism.svg (accessed 2023-11-05). (https://commons.wikimedia.org/wiki/File:Tryptophan_metabolism.svg)
I know what some of you may be thinking right now so let’s just address this elephant and grab it by the trunk. You may be thinking something like:
“Niacin? THAT’s the big new development? B3?! That’s liver-toxic! We’re on the Love Your Liver program, LADY! Have you lost your ever-loving mind?!”
“But if it’s not liver toxic, why do my search engine results and the medical authorities say it’s TOXIC? Why is it used as a DRUG?!?!”
Go ahead and search if you are curious. I've read through just about all of the first few pages of websites and checked all the references behind the alarming headlines you’ll see.
https://duckduckgo.com/?hps=1&q=niacin+liver+toxicity&ia=web (https://duckduckgo.com/?hps=1&q=niacin+liver+toxicity&ia=web)
I pored myself into the research when I first tried nicotinic acid (NA) because by then, I had already realized I had taken in sooo many toxins in pursuit of better health. "Liver Toxicity" seemed to be the most repeated and serious adverse reaction accusation against niacin. But I was convinced of how amazing it was for the liver from reading all sorts of studies, cell studies, human, animal, long-term, short-term, controlled trials, etc... And it ended up helping so many of my issues (but certainly not all, that's why I'm here) and my children's issues as well.
I looked past the alarming headlines and combed through ALL of the papers referenced in the articles that I could, ahem “borrow for free via the interwebz”, describing “nicotinic acid” as hepatotoxic. Feel free to click on the links to the full papers to see for yourself. It’s been over 60 years since nicotinic acid became the most recommended treatment (until more profitable and toxic statins came along) for high cholesterol after Rudolf Altschul and Abram Hoffer wrote their magnum opus on nicotinic acid for hypercholesterolemia (high cholesterol)1. I only found 8 case reports over that 60-year period, and those have serious problems.
I’ll go through them and please read through all of this before voicing your objections to nicotinic acid (NA). I am not counting any nicotinamide, sustained-release, extended-release, time-release and/or any combo with statins or anti-flushing agents for the very good reasons discussed in the forthcoming Niaspiracy article. WE are only ever going to discuss and advocate for (if you're not too scared) immediate-release, pure nicotinic acid and WE are going to be just as careful with it as any other supplement Dr. Smith has endorsed here.
If you find a paper I missed, please feel free to tag me on the network. The paper must concern immediate-release(IR)/crystalline(C) nicotinic acid ONLY and the case study patient, study participants or retrospective cohorts, active drug arm, etc., must not have been taking any LIVER TOXIC things (ex: statins, anti-flushing agents) in combination with the IR/C nicotinic acid. Best of Luck! -[KK]
Now here’s the headlines of the scary-sounding case studies. A case study is just a doctor describing one (or sometimes more) patient’s experience. It’s really not the best evidence to make sweeping characterizations of anything with.
Sounds scary right? Let’s say you didn’t know how to get a full paper for free off Sci-Hub.st 😉 (because all of these case reports are behind paywalls even decades later!) and this is all you saw. Is this enough to put someone off niacin for good and never consider it again? Is it enough evidence to make someone assume that any niacin they took damaged their liver and kicked their dog, even weeks after discontinuation? And then that person continues to believe that even if they were also consuming the dog’s flea treatments at the same time and AFTER stopping NA? Yeah, for most people this would probably be enough, but we’re not like most people. Let’s be good little Nutrition Detectives and look closer….
CASE STUDY 1: Riven (1959)[2]
So he was an “under-type” (very underweight) and had familial hypercholesterolemia (described as a genetic condition that results in much higher cholesterol in the blood even in young and healthy-weight patients) and this….”doctor”…thought it was a good idea to treat it with 30 grams of LARD (retinoids) and CORN OIL (PUFA). I realize it was the late fifties but wow, the veterans deserve better.
When he came back to the doctor his cholesterol had risen even further (DUH) so the doctor gave him nicotinic acid, and his xanthoma (a fatty accumulation of carotenoids, retinoids and the like) started to disappear and cholesterol went down but they didn't take him OFF THE CORN OIL AND LARD.
And then when he went off the NA because “itching”, then restarted it with no itching, and when he stopped it for the last time, two weeks later he got jaundice, itching, and (of course) high cholesterol again and the paper calls NA hepatotoxic. Clearly, this poor guy already had a very toxic liver and they loaded him up with retinoids in the lard and polyunsaturated fatty acids in the corn oil to make it worse.
Because NA itself is its own best anti-flushing agent, the itching would have stopped within a few days. But because he was still “in-toxing” with the lard and corn oil, the initial itching reaction to NA never subsided. “THE POISON ALWAYS WINS!” as Dr. Smith says and IR-NA is not a poison…but CORN OIL and LARD are! You’ll see the same pattern repeat in all but one case in this article.
CASE STUDY 2: Patterson (1983) [3]
The man was taking a massive amount of nicotinamide, a HUGE amount of Thiamine (which apparently 100 mg will kill the fleas on your dog)[4][15], and 300 mg of B6 (we know that’s an aldehyde, no b6 toxicity support groups for this poor fellow), and 250 mg of B5 (required daily amount of B5 is listed at 10 mg)
[15]
My opinion is that his heavy-handed dosing of dubious “B-vitamins” for his depression exacerbated hepatotoxicity he likely already had because he was depressed, which is also a factor in dementia.
“Next patient please!”
CASE STUDY 3: Clementz (1987) [5]
Here was a salesman who underwent open heart surgery at 44-45 years old which is pretty young and he had high cholesterol, so he clearly had liver damage already before NA. The doctor said he was on no other medication. Was the salesman lying to the doctor about other drugs he may have been taking? Salesmen do lie, that’s a fact! Did he have a smoldering infection from his past heart surgery? Did his job as a traveling salesman require him to put in long hours, eat crap food, and maybe use a drug that was popular in the eighties that causes heart damage and hepatotoxicity like…cocaine?
Why did the doctor do a ‘re-challenge' if he was certain NA was the culprit? Re-challenges are done to rule out which drug caused the illness if there have been exposures to multiple drugs. This second time around it took three times as long for him to get sick! That doesn't make any sense. Maybe he dumped a lot of toxic bile in the first round of NA. Maybe he didn’t maintain the thrice-daily dosing and took large make-up doses that dumped way too much toxic bile.
Did the NA open the floodgates of that toxic bile from his 46 years of stressful, heart damaging lifestyle? It has been documented that NA can cause the body to produce and excrete up to 2-5 times more bile than magnesium sulfate. The patient did make a full recovery after a hospital stay and cessation of the NA, so what was it… the NA or the old toxic bile he dumped that caused his illness or something he was consuming that he didn’t tell the doctor about?
CASE STUDY #4: Sugerman (1974) [6]
This poor old man got brain damage from a stroke brought on by a suicide attempt (by carbon monoxide poisoning) and they put him on relatively small amount of 250mg of NA and a whopping 500mg thiamine (again, flea killer) and vitamin C (also kills fleas)4 and can inhibit ADH & ALDH. Clearly this man was very liver toxic for a long time
Bile was in his urine and blood. Liver biopsy showed normal results and he only got worse after stopping the NA. Was he still taking the other two?
Two very important things here. One, giving the wrong nutrients when a patient is clearly showing signs of pellagra (niacin deficiency) can dramatically worsen the pellagra patient’s symptoms.
[16]
Second, if they left him on the high dose vitamin C and thiamine (B1), there is a study showing that during lead toxicity (from leaded gasoline (it was 1974) that he inhaled during his suicide attempt, which causes liver and brain damage as primary symptoms), high dose B1 plus vit C caused testicular cells to self-destruct more (apoptosis)
https://pubmed.ncbi.nlm.nih.gov/16513100/ (https://pubmed.ncbi.nlm.nih.gov/16513100/)
Depression--assumed by his suicide attempt and "boredom"--goes hand in hand with the dementia aspect of the famous “4 D’s of pellagra" (pellagra being the niacin deficiency disease); diarrhea, depression, dermatitis, and death[7].
CASE STUDY #5: Patel (1993) [8]
He was an under-type for sure at that weight. But still he had taken NA for at least two years without an issue. So what happened? New girlfriend?
Yohimbine is some pretty toxic stuff9 and a skinny old man without much fat tissue to store toxins took it for six weeks? I think it’s clear what the culprit was…the new girlfriend! (wink, wink).
CASE STUDY #6: Leung (2018) [10]
Yikes, this poor woman was really sick and toxic. Prednisone? Been there-that stuff is horrid. Mycophenolate mofetil? Two immunosuppressants and she tapered off steroids too fast? THAT ALONE is EXTREMELY dangerous! How long was she on those? And then they gave her toxic pharma niacin instead of the immediate-release she was tolerating for years?
SERIOUSLY? Mycophenolate, insulin, steroids, furosemide, spironolactone and metronidazole-NOT CONSIDERED??!
They may have killed the patient, but they nailed that tricky little decades-spanning serial killer of exactly one person ever, niacin. No way it was those other things. /sarcasm
CASE STUDY #7: Schafellner (2017) [11]
A single dose of 20,000mg niacin and what else…….
Some b’s and probiotics and….CLINDAMYCIN? Well obviously it was the clindamycin!
“Our model say it was the Niacin!” Ummm let’s take a look at livertox.nih.gov[12]…and verify.
But first lets talk about BIG DOSES, like Blue Whale size doses.
Sure that was a big dose, but no one ever had needed a liver transplant from one big dose of niacin before and no one has died (I was obviously being sarcastic in case #6), the LD50 in rats (dosage per kg of body weight that would be lethal to half of the laboratory animals) of Niacin is 7 GRAMS/kg for a rat[13] So to convert that to human dose then the LD50 oral for a human (multiply by .162 according to this resource [17]) would theoretically be 567mg/kg. Let's say she's lean because she's a runner and she weighs 50kg (110 lbs. ), it would could take a dose of 56,700 mg to *maybe* kill a person of her stature. We really don't know what a lethal dose is in humans because no one has ever died from taking too much Niacin.
[13]
TDLo means the TDLo "The lowest dose causing a toxic effect." The first one is macular edema for 31,200mg/kg. Wow so if this girl took the same amount that would be.... almost 3 and half POUNDS of nicotinic acid and she'd have blurry vision? I like NA but that seems a little crazy, but I can't get the full paper.
.https://pubmed.ncbi.nlm.nih.gov/9624021/ (https://pubmed.ncbi.nlm.nih.gov/9624021/)
I can't see any abstracts and the second one is for a man who took 9,713 mg/kg and got lactic acidosis, okay that's serious but was okay. That would be a little over a POUND of nicotinic acid for runner girl.
https://pubmed.ncbi.nlm.nih.gov/2014436/ (https://pubmed.ncbi.nlm.nih.gov/2014436/)
Ohhh....... it was sustained release. You'll find out why sustained release is no good in the Niaspiracy article.
Let's now look up Clindamycin on Livertox database.....
[12]
"Clindamycin therapy has also been linked to a CLINICALLY APPARENT, IDIOSYNCRATIC LIVER INJURY that arises between 1-3 WEEKS after starting..."
It is pretty obvious it was the clindamycin.
CASE STUDY #8: Pardue (1961) [14]
So this guy has very bad hypertension that’s already causing aortic issues, he’s peeing blood, his kidneys are getting strangled and a shunt was put in, then they found the main artery to his right leg was completely blocked and the left leg artery was narrowed. His neck arteries (carotids) were also very narrowed and an ECG showed a previous heart attack. He still hasn’t taken ANY niacin yet at this point, keep in mind.
Priscoline? I can’t find much on that. What else is this guy doing to make himself so sick? Clearly his liver too, has been in terrible shape for quite a while already from what we know.
Nylidrin hydrochloride? Another old-timey drug with not a lot of toxicity info I can find.
That serum glutamic oxalacetic transaminase (also known as AST on liver function tests) is normal. Bodansky units are obsolete now when testing alkaline phosphatase. I have no idea what that means. Blood is a little “thin”, albumin (blood proteins that help maintain osmotic pressure as one important function) is a little low.
The title said “Severe Liver Dysfunction”? Well, WE know that his liver was already toxic but still there's no jaundice, ascites (fluids in the abdominal area), and no liver enlargement. So they stopped his niacin when he became swollen in the ankles, hands and face only in the last month after six months of niacin, but he was on “priscoline” for a year at this point and “nylidrin” was administered at the same time as the nicotinic acid. What was this guy in-toxing with in the first place to get crusty in every cavity and why aren’t the pharma drugs suspected for the coagulation and liver abnormalities?
And the cholesterol is back high again! But at least they got that ALP normalized and got his blood a little thicker. But I’m sure the man did not last too long after his last appointment, especially without any more NA.
Well that's the end. Yup, that’s really all of them I could find.
So is “high-dose” immediate-release nicotinic acid toxic to the liver? NOPE! Case: CLOSED!
In fact it's quite the opposite. Nicotinic acid is terrific and necessary for liver health. And just to really seal the deal on that statement, here are some home-run studies that discuss the myriad of benefits of NA sufficiency and supplementation for liver health and the negative impact NA insufficiency (which causes lack of NAD+ in the liver among others) can have on liver health.
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis–like phenotypes
https://www.jbc.org/article/S0021-9258(21)01194-7/fulltext (https://www.jbc.org/article/S0021-9258(21)01194-7/fulltext)
Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention
https://www.nature.com/articles/s41598-018-38002-7 (https://www.nature.com/articles/s41598-018-38002-7)
Niacin regresses collagen content in human hepatic stellate cells from liver transplant donors with fibrotic non-alcoholic steatohepatitis (NASH)
https://ncbi.nlm.nih.gov/pmc/articles/PMC9274597/ (https://ncbi.nlm.nih.gov/pmc/articles/PMC9274597/)
Niacin for treatment of nonalcoholic fatty liver disease (NAFLD): novel use for an old drug?
https://ncbi.nlm.nih.gov/pmc/articles/PMC9274597/ (https://ncbi.nlm.nih.gov/pmc/articles/PMC9274597/)
Association between Dietary Niacin Intake and Nonalcoholic Fatty Liver Disease: NHANES 2003-2018
https://pubmed.ncbi.nlm.nih.gov/37836412/ (https://pubmed.ncbi.nlm.nih.gov/37836412/)
The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate
https://pubmed.ncbi.nlm.nih.gov/10745276/ (https://pubmed.ncbi.nlm.nih.gov/10745276/)
Nicotinamide Adenine Dinucleotide Metabolome Is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-Related Liver Disease
https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep4.1530 (https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep4.1530)
High-dose Niacin is a promising treatment for Non-Alcoholic Fatty Liver Disease
https://researchfeatures.com/high-dose-niacin-promising-treatment-non-alcoholic-fatty-liver-disease/ (https://researchfeatures.com/high-dose-niacin-promising-treatment-non-alcoholic-fatty-liver-disease/)
Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis
https://www.aging-us.com/article/101743/text (https://www.aging-us.com/article/101743/text)
Inadequate Niacin Intake Disrupts Growth and Retinol Homeostasis Resulting in Higher Liver and Lower Serum Retinol Concentrations in Male Rats
https://www.sciencedirect.com/science/article/abs/pii/S0022316623724322#:~:text=Inadequate%20Niacin%20Intake,open%20overlay%20panel (https://www.sciencedirect.com/science/article/abs/pii/S0022316623724322#:~:text=Inadequate%20Niacin%20Intake,open%20overlay%20panel)
Decreased liver B vitamin-related enzymes as a metabolic hallmark of cancer cachexia
https://www.nature.com/articles/s41467-023-41952-w (https://www.nature.com/articles/s41467-023-41952-w)
Pharmacologic Therapy with Niacin for Nonalcoholic Fatty Liver Disease (NAFLD): Emerging Evidence
https://www.scientificarchives.com/article/pharmacologic-therapy-with-niacin-for-nonalcoholic-fatty-liver-disease-nafld-emerging-evidence#:~:text=In%20vivo%20and%20in%20vitro,inflammatory%20marker%20C-Reactive%20Protein (https://www.scientificarchives.com/article/pharmacologic-therapy-with-niacin-for-nonalcoholic-fatty-liver-disease-nafld-emerging-evidence#:~:text=In%20vivo%20and%20in%20vitro,inflammatory%20marker%20C-Reactive%20Protein)
Dietary nicotinic acid supplementation improves hepatic zinc uptake and offers hepatoprotection against oxidative damage
https://pubmed.ncbi.nlm.nih.gov/21262064/ (https://pubmed.ncbi.nlm.nih.gov/21262064/)
Nicotinic acid attenuates experimental non-alcoholic steatohepatitis by inhibiting the NLRP3 inflammasome/pyroptosis pathway
https://pubmed.ncbi.nlm.nih.gov/37604293/ (https://pubmed.ncbi.nlm.nih.gov/37604293/)
Nicotinic Acid against Acetaminophen-Induced Hepatotoxicity via Sirt1/Nrf2 Antioxidative Pathway in Mice
https://pubmed.ncbi.nlm.nih.gov/34193673/ (https://pubmed.ncbi.nlm.nih.gov/34193673/)
Dietary Nicotinic Acid Supplementation Ameliorates Chronic Alcohol-Induced Fatty Liver in Rats
https://pubmed.ncbi.nlm.nih.gov/24848081/ (https://pubmed.ncbi.nlm.nih.gov/24848081/)
(1) Altschul, R.; Hoffer, A. The Effect of Nicotinic Acid on Hypercholesterolæmia. Can. Med. Assoc. J. 1960, 82 (15), 783–785.
https://pubmed.ncbi.nlm.nih.gov/6390462/ (https://pubmed.ncbi.nlm.nih.gov/6390462/)
(2) Rivin, A. U. Jaundice Occurring during Nicotinic Acid Therapy for Hypercholesteremia. J. Am. Med. Assoc. 1959, 170 (17), 2088-2089.
https://doi.org/10.1001/jama.1959.63010170008010c (https://doi.org/10.1001/jama.1959.63010170008010c). (https://www.zotero.org/google-docs/?vH8ArI) https://drive.google.com/file/d/1ApHSEcKlGVBnQAZ_A5MxEXPclZfW5IzW/view?usp=sharing (https://drive.google.com/file/d/1ApHSEcKlGVBnQAZ_A5MxEXPclZfW5IzW/view?usp=sharing)
(3) Patterson, D. J.; Dew, E. W.; Gyorkey, F.; Graham, D. Y. Niacin Hepatitis. South. Med. J. 1983, 76 (2), 239–241.
https://doi.org/10.1097/00007611-198302000-00023 (https://doi.org/10.1097/00007611-198302000-00023). (https://www.zotero.org/google-docs/?vH8ArI) https://drive.google.com/file/d/1QLLjNl1e1FbtjL0AycvC74UWAkBJQQgj/view?usp=sharing (https://drive.google.com/file/d/1QLLjNl1e1FbtjL0AycvC74UWAkBJQQgj/view?usp=sharing)
(4) Lawton-Wall, J. Vitamin Composition for Treatment of Flea Infestation in Animals. US5021424A, June 4, 1991.
https://patents.google.com/patent/US5021424A/en (https://patents.google.com/patent/US5021424A/en) (accessed 2023-11-27).
(5) Clementz, G. L.; Holmes, A. W. Nicotinic Acid-Induced Fulminant Hepatic Failure. J. Clin. Gastroenterol. 1987, 9 (5), 582–584.
https://doi.org/10.1097/00004836-198710000-00022 (https://doi.org/10.1097/00004836-198710000-00022). (https://www.zotero.org/google-docs/?vH8ArI)
https://drive.google.com/file/d/1E2PObENCi_Bx5tAnk97TSUlZZyIUkYnl/view?usp=sharing (https://drive.google.com/file/d/1E2PObENCi_Bx5tAnk97TSUlZZyIUkYnl/view?usp=sharing)
(6) Sugerman, A. A.; Clark, C. G. Jaundice Following the Administration of Niacin. JAMA 1974, 228 (2), 202.
https://doi.org/10.1001/jama.1974.03230270046027 (https://doi.org/10.1001/jama.1974.03230270046027). (https://www.zotero.org/google-docs/?vH8ArI)
https://drive.google.com/file/d/1HaTBUO6nIQdTvoTn-qM-OKaej1SEP9oy/view?usp=sharing (https://drive.google.com/file/d/1HaTBUO6nIQdTvoTn-qM-OKaej1SEP9oy/view?usp=sharing)
(7) Paudel, V.; Chudal, D. Classical Pellagra, the Disease of 4 Ds, the Forgotten Entity. Pan Afr. Med. J. 2020, 36 (219).
https://doi.org/10.11604/pamj.2020.36.219.24806 (https://doi.org/10.11604/pamj.2020.36.219.24806). (https://www.zotero.org/google-docs/?vH8ArI)
(8) Patel, S. D.; Taylor, H. C. Intrahepatic Cholestasis during Nicotinic Acid Therapy. Cleve. Clin. J. Med. 1994, 61 (1), 70–75; quiz 80–82.
https://doi.org/10.3949/ccjm.61.1.70 (https://doi.org/10.3949/ccjm.61.1.70).
https://drive.google.com/file/d/1_vvHvlPBWf40kpUKHhmGmJj1P5KHV4Ba/view?usp=sharing (https://drive.google.com/file/d/1_vvHvlPBWf40kpUKHhmGmJj1P5KHV4Ba/view?usp=sharing)
(9) What Is Yohimbe?. Verywell Health.
https://www.verywellhealth.com/safety-concerns-of-yohimbe-89535 (https://www.verywellhealth.com/safety-concerns-of-yohimbe-89535) (accessed 2023-11-27).
(10) Leung, K.; Quezada, M.; Chen, Z.; Kanel, G.; Kaplowitz, N. Niacin-Induced Anicteric Microvesicular Steatotic Acute Liver Failure. Hepatol. Commun. 2018, 2 (11), 1293–1298.
https://doi.org/10.1002/hep4.1253 (https://doi.org/10.1002/hep4.1253). (https://www.zotero.org/google-docs/?vH8ArI)
https://drive.google.com/file/d/1z-hEB1F1fFa_Qw2Nw7MICCfG2kFQ3Cr-/view?usp=sharing (https://drive.google.com/file/d/1z-hEB1F1fFa_Qw2Nw7MICCfG2kFQ3Cr-/view?usp=sharing)
(11) Schaffellner, S.; Stadlbauer, V.; Sereinigg, M.; Mìller, H.; Högenauer, C.; Fickert, P.; Krumnikl, J.; Lackner, C.; Kniepeiss, D.; Stauber, R. E. Niacin-Associated Acute Hepatotoxicity Leading to Emergency Liver Transplantation. Am. J. Gastroenterol. 2017, 112 (8), 1345–1346.
https://doi.org/10.1038/ajg.2017.171 (https://doi.org/10.1038/ajg.2017.171). (https://www.zotero.org/google-docs/?vH8ArI)
https://drive.google.com/file/d/1QpDAajpawlVax3YGFDBDqMTW1gB8_CZW/view?usp=sharing (https://drive.google.com/file/d/1QpDAajpawlVax3YGFDBDqMTW1gB8_CZW/view?usp=sharing)
(12) Clindamycin. In LiverTox: Clinical and Research Information on Drug-Induced Liver Injury; National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD), 2012.
https://www.ncbi.nlm.nih.gov/books/NBK548292/ (https://www.ncbi.nlm.nih.gov/books/NBK548292/) (accessed 2023-11-27).
(13) PubChem. Nicotinic acid.
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(14) Pardue, W. O. Severe Liver Dysfunction During Nicotinic Acid Therapy. JAMA 1961, 175 (2), 137.
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(16) MICHEL SERDARU, CHANTAL HAUSSER-HAUW, DOMINIQUE LAPLANE, ANDRÉ BUGE, PAUL CASTAIGNE, MAURICE GOULON, FRANÇOIS LHERMITTE, JEAN-JACQUES HAUW, THE CLINICAL SPECTRUM OF ALCOHOLIC PELLAGRA ENCEPHALOPATHY: A RETROSPECTIVE ANALYSIS OF 22 CASES STUDIED PATHOLOGICALLY, Brain, Volume 111, Issue 4, August 1988, Pages 829–842, https://doi.org/10.1093/brain/111.4.829 (https://doi.org/10.1093/brain/111.4.829)
(17)Nair, A. B.; Jacob, S. A Simple Practice Guide for Dose Conversion between Animals and Human. J Basic Clin Pharm 2016, 7 (2), 27–31. https://doi.org/10.4103/0976-0105.177703 (https://doi.org/10.4103/0976-0105.177703).
What is the "Niacin Flush"?
First, for those of you aware or unaware of the "niacin flush", you should know that it is NOT harmful, it doesn't happen to everyone, BUT it can be a bit surprising and even scary if you didn't know it might be coming. This article is intended to tell you all about it!
IF (and it's a BIG "if", see below) a "niacin flush" happens, it may involve one or more of the following temporary symptoms on the face, arms, and/or chest:
Begins 5-30 minutes after taking NA, lasts up to 1 hour (2 hours max)
Skin redness
Skin warmth/heat
Itchiness
Tingling
Note the above symptoms seem similar to a sunburn
Peaks, then fades away
There may be some shivers and cold sensation after the initial warmth
Why did I say "IF" it happens? Because most people don't experience it:
The above chart is from a study with patients with END STAGE RENAL DISEASE (aka kidney failure) on 100mg of NA1. 23 out of 25 patients didn't flush, and the two who did were easily "treated" with basically a baby aspirin (we'll talk about this). They were OK, and you'll likely be more than OK if you flush, you may even like it 😊
[Note from Dr. Smith...when I was much more toxic in the past, I took some flush niacin once and didn't like the "flush"...it was much stronger for me back then, than it was when I started using it again (now that I'm much less toxic)...also, as Kelsey mentioned, I do sort of like it now that I know more about it and am accustomed to it]
“Flushing” is due to the dilation (widening, opening) of the smallest blood vessels in the skin called capillaries2. One theory of its cause is the nicotinate binding and re-sensitizing the temperature sensors in the skin (TRPV receptors) that have been desensitized by toxins (capsaicin, retinoids, for example).
The "flush" is NOT a histamine reaction, as many of you and Dr. Smith (previously) have been told. In fact, the study above with kidney failure folks showed it HELPED ITCHING precisely because of "its anti-inflammatory reaction, anti-xerosis [anti-dry skin], and mast-cell stabilizing effects [as in, positively affecting histamine problems!]."
Can I Shut Down the Flush If I'm Worried About It?
YES, you can, and it is easy to do...so read the following, be prepared, and try to relax. As was mentioned above, aspirin can be used to shut down the flush. This should NOT be done regularly, it's to be used if you are REALLY, REALLY uncomfortable and freaking out.
As always, if you follow the INSTRUCTIONS in this section on how to take the NA, how to increase slowly, what to take with the NA, what to NOT take with the NA, what the flush actually is, and what the flush looks & feels like, you shouldn't have any problems. On the other hand, there is "if you're going to be DUMB, you better be TOUGH". Choose your own adventure, right?
I recommend that everyone make sure they have an aspirin in the house JUST IN CASE if you’re going to take above 50 mg, or if you increase your NA dose too quickly, or you tend to be on the more ANXIOUS side. Again, not because the flush is a problem, but mainly for your peace of mind so you have an option.
What do I mean by aspirin?
Study above used 100 mg aspirin
Baby aspirin are 81 mg/tablet
Normal aspirin and Alka-Seltzer are 325 mg/tablet
Half a tablet of either of these would work
Any/all of these can work, the dissolved Alka-Seltzer works the quickest
Only take aspirin to shut down the flush IF you can’t stop repetitively thinking that you’re having an allergic reaction--even though the flush is NOT an allergic reaction3--and you're about to call the ambulance if it doesn’t stop RIGHT NOW.
If you do call an ambulance and tell them you took flush niacin, they will not take you seriously because they know you're not in danger (they might even chuckle at you a bit). The ER doc will think you wasted their time, and the worst part is it will be EXPENSIVE. So, while aspirin may not be great for you, neither is a HUGE medical bill for them to tell you that your non-allergy problem is already fading away on its own. So have the aspirin ready and don't get a big hospital bill, OK?
Other Possible TEMPORARY Flush Symptoms
Tachycardia: (increased heart rate)
Slight increases in heart rate are likely normal due to NA’s vasodilatory (widening of blood vessels) More room for blood means it’s possible for your heart to sense it’s time to beat a little faster to maintain blood pressure.
More significant increases in heart rate may come from too much acidity from larger single doses (above 150-200mg) of NA. Some of the NA consumed will still be in the acid form and diffuse into the blood and this can demand the body use its “blood buffer” systems to maintain normal blood pH. One of the primary blood buffer systems involves the release and catabolism (break down) of the abundant essential amino acid, glutamine from intracellular storage, to produce ammonia4 and release bicarbonate from the kidneys to counter the acid15 (https://doi.org/10.1002/bmb.2004.494032050388). This process something your body does all the time, but your cells do better when they have the glutamine inside and available for the cellular processes that NA kicks off, not in the blood. Small pH changes up (basic) or down (acidic) on the pH scale can affect heart rate as the body adjusts. Your body has plenty of acids to deal with and neutralize all the time, and there’s no need to put additional burden on those systems with higher doses of NA if you don’t have too. At higher doses, buffering (neutralizing the acid with a base) should be considered, but higher doses are NOT recommended without a careful study of all of the Niacin articles, and several other MAJOR requirements we go over in those, or a direct client relationship with Dr. Smith.
Increased heart rate could also be a consequence from increased bile production and excretion properties of NA or nicotinate ions, not from the NA itself. That bile, as you should hopefully know by now, is itself acidic and has toxins in it, and some of that can and does find its way back into the blood. NA has been shown to also decrease SOME bile/fatty acid/toxin re-absorption, but possibly not significantly enough at first to be fully protective. So it could be called a “bile agitator”. Heart rate increases are sometimes an allergic/toxicity reaction and your heart could be responding to those bile acids in the blood that are exactly why we don't feel good sometimes, and this may be more than the amount of bile coming into circulation than you are currently used to.
Panicking when flushing the first time when not properly informed can also cause increased heart rate. Try not to panic, and of course don’t take huge amounts on an empty stomach that could increase chances of flushing.
Dry Skin
NA may speed up the detox pathway of stored toxins such as accumulated retinol in the layers of the skin, this could lead to increased peeling and dryness when the body is finally able to turn them into retinaldehydes and retinoic acids13 (https://doi.org/10.1101/2023.02.19.529168). The good news is that NA also helps protect the rest of the skin layers from damage at the same time this is happening16 (https://www.zotero.org/google-docs/?tFgtdJ).
Eye Issues
NA is a vasodilator (Increases the relaxation of blood vessels) . This includes blood vessels supplying the eye. A minority of NA users in NA-using chats, have reported mild temporary blurred vision or slight pressure as the eye is more hydrated from the increased blood flow. These were people taking over 1-3 grams. More noticeable symptoms could be the result of NA speeding detox enzymes in the eye and acting upon accumulated toxins (IE: Retinol to Retinaldehyde to Retinoic Acid) Ironically, the cure for these reported symptoms is generally continued NA use so the toxins can continue to be moved through the detox pathways and the vasodilation helps to shuttle them out of the eye. Lower dose or frequency if this becomes uncomfortable or vision-limiting for you. Do not upset yourself by googling "niacin eye damage" if you can't understand that the alarming-sounding eye conditions they are describing is actually just from increased hydration in the eye and completely reversible with lower doses(stopping entirely will only slow the reversal of the symptoms).
Nausea, Diarrhea, Vomiting, and anything else you have experienced from increased bile production or “dumping”
This is unlikely at lower (less than 200mg) and even less likely when FOLLOW INSTRUCTIONS and have a good fiber and protein-containing meal and clean water in your tummy first. Don’t take NA on an empty stomach even at smaller doses. Being an amino acid, it’s generally thought that your body is more receptive to it when present with food, as if it encountered the NA from the food itself.
*YOUR* Bile Dumping Symptoms:
If you have been on the LYL program for a while, you should be aware what YOUR symptoms are when bile “dumps” happen for YOU. Because NA increases bile production and excretion, these symptoms, whatever they are for you, could occur as well. Adjust your dose accordingly, by half seems to be the correct course of action, but do NOT stop suddenly. I will go over the reasons why in the forthcoming Niaspiracy article.
(1) Ahmed, H. M.; Yossif, E.; Abd-Elkader, A. S.; Abdel Aziz, E. M. The Efficacy and Safety of Niacin on Hyperphosphatemia in ESRD Patients Undergoing Hemodialysis: Randomized Controlled Trial. Egypt. J. Intern. Med. 2022, 34 (1), 33.
https://doi.org/10.1186/s43162-021-00080-x (https://doi.org/10.1186/s43162-021-00080-x)
(2) Kamanna, V. S.; Ganji, S. H.; Kashyap, M. L. The Mechanism and Mitigation of Niacin-Induced Flushing. Int. J. Clin. Pract. 2009, 63 (9), 1369–1377.
https://doi.org/10.1111/j.1742-1241.2009.02099.x (https://doi.org/10.1111/j.1742-1241.2009.02099.x)
(3) Nagata, K.; Ando, D.; Ashikari, T.; Ito, K.; Miura, R.; Fujigaki, I.; Ando, M.; Ito, N.; Kawazoe, H.; Iizuka, Y.; Inoue, M.; Yashiro, T.; Hachisu, M.; Kasakura, K.; Nishiyama, C. Butyrate, Valerate, and Niacin Ameliorate Anaphylaxis by Suppressing IgE-Dependent Mast Cell Activation: Roles of GPR109A, PGE2, and Epigenetic Regulation. bioRxiv February 21, 2023, p 2023.02.19.529168.
https://doi.org/10.1101/2023.02.19.529168 (https://doi.org/10.1101/2023.02.19.529168)
(4) Smith, D.; Wang, T.; Spanel, P.; Bloor, R. The Increase of Breath Ammonia Induced by Niacin Ingestion Quantified by Selected Ion Flow Tube Mass Spectrometry. Physiol. Meas. 2006, 27 (6), 437–444.
https://doi.org/10.1088/0967-3334/27/6/001 (https://doi.org/10.1088/0967-3334/27/6/001)
AVOID Taking Phenolics (aka Polyphenols, Bioflavonoids, Tannins, Phytoestrogens, etc.) with NA:
Do NOT take NA with “Phenolics''. Phenolics attach onto the nicotinate receptors and can either activate or inhibit them, so if you take them with nicotinic acid, they’ll be “in the way” so-to-speak. Nicotinic acid/nicotinate (NA) has a half-life of 25-45 minutes1. That means half of the amount consumed will be cleared from the body if not used, after that time. If phenolics are “in the way” while NA is present, NA cannot be absorbed as well, or bind to receptors, or bind to toxins and produce the beneficial results we want with the same effectiveness. Basically, consuming phenolics with NA will cause much of the nicotinate to be “peed” out.
Many other drugs and herbal compounds will also bind to, but not ideally activate nicotinic receptors in the body. This is actually part of the reason for some temporary benefits felt when consuming these compounds. See below for some examples:
2
Phenolics are often found in high amounts in COFFEE, TEA, brightly-colored and strong-smelling herbs and foods (polyphenols), anything containing “benzenes” or preservatives like sodium benzoate.
For example:
High phenol foods include berries, dark-skinned grapes, pomegranates, plums, walnuts, chocolate, coffee, green tea, onions, kale, parsley, tea, red wine, soybeans, cloves, peppermint, star anise, oregano, rosemary, sage, thyme, black carrots, Brussels sprouts, broccoli, yam, coriander, and tomato. Phenolic acid accounts for about 30% of all known polyphenols, while flavonoids make up over half of the currently known polyphenols. Mint, black carrots, ginger, turmeric extracts, long melon, Brussels sprouts, broccoli, yam, coriander, and tomato have high antioxidant capacity3.
AVOID Taking Picolinates Too Close to NA:
Zinc picolinate or any other supplement containing picolinate should not be taken with NA. They are very similar and come from the same tryptophan metabolic pathway, but picolinate will stop NA from being turned into NAD+ by inhibiting the first step in the pathway4. Just take your Keystone Minerals, Liquid Zinc Drops, or zinc picolinate capsules away from your NA.
How Long Apart Should I Separate Phenolics & Picolinates From NA?
Separate them by at least one hour, before or after
Even longer, up to 2-3 hours apart, is even better
IF you CAN'T separate them enough, it's better to take the NA with them, then to not take it at all!
(1) NIACOR® (Niacin Tablets, USP)500 mg.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ce739d68-d89c-437c-90fb-3c0c45140f22 (https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ce739d68-d89c-437c-90fb-3c0c45140f22) (accessed 2023-11-06).
(2) Ren, N.; Kaplan, R.; Hernandez, M.; Cheng, K.; Jin, L.; Taggart, A. K. P.; Zhu, A. Y.; Gan, X.; Wright, S. D.; Cai, T.-Q. Phenolic Acids Suppress Adipocyte Lipolysis via Activation of the Nicotinic Acid Receptor GPR109A (HM74a/PUMA-G). J. Lipid Res. 2009, 50 (5), 908–914.
(3) Brave Search: "High Phenol Foods" (https://search.brave.com/search?q=high+phenol+foods&source=desktop)
(4) Ghanem, M. S.; Caffa, I.; Del Rio, A.; Franco, J.; Parenti, M. D.; Monacelli, F.; Cea, M.; Khalifa, A.; Nahimana, A.; Duchosal, M. A.; Ravera, S.; Bertola, N.; Bruzzone, S.; Nencioni, A.; Piacente, F. Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery. Pharmaceuticals 2022, 15 (7), 848.
https://doi.org/10.3390/ph15070848 (https://doi.org/10.3390/ph15070848)
NA Phonies (do NOT buy/take these!!!):
Do ***NOT*** use the following:
“Flush-free” niacin
“No-flush” niacin
Sustained-release, extended-release, or slow-release formulations of NA
Nicotinamide Riboside
NMN (nicotinamide mononucleotide)
Inositol nicotinate
Copper nicotinate
Chromium polynicotinate
Nicotine (patches, gum, smoking, chewing, etc.)
“NAD+ increasers”
Prescription Niacin
Do NOT take any of the list and examples above. They are NOT better than NA. They are (expensive) garbage.
The bottle must literally state “nicotinic acid” on it:
It should be free of excessive flow-agents and additives or any other combos with other herbs or nutrients. For example, Solaray sells an NA that has Aloe Vera, do NOT use that one. Aloe Vera has compounds that limit NA’s effectiveness.
Approved NA (DO Take these!!!)
Dr. Smith has very kindly allowed me to link my Amazon List of approved NA-related products here in the network. If you like these new articles and the research I present, and your results, it would be so kind of you to use these links to show your appreciation :D
This one is a good choice, even though it doesn’t say nicotinic acid, it is (you can tell by the 3rd image, where they notify you of the possible "hot flush"):
Dr. Clark's 25 mg Nicotinic Acid Capsules (https://www.amazon.com/dp/B004SQM5D2/?coliid=I1FH9CAMX4NKZ9&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_5CZPSC9EQD2RMB4PETE3)
If you are just starting out on trying NA, this 25mg capsule is perfect. Do not feel you HAVE to take high doses to benefit, but I will give you a few other options here that check out.
Higher Dose Options (may use after reading everything, starting slowly, and following the guidelines)
Again, do not have to take higher than beginner doses of 25mg until you have read all of the Niacin material. I really care about this amazing molecule, NA, and I care about the health of everyone I tell about it. You all have shown a great deal of intelligence just by becoming members here and practicing all the amazing principles Dr. Smith brought to us. I have faith the vast majority of you will be pursuing this new development as carefully, if-not-more so than previous ones.
Nutricost Nicotinic Acid 100mg Capsules (https://www.amazon.com/dp/B08WYVC3ZH/?coliid=I1H0L3S1KQAYXW&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_X0HVDQQYGZCHQX059DP0)
I give these to my kids sometimes. They are good, I can tell it's high purity NA and the fillers aren't too bad seeing as rice flour is listed first. Not sure why the back says "softgels" they are just normal capsules.
High Dose ( DO NOT start with these, please work up to these after reading everything and being good LYL adherents)
Swanson Nicotinic Acid 500 mg Capsules (https://www.amazon.com/dp/B00068SJ40/?coliid=I3C1PGVW5BBSUZ&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_5Z831WG28E7517Y19J86)
I've had these they seem effective and relatively pure.
Dr. Clark's 500 mg Capsules (https://www.amazon.com/dp/B00XLZTBOC/?coliid=I3IMJWQDG750XJ&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_5CZPSC9EQD2RMB4PETE3)
Life Extension Nicotinic Acid 500mg capsules (https://www.amazon.com/dp/B000PBX32G/?coliid=I2MFYP4O3HNXGC&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_X0HVDQQYGZCHQX059DP0)
Life Extension isn't our favorite organization, I know. But I've had these, they are fine and work well for me and a lot of others have tried them recently with good results.
Bulk Supplements Nicotinic Acid 500mg Capsules (https://www.amazon.com/dp/B0BB8HRSM6/?coliid=ICSY7V4LROS85&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_X0HVDQQYGZCHQX059DP0)
This company has sent me poor quality Niacin once in the the past. I had a bag from about a year and half ago that seemed to have niacinamide as a filler, but it seems to have improved greatly. I have a 50kg drum of it, I liked it so much. My NA from them since has been really superb. I'll write an article about how to evaluate your NA for purity and test for niacinamide contamination.
Piping Rock Nicotinic Acid 1,000 mg Capsules (https://www.amazon.com/Piping-Rock-Capsules-Non-GMO-Supplement/dp/B082TS1QSD?crid=1VQ9KB98TAGT1&keywords=piping+rock+niacin&qid=1701345506&sprefix=piping+rock+niaci%2Caps%2C258&sr=8-3&linkCode=ll1&tag=kelseysupplie-20&linkId=f7e910c2631f1f6bbc56605ceb395838&language=en_US&ref_=as_li_ss_tl)
I have not tried this brand but the first filler is rice flour and it's got all the right labels on it. USA-made, GMP. I've learned to tell from the reviews of these various NA products, if they are more likely to be effective and pure. Even the bad ones, lol.
MaineGirl *flushed*. Oh noez, I'll alert the media....
That's all for now. I will keep this article updated if anything changes. When you post about your NA experience, it will be very helpful to me if you state what brand you are taking. Unfortunately, high quality and pure NA is the exception and not the rule. When in doubt, link me the NA you are able to source, and I'll help you choose.
Also, If you live outside the US or you have trouble getting these listed above. Please DM or tag me with what your options for NA in your area and I'll help you make an educated guess as to if it will meet our needs. I will also update this article with international options.
Lastly...I've heard this a lot:
"I already take Niacin/I think I get enough in food/It's in my B-complex and won't NA deplete other B's?"
If your fortified food, B-complex, or multivitamin says “NIACIN” and you think you’re covered, you are probably NOT. It’s nearly always NIACINAMIDE, check the ingredients list! It MUST say nicotinic acid on the back of the label. If you just grab a bottle labeled on the front as “niacin” from the shelf or send your partner out to get niacin, there’s a good chance it will not meet the above requirements.
Typical garbage B-complex:
Nearly all B-complexes, multis, and fortified foods have niacinamide. The main reason for this is so you don't get the niacin “flush”, freak out, and send it back…which would cost manufacturers and retail outlets lots of money.
Watch out for newer labeling that says "Niacin Equivalents" or "NE". A manufacturer can even label the food as having one "NE" if it has 60 mg of Tryptophan in it.
Niacin doesn't "deplete" "B-vitamins" or "Methyl Groups". It's an amino acid, remember? Just trust me on this for now and I'll write about it soon enough.
Happy Healing and be safe!
These instructions are for EVERYONE, LYL members and/or the general public NOT Adhering to Love Your Liver principles.
Base level, EVERYONE starts here: 25mg maximum daily supplementation with nicotinic acid (FLUSH NIACIN) after finishing a meal with protein and fiber and a little bit more water than you would normally consume.
Non-LYL folks (including the types of folks below) should MAX out at 25mg TWICE a day (50mg total):
People still very liver-toxic (AKA: very ill, chronically ill)
Elderly LYL adherents
People still struggling to adhere fully (but at least moderately) to core concepts and practice of stopping “IN-TOXING” while on LYL.
Make sure you have your water intake figured out, watch the hydration video if you haven't already (the NA will likely increase your water requirements):
https://members.nutritiondetective.com/posts/love-your-liver-hydration-fluid-intake-basics (https://members.nutritiondetective.com/posts/love-your-liver-hydration-fluid-intake-basics)
LYL people also start with 25mg nicotinic acid (FLUSH NIACIN) ONCE A DAY after a meal with protein, fiber, and ample clean water while adhering to the other NA guidelines already given.
Do this for ONE WEEK if you feel better, the same, or even slightly worse after your dose.
If you are feeling OKAY (even with mild detox symptoms) on this amount, consider remaining on this amount or increasing to twice-a-day dosing at 25mg for ONE WEEK with same mealtime advice and toxin or NA-inhibitor avoidance strategies (“GENERAL GUIDELINES”) as above.
If you don’t feel OKAY With NA at any current dose, REMEMBER to only cut your dose by half each day if you are reducing or stopping your dose. DON'T suddenly stop.
IMPORTANT: You may experience the famous “niacin flush” the first time or few times at 25 mg or when you increase your dose, but the chances are low at that amount and especially if taken with a meal and water. If you do, know that this is NOT an allergic reaction and it is demonstrably and proven harmless and even beneficial. See “Flushing Symptoms” article.
Continue re-assessing dose week by week, and consider going up by 25 mg with a meal or with 2 or 3 meals but DO NOT TAKE MORE THAN 150-200 mg total per day UNLESS you are BUFFERING! Higher doses can demand that the body “buffer” the acidity of the Nicotinic Acid to maintain normal blood pH and while your body typically can do that no problem, it’s not ideal for our efforts.
So you’ve read ALL the previous NA articles and reviewed the case reports, and have come to see that immediate-release nicotinic acid is not--by any stretch of the imagination--hepatotoxic, you're familiar with your bile-detox-dump patterns, you at least understand the concept of retracing, you're not excessively in-toxing, and you're committed to following the guidelines for taking and dosing your NA...
Maybe by now you've already tried, or are ready to try some low doses of NA (25mg-150mg), but now you want to try feeling the “FLUSH”? Feel the warmth and increased blood flow in every blood vessel in your body, and the sparkly tingles and really use NA to do some major, rapid, clean-up?
You want to get “de-toxed” like a 9-11 firefighter? You want your high cholesterol to be gone and quick? You wanna get lean and look younger and have nice, clear skin and forgo the need for deodorant?
Sounds pretty fantastic right?
BUUUUUTTTT……and this is a “VERY-BIG-BUT”
READ THIS guide CAREFULLY before attempting anything over 150 mg-200 mg of nicotinic acid and know that even with perfect, SANE, cautious usage, retracing symptoms are probably going to occur and occur relatively quickly (this is a GOOD thing overall, it's just confusing when it happens!).
A few of Dr. Smith’s pearls to keep in mind:
Here’s a new one for you, from me [KK]:
“FLUSH NIACIN…It ain’t toxic, YOU IS!!!”
This means that flush niacin is going to be clearing up all sorts of stuff….years of gunk, literal “brown crud” and “heavy metals” and fatty toxins, bile acids, retinoids, hormones, mycotoxins, aldehydes, alcohols, “whatever they say coof is this week”, etc… is going to come out of your liver and other tissues where they have accumulated, locked down in storage, your body waiting to FINALLY have the needed amounts of the required co-factor to take them to the one-way-poo-poo-choo-choo-train out of the body.
That leads me to quote another pearl we do well to keep in mind here:
“It’s a poison going in and it’s a poison going out”
NA powers over 400 enzymes (that we know of, see spreadsheet of enzymes connected with NA here (https://docs.google.com/spreadsheets/d/1ryMDA6e5ugeYg1KHbou5aThm2fV8btOY/edit?usp=sharing&ouid=101312185800432673420&rtpof=true&sd=true)), and hundreds of those are detoxification enzymes, including MANY involved in alcohol and aldehyde detoxification. But remember how Dr. Smith tells us that, for example: retinol/retinyl esters we eat or that come out in the bile turn into retinol, those turn into retinaldehyde and finally and irreversibly into retinoic acids...and the acids are the worst for you but you've go through it to get out of it?
This is EXACTLY WHY we do NOT take higher doses if you are still significantly in-toxing, (i.e. lots of polyphenols, pharma/otc drugs, herbal supplements, illicit drugs, sussy supplements), you haven’t learned to trust your body's signals yet, and or are very sensitive and chronically ill/elderly, or in any way illiterate (can’t read too good).
Under-types and "sensitive" types should be especially careful with NA, just as with their other supplements. You should be 80%+ with your Love Your Liver diet and avoidance strategies and general philosophy of healing, have your other deficiencies sorted out, and your water and electrolytes (sodium, potassium, magnesium), and be familiar with your optimal charcoal dose (which will likely increase as the NA helps you poop better), and all that good stuff figured out too before you turn your amp up to eleven with NA and start rocking out….
Got all that? If you didn't adhere to all that and you had a bad time, do not stop immediately, cut dose by no more than half at a time per day and titrate down to low dosing guidelines from earlier on in the course section
You may just be too sensitive right now to handle higher doses. Please keep in mind that there is plenty of research to suggest even low doses of nicotinic acid are very restorative. There is no need to push yourself past tolerance to "go faster".
From Niacin Dosing Article for review:
What Happens when you take Niacin?
“In your body, it’s actually nicotinate that does all the good stuff we’re looking for. It binds the receptors and is the ideal substrate for making NAD+, a basic building block of life. How do we get from nicotinic acid to nicotinate then?”
When you consume nicotinic acid, the hydrogen atoms on the molecules of nicotinic acid disassociate (break off) from a majority of the nicotinic acid in the aqueous (wet) environment of your stomach. The hydrogen associates with water molecules in your tummy making H30+.(hydronium). The more H30+ in a solution, the more acidic (lower pH) that solution is considered (in this case, the stomach contents)..
This is nothing to worry about, as your stomach is designed for very acidic conditions (1-2 pH) and nicotinic acid with a pH of about 3 is not a big deal. We take in acidic foods and drinks all the time. However, there may be excess acidity introduced to the body when using large (over 0.5-1 gram) doses of nicotinic acid on a regular basis.’
[More significant reactions to nicotinic acid and increased heart rate] “may come from too much acidity from larger single doses (150-200mg) of NA. Some of the NA consumed will still be in the acid form and diffuse into the blood and this can demand the body use its “blood buffer” systems to maintain normal blood pH. One of the primary blood buffer systems involves the release and catabolism (breakdown) of the abundant essential amino acid, glutamine from intracellular storage, to produce ammonia and release bicarbonate from the kidneys to counter the acid. It's totally something your body does all the time, but your cells do better when they have the glutamine inside and available for the cellular processes that NA kicks off, not in the blood. Small pH changes up (basic) or down (acidic) on the pH scale can affect heart rate as the body adjusts. Your body has plenty of acids to deal with and neutralize all the time, there’s no need to put additional burden on those systems with higher doses of NA if you don’t have too. At higher doses, buffering (neutralizing the acid with a base) should be considered”
3
Also, nicotinic acid/nicotinate will stimulate increased hydrochloric acid secretion in the stomach. The pyloric sphincter is also operated by sensing the pH of the stomach. In a healthy person, it remains tightly shut like a closed camera aperture until it senses that the stomach contents has become low enough pH that it’s ready to move past the stomach and down the rest of the digestive system. So if you artificially induce a bunch of acid to the stomach the sphincter may open up, regardless of how much food you have and then that bile is much more likely to get refluxed into the stomach and that could be a recipe for nausea, diarrhea, vomiting, indigestion and upset stomach (that means a “total barf-o-rama” for the kids in the back).
Oh and that's not all…nicotinic acid/nicotinate is also a MAJOR choleretic (stimulates the excretion of bile) and cholagogic (stimulates the production of bile)(2). So a BUNCH more bile is going to come out into the duodenum (the little area under the stomach sphincter where bile is released) upon ingestion.
How do we avoid some of that discomfort and supplement some needed minerals at the same time? As you saw above nicotinic acid will dissociate into nicotinate anions and result in more acid in your system and bloodstream. For example: sodium nicotinate will break into a sodium cation(+) and a nicotinate anion(-), yet it will not add any more acidity to your system.
According to the paper by the OG Niacin Duo; Dr. Rudolf Altschul and Dr. Abram Hoffer, sodium nicotinate has the same cholesterol lowering-effects as nicotinic acid and they claim that it was much better tolerated by their patients (1). And it’s clear from all the research I’ve uncovered, that it's the nicotinate doing all the work, so why get a tummy ache over it when you don’t have to?
How did I figure out that buffering was helpful? I learned the hard way so you don't have to! I gave myself acid-damage cavities (yes I got Mountain Dew mouth) from drinking large daily doses of unbuffered nicotinic acid. My mom is a dentist, and she was very displeased at having to fill some of them for me. You wouldn't believe how many head shakes and sighs I got in her operatory chair that day. I wasn't even paying attention as the cavities developed, just brushing my teeth twice a day like everybody else! I vowed to her I'd try to re-mineralize the smaller ones so I invented some pretty great tooth powder and learned the awesome benefits of the buffered niacin. So please don't wreck your teeth, even if your digestive system can handle it, remember that your teeth are an important part of that system too and do not regenerate as quickly as other parts of the body.
So Let's get ready to BUUUUUFFFFFEEER
You’ve never heard of “buffering” a supplement before? Sure you have. All chelated minerals for example zinc picolinate, magnesium glycinate, potassium gluconate, and on and on, are “buffered” or made into a pH-neutral compound this way. There’s also buffered vitamin c and buffered Aspirin:
This is done to help absorption and prevent negative side effects from the acid portion of the supplement.
So get ready because we're gonna do some……SCIENCE!!!! Yay SCIENCE!!
Ever made a “volcano” with baking soda and vinegar in elementary school? Wasn’t it just the- most-funnest-thing-ever? Baking soda is a base. Vinegar is an acid. Mix them together and carbon dioxide bubbles out and you are left with sodium acetate which is neutral (7pH). Since vinegar and nicotinic acid and vinegar both have the same carboxylic acid group as nicotinic acid does, they react similarly and to almost full completion.
Soooo much fun!
Yeah that’s BASIC-ally what we are doing here. And this time… you’re going to DRINK the lava…Are you ready to feel the “BURN”??? (just kidding!)
Instructions and Options For Buffering Nicotinic Acid (acid) With Alkaline Mineral Salt (base)
BEST PRACTICE: Weigh out each individual dose of nicotinic acid and buffer with the correct amount of mineral base.
Loose nicotinic acid powder (acid):
Bulk Supplements Nicotinic Acid Powder (https://www.amazon.com/dp/B00ENRG3XY/?coliid=INRZKW48C3WAW&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_MG5EVQFHFVKA06PH91XJ)
Nutricost Niacin Powder (https://www.amazon.com/dp/B010RBSLRU/?coliid=IVQJ8SR80XLQ9&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_7CWXPDTZ5EC5XM15ANX1)
Loose Alkaline “salt” (base) options:
Sodium bicarbonate (baking soda)
Nutricost Sodium Bicarbonate Powder (https://www.amazon.com/dp/B08M4FZJ4Z/?coliid=IWVXHFSLMZLAF&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_7CWXPDTZ5EC5XM15ANX1)
Earthborn Elements Baking Soda Powder (https://www.amazon.com/dp/B078Z2ZMNR/?coliid=I1C8KFYOUE2JE0&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_7CWXPDTZ5EC5XM15ANX1)
Pure Baking Soda Powder (https://www.amazon.com/dp/B0753YZ3FS/?coliid=I2SEEVAA0NVVAH&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_7CWXPDTZ5EC5XM15ANX1)
Potassium Bicarbonate (KHCO3)
Earthborn Elements Potassium Bicarbonate Powder (https://www.amazon.com/dp/B07YN71Q9G/?coliid=I31EDL5SA929S6&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_7CWXPDTZ5EC5XM15ANX1)
Bulk Supplements Potassium Bicarbonate Powder (https://www.amazon.com/dp/B075GTXBQR/?coliid=I2IXO6LJAZJEII&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_7CWXPDTZ5EC5XM15ANX1)
Nutricost Potassium Bicarbonate Powder (https://www.amazon.com/dp/B08M142Z2J/?coliid=I3JG4WQYKTUBL1&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_7CWXPDTZ5EC5XM15ANX1)
Magnesium Carbonate MgCO3
Pure Magnesium Carbonate Powder (https://www.amazon.com/dp/B08Y665J5Q/?coliid=I4I2B4JYFMXED&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_E7BBN4Z4THFR0GCTZHYR)
Bulk Supplements Magnesium Carbonate (https://www.amazon.com/dp/B00EOWINQS/?coliid=I3HU3CCBMAGJE2&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_E7BBN4Z4THFR0GCTZHYR)
Bulk Supplements Magnesium Hydroxide Powder (https://www.amazon.com/dp/B00GUOWEL8/?coliid=I1SFD8XFR6RMQM&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_E7BBN4Z4THFR0GCTZHYR)
Equipment:
Milligram Scale: a small scale that is accurate to the milligram (mg or 1,000th of a gram) and can weigh up to 20 grams of powder. This will be for single doses, and deliver best for accuracy in dosing for sensitive people.
Milligram Scale with Case and Four Powder Pans (https://www.amazon.com/dp/B0B3RFPYVS/?coliid=I3MCGCKKSD1STR&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_39C3SNGSJJETACXWDRD0)
Small Scoops/Spoons:
Norpro Mini Measuring Spoons from ND Shop (https://nutritiondetective.com/products/norpro-mini-measuring-spoons)
*use for approximate doses by volume
Steel Lab Spoons (You're a really cool scientist if you start using these.)
Amazon Link: 22 Pieces Steel Lab Spatula Micro Scoop Set (https://www.amazon.com/dp/B0824DBV87/?coliid=I14QT2SPTER3WL&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_39C3SNGSJJETACXWDRD0)
Buffering Your NA by Exact Mass Chart and Instructions
It's a good idea to print this chart out and keep it where you take your supplements and make notes. Here is the file to print out each chart, each of the three methods are on separate sheets: (chart link) (https://docs.google.com/spreadsheets/d/1usuu45schk3-KMh4QwWCpuK976z6k-aK/edit?usp=drive_link&ouid=101312185800432673420&rtpof=true&sd=true)
1. Turn your scale on. Use flat, smooth surface. Set scale to “milligram"
2. Put weigh-boat or small cup onto the scale and press the “tare” button
3. Carefully dispense your desired amount of nicotinic acid into the cup until the scale reads the desired mass.
4. Place all of your correctly weighed NA into your drinking glass
5. Put weigh-boat back on the scale, make sure it reads zero again or tare it so it reads zero once more.
6. Dispense the amount of buffer into the cup until the scale reads the correct corresponding mass for the amount of NA you dispensed and the type of buffer.
7. Put this weighed buffer into your drinking glass with the NA. and add at least 6-8 oz. of distilled or R.O. water, it will bubble so be aware that it could spill over if your glass is too small.
Note: If using MgCO3 OR MgOH2 as your buffer, add a small amount of warm or hot water to your dispensed powders, swirl and allow to bubble (magnesium hydroxide will not bubble) and react. The solution with either should turn clear or more clear, add the desired amount of warm or room temperature distilled or R.O. water.
Less-Good Practice: Buffering Your NA dose by Volume (Not Exact)
Print out this chart for quick reference in your laboratory : ) or kitchen (chart link) (https://docs.google.com/spreadsheets/d/1usuu45schk3-KMh4QwWCpuK976z6k-aK/edit?usp=drive_link&ouid=101312185800432673420&rtpof=true&sd=true)
Buffering by volume is not necessarily recommended for doses under 150mg. Under-buffering (not quite enough base) seems to be favorable than over-buffering (too much base), in my opinion.
Use the correct teaspoon fraction to dispense your desired NA dose in milligrams (in parenthesis) into your drinking cup.
Use a new spoon or wash your previous measuring spoon and use it to dispense the correct amount of buffer according to amount of NA dispensed and buffer type. Put the buffer into the drinking cup with the NA and add at least 6-8 oz of distilled or R.O. water, it will bubble so be aware that it could spill over if your glass is too small.
Note: If using magnesium carbonate OR magnesium hydroxide as your buffer: Add a small amount of warm or hot water to your NA and buffer powders, swirl and allow to bubble (magnesium hydroxide will not bubble) and react. The solution should turn clear or more clear, add the desired amount of distilled or R.O. water.
Buffering Your NA Capsules with Buffer Capsules
This method is not exact and possibly not the most effective when it comes to the magnesium oxide pills. You will know if the magnesium oxide has not reacted sufficiently with the NA if you get loose bowels.
Ingredients:
Nicotinic Acid Capsules.
See buying guidelines article for what to purchase and use. (Buying NA Guidelines link) (https://members.nutritiondetective.com/posts/love-your-liver-nicotinic-acid-buying-guidelines-super-important-by-kelsey-kenney)
Buffer Capsule Options:
Sodium Bicarbonate (baking soda) Capsules
Sodium Bicarbonate Capsules 800mg (https://www.amazon.com/dp/B0979K41MY/?coliid=I3RE01901DTBZK&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_SZYPFV6QS31B3MM44JSP)
Baking Soda (Sodium Bicarbonate) Capsules 800mg (https://www.amazon.com/dp/B0979HCWYB/?coliid=I1B7VTVYAI56J2&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_SZYPFV6QS31B3MM44JSP)
Baking Soda (Sodium Bicarbonate) Capsules 600mg (https://www.amazon.com/dp/B00JMPF7IE/?coliid=IXKPCBFC1TCEE&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_SZYPFV6QS31B3MM44JSP)
Potassium Bicarbonate Capsules
Potassium Bicarbonate Capsules 800 mg. (https://www.amazon.com/dp/B07YN71Q9G/?coliid=I31EDL5SA929S6&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_SZYPFV6QS31B3MM44JSP)
Potassium Bicarbonate Capsules (https://www.amazon.com/dp/B0BMQZNQ6S/?coliid=I21NCG4GNO9DQR&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_ZH4AM3CN5R0Y569MA3XR)
Sodium and Potassium Bicarbonate Blend Capsules
Sodium and Potassium Bicarbonate Blend Capsules 800mg (https://www.amazon.com/dp/B07S25GG4T/?coliid=I2X9DQL79NRWLW&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_SZYPFV6QS31B3MM44JSP)
Sodium and Potassium Bicarbonate Capsules 800mg (https://www.amazon.com/dp/B08R6QYRM7/?coliid=I2Q3P3B16T1CSJ&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_SZYPFV6QS31B3MM44JSP)
Magnesium Oxide Capsules
Magnesium Oxide Capsules 500 mg Capsules (https://www.amazon.com/dp/B0BB8CXD6R/?coliid=I2XU905F8SE8SK&colid=8N5HJF9Y9NQC&psc=1&ref_=cm_sw_r_cp_ud_lstpd_SZYPFV6QS31B3MM44JSP)
Nutrition Detective Shop-Magnesium Oxide 500 mg Capsules (https://nutritiondetective.com/products/douglas-labs-magnesium-oxide)
Print out this chart for quick reference in your laboratory : ) or kitchen (chart link) (https://docs.google.com/spreadsheets/d/1usuu45schk3-KMh4QwWCpuK976z6k-aK/edit?usp=drive_link&ouid=101312185800432673420&rtpof=true&sd=true)
Dispense capsule(s) that make up the right dose of NA for YOU
Dispense the desired buffer capsule(s) and buffer type corresponding to that NA dose.
Swallow at the same time, warm water is best to help speed up dissolution of the capsules and the reaction.
PLEASE NOTE THE LARGE AMOUNT OF POTASSIUM corresponding to some of these doses. DO NOT take too much potassium if you don't know what you are doing even if you are tolerating that much nicotinic avid with another buffer and you have not figured out how your body reacts to potassium supplementation. Be careful with big jumps in potassium supplementation!
https://members.nutritiondetective.com/posts/love-your-liver-potassium-dosing-foods-supplements (https://members.nutritiondetective.com/posts/love-your-liver-potassium-dosing-foods-supplements)
Because of the large increase in bile you will likely experience, it’s nice to have some charcoal to help soak up some of the extra bile. Because NA is a nutrient and not a toxin, charcoal will not adsorb it, but will absorb some of what the NA helps encourage out of your liver and bloodstream. Start by taking the amount of charcoal that you already know you can tolerate without constipation with your NA or buffered NA dose if you feel like you could benefit from more efficient and safer clearing of your bile “recipe”. If you find your pooping is consistently good with this amount of charcoal in your NA “cocktail” and you feel like you could use more protection from the toxins on their way out, increase your charcoal to comfort. Troubleshoot using the same principles in the soluble fiber and charcoal sections of this program.
(1)Altschul, R.; Hoffer, A. Effects of Salts of Nicotinic Acid on Serum Cholesterol. Br Med J 1958, 2 (5098), 713–714. https://doi.org/10.1136/bmj.2.5098.713 (https://doi.org/10.1136/bmj.2.5098.713). https://drive.google.com/file/d/1NgQIAy5XA2VfQyYCIpd9j35slSdW5Kbm/view?usp=sharing (https://drive.google.com/file/d/1NgQIAy5XA2VfQyYCIpd9j35slSdW5Kbm/view?usp=sharing)
(2)Stepanini, M. The cholagogic and choleretic effect of sodium nicotinate. Amer. Jour. Dig. Dis. 17, 337–338 (1950). https://doi.org/10.1007/BF03002584 (https://doi.org/10.1007/BF03002584) https://drive.google.com/file/d/1gVcDq4ksA8XPIFnIxNXSukmYMIh4U9GJ/view?usp=sharing (https://drive.google.com/file/d/1gVcDq4ksA8XPIFnIxNXSukmYMIh4U9GJ/view?usp=sharing)
Remember, NA is an AMINO ACID derived from Tryptophan, it is NOT a "B-vitamin"!
When WE say "Niacin", we mean nicotinic acid (NA) OR nicotinATE OR flush niacin. We don't mean ANYTHING else! We often will call it NA (short for Nicotinic Acid) here to be PRECISELY CLEAR. We don't call it "vitamin B3" either, just as we'd stop calling vA a "vitamin" if people could still know what we were talking about!
You will hear this OVER and OVER again:
DO NOT take niacinamide or nicotinamide!
There are many other things related to NA below that you should NOT take! Do not try to reinvent the wheel and be some rogue experimenter. Kelsey has already reviewed all the research, and it is quite clear that NA is the only thing you want
FOLLOW THE INSTRUCTIONS we give you!
If you are dosing 150-200mg or more of NA per day, BUFFER IT!
The acidic nature of NA can raise your acidity and this is FIXED VERY SIMPLY by following Kelsey's buffering instructions (see related NA buffering article!)
The flush is NOT DANGEROUS and it is NOT AN ALLERGIC/HISTAMINE REACTION
Take the same dose of NA for long enough, the flush decreases in strength & intensity
Over time, the flush from the SAME DOSAGE will eventually go away
As you grow used to the flush, you might actually start to enjoy it
Have a baby aspirin or normal aspirin around in case you really want to shut down the flush quickly, particularly for you ANXIOUS types
If you have NA-flushed before when you used to be MORE TOXIC and it was quite intense, it will likely be LESS now because the LYL makes us LESS TOXIC
Want the flush to be as minimal or non-existent as possible to begin? TAKE ONLY A TINY BIT!(ie. fingertip dust worth)
Also do a lower-carb, higher-protein, higher soluble-fiber full meal with it, that will help minimize the flush (if that's your goal)
We also are likely going to start at a lower dose than you did before, at only 25mg or even less!
You can take NA with a flush up to 3x max per day
Increasing one's dose of NA further will increase the flush (aka restore to previous intensity)
The bigger the increase, the more the flush returns in intensity
Taking breaks from the NA will bring back flush intensity (aka restore to previous intensity)
The longer the break, and the more toxicity you take in during the break, the more the flush returns in intensity
Once you know how the flush feels and are not scared of it (maybe even enjoy it), the only people the flush will bother are other people who see you looking flushed pinkish/red
How you can manipulate the "flush intensity" with FOOD:
First, ALWAYS take with a meal, OR at least with SOME food, containing:
Some carbs
Less carbs = WEAKER flush, more DELAYED start to flush
More carbs = STRONGER flush, QUICKER start to flush
Soluble fiber
More soluble fiber = WEAKER flush, more DELAYED start to flush
Less soluble fiber = STRONGER flush, QUICKER start to flush
Some protein
More protein = WEAKER flush, more DELAYED start to flush
Less protein = STRONGER flush, QUICKER start to flush
Possibly some charcoal (see articles!)
DON'T take Niacin with these things:
NOT On an empty stomach
Take your NA after you eat, not before
Try to take your NA within at least 60 minutes of eating
NOT with high-polyphenol foods (COFFEE, CHOCOLATE, proanthocyanidins, bioflavonoids, isoflavones & phytoestrogens)
High-polyphenol foods are typically brightly, strongly, or darkly colored (can basically be any color except white, is the general rule)
Separate by 1-2 hours before or after
NOT with Zinc Picolinate or any other mineral picolinate
This includes the ND Keystone Minerals, ND Liquid Zinc, or any other mineral PICOLINATE
Separate by 1-2 hours before or after
ONLY use Niacin that is one of the following:
Nicotinic acid or nicotinATE (ex. sodium nicotinate)
We ONLY use nicotinic acid aka NA, aka "flush niacin", aka nicotinate
In the buffering article, Kelsey teaches you how to make your own sodium nicotinate, or potassium nicotinate, or magnesium nicotinate
It is HIGHLY unlikely that you will find any mineral nicotinates FOR SALE with the minerals that we use here (magnesium, sodium, potassium, zinc, selenium, molybdenum)...until WE come out with them 😉
Flush niacin (or it says somewhere that it may cause flushing)
Free or almost-free of excessive fillers, additives, or other ingredients
Do ***NOT*** use ANY of the following:
NO “Flush-free” or “No-flush” niacin
NO Sustained-release, extended-release, or slow-release formulations of NA
NO Nicotinamide Riboside
NO NMN (nicotinamide mononucleotide)
NO Inositol nicotinate
NO Copper nicotinate aka MitoSynergy
NO Chromium polynicotinate
NO Nicotine (patches, gum, smoking, chewing, etc.)
NO “NAD+ increasers”
NO Prescription Niacin
BUFFERING - Realize that NA in higher doses brings an acidic load with it
MAKE SURE YOU ARE BUFFERING! This solves the acidity problem entirely
Signs you need to buffer your NA or you aren't buffering enough:
Taking more than 150-200 mg TOTAL NA per day
Noticeable (or significantly increased) ammonia smell to your:
Breath
Urine
Body odor or sweat
Buffering with baking soda (sodium bicarbonate) adds sodium to your diet
If you get too much sodium for you, it might show up as increased thirst or dry mouth, increased heart rate, and/or increased blood pressure
Buffering with potassium bicarbonate adds potassium to your diet
If you get too much potassium for you, it might show up as heart rhythm issues (palpitations), and/or increased thirst or dry mouth
Buffering with magnesium carbonate adds magnesium to your diet
Too much magnesium BY MOUTH can lead to loose bowels and/or stomach gurgling
CHARCING - Realize that NA is a choleretic (increasing bile production) and a cholagogue (promoting the flow of bile from the liver and gall bladder into the intestines)
It helps speed up ALDH (helps detox) and this also helps increase bile in general
Know your own bile-detox-dumping symptoms in general, and start with lower doses (NA will help your constipation! (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523733/))
The idea is to take the charcoal with the NA, so that it "catches" the increased bile the NA helps produce and dump
As you poop better, start adding activated charcoal in when you take your NA
If you are already taking activated charcoal, CONTINUE taking it, increase as you are able, and take it WITH your NA
Doses are completely based on the individual, there are no strict guidelines here
See "Activated Charcoal for vA Detox (https://members.nutritiondetective.com/posts/love-your-liver-activated-charcoal-for-va-detox)" articles
Low-dose NA guidelines (EVERYONE STARTS HERE!!!)
These are for ANYONE starting on NA for the first time!
INCLUDING newbies to LYL or LYL veterans who have never done NA
People who are STILL IN-TOXING and "just want a pill" will NEVER LEAVE this low-dose level! This is people like your family and friends who don't want to change their diet & lifestyle habits
To be clear, low-dose NA can help just about anyone. Studies with 50mg of nicotinic acid have shown great results, so don't feel you have to do the high-dosing below to get benefits
Start at 25mg per day (OR LESS if you are an ANXIOUS or very VERY SENSITIVE type)
NA powder can be mixed with water and does not taste bad
Capsules can be opened up so less can be taken
You could, but you don't have to, take a dose of NA up to 3x/day (once a day is totally fine too!)
Taking multiple separate doses a day can get you through the "reducing the flush intensity" phases much more quickly
Once you feel like you are OK with the flush at a certain dose, then you can increase your next dose by 25mg
MAX for this stage is 200mg TOTAL per day
TOTAL means ALL of the day's doses added together
You may or may not need to buffer at this level
If you don't want to buffer and you are getting ammonia/acidity symptoms (see previous list of symptoms), then simply reduce your dose to a level where the symptoms are not present, OTHERWISE START BUFFERING
High-dose NA guidelines
If you're a good reader, read this AT LEAST TWICE through, and take notes
If you're a bad reader, read this 3x today, 3x tomorrow, and take notes
These instructions are VERY CLEAR. Disregard them or poorly understand them AT YOUR OWN RISK
This stage is ONLY for those who:
Are doing 80+% of the LYL principles, 80%+ of the time
AKA not a LYL noob
Are working on correcting their ZINC, SELENIUM, MOLYBDENUM, MAGNESIUM, & POTASSIUM deficiencies
Have properly progressed through the low-dosing stage described above
PROMISE to BUFFER the NA as Kelsey describe in this article
Are COMFORTABLE with the flush, OR never flushed on the low-dose stage
Those who don't flush at lower doses should be aware it will likely happen at higher doses!
KNOW what their typical toxic-bile-detox-dumping symptom patterns are
Understand the concept of RETRACING aka UNWINDING aka HEALING CRISIS, and hopefully you've already experienced it with the program
Are familiar with their needs and tolerances for soluble fiber foods and/or supplements, & activated charcoal
Understand that you can REDUCE your dose of Niacin AT ANY TIME, FOR ANY REASON
See above for why you may not want to stop COMPLETELY all at once
This will use either 500mg NA capsules or bulk Nicotinic Acid powder
One should already be up to 200mg of NA a day before starting this
The next jump from 200mg is to one 500mg capsule (or 1/4 tsp of nicotinic acid powder, which is 625mg)
500mg a day is a great dose, don't hesitate to stay there if you want, for simplicity (one capsule, one dose/day) and low buffering requirements
Otherwise, jumps of 500mg (or 1/4 tsp of nicotinic acid powder, which is 625mg) once you are OK with the flush at any particular dose, is OK
MAX DAILY DOSE that most Niacin groups push to is 3000mg/day TOTAL
For those of you who won't listen to reason, we don't suggest going over 5000 mg total per day, and if you push this dose, KNOW THAT THIS IS NOT A LONG-TERM DOSE
My personal experience is that RETRACING of old health issues happens FAST & FURIOUS at this type of intake level. YOU HAVE BEEN WARNED
Once a retracing episode starts, it will finish on its own, unless you want to do things like medications to damage your liver and shove it right back into the places it was trying to come out of. These warnings are here for a reason, folks!
Stopping, taking a break, or backing off:
First, realize that the following symptoms are NOT to be expected, but CAN happen and fall within the realm of "normal" at the BEGINNING of supplementing NA, and you can reduce them by simply reducing your dose(if you want to):
First, ARE YOU ALREADY BUFFERING? If not, START!
Increased heart rate
Dry skin (see if more hydration helps, also you can know not to worry if other skin issues are improving at the same time, this may be part of the vA detox process of the skin, see Mea Culpa article)
Eye issues - mild temporary blurred vision or a feeling of slight pressure in the eyes
Nausea, diarrhea, vomiting, and anything else you have experienced from increased bile production or “dumping”
The ABOVE SYMPTOMS mean YOU need CHARCOAL to soak up that bile!
If you want to back off of NA for any reason, we DON'T suggest dropping off to zero suddenly
Again, ARE YOU BUFFERING YET? If not, START!
Use activated charcoal with the NA to soak up bile if you can
Dropping your dose by only HALF would be a good first step for at least 3-7 days before dropping more
If you suddenly stop completely, your detox enzymes will slow down while your bile production will likely stay elevated, and this will make you FEEL BAD
Remember, taking breaks from the NA will bring back flush intensity
If you still aren't sure what to do, go back and read this Summary and any related linked articles AGAIN!
Simple Buffered Nicotinic Acid SKIN SPRAY
This spray is gentle (for the majority of people) to use on boo-boos and sensitive or irritated areas of the skin. Test a small area before applying to the rest of the skin. Apply as often as feels appropriate for your health situation and scale back dose if any unmanageable re-tracing or detox symptoms occur.
For studies, discussion, materials buying links, related to the use of topical nicotinic acid or nicotinate salts, please join me on Telegram at : https://t.me/niasource (https://t.me/niasource)
Materials and Ingredients
4 oz. Amber or other light-protective glass spray bottle (wash glass in dishwasher or boil before use)
Spoon or stir stick.
Glass measuring cup with pour-spout and handle
Small funnel to fit into neck of bottle (optional)
Teaspoon set or milligram scale
½ tsp. Nicotinic acid (1,111 mg)
⅛ tsp. Sodium bicarbonate (baking soda) (631 mg)
Distilled or reverse-osmosis purified water
Preparation
Bring a cup (8 oz.) of water to a boil and then set aside.
Measure or weigh out on a milligram scale your nicotinic acid (½ tsp or 1111 mg) and dispense the powder into the measuring cup.
Measure or weigh out the baking soda on a milligram scale the baking soda (⅛ tsp or 631 mg) and dispense the powder into the same measuring cup.
Pour a small amount of the still-hot boiled water onto the powders in the measuring cup (1 oz. or so) and stir until well dissolved and bubbling slows. Don't worry, nicotinic acid is incredibly heat-stable, you won't hurt it. *If your solution smells like ammonia after this step or the next, please do not use, your niacin may be of low purity, please let me know what brand you used if this happened*
Fill the measuring cup with more warm water to reach the 4 oz. line.
Carefully pour this solution into your glass spray bottle with the spout of the measuring cup or use a small funnel for easier dispensing.
Insert spray bottle attachment and tighten well. Allow to cool before applying.
Tips
Discard any remainder after 4-8 weeks or if the solution becomes cloudy and/or difficult to dispense. Store in the fridge for a longer shelf-life. If you love it, you may double the recipe if using an 8 oz. glass spray bottle ( or two 4 oz. bottles) and fill water to 8 oz. line at step 5.
"Mag-Ka-Nic" SPRAY
This spray is more concentrated than the "All Over" formula, it can be used to calm sore muscles or joints, in the same way as magnesium oil or lotion. Use only on intact skin that is not dry/flakey, or irritated. It is very likely that this spray could help increase your potassium and magnesium levels in a way close to Mag-Ka-hol with regular use. It may be alright to use on sensitive skin without sting, but it's not been tested for that. Test a small area before applying to the rest of the skin. Apply as often as feels appropriate for your health situation and/or based on your hair test results/ Dr.'s guidance and scale back spray dose if any unmanageable re-tracing or detox symptoms occur-whatever you think they might be.
For research, discussion, and buying links related to the use of topical nicotinic acid or nicotinate salts please join me on Telegram at : https://t.me/niasource (https://t.me/niasource)
Materials and Ingredients
4 oz. Amber or other light-protective glass spray bottle (wash glass in dishwasher or boil before use)
Spoon or stir stick.
Glass measuring cup with pour-spout and handle
Small funnel to fit into neck of bottle (optional)
Teaspoon set or milligram scale
1 1/2 tsp. Nicotinic acid (3,333 mg)
1/4 tsp. Potassium bicarbonate ( 1,171 mg)
3/4 tsp. Magnesium Carbonate (1,812 mg)
Distilled or reverse-osmosis purified water
Preparation
Bring a cup (8 oz.) of water to a boil and then set aside.
Measure or weigh out on a milligram scale your nicotinic acid (1 1/2 tsp or 3,333 mg) and dispense the powder into the measuring cup.
Measure or weigh out the magnesium carbonate on a milligram scale (3/4 tsp or 1,812 mg) and dispense the powder into the same measuring cup.
Measure or weigh out the potassium bicarbonate on a milligram scale (1/4 tsp or 1,171 mg) and dispense the powder into the same measuring cup.
Pour a small amount of the still-hot boiled water onto the powders in the measuring cup (1 oz. or so) and stir until well dissolved and bubbling slows down. Don't worry, nicotinic acid is incredibly heat-stable, you won't hurt it *If your solution smells like ammonia after this step or the next, please do not use, your niacin may be of low purity, please let me know what brand you used if this happened*
Fill the measuring cup with more warm water to reach the 4 oz. line.
Carefully pour this solution into your glass spray bottle with the spout of the measuring cup or use a small funnel for easier dispensing.
Insert spray bottle attachment and tighten well. Allow to cool before applying.
Tips
Shake well before use, settling is normal. Not shaking it before spraying may clog the spray mechanism. Rub this spray well into the area you want to treat for better absorption and effectiveness. Discard any remainder after 4-8 weeks. Store in the fridge for a longer shelf-life. If you love it, you may double all the quantities in the recipe, using an 8 oz. glass spray bottle instead (or fill (2) 4 oz. bottles ), and fill water to 8 oz. line at step 6.
Did you know that one of the main reasons coffee enemas are effective for many (besides the induced expulsion of toxic bile) is because of coffee's small amount of nicotinic acid? It's also one reason why coffee is addictive. Your body craves the caffeine of course AND the NA! Did you know that some people's cravings for alcohol, chocolate, coffee, tea, etc... lessen or completely go away upon nicotinic acid supplementation, sometimes even at low doses?
Anyways...back to the butt of the matter...
You can skip the brew, the tubes, bucket, mess, and uncomfortable amounts of fluid up your rear-end, yet still have all the benefits of 10+ Venti coffee-enemas in 1 small 4-8oz, easy and disposable method I came up with after reading the following summary article and the study it referenced:
https://cfsremission.com/2017/04/15/real-niacin-improves-ibdibs-and-likely-cfsfm/ (https://cfsremission.com/2017/04/15/real-niacin-improves-ibdibs-and-likely-cfsfm/)
https://www.embopress.org/doi/full/10.15252/emmm.201606987 (https://www.embopress.org/doi/full/10.15252/emmm.201606987)
For studies and sources related to the use of topical nicotinic acid or nicotinate salts please join me on Telegram at : https://t.me/niasource (https://t.me/niasource)
Materials and Ingredients
4 oz. disposable "Fleet" or other brand saline enema
Glass measuring cup with pour-spout and handle
Small funnel to fit into neck of bottle (optional)
Thermometer for liquids
Small funnel to fit in enema bottleneck (optional)
Teaspoon set or milligram scale
1/4 tsp. Nicotinic acid
1/8 tsp. Sodium bicarbonate (baking soda)
Distilled or reverse-osmosis purified water
Preparation
Bring a cup (8 oz.) of water to a boil and then set aside. I like to boil extra in case I mess up and ensure that I don't boil off too much water. When I use my very handy electric kettle, I boil 16 oz for everything because has a 2 cup (16 oz minimum)
Measure or weigh out on a milligram scale your nicotinic acid (1/4 tsp. ) and dispense the powder into the measuring cup.
Measure or weigh out the baking soda on a milligram scale 1/8 tsp. and dispense the powder into the same measuring cup.
Pour a small amount of the still-hot boiled water onto the powders in the measuring cup (1 oz. or so) and stir until well dissolved. Don't worry, nicotinic acid is incredibly heat-stable, you won't hurt it. *IMPORTANT: If your solution smells like ammonia, you may have niacin of low purity, please do not use and let me know what brand you used*
Fill the measuring cup with more warm water to reach a little amount above the 4 oz. line. and set aside.
Open the Fleet Enema box, tear off plastic wrap around the cap and unscrew the cap. Pour that stuff down the drain, nobody needs more phosphates. Rinse the bottle out with clean water. Keep the enema applicator and it's cap.
Use the thermometer to check to see if your enema solution has cooled. Do not use if it's above 101 degrees F. or so. Test it out like you would a warmed-up baby bottle (squeeze a little on your wrist). You can wait until it reaches room temperature but it is possible that it will be more difficult to retain.
Carefully pour your enema solution into the emptied and rinsed fleet bottle with the spout of the measuring cup or use a small funnel for easier dispensing.
Screw the enema applicator back on and...well....you can take it from here, Instructions are printed with each bottle.
Tips
This enema is best used after a recent bowel movement or following an enema with purified warm water, but it is not necessary. If you love it, you may double the recipe and use a 7.8 oz. saline enema bottle, fill water to 8 oz. line at step 6. If you are having trouble evacuating, consider using the Hypertonic Saline+Nicotinic Acid Solution Recipe with the disposable enema method.
My Amazon Link for All Recipe Materials ( Thank you for your support!) (https://www.amazon.com/hz/wishlist/ls/8N5HJF9Y9NQC/ref=nav_wishlist_lists_2)
Links for this recipe:
Disposable Fleet Enema 4.5 oz (https://amzn.to/48Bzu71)
Disposable Fleet Enema 7.8 oz. (https://amzn.to/3RkB3iB)
Cosori Electric Kettle (https://amzn.to/47uoNSu)
Bulk Supplements Nicotinic Acid Powder (Always tests very pure for me) (https://amzn.to/41W2yUr)
Purebulk Affiliate Link:
Purebulk Nicotinic Acid Powder and Capsules (Also has tested pure, many lots tested) (https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=4902409.rdqJJsoRLT)
When you start SLOWLY & properly on these, and get them going, you will improve your symptoms and detox faster
Hey...this is going to sound super-amazing-great...
DON'T jump in faster than I suggest, OK?
This combo, DONE CORRECTLY, has the capability of helping this process (aka reducing your health issues) more than anything else. Here is why, based on the research and client feedback I've gained so far.
Sunfiber/PHGG:
Improves pooping (constipation especially, also diarrhea!)
Improves microbiome (more good guys, less bad guys)
Improved constipation and less secondary bile acids MEANS that it is helping to fix "bile leakage", more bile is in the GUT where we want it
More pooping = more bile leaving the RIGHT way
Activated Charcoal (see giant section on this):
Soaks up more toxic bile (and the toxins it contains) than anything else, bar none
Charcoal without enough bile in the intestines = CONSTIPATION
So, SUNFIBER gets the bile staying in the intestines more, then the CHARCOAL can soak it up!
General things before reading further...
If you are CONSTIPATED, start with SUNFIBER, get your pooping better (this takes time!), then work on adding the CHARCOAL
If you have LOOSE BOWELS / DIARRHEA, start with CHARCOAL to get that under control, then start working in the SUNFIBER
Final thoughts:
Do this right, things WILL get better quickly.
Sunfiber (and the activated charcoal it will allow you to do in the future) may be the most important development in the Love Your Liver, vA detox, gut biome, POOPING, and less toxic bile approach to restoring health.
Sunfiber does multiple things:
Normalizes/regulates the gut biome
Decreases secondary bile acid production in the gut (this reduces cholestasis aka toxic bile leakage, what we want!)
Increases bile production & excretion
Reduces constipation (also helps reduce diarrhea in other studies), improves pooping
These are all important things to our process. That said, NOT RUSHING IN to dosing is IMPORTANT! This is because the increased bile dumping and gut biome shifting can be a little rough if you start out of the gate too fast!
There will be two parts to this article. The first part will be the “do this” plan of action.
The second part will be the research on Sunfiber/PHGG (Partially Hydrolyzed Guar Gum).
FIRST, DO NOT BUY NORMAL GUAR GUM!!! This is NOT what we want! It is a problem, and if you try to be cheap or substitute it for whatever reason, you will not do well. Do not post research on guar gum and try to compare it to partially hydrolyzed guar gum. These things are VERY DIFFERENT, and if you decide to F around, then you will find out.
I don’t care what brand of Sunfiber/PHGG you get. If it says Sunfiber on the label, then you have the right stuff. Please don’t ask me about acacia fiber, or tapioca starch, or other fibers that don’t have anywhere near the research that Sunfiber has on it. Sunfiber/PHGG is what we are working with.
We sell one of the very few organic Sunfiber options on the market!
Nutrition Detective Organic Sunfiber (https://nutritiondetective.com/collections/membership-collection/products/organic-sunfiber-vip)
Here is how to use it in the FIRST TWO WEEKS:
Take only a PINCH (you can “pinch” it or use the fractional teaspoon, I don’t care) per day
It is OK if you are sensitive and want to start with even LESS
This can be mixed in food or any drink. You won’t notice it. It does NOT “gel” or thicken
You can spread it out through the day in a bottle of water (better for sensitive types)
OR you can take it all at once
Do NOT go over this dose for the first 2 weeks. This is to allow your gut biome to adjust
Do NOT change anything you were doing to help your pooping
Do NOT increase anything else (supplement- or agitator-wise) that increases bile dumping during this 2 weeks (ie. lactoferrin, sodium chlorite, other soluble fiber, etc)
Sunfiber/PHGG will start adjusting/fixing your gut biome. You will likely notice some gut-related symptoms. It is NORMAL and OK…just don’t push it! If your bowel habits do shift around, examples include:
Increased gas (may smell or may not smell at all)
Burping
Temporary bloating OR previous bloating/distension may go down quickly
If you tend towards constipation, your bowels may get a bit loose
If you tend towards loose bowels, you may get a little constipated
You are not having a negative reaction if any of the above happen! Your gut biome is merely re-organizing itself. That said, if you need to take a break for a day or 3, go ahead, whatever comes up will pass. Then, resume the process until you have taken 14 total days of a “pinch”.
Once you are past the first two weeks, then you can:
Stay at a pinch if it seems to be working well enough,
OR Go up as slowly as you like (best for sensitive types),
OR try going up by ¼ scoop or sachet per week (for “normal” type reactors)
OR just go whole-hog and jump up to a scoop (never forget though, “if you’re going to be dumb, you better be tough!)
What is the best dose, Dr. Smith?
The best dose (AFTER the 2 weeks of the “pinch”) is whatever helps you poop better!
If a lower amount works best for you, don’t waste your money taking more than that!
Some people have had good results with only a pinch
Most research is done on doses of 5-10 grams per day (the scoops/sachets are typically around 7 grams), so 1 serving per day fits this
MAX daily dose is 1 scoop, 2x/day (this is the ceiling, this is not a recommendation)
Now, go forth and poop better!
REMINDER: Do NOT let this amazing research convince you to jump into Sunfiber/PHGG too quickly, or to take MORE than YOU need
Less secondary bile acids (this is what we want!):
Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769658/)
“the conversion of primary BAs into secondary BAs calculated by deoxycholic acid/(cholic acid + deoxycholic acid) in serum decreased significantly in the PHGG group after 12 weeks (p < 0.05), but not in the placebo group.”
Also, in those with diarrhea, Sunfiber normalized the poop & did NOT increase the frequency of pooping:
“Diarrhea is defined as loose, mushy, or watery stools or a stool frequency of more than three bowel movements per day…In this study, fecal characteristics were normalized by PHGG, but not affected the fecal frequency.”
PHGG protects the liver against ethanol (ALCOHOL) injury and reduces malondiALDEHYDE production:
Hepatoprotective Potential of Partially Hydrolyzed Guar Gum against Acute Alcohol-Induced Liver Injury in Vitro and Vivo (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31035540/)“PHGG co-administration decreased serum amino transaminases [reduced liver enzymes AST & ALT] and cholinesterase levels of acute alcohol intoxicated mice, while hepatic pathologic morphology was depleted. Activity of superoxide dismutase, catalase, and glutathione peroxidase was recovered to 198.2, 34.5, 236.0 U/mg protein, respectively, while malondialdehyde level was decreased by 76.3% (PHGG, 1000 mg/kg∙day)...Findings gained suggest that PHGG can be used as functional food supplement for the treatment of acute alcohol-induced liver injury.”
More pooping out of bile acids:
The cholesterol-lowering effect of guar gum is not the result of a simple diversion of bile acids toward fecal excretion (https://pubmed.ncbi.nlm.nih.gov/9307936/)
“In rats fed…PHGG, the fecal excretion of bile acids and neutral sterol was higher than in controls”
Why we do NOT use regular GUAR GUM:
“The intestinal (ileal or cecal) reabsorption of bile acids was not reduced, but rather increased, by GUAR”
PHGG reduced fatty liver:
Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117741/)"Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels, liver fat accumulation, liver inflammatory (tumor necrosis factor-α and monocyte chemotactic protein-1) and fibrogenic (collagen 1a1 and α smooth muscle actin) marker levels, and liver myeloperoxidase activity, which were significantly attenuated by PHGG treatment.
…
it decreased lipopolysaccharide [endotoxin] signaling through the gut-liver axis.
…
PHGG partially prevented NAFLD development in mice through the gut-liver axis”
Less leaky gut (so less toxic bile reaching the kidneys, so better kidney health), more Lactobacillus, better gut biome:
Dietary Fermentable Fibers Attenuate Chronic Kidney Disease in Mice by Protecting the Intestinal Barrier (https://pubmed.ncbi.nlm.nih.gov/29659957/)“Supplemental feeding with fermentable dietary fibers, such as…PHGG, might be effective for the prevention or management of chronic kidney disease by restoring colonic barrier integrity and microflora composition, as shown in mice.
…
The CKD+PHGG [chronic kidney disease + PHGG]…had greater expression of…Lactobacillus (2.7- to 4.0-fold) concentrations than the CKD [chronic kidney disease] group.”
Less laxative use (less constipation), less diarrhea, more Bifido:
Partially hydrolyzed guar gum: clinical nutrition uses (https://pubmed.ncbi.nlm.nih.gov/12781858/)
“Addition of PHGG to the diet reduced laxative dependence in a nursing home population. PHGG also reduced the incidence of diarrhea in septic patients receiving total enteral nutrition and reduced symptoms of irritable bowel syndrome. PHGG also increased production of Bifidobacterium in the gut.”
Less bloating, less gas, and all sorts of gut improvements:
Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritable bowel syndrome (https://pubmed.ncbi.nlm.nih.gov/26855665/)“A 12-week administration of PHGG led to a significant improvement of journal bloating score in the PHGG group versus placebo, as well as in bloating+gasses score.
…
PHGG increases the concentration of bifidobacterium and lactobacilli species and increases short-chain fatty acids in the colonic lumen [8 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR8)–13 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR13)]. It has also been shown to have a positive effect on some medical conditions, e.g., reducing blood cholesterol and controlling blood sugar levels [14 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR14)–16 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR16)]. In addition, it was found to be effective in the treatment of acute diarrhea in children and adult patients of intensive care units [17 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR17)–19 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR19)]. PHGG has proved to be effective in softening and improving fecal output and increasing bulking capacities (fecal weight, frequency of defecation, and fecal excretory feeling) [10 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR10), 11 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR11), 20 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR20), 21 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR21)] It has also been investigated as a possible treatment for IBS and found to have a positive effect, especially in constipation-predominant IBS [22 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR22)–26 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744437/#CR26)].”
Less flu (aka toxic bile dump into the blood) in those who used PHGG:
The effect of partially hydrolyzed guar gum on preventing influenza infection (https://pubmed.ncbi.nlm.nih.gov/33745569/)“Stool pH and BSS were different between patients with and without PHGG intake and those with and without influenza onset, suggesting that PHGG can affect the intestinal environment and thus contribute to reducing the incidence of influenza.”
For “OVER” types, PHGG increased satiety (decreased appetite) & decreased between-meal snacking:
Post-meal perceivable satiety and subsequent energy intake with intake of partially hydrolysed guar gum (https://pubmed.ncbi.nlm.nih.gov/25851425/)
“The addition of PHGG showed significant acute (studies 1 and 3) and long-term (studies 1 and 2) satiety effects compared to the control and/or an equal amount of carbohydrate or other types of soluble fibre. Study 2 also indicated that the prolonged consumption of PHGG may significantly (P < 0.05) reduce energy intake from whole-day snacking. PHGG could be an ideal natural soluble fibre for delivering acute and long term satiety effects for comfortable appetite control.”
Also for “OVER” types, PHGG decreased the amount of weight gain in hamsters on a high-fat diet, while their Caloric intake remained the same:
Partially hydrolyzed guar gums reduce dietary fatty acid and sterol absorption in guinea pigs independent of viscosity (https://pubmed.ncbi.nlm.nih.gov/22669591/)
“Guinea pigs (n = 8 per group) were fed high fat diets (17/100 g) that contained 12/100 g of cellulose, PHGG1, or PHGG2 for 4 weeks. Despite the differences in viscosity, the two PHGG exerted similar physiological effects. Compared to the control cellulose group, the body weight gain was lower in animals fed PHGG, although no effect on food consumption was observed.”
For “UNDER” types: PHGG helps relieve depression & stress-related weight loss (aka toxic bile dumps leaking into the blood, making one not want to eat so they don’t dump even more bile):
Partially Hydrolyzed Guar Gum Modulates Gut Microbiota, Regulates the Levels of Neurotransmitters, and Prevents CUMS-Induced Depressive-Like Behavior in Mice (https://pubmed.ncbi.nlm.nih.gov/34125489/)“PHGG is orally administered to mice with depression induced by chronic unpredictable mild stress (CUMS) in two animal experiments (prevention trial and intervention trial) to characterize the potentially protective effect of PHGG. The results in the prevention trial show that PHGG significantly inhibits the loss of body weight, and prevents CUMS-induced depressive-like behavior in mice…This study suggests that moderate daily intake of PHGG can contribute to relieving depressive-like behavior.”
Also for “UNDER” types, PHGG prevented sarcopenic obesity (aka “skinny-fat”):
Partially Hydrolyzed Guar Gum Suppresses the Development of Sarcopenic Obesity (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/35334814/)
“PHGG increased grip strength and the weight of skeletal muscles…Concerning innate immunity, PHGG decreased the ratio of inflammatory cells, while increasing the ratio of anti-inflammatory cells in the small intestine. The present study demonstrated the preventive effect of PHGG on sarcopenic obesity.”
PHGG reduced the effect of an artery-clogging high-fat diet on hamsters while also prolonging the time until they “threw a blood clot” (arterial thrombus, often known to people as a heart attack, stroke, or deep vein thrombosis):
Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeCl (https://www.researchgate.net/publication/24187516_Partially_hydrolyzed_guar_gum_supplement_reduces_high-fat_diet_increased_blood_lipids_and_oxidative_stress_and_ameliorates_FeCl)
"High fat-diet increased plasma triglyceride, total cholesterol, LDL, VLDL, methylguanidine and dityrosine level and accelerated FeCl3-induced arterial thrombosis formation (from 463 +/- 51 to 303 +/- 45 sec). Low dose PHGG supplement significantly decreased the total cholesterol, LDL, methylguanidine and dityrosine level and delayed the time for arterial thrombosis formation (528 +/- 75 sec). High dose PHGG supplement decreased the level in triglyceride, total cholesterol, LDL and VLDL and further delayed the time for arterial thrombus (671 +/- 36 sec).”
Sunfiber research archive:
https://sunfiber.com/research/ (https://sunfiber.com/research/)
The most comprehensive search I could think of for Pubmed entries that mention Sunfiber/PHGG:
https://pubmed.ncbi.nlm.nih.gov/?term=%28%28partially+hydrolyzed+guar+gum%5BTitle%2FAbstract%5D%29+OR+%28partially+hydrolysed+guar+gum%5BTitle%2FAbstract%5D%29+OR+%28PHGG%5BTitle%2FAbstract%5D%29+OR+%28sunfiber%5BTitle%2FAbstract%5D%29%29&sort= (https://pubmed.ncbi.nlm.nih.gov/?term=%28%28partially+hydrolyzed+guar+gum%5BTitle%2FAbstract%5D%29+OR+%28partially+hydrolysed+guar+gum%5BTitle%2FAbstract%5D%29+OR+%28PHGG%5BTitle%2FAbstract%5D%29+OR+%28sunfiber%5BTitle%2FAbstract%5D%29%29&sort=)
ARTICLE SPONSORS: Sue Dahl (https://members.nutritiondetective.com/members/2543936) and Anonymous Sponsor. THANK YOU!
Here is what we will cover, with foundational information first, the important "how to use" info next, then debunking some of the myths about charcoal, and then the scientific justification showing charcoal actually does what we believe it does last:
Overview, and Charcoal vs Other "Binders"
What is the history of humans and animals using charcoal?
What type of charcoal should I get?
Pills versus powder?
How are we going to use the charcoal?
How should we dose the charcoal?
What if charcoal causes constipation?
What about the supposed "nutrient-depletion" effect I've heard of regarding charcoal?
What is the difference between soluble fiber and charcoal?
Does charcoal lower VA by binding to carotenoids and retinoids?
Does charcoal bind to other toxins?
How does charcoal compare with other bile acid binders like cholestyramine?
An anecdotal story about long-term detox with charcoal and clay
If you are NOT pooping AT LEAST 2X PER DAY, then you should NOT be messing with daily charcoal! Let me be clear. CHARCOAL WILL CONSTIPATE YOU FURTHER IF YOU'RE ALREADY CONSTIPATED, OR HAVE MAJOR CONSTIPATION TENDENCIES. Just don't.
POOPING is the best way to get rid of bile. NOT POOPING by taking charcoal when you shouldn't means that you are NOT getting rid of the bile-filled charcoal anyway! Stop it. POOP FIRST, WORRY ABOUT BINDING BILE LATER.
If you are a constipated type, but you know it helps your certain gut-related symptoms AS NEEDED, like nausea or heartburn, then use it only when you need to.
Charcoal IS NOT ABSORBED into the bloodstream! This means it CANNOT absorb bile in the BLOOD. It CAN absorb bile in the DIGESTIVE TRACT. These are some gut-related symptoms that are likely caused by overly toxic bile in your guts that charcoal might directly help relieve:
Stomach symptoms (powder in water is best, NOT capsules) - nausea, morning sickness, acid reflux, GERD, belching, stomach pain, excess flatulence
Intestinal-related symptoms - diarrhea, loose stools, burning/acid feeling to stools, excessive flatulence (better to figure out the foods causing it first)
A greatly-expanded version of this article--containing detailed descriptions, instructions, references, within 13 separate sections--is available in the Advanced Vitamin A Detox program (https://members.nutritiondetective.work/courses/2277507/). I would like to thank Sue Dahl (https://members.nutritiondetective.com/members/2543936) and an anonymous sponsor for making those articles a reality.
Here is the full list of topics covered in the Advanced program articles on charcoal:
Overview, and Charcoal vs Other "Binders"
What is the history of humans and animals using charcoal?
What type of charcoal should I get?
Pills versus powder?
How are we going to use the charcoal?
How should we dose the charcoal?
What if charcoal causes constipation?
What about the supposed "nutrient-depletion" effect I've heard of regarding charcoal?
What is the difference between soluble fiber and charcoal?
Does charcoal lower VA by binding to carotenoids and retinoids?
Does charcoal bind to other toxins?
How does charcoal compare with other bile acid binders like cholestyramine?
An anecdotal story about long-term detox with charcoal and clay
I will be referring to "activated charcoal" and "activated carbon" as simply charcoal for the rest of this article. Don't try to make activated charcoal on your own at home, please.
This article will not be discussing zeolite or clays for detox. Zeolites do not detox VA from what I have seen (they do work on glyphosate, but so does an organic diet), and clays can contain lead that IS bioavailable when you digest it (that's really BAD).
For a brief history of charcoal's use by humans and animals, see these two links: THE HISTORY OF ACTIVATED CARBON (https://www.jurassiccarbon.com/blogs/news/12186281-the-history-of-activated-carbon) and Charcoal: An Ancient Remedy (https://not-the-norm.com/blogs/news/77933124-charcoal-an-ancient-remedy)
I only suggest using hardwood or bamboo charcoal, not coconut. Hardwood is much cheaper and is also much easier to clean out of things (you'll understand the importance of this soon enough, if you don't already).
I only suggest using charcoal powder, unless you want to pay nearly 12x more per gram to have it put in capsules for you.
Charcoal can be used EXTERNALLY/TOPICALLY and/or INTERNALLY/ORALLY. I cover dosing strategies and troubleshooting in the Advanced program articles.
These websites have good information on how to use charcoal for various health issues: CharcoalRemedies.com (https://members.nutritiondetective.com//CharcoalRemedies.com), CharcoalTimes.com (https://members.nutritiondetective.com//CharcoalTimes.com), and Natural Remedy – Activated Charcoal (https://delrosalstudio.wordpress.com/2013/03/24/natural-remedy-activated-charcoal/).
I'm also attaching the CharcoalRemedies.com website's free e-book below (if you sign up for their newsletter, you'll get it too, or you can just download it here):
Charcoal Gods Humble Doctor.pdf (https://media2-production.mightynetworks.com/asset/15585820/Charcoal_Gods_Humble_Doctor.pdf)
Charcoal Gods Humble Doctor.pdf (https://media2-production.mightynetworks.com/asset/27065422/Charcoal_Gods_Humble_Doctor.pdf)
Here is their article on charcoal baths and soaks (https://charcoaltimes.com/2015/11/12/charcoal-baths-and-soaks/). I cover many tips on charcoal baths in the Advanced program articles.
I suggest, as with anything "detox-related", that you start LOW and SLOW. Suggested starting doses for the following methods are below:
Oral: Start with 1/4 tsp or 1 pill per day.
Bath: Start with 1/4 cup in a bath.
Footsoak: Start with 1/8 cup in a footsoak-size basin.
I would suggest maintaining at the same dose for 2-3 days before going up, to allow time to watch for any detox-accumulation symptoms building up.
Regarding maximum doses, I believe that long-term, there is no need to go above 1 TBSP charcoal, taken in water, 1 or 2 times per day.
If you are already constipated, DON'T TAKE CHARCOAL!!! If you get constipated from charcoal, I would suggest you try one or more of these things to help yourself:
Drink more fluids.
Reduce your dose of charcoal.
Use something non-toxic and non-habit-forming to help your bowel regularity. See this article (https://members.nutritiondetective.com/posts/vitamin-a-detox-principle-2-you-need-to-poop-2x-a-day-or-more) for more information on that topic.
Try topical approaches instead of oral approaches.
Charcoal DOES NOT deplete good nutrients in any way. See the Advanced program articles for my thorough debunking of this myth. That said, it's probably OPTIMAL to take charcoal an hour before or after any other food or supplements. Taking it first thing in the morning or last thing at night is the easiest way to go about this.
Charcoal does adsorb and "deplete" VA by binding to bile in the gut. I cover those references in the Advanced program articles. Charcoal also binds to many other toxins (including oxalates!) and is comparable in strength of effect to cholestyramine, but without the massive side effects list.
What is a charcoal poultice? It's a combination of charcoal + soluble fiber / mucilage + water. Basically the same as a "mask".
If you can't take charcoal orally due to constipation or other negative reactions you might have had to it, this approach will NOT constipate you, and shouldn't cause any negative reactions!
Here is a recipe that works well:
Activated charcoal (https://amzn.to/3TtK4Wt)
I always prefer hardwood or bamboo charcoal, only use coconut if it is your only option
Psyllium husk/fiber (https://amzn.to/3eVfYMv), preferably organic
Finely ground is preferred
Mix equal parts of the above 2 things together (1:1 ratio by volume, such as 1 TBSP of each), with clean water, enough to make a paste/mask consistency
This is EASY. Don't overthink this!
I think that psyllium is MUCH preferable for the poultice instead of the common ground flax seeds suggested on the internet
Where might you apply this?
Over skin issues of any type
Over painful areas
Over the liver & gallbladder itself
Over the stomach area (where the bottom of your ribs come together) if you have GERD or reflux issues and can't take charcoal orally
How long should you leave it on?
Any amount of time is OK, a longer time is preferable to extend the time of adsorbing toxins through the skin
Once the poultice has completely dried all the way through, it is NOT adsorbing anything any more, so that poultice is basically "used up"
Be wary of making a mess. Charcoal does not "stain", but can be a pain to get out!
Suggestions:
Don't make the poultice too "juicy" or it will run off charcoal-y water
Put a towel or something absorptive underneath you
Wrap plastic wrap (Saran wrap is one example) around the poultice on your body to let you move around without making a complete mess
More information on charcoal poultices here:
https://charcoalremedies.com/?s=poultice (https://charcoalremedies.com/?s=poultice)
***If you get yourself into too much detox-dumping, a good recipe to get out of it might look like this:
REDUCE/STOP AGITATORS (https://members.nutritiondetective.com/posts/love-your-liver-agitators-video)
MAGNESIUM CHLORIDE + POTASSIUM CHLORIDE BATH (https://members.nutritiondetective.com/posts/mag-ka-hol-potassium-recipe-also-mag-potassium-bath)
HINT: One charcoal poultice is not going to do much. You will need to make these a regular thing to notice effects. Don't do one and come on the network wondering why "nothing has happened yet". Thanks in advance
ARTICLE SPONSORS: Sue Dahl (https://members.nutritiondetective.work/members/2543936) and Anonymous Sponsor. THANK YOU!
There is a lot in here about charcoal. Many of the charcoal-binding-VA references are towards the end, so that you can get to the "useful stuff" sooner. I will not be discussing other "binders" here other than the short blurbs on zeolite and clays below...if you have specific questions on those for me, theInner Circle (https://members.nutritiondetective.work/groups/1572544/) is the place for things of that nature.
I will be referring to "activated charcoal" and "activated carbon" as simply charcoal for the rest of this article. Don't try to make activated charcoal on your own at home, please. Really...don't do it.
RE: Zeolite (something I used here in the past). I have not seen any research on zeolite reducing VA, the research I did see didn't show any effectiveness in reducing VA (https://www.onlinelibrary.wiley.com/doi/abs/10.1111/j.1439-0442.2005.00705.x) (thanks Larry Roundtree (https://members.nutritiondetective.com/members/2538779) for the link), yet in one study there was less (not NONE) bone damage in chickens given VA and zeolite together. Zeolite does bind to glyphosate! That said, eating organic does nearly all of the work for you (https://www.sciencedirect.com/science/article/abs/pii/S001393511400067X), reducing pesticide/organophosphate levels in urine by 90% in only one week! Zeolite does have different affinities for toxins than charcoal, so using them together is a great approach.
If you want to use any type of CLAY, that is up to YOU. Clay is pretty gross to take, it can be quite contaminated with toxic things--read HERE (https://www.drchristianson.com/blog/dangers-of-bentonite-clay/) about the reality of bentonite clays being contaminated with LEAD and this lead is freed up to be absorbed by stomach acid--and I simply won't use it personally (if I won't use it, then I know others likely won't either). If you get along with clay but not with charcoal and you want to use it instead, be my guest...I am NOT claiming it does the same things that I have the research on charcoal for, and it may very well be toxic! I do not have the time to research all the different types of clays, particularly when I have seen compliance with them to be very low (and I've also had people have very strong reactions to clay, so I moved away from them in general).
Diatomaceous earth (DE) is NOT clay, and does not really detox much of anything (if you disagree, show me research, not bloggers and Youtubers making unfounded claims).
See the following two articles [my emphasis added]:
THE HISTORY OF ACTIVATED CARBON (https://www.jurassiccarbon.com/blogs/news/12186281-the-history-of-activated-carbon)
"The exact date and time that man began using activated carbon or charcoal is lost to history. However, there is evidence of its usage and importance throughout history, from the ancient world to the modern era.
Around 3750 B.C., the Ancient Egyptians made use of charcoal to smelt ores to create bronze. By 1500 B.C., according to the first documented use of charcoal as written on papyrus, the Egyptians’ use of charcoal had progressed, using the material to absorb unpleasant odors, cure intestinal ailments and even preserve the dead.
In 400 B.C., the Ancient Hindus and Phoenicians had started using charcoal to purify water because of its antiseptic properties. The Phoenicians were noted for charring barrels to hold water on long sea voyages. This practice was adopted by many other seafarers throughout history, including Christopher Columbus, and continued until the 1800s.
Though charcoal was in steady use throughout the centuries, it made a strong resurgence in the late 1700s. More doctors, chemists and other scientific figures began experimenting with the material for both medical and manufacturing processes. In 1773, chemist Carl Wilhelm Scheele quantified the adsorption forces for porous carbon by measuring the volume of gases adsorbed by the material. In 1776, Lowitz performed the first experiments that proved that carbon could be used to decolor solutions, noting the adsorptive properties of charcoal in liquid phase.
One of the biggest discoveries in this period, however, was in 1794, when an English sugar refinery found that carbon could be used as a decoloring agent. This revolutionized the sugar industry, which was looking for a way to produce a whiter, more appealing product. In turn, this development pushed the experimentation of activated carbon further. By 1805 all of Europe was using charcoal to decolor sugar.
Charcoal continued to be a strong force in the 19th century, especially in medicine. It was used for poultices, sloughing ulcers and treating gangrenous sores. After the activated carbon process was developed around 1820, it became noted in medical journals as an antidote for poison and a treatment for intestinal disorders. In 1883, French chemist, Gabriel Bertrand, in an effort to prove charcoal’s worth as a poison treatment, swallowed arsenic mixed with charcoal. Others followed suit and performed the same trick.
In 1862, Frederick Lipscombe helped pave the way for commercial applications of activated carbon by using the material to purify potable water. German physicist, Heinrich Kayser, coined the term “adsorption” to describe charcoal’s ability to uptake gases in 1881.
Activated carbon was first produced on an industrial scale at the beginning of the twentieth century. In 1909 a plant named “Chemische Werke” was built to manufacture carbon for commercial use, producing various carbon such as Eponit, Purit, Norit (http://www.norit.com/company/our-history/) and Calgon The Norit Company, a manufacturer in Holland, was started in 1911 and became widely known in the sugar industry for their powdered solutions, widely used in the chemical and food industries for decolorization.
During World War I activated carbon was used in gas masks worn by American soldiers to protect them from poison gas. This development led to the production of granular carbon on a large scale.
Today, the uses of continue to grow. It can be found in virtually every hospital, clinic or doctor’s office in the world, used on almost a daily basis. The material is used in a variety of industries, including corn and cane sugar refining (http://www.norit.com/markets-and-applications/food/), gas adsorption (http://www.norit.com/markets-and-applications/flue-gas-treatment/), dry cleaning (http://www.norit.com/markets-and-applications/chemicals/), pharmaceuticals (http://www.norit.com/markets-and-applications/pharmaceutical/), fat and oil removal (http://www.norit.com/markets-and-applications/food/), alcoholic beverage production (http://www.norit.com/markets-and-applications/beverages/) and much more. The biggest market for activated carbon is in the purification of municipal water supplies. Activated carbon filters are used in water treatment to remove organic compounds that produce carcinogens during the disinfection of water. The second biggest market for activated carbon is removal of heavy metals in the coal fire powder plants in USA and Canada from 2014.
The new market for activated carbon is for home use to remove the odor to keep air plash. [sp - I think they mean "fresh"?]
Charcoal: An Ancient Remedy (https://not-the-norm.com/blogs/news/77933124-charcoal-an-ancient-remedy)
"A Spark in the Dark
On the face of it there is nothing reassuring about wildfires. As I write this, they are devastating the lands of Indonesia, destroying forests and countless species of wild animals, as well as driving people from their homes. Yet they leave behind an incredible substance renowned in history for its healing powers. This commonly known compound, charcoal, has been used by man and beast alike for possibly thousands of years. Charcoal is one of the most powerful antidotes known to man, and as grimy as it may appear, this very ordinary material can purify your system like no man-made medicine can.
Albeit a remnant of an incredibly destructive power, there is nothing remotely dangerous about charcoal. Quite the contrary, it is a life saver. Still today a charcoal drink is the go-to treatment in emergency rooms after a suspected overdose or poisoning. Centuries’ worth of evidence speaks of the many beneficial qualities of charcoal. It is natural, safe, non-toxic and relieves several ailments including drug overdose1, poisoning11, stomach disorders11 and high blood cholesterol12. One study carried out using rat models even suggests the ability of charcoal to increase the lifespan of mammals by 43%13.
Purposefully Eating Dirt?!
Charcoal may be as unappetizing as a substance can be, however, eating non-food materials such as charcoal and clay is a practice that can be observed throughout the world. The purpose of this seemingly unnatural behavior can actually be explained scientifically. Since ancient times, animals and humans have relied on charcoal to counteract the ill-effects of harmful materials that have been ingested, intentionally or otherwise. This is especially valid for wild animals and ancient peoples who had to depend upon limited food resources. The diet of charcoal-eating animals includes a variety of plants that contain a high amount of phenolic and other harmful compounds that interfere with their digestion. Studies have confirmed that ingested charcoal render these toxins harmless once inside their guts.
During one experiment, scientists found that feeding activated charcoal to goats increased their intake of juniper, a plant that contains a toxic terpenoid. Goats love to eat juniper but this plant toxin limits them from eating it. Researchers fed juniper to twenty goats over the course of ten days. Ten of these goats were given a daily dose of activated charcoal. At the end of the trial period, results indicated that those ten goats who were given the charcoal treatment could tolerate more juniper than the goats who did not receive the treatment17.
Natural Instincts
Animals knew the medicinal properties of charcoal before man and many species of wild beast are known to eat charcoal resulting from bonfires or lightning strikes1. Many scientific studies exist to confirm these observations, the most quoted case of this phenomenon is of the Red Colobus monkeys on Zanzibar Island in Africa2, which is the only primate other than humans that is reported to demonstrate this behaviour. However, many other animal species dwelling in natural habitats, including deer, wild ponies, camels1 and Okapis3 have been known to eat charcoal. Many domestic animals and birds such as dogs, cats, horses and chicken are also known to eat charcoal at times.
Age Old Wisdom
Our prehistoric ancestors have also been discovered to follow this unusual practice of eating charcoal. Fossilized excretions of the Neanderthals have been found to carry traces of ingested charcoal, and there is evidence to believe that Native American Indians used ground charcoal mixed with water as a remedy for digestive disorders1. Aborigines were reported to use charcoal powder to heal their wounds15. The first recorded history of consumption of charcoal for medicinal uses dates back as far as 1500 BC4. Egyptian papyri reveal the use of charcoal to treat decaying wounds and intestinal disorders4. Records of Hippocrates and Pliny in 400 BC also provide information on the use of charcoal to treat a variety of diseases including epilepsy and anthrax. These accounts - both anecdotal and otherwise - sparked an interest in the medicinal properties of charcoal amongst the modern scientific community4.
They Bet their Lives on It!
Determined to prove the antidotal power of charcoal, two French scientists did just that! One is M. Bertrand, a French chemist who in early 1813, swallowed charcoal along with Arsenic trioxide - a deadly poison. So strong was his faith in the detoxification power of charcoal that he believed charcoal would help him survive the lethal effects of poison. And survive he did7.
The second scientist was one Pierre Fleurus Touery, again French, who performed as daring a demonstration before the French Academy of Medicine in 1852. He gulped down an equally lethal poison, strychnine mixed with charcoal. Despite the fact that he swallowed an amount ten times higher than the lethal dose, he survived the stunt unscathed7.
However, it took almost another decade for charcoal to be accepted widely by the medical practitioners as a ‘universal antidote”6. A review published in the Journal of Paediatrics in 1963 named ‘The black bottle’ by Holt et al owns the credit for that9. Since then the reputation of charcoal as a remedy for toxin ingestion has been spreading like wildfire – excuse the pun!
Charcoal, a Block of Black Magic
Being chemically inert, the therapeutic capacity of charcoal solely depends upon its ability to physically trap other substances. Due to its elemental nature, charcoal can bind to other compounds including various toxins, organic materials, gases, and even microorganisms.
The Science Behind the Magic
A piece of charcoal may look and feel solid in your hands. Yet it posesses a labyrinth of microscopic pores and tunnels that are invisible to the naked eye. When a piece of carbon-rich material - usually wood - is burnt at a temperature as high as 1000 degrees Celsius, all of its components except carbon turn into vapour. The high pressure building-up inside the solid material drives these vapours out, leaving behind a carbon skeleton that is highly porous. Once within our body, charcoal binds with toxin particles forming a stable toxin-charcoal complex. This complex is larger than the microscopic channels in the gut walls through which the free toxin particles would easily pass. Therefore the absorption of toxins through gut membranes is restricted. Since the foreign particles are safely concealed within the pores of the charcoal structure, they do not get a chance to harm our tissues. This in turn prevents enzymes reacting upon the toxins thus eliminating the risk of poisons being metabolised and harming the liver tissues.
The following illustration will help you understand this better. Since our bodies cannot absorb nor break down charcoal, it is then excreted through our stools along with the toxins they are carrying5. As a result, the poisons are safely driven out of our systems before they get a chance to harm us. The porous nature of the charcoal structure increases the surface area available for
adsorption thereby enhancing the rate and capacity of detoxification by many folds. A piece of charcoal can adsorb up to two hundred times its own weight1 in toxic and pathogenic material! Charcoal acts as a powerful oxidising agent as well. It contains a large amount of oxygen within the microscopic holes of the carbon structure14.
These oxygen molecules react with most foreign materials oxidising and converting them into harmless matter. This property is particularly useful in nullifying toxins found in our gut.
Antimicrobial properties of charcoal are well known as well. Charcoal can arrest and suppress disease-causing bacteria, fungi and viruses. While the widest use of charcoal as an antimicrobial is in water purification, we can safely assume that it will do the same thing inside our systems.
Artificially 'Activated' (Medicinal) versus Naturally 'Active' (or Potentised)
Natural charcoal remaining after the forest fires was what healed ancient men and animals. Looking back at the evidence piled up throughout the centuries, one can hardly doubt its effectiveness. The modern man however, driven by the desire to make everything better and fast, has found ways to “activate” a substance already active. “Activated” charcoal is produced by treating charcoal with steam, hot air or chemicals. This treatment eats away the carbon structure, increasing the number of pores in the process. This results in a greater surface area for adsorption. The more pores there are the more
activated the charcoal is. Accordingly we can now find activated and superactivated charcoal on the market.
Super Powers Turned Bad
These “activated’ and “superactivated” charcoals claim to have such super adsorptive powers that they can rapidly trap greater amounts of materials. This claim is true. These greedier versions of benign ‘natural’ charcoal can arrest more toxins in lesser time. But there is a catch. Adsorptive action of this charcoal is non-selective; meaning that it cannot tell apart a vitamin molecule from a toxin. Therefore they will remove not only toxins but most of the essential nutrients such as minerals and vitamins as well. They will also damage those friendly microbes in our gut who help us with digestion and disease control. You can thank their so-called “super power” for that!
NOTE: The above statements about "non-selective" adsorption of nutrients / minerals / vitamins / gut microbes is ENTIRELY UNTRUE and is debunked in a later section here. Note how they have references for many other things in this article, yet there are NO REFERENCES for these RUBBISH statements. IGNORE THE ABOVE PARAGRAPH.
Choose pure natural hardwood charcoal to detox safely, gently, daily.
Resources
1. Engel, Cindy. Wild health: lessons in natural wellness from the animal kingdom. Download iTunes eBook, 2003, pp 71-72 (Retrieved from:
HTTP://BOOKS.GOOGLE.LK/BOOKS?ID=8FWQLH2A2CKC&PRINTSEC=FRONTCOVER#V=ONEP (http://books.google.lk/BOOKS?ID=8FWQLH2A2CKC&PRINTSEC=FRONTCOVER#V=ONEP)
AGE&Q&F=FALSE accessed on 22.10. 2013)
2. Struhsaker, Thomas T., David O. Cooney, and Kirstin S. Siex. "Charcoal consumption by Zanzibar red colobus monkeys: its function and its ecological and demographic consequences." International Journal of Primatology 18.1 (1997): 61-72.
3. HTTP://MUSEUMVICTORIA.COM.AU/MELBOURNEMUSEUM/DISCOVERYCENTRE/WILD/BIOGEOG (http://museumvictoria.com.au/MELBOURNEMUSEUM/DISCOVERYCENTRE/WILD/BIOGEOG)
4. Dinsley, John. CharcoalRemedies. com: the Complete Handbook of Medicinal Charcoal and Its Applications. CharcoalRemedies.com, 2005.
5. Irwin, Richard S., and James M. Rippe, eds. Irwin and Rippe's intensive care medicine. Wolters Kluwer Health, 2008.
6. Yatzidis, Hippocrates. "Activated charcoal rediscovered." British medical journal 4.5831 (1972): 51.
7. Lapus, Robert Michael. "Activated charcoal for pediatric poisonings: the universal antidote?." Current opinion in pediatrics 19.2 (2007): 216-222.
8. Altman, Lawrence K. Who goes first?: The story of self-experimentation in medicine. University of California Pr, 1987, Pp 97-98.
9. Holt Jr, Emmett, and Peter H. Holz. "The black bottle: A consideration of the role of charcoal in the treatment of poisoning in children." The Journal of pediatrics 63.2 (1963): 306-314.
10. Historical production and use of carbon materials. http://www.caer.uky.edu/carbon/history/carbonhistory.shtml (http://www.caer.uky.edu/carbon/history/carbonhistory.shtml). [Accessed 16 November 2013]
11. Lucas, G. H. W., and V. E. Henderson. "The value of medicinal charcoal (Carbo Medicinalis CF) in medicine." Canadian Medical Association Journal 29.1 (1933): 22.
12. Neuvonen, P. J., et al. "Activated charcoal in the treatment of hypercholesterolaemia: dose-response relationships and comparison with cholestyramine." European journal of clinical pharmacology 37.3 (1989): 225-230.
13. Frolkis, V. V., et al. "Effect of enterosorption on animal lifespan." Artificial Cells, Blood Substitutes and Biotechnology 17.3 (1989): 341-351.
14. Bird, J. "" Vegetable Charcoal: Its Medicinal and Economic Properties, with Practical Remarks on Its Use in Chronic Affections of the Stomach andBowels." John Churchill. London (1857).
15. Williams, Cheryll. Medicinal Plants in Australia Volume 4: An Antipodean Apothecary. Rosenberg Publishing, 2013.
16. Bisson, Matthew G., Cody B. Scott, and Charles A. Taylor Jr. "Activated charcoal and experience affect intake of juniper by goats." Journal of Range Management (2001): 274-278.
First, before you rush off to buy any activated charcoal on the internet, I'm going to suggest that you buy HARDWOOD or BAMBOO charcoal, and NOT coconut charcoal. The hardwood charcoal powder I use is on my Amazon list here (https://amzn.to/3jxHgEG).
Hardwood charcoal has decades of research behind it, and is the form of charcoal that earned the "reputation" for charcoal in the scientific literature. Hardwood charcoal is a slightly larger particle size than coconut charcoal is, which makes it easier to CLEAN off/out of things (you will only appreciate this fact when you have used both and have seen the difference yourself).
Why not coconut charcoal? Enough people in this network and elsewhere on the internet are reporting sensitivities to coconut products, INCLUDING coconut charcoal (https://coconutallergy.blogspot.com/2016/07/i-really-am-allergic-to-water-coconut.html). I don't personally use or trust anything coconut these days, as it has become nearly as pervasive as corn and soy (particularly in supposed "health-conscious" products, it's in EVERYTHING), and that makes my alarm bells go off all over the place. Considering the similar pervasiveness to corn and soy, should we be surprised that coconut allergies are also rising?
Get hardwood or bamboo charcoal. Hardwood is generally a lot less expensive than bamboo. Forget about all the fancy marketing schemes saying one is better than the other.
Charcoal has almost no taste, and only a tiny bit of grittiness. It mixes into water with a bit of stirring or some shaking in a jar (my preferred method). People have been brushing their teeth with it by itself for a VERY long time, and the mainstream demonizing of charcoal in dental care makes me think it is quite useful there too (see this article for a scientific discussion of why charcoal is not bad for toothbrushing in any way (https://charcoaltimes.com/2020/10/10/concerned-about-the-safety-of-activated-charcoal-toothpaste/), regardless of the other garbage you may read on the internet).
What I'm getting at is that the taste of charcoal is a NON-ISSUE. Sure, the black water looks scary or gross, yet the taste does not match it at all.
If you want to use charcoal topically in any way (including baths or footsoaks), then you will absolutely want the powder in bulk (https://amzn.to/3kwT7o0). As you're about to see, the price differences alone will make you want to use only the powder.
There is really no reason to get charcoal capsules or tablets--you can buy a capsule maker, empty capsules, and make your own at home and still come out way ahead--unless one insists upon pills and is excited about paying 11.5x more per gram of charcoal than they need to. Let me do the math quickly here.
Amazon's choice for pills (https://amzn.to/3mqfSKY) (coconut charcoal, hardwood pills are almost impossible to find!): 100 capsules, 600 mg per capsule. 60 grams total for $13.66 cost. $0.23 per gram.
The hardwood charcoal powder I linked above is 1.13 kg (1,130 grams) of charcoal for $24.99. $0.02 per gram.
That's an 11.5x price increase to have a company put a non-offensive-tasting powder into capsules for you. I would HIGHLY suggest getting the powder for oral and/or topical use.
The two main approaches to using charcoal for health are internal (by mouth) or externally (applying it to the skin in various ways). It is much the same as with using magnesium, for those of you who are familiar.
If you consider yourself a SENSITIVE type of person (reacting strongly to things is common for you), then I would suggest STARTING LOW and SLOW with TOPICAL/EXTERNAL approaches, NOT oral/internal use!
Charcoal taken orally is NOT ABSORBED into the bloodstream. It will grab onto VA in the gut, along with grabbing onto bile that contains VA and other toxins (https://pubmed.ncbi.nlm.nih.gov/7392829/), and then increasing the excretion of that bile with the poop (http://Effect%20of%20activated%20carbon%20beads%20on%20serum%20lipid%20levels%20and%20fecal%20bile%20acid%20excretion%20in%20rats). The important thing to remember about charcoal is that it can only DIRECTLY affect things INSIDE the guts. Over time, this INDIRECTLY affects the toxin load throughout the entire body. This is also true of soluble fiber, with one major difference I'll cover in a following article.
HEADS-UP #1: As with anything, some people don't get along with activated charcoal taken internally. This is why I always recommend starting LOW & SLOW in dose, and LISTENING TO YOUR BODY. Those people who don't feel good on it should NOT take it orally (or at least improve their health situation A LOT before trying it again). You may have heard me say the same thing about soluble fiber, yet it seems that everyone has to learn their own lesson the hard way! If taking charcoal doesn't feel good, follow the complicated instructions below:
Patient: "Doc, it hurts when I do this..."
Doctor: "Then don't do that!"
If something doesn't feel right, it's probably NOT right for you, or at least it's not right for you YET.
Be aware of going too hard, too fast...remember some of my favorite sayings about being too aggressive with detox things:
"If you're going to be dumb, you better be tough."
"Any thing can cause anything."
If you are ever pushing ANY "detox" things too hard and you feel WORSE, then BACK OFF. It's really that simple.
Minimizing reactions is done by STARTING LOW AND SLOW. It's called a "dose-dependent" response.
All the above said, a strong initial reaction to charcoal may be a detox reaction instead of a negative reaction. The only way to find out for sure if it is helping or not is to try the charcoal again, after the first reaction has passed completely, at a SMALLER dose. If it was helping, the later smaller doses should NOT be as strong/intense as the first one, and you should notice some (however small) improvements along the way.
There is a TON of information on how to use charcoal both internally and externally at these two websites (they are run by the same people, so they will be redundant):
CharcoalRemedies.com (https://members.nutritiondetective.com//CharcoalRemedies.com)
CharcoalTimes.com (https://members.nutritiondetective.com//CharcoalTimes.com)
USE THE SEARCH ENGINE ON THOSE WEBSITES FOR WHATEVER CONDITION YOU WANT TO TREAT. It is super helpful!
Here is an additional website with more charcoal remedy ideas: Natural Remedy – Activated Charcoal (https://delrosalstudio.wordpress.com/2013/03/24/natural-remedy-activated-charcoal/)
I'm also attaching the CharcoalRemedies.com website's free e-book below (if you sign up for their newsletter, you'll get it too, or you can just download it here):
Charcoal Gods Humble Doctor.pdf (https://media2-production.mightynetworks.com/asset/15853262/Charcoal_Gods_Humble_Doctor.pdf)
Here is their article on charcoal baths and soaks (https://charcoaltimes.com/2015/11/12/charcoal-baths-and-soaks/). I'm going to give you some tips on keeping your charcoal bath-time a bit less messy below:
Start LOW and SLOW, with 1/4 cup of charcoal at first. Note in the article that people were describing detox/dumping type reactions, so don't push it right away!
Use hardwood charcoal. It really is much easier to clean off of things. Charcoal DOES NOT STAIN, but it can be a real pain to fully get out of certain things.
Charcoal very easily "poofs" up. Take care when opening containers of charcoal, and be gentle with how you scoop or otherwise manipulate the powder. While it doesn't spill out of measuring spoons or cups any more than anything else, it is very noticeable when it does.
Do your best to not breathe in the charcoal dust that might "poof" up.
It is probably easiest to do the clean-up from charcoal baths in a shower-bath combo (https://remodelerplatform.blob.core.windows.net/wwwnwfamncom/gallery/original/18ff8c7b-a4d9-40a4-acc1-19b97ebd40d0.jpg).
Obviously, do your best to not splash around the charcoal water outside of the bath.
Unless you want to have to wash your hair 2 or 3 times with clean water to get all the charcoal out, I'm going to suggest NOT putting your head in the water.
When you are done, wash yourself off with soap FIRST, then use your hand or a soapy sponge to wipe off (then rinse off) the charcoal from the bath. Wash yourself in order from your head downward, and frequent rinsing helps tell you parts you may have missed.
Some places may require a double washing-off...especially your FEET before you step out of the tub!
You may want to get a back scrubber (https://amzn.to/2JmXVid), so you're able to wash off the parts of your back that your hands can't reach.
You will likely get charcoal you missed on your towel when drying off. Other than the appearance, it is no big deal.
Yes, you can add other things to the bath, including magnesium chloride and/or baking soda. Between the charcoal and the baking soda, any toxins in the tap water will be adsorbed and/or neutralized.
IMPORTANT: The main practitioner of those websites has been noted to promote a vegan diet and VA supplementation...I would strongly suggest to avoid those both, and also realize that he had to become an expert in charcoal to DETOXIFY his clients from their own self-poisonings. Take the charcoal information and leave anything related to those two topics.
Here is another e-book on how to use activated charcoal from Zen Principle, the company that sells the big bag of hardwood activated charcoal on my Amazon list (https://amzn.to/3lvN83k):
Hardwood Activated Charcoal Powder E-Book.pdf (https://media2-production.mightynetworks.com/asset/16240673/Hardwood_Activated_Charcoal_Powder_E-Book.pdf)
Here's an important concept with charcoal...it has to be very close to the VA or toxins to "grab" (adsorb) them. So...
Using charcoal applications EXTERNALLY/TOPICALLY will grab onto VA/toxins/bile in the skin and subcutaneous bodyfat. A person with VA-related skin issues, or whose livers are so backed-up/slowed from VA and other toxins, will likely benefit from this method. If you are at all hesitant about charcoal, starting with EXTERNAL/TOPICAL approaches is HIGHLY RECOMMENDED.
Taking charcoal INTERNALLY/ORALLY will grab onto VA/toxins/bile in the gut. A person with gut issues, particularly if they lean heavily towards loose bowels, will likely benefit greatly from this method.
Both internal and external methods can be used simultaneously...but don't start with them both at the same time, and don't go up in dose on both at the same time!
Let's start off by going over *rough* equivalences in volumes, weights, and pills.
1/4 tsp charcoal powder = 750 mg = 1.5 pills
1/2 tsp charcoal powder = 1500 mg = 2 pills
1 tsp charcoal powder = 3000 mg = 6 pills
1 TBSP charcoal powder = ~10 grams = 20 pills
As we go on from here, it will quickly become painfully obvious that as charcoal doses get higher, the number of pills necessary becomes obnoxiously high, while the powder doses are quite manageable (and extremely inexpensive in comparison)
Oral: Start with 1/4 tsp or 1 pill per day. (or even less if you wish)
Bath: Start with 1/4 cup in a bath. (or even less if you wish)
Footsoak: Start with 1/8 cup in a footsoak-size basin. (or even less if you wish)
I would suggest maintaining at the same dose for 2-3 days before going up, to allow time to watch for any detox-accumulation symptoms building up.
Remember, YOU are searching for the "GOLDILOCKS DOSE" for YOU. You want it to be JUST RIGHT, not too little and not too much. No one here ever said here that "more is better" and that only if you're pushing the limits are you worthy of praise. Get that nonsense out of your head, or don't complain when you cause yourself problems.
I'm going to put my suggestion first. I believe that long-term, there is no need to go above 1 TBSP charcoal, taken in water, 1 or 2 times per day. I'm going to cover some other published charcoal dosing strategies, NOT as a suggestion, but more as evidence of the relative SAFETY of charcoal at extremely high dose levels.
IF you just read the above paragraph and have now decided that you're going to jump in the deepest of the deep end at 1 TBSP, 2x per day (or MORE), know that I'm disappointingly shaking my head and suspecting I know what is coming for you. START SLOWLY AND OBSERVE.
The following is a summary of the "Charcoal Detox Protocol", written by a Kimberly at CharcoalTimes.com (https://charcoaltimes.com/2694-2/):
Weeks 1-3: 1 TBSP charcoal, taken 5x per day.
Weeks 4-13: 1 TBSP charcoal, taken 3x per day.
Maintenance, Weeks 14+: 1 TBSP charcoal, taken 1x per day.
I will remind you of several things before you decide to jump into this entirely arbitrary program.
One, this person was NOT on this program, so they were likely "in-toxifying" themselves EVERY DAY. Note what I said about the doctor who runs Charcoal Times, he is a VA supplement pusher and vegan. You, by being here and on this program, are ALREADY DETOXING at a very high rate...what we have seen and experienced here is that people on this program cannot and don't need to "push detox" as hard as others outside of here (or they pay a price in excessive detox-toxicity symptoms). That's why I believe 1-2 TBSP total per day of charcoal is a good ceiling for long-term and short-term use.
Two, the soluble fiber you are likely already consuming is doing much of the same work as the charcoal...for many isolated soluble fibers, a TBSP is 6 grams worth...so if you're doing ~18 grams of soluble fiber per day from beans and/or whole grains for example, you're already at 3 TBSP worth of VA-binding/excreting compounds. See why I don't think you need to push charcoal as hard as they did above?
Finally, the real MEGA-DOSING of charcoal in ACUTE INTOXICATIONS aka POISONINGS (https://pubmed.ncbi.nlm.nih.gov/3285126/) (see full paper attached below)...remember, I'm putting this here to show you the SAFETY of charcoal, not to suggest you do doses like this!
Oral Activated Charcoal in the Treatment of Intoxications.pdf (https://media2-production.mightynetworks.com/asset/15853748/Oral_Activated_Charcoal_in_the_Treatment_of_Intoxications.pdf)
"In acute intoxications 50 to 100g activated charcoal should be administered to adult patients (to children, about 1 g/kg) as soon as possible.
In severe acute poisonings oral activated charcoal should be administered repeatedly, e.g. 20 to 50g at intervals of 4 to 6 hours, until recovery or until plasma drug concentrations have fallen to non-toxic levels. In addition to increasing the elimination of many drugs and toxins even after their systemic absorption, repeated doses of charcoal also reduce the risk of desorbing from the charcoal-toxin complex as the complex passes through the gastrointestinal tract."
NOTE: In these mega-doses, it is NORMAL for them to have to give a LAXATIVE to avoid major CONSTIPATION. You have been warned.
At 10 grams equaling 1 TBSP worth of charcoal powder, that's a lot of charcoal in a very short time! If this was a pharmaceutical, we could likely expect PAGES of SIDE EFFECTS from crazy doses like those above, right? Here's the section on charcoal side effects from that same review article, and it doesn't even cover a HALF PAGE (I will be interjecting the quote below with my commentary):
5. Toxicity and Side Effects of Activated Charcoal
Activated charcoal has not of itself been associated with specific toxicity (Nau et al. 1958a,b, 1962). In uraemic patients continuous treatment with oral charcoal 20 to 50 g/day over periods of 4 to 20 months has not resulted in any significant side effects (Yatzidis 1972), although rapid ingestion of large doses of charcoal may cause vomiting.
20-50 grams a day (that's 2-5 TBSP worth), for 4-20 months straight, caused NO PROBLEMS. The "nutrient depletion" scare about charcoal is a MYTH. Also, if you choke down too much of ANYTHING too fast, you might throw it back up (brilliant observation there).
Constipation or sometimes diarrhoea have occurred in some subjects receiving activated charcoal as a watery suspension.
Constipation from charcoal can happen, and is easy to systematically address. I will address that below. As for the diarrhea, I have not had anyone report that issue to me to this point. "Watery suspension" (aka charcoal in water) is also called a "charcoal slurry" around the interwebz, that's the way most people take larger doses of powder (rather than the fistfuls of pills).
Major complications associated with the use of activated charcoal have been due to the aspiration of charcoal and gastric contents (Harsch 1986; Pollack et al. 1981).
Here's some tips to solve these potential problems: 1) don't breath in charcoal dust in general, 2) don't drink & drug yourself unconscious to the point they have to give you charcoal by a tube down your throat (and then have it go into your lungs), and 3) don't get poisoned (likely cause here is alcohol and/or drug overdose), then take huge doses of charcoal, then vomit, then breathe back in the vomit into your lungs. That's bad, mmmmmkay?
Hopefully the above suggestions are within everyone's reach. I'm pretty darn sure that if you're here, you can manage it.
There has been at least 1 case of charcoal-containing empyema (Justiniani et al.1985)
Here's that paper...Charcoal-Containing Empyema Complicating Treatment for Overdose* (https://www.sciencedirect.com/science/article/abs/pii/S0012369215408724)...it involves an alcohol-and-drug-overdose (insert *shocked face* here)...I believe the saying goes, "play stupid games, win stupid prizes!"
and 1 case of intestinal obstruction caused by huge amounts (300g) of charcoal (Anderson & Ware 1987).
30 TBSP of charcoal, and he got "blocked up". NO...REALLY??? Don't do that!
Possible constipation caused by activated charcoal can be treated with sorbitol, paraffin oil, or lactulose. It should be noted that activated charcoal adsorbs many laxatives (e.g. sennosides) and prevents their action. Some commercially available charcoal preparations contain large amounts of sorbitol or sodium bicarbonate. Repeated administration of these preparations in high doses may cause severe adverse effects (hypotension, electrolyte disturbances), themselves requiring medical intervention (Goldberg et al. 1987). Thus, the use of various extra agents in combination with activated charcoal must be weighed against the potential risks.
I'll go over how to manage or avoid charcoal-associated constipation next. We would much rather manage the constipation in other ways than herbal or chemical laxatives, which have always had known problems (habit-forming, potassium depletion, etc.).
If you are already constipated in general, then you may want to do TOPICAL APPROACHES rather than oral approaches...this way, your gut is not involved at all. If you are a person who regularly deals with constipation, you need to be very aware of this if you decide to try charcoal orally. It is STILL POSSIBLE that charcoal used topically/externally could constipate a person.
If you get constipated from oral charcoal, there are three main approaches that you can use (singly or in combination):
Drink more fluids. Definitely take your charcoal with a full glass of water, and you will likely need to increase your overall fluid intake across the day. Both charcoal and soluble fiber need to soak up water to do their job properly, so make sure they have enough around!
Reduce your dose of charcoal. This should seem obvious. If you find that you can take 1/4 tsp of charcoal with no bowel changes, yet 1/2 tsp causes you to drop from pooping 2x/day down to 1x/day, then drop back down to 1/4 tsp per day!
Use something non-toxic and non-habit-forming to help your bowel regularity. See this article (https://members.nutritiondetective.com/posts/vitamin-a-aldehyde-glyphosate-detox-principle-2-you-need-to-poop-2x-a-day-or-more) for more information on that topic.
I will thoroughly debunk this myth here.
First, did you know that there is not a single study showing actual in vivo (inside a real living thing, human or animal) nutrient depletion from charcoal? Remember this quote from a previous article here?
Activated charcoal has not of itself been associated with specific toxicity (Nau et al. 1958a,b, 1962). In uraemic patients continuous treatment with oral charcoal 20 to 50 g/day over periods of 4 to 20 months has not resulted in any significant side effects (Yatzidis 1972), although rapid ingestion of large doses of charcoal may cause vomiting.
No toxicity, no significant side effects (which would include symptoms of nutrient depletion), from 4-20 months of continuously taking 2-5 TBSP of charcoal a day in uraemic patients! What is uraemic aka uremic, you ask? It means a state of severe kidney damage, as in kidney failure, as in heading for dialysis...so obviously a group of people who are already quite toxic and likely also very nutrient-depleted. If the charcoal was going to worsen nutrient depletions, it would have shown up as symptoms! Also, don't forget that Grant Genereux cured himself of chronic kidney disease with his variation of a low VA diet.
Where did the nutrient depletion reputation of charcoal come about from then? It came about from this study (https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1745-4557.2004.tb00647.x), where charcoal was mixed with APPLE JUICE!!!
"The effect of activated charcoals (0, 0.5, 1.0, 2.0 and 3.0 g/L of powdered and granular activated charcoals) on the content of several water‐soluble vitamins in apple juice was studied. Apple juice samples with activated carbon added were mixed for 0 (control), 5, 10, 20, and 30 min, respectively. The content of water‐soluble vitamins was analyzed by HPLC. Considerable reduction in ascorbic acid (Vit C), niacin, pyridoxine (Vitamin B6), thiamine (Vitamin B1) and biotin concentrations was found while there was a dramatic improvement in the color and clearness of apple juice. The highest decrement in water‐soluble vitamins was obtained at 3.0 g/L powdered activated charcoal. Statistical analysis of the data showed highly significant differences (P |< 0.05, P < 0.01) in the water soluble vitamins, color and clearness of the apple juice samples between the dosages of activated charcoals but no significant differences induced by the mixing periods."
This is the state of modern science, folks. Charcoal has been around for DECADES in medicine, yet no one actually does a human or animal study on nutrient depletion from charcoal. Probably because it's easier to do scare tactics on people who don't look up references combined with the research simply not existing. Wild statements are made about the "dangers" of charcoal based on ONE stupid study on APPLE JUICE. I am not joking.
Is it possible that charcoal can actually take toxin-containing foods and make them functionally "more nutritious"? The following study on cattle (https://scholars.unh.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1209&context=nhaes) makes it appear so:
DMI = dry matter intake
NDF = neutral detergent fiber
CP = crude protein
BCS = body condition scoring (higher is generally better)
"The objectives of these studies were to determine whether the adverse effects of feeding poor-quality forages could be alleviated by adding activated carbon as a feed additive through observing the effect of activated carbon on apparent nutrient digestibility and taste preferences. In Exp. 1, 6 multiparous, late-lactation Holstein cows were assigned to a replicated 3 × 3 Latin square. All cows were fed a basal diet containing approximately 60% poor-quality corn silage containing the mycotoxin deoxynivalenol [an alcohol mycotoxin also known as vomitoxin]. The 3 treatments were 0, 20, or 40 g of activated carbon top-dressed once daily at the p.m. feeding. Cows fed activated carbon had increased DMI and apparent total-tract nutrient digestibilities of NDF, hemicellulose, and CP. Cows fed activated carbon also had increased milk fat content and showed increased BCS. In Exp. 2, 3 cannulated, primiparous, early-lactation Holstein cows were used in a 3 × 3 Latin square design. The cows were fed 0, 20, or 40 g of activated carbon per day using good-quality forage, which resulted in no differences in apparent total-tract nutrient digestibility or milk composition and yield. In Exp. 3, 6 early-lactation, primiparous Holstein cows were assigned to a sequential elimination trial with access to 0, 10, 20, 40, or 80 g/d of activated carbon in a cafeteria-style feeder to determine taste preference. Cows were fed a diet similar to that in Exp. 2. As activated carbon increased, preference for that particular feed decreased. Results indicated that activated carbon improves apparent total-tract nutrient digestibilities when cows are fed poor-quality (mycotoxin-laden) silage, but activated carbon should not be used when good quality forage is fed."
Let's see. The cows who got toxin-filled feed combined with charcoal:
Ate more food, implies a better appetite ("increased DMI")
Digested fiber and protein better ("total-tract nutrient digestibilities of NDF, hemicellulose, and CP")
Put more fat into their milk ("increased milk fat content", likely a side-effect of increased detox of fat-soluble toxins)
Had better "cow physiques" ("increased BCS")
There is absolutely NO EVIDENCE anywhere of charcoal causing any nutrient depletion of any type. In fact, the study above shows quite the OPPOSITE.
Just to hammer this point home, below is a research review of 112 studies on the use of biochar (basically charcoal) in cattle feed. Note that ONLY improvements were seen, and the only hand-wringing done by the researchers is regarding the THEORETICAL "problem" of the REAL EFFECT of biochar adsorbing CAROTENOIDS (yay!) and the alcohol called "Vitamin" E aka tocopherOL.
The use of biochar in animal feeding (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679646/)
"Biochar, that is, carbonized biomass similar to charcoal, has been used in acute medical treatment of animals for many centuries. Since 2010, livestock farmers increasingly use biochar as a regular feed supplement to improve animal health, increase nutrient intake efficiency and thus productivity. As biochar gets enriched with nitrogen-rich organic compounds during the digestion process, the excreted biochar-manure becomes a more valuable organic fertilizer causing lower nutrient losses and greenhouse gas emissions during storage and soil application. Scientists only recently started to investigate the mechanisms of biochar in the different stages of animal digestion and thus most published results on biochar feeding are based so far on empirical studies. This review summarizes the state of knowledge up to the year 2019 by evaluating 112 relevant scientific publications on the topic to derive initial insights, discuss potential mechanisms behind observations and identify important knowledge gaps and future research needs. The literature analysis shows that in most studies and for all investigated farm animal species, positive effects on different parameters such as toxin adsorption, digestion, blood values, feed efficiency, meat quality and/or greenhouse gas emissions could be found when biochar was added to feed. A considerable number of studies provided statistically non-significant results, though tendencies were mostly positive. Rare negative effects were identified in regard to the immobilization of liposoluble feed ingredients (e.g., vitamin E or Carotenoids) which may limit long-term biochar feeding. We found that most of the studies did not systematically investigate biochar properties (which may vastly differ) and dosage, which is a major drawback for generalizing results. Our review demonstrates that the use of biochar as a feed additive has the potential to improve animal health, feed efficiency and livestock housing climate, to reduce nutrient losses and greenhouse gas emissions, and to increase the soil organic matter content and thus soil fertility when eventually applied to soil. In combination with other good practices, co-feeding of biochar may thus have the potential to improve the sustainability of animal husbandry. However, more systematic multi-disciplinary research is definitely needed to arrive at generalizable recommendations."
Following the above review's references, I found this paper showing that a combination of biochar (charcoal), bentonite, and zeolite given to chickens with their feed, with or without fungal-toxin contamination added (aka mycotoxic), resulted in ONLY BENEFITS TO BOTH THE CHICKENS AND THEIR EGGS and decreased the YELLOW COLOR of the yolks (reduced VA).
Effect of biochar, zeolite and bentonite feed supplements on egg yield and excreta attributes. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6679646/)
"Bond Brown Layer (BBL) pullets (n = 200, 18 weeks old) were randomly assigned to 10 dietary treatments involving biochar, zeolite and bentonite at nil, 1%, 2%, and 4% w/w supplementation of commercial layer feed. Each treatment was applied to four cages, with five birds per cage, a total of 20 birds per treatment. Birds were maintained on these diets for 25 weeks. Feed conversion ratio was significantly improved (P = 0.001) with biochar-supplemented feed compared with the control and other treatments. Average egg weight was also significantly improved in the treatment groups compared with the control; however, shell weight, shell breaking strength, shell thickness, shell deformation and shell reflectivity, and internal egg-quality traits of albumen height and Haugh unit were not consistently different (P > 0.05). Yolk colour score was decreased significantly (P = 0.001) with the use of increased rate of additives. Intestinal villi height and crypt depth were increased on amended diets. Egg yield was decreased when birds were placed on a fungal contaminated feed. The feed amendments ameliorated this effect, with the best result achieved on a 2% biochar diet. Improved egg production was also noted under commercial certified organic production conditions trialling 2% biochar feed supplementation compared with the control. Thus, supplementation of feed with biochar, zeolite and bentonite improved production performance traits of egg yield and feed conversion ratio, with these additives potentially acting as detoxifiers or inhibiting growth of microbial pathogens, slowing digestion or altering the gut anatomy and microbiota to improve feed conversion ratio."
To summarize, there is NO EVIDENCE of any sort of long-term nutrient depletion from charcoal. FULL STOP. There IS evidence of it depleting VA and improving both cattle and chicken health though!
All that being said, to MINIMIZE any possible effect on our nutrition, it is probably OPTIMAL to take the charcoal at least an hour away from food and supplements. The best times for this are upon waking and/or before bed, however, any time during the day you can get this time separation is fine. Note that the cows actually were given the charcoal by it being sprinkled over the top of their food ("top dressed"), so I DON'T believe that they have to be separated.
I asked Tyler Ginter (https://members.nutritiondetective.com/members/4309297) to make this diagram for me, to help illustrate the differences in bile release/dumping versus bile binding/excretion for fats, soluble fiber, and charcoal:
What can you take away from that diagram?
Fats are not helpful in this VA Detox process at all. Excessive unnecessary (think, "added") fats/oils are actually counter-productive to the whole process.
NOTE: Underweight people will likely still need added fats in their diets (I've covered this in detail in my video Q&As), while overweight people should absolutely be adding as LITTLE fat (other than what is naturally-occurring in whole foods) to their diet as possible.
Soluble fiber is the long-term, daily food source of the most important VA Detox compounds, yet it can cause bile release/dumping, which can temporarily aggravate symptoms if pushed too hard.
Charcoal is a supplemental approach to VA Detox and shouldn't have to be used permanently. The big benefit of charcoal is that it doesn't cause bile release/dumping, which means it can be used by many people (not all) to "calm down" excessive detox-toxicity-related symptoms...BUT, as many have seen with "detox" things, detox reactions can still happen even though they aren't "supposed to".
This first paper seems extremely important, as the researchers are concerned about "VA deficiency" and how charcoal applies to low VA diets, probably because they know that charcoal lowers VA in the body overall:
[Active carbon diets and early vitamin A deficiency; application to the preparation of diets without vitamin A] (https://pubmed.ncbi.nlm.nih.gov/21027584/).
Lorène C (https://members.nutritiondetective.work/members/2540188) tried to get hold of the above paper for me from the group in France that published it initially, however, she has had no luck.
First, see the previously quoted papers about cattle and chickens regarding charcoal/biochar grabbing onto carotenoids.
Here are some others:
Activated Carbon for Purification of Edible Oils (http://www.vulcascot.co.at/media/content/downloads/norit_edible_oils.pdf)
"However in case of very high concentrations of persistent pigments such as chlorophylls, xanthophylls and carotene, activated carbon can be used to improve the bleaching effect or support the thermal decomposition of pigments such as carotene in the deodorization process step."
Characteristics of activated carbon and carbon nanotubes as adsorbents to remove annatto (norbixin) in cheese whey (https://www.ncbi.nlm.nih.gov/pubmed/23978061) (annato is a carotenoid)
Decolorization of Cheddar cheese whey by activated carbon (https://www.ncbi.nlm.nih.gov/pubmed/25704972)
Kaolin-Carbon Adsorbents for Carotene Removal of Red Palm Oil (https://www.ncbi.nlm.nih.gov/pubmed/11237447)
Removes retinoids from liver AND serum samples: Characterization of Vitamin A Metabolome in Human Livers With and Without Nonalcoholic Fatty Liver Disease (https://jpet.aspetjournals.org/content/370/1/92)
Owing to the lack of blank retinoid-free liver tissue, charcoal-treated blank human serum free of retinoids was used as a blank matrix.
Therefore, to allow normalization for extraction recovery of the retinoids using isotope-labeled internal standards, LC-MS/MS methods for vitamin A metabolome were developed using retinoid-free charcoal-treated serum as a reference matrix and deuterated internal standards. The validity of this approach was confirmed by the determination that the slopes of the standard curves from liver and charcoal-treated serum were equal.
Strips retinoids from fetal bovine serum (FBS): Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection (https://elifesciences.org/articles/03206)
"Prior to addition of retinoids, the cells were grown overnight in DMEM containing 10% charcoal-stripped FBS (to removes retinoids)..."
Relationship between Binding Affinities to Cellular Retinoic Acid-binding Protein and in Vivo and in Vitro Properties for 18 Retinoids (https://cancerres.aacrjournals.org/content/canres/40/2/212.full.pdf)
A new rapid assay has been developed for measurement of the binding of [3H]retinoic acid to cellular retinoic acid-binding protein. The assay, which uses activated charcoal for the separation of bound from unbound retinoic acid...
Analysis of vitamin A and retinoids.pdf (https://media2-production.mightynetworks.com/asset/15863344/Analysis_of_vitamin_A_and_retinoids.pdf)
"Fatty-acid free, or charcoal-stripped FBS is a retinoid depleted alternative for cell culture experiments that may help to overcome the lot-to-lot variation in baseline retinoid medium content."
Hey, taking out free fatty acids will only help the body to NOT STORE more VA in the liver! That's another bonus!
Physicochemical Parameters Affecting the Charcoal Adsorption Assay for Quantitative Retinoid-Binding Measurement (https://www.sciencedirect.com/science/article/abs/pii/S0003269784710906)
A BRIEF REVIEW ON SYSTEMIC RETINOIDS (https://ijpsr.com/bft-article/a-brief-review-on-systemic-retinoids/?view=fulltext)
Teriflunomide:
With Isotretinoin and Acitretin: Using the teriflunomide with isotretinoin and acitretin is known to induce hepato-toxicity and tends to increase the risk of liver injury associated with leflunomide. Elevated liver enzymes, jaundice, hepatic failure, hepatitis and acute hepatic necrosis have been reported for teriflunomide, which is the principal active metabolite of leflunomide. The combination has to be used with extreme caution. It is very important to measure the liver enzyme and bilirubin levels before starting teriflunomide therapy. The combination should be avoided if the patient has elevated liver enzymes or any pre-existing liver disease. Teriflunomide should be discontinued if the patient develops elevated serum ALP levels and wash out procedures with activated charcoal should be performed 58.
With Bexarotene: Using these drugs in combination may increase the risk of infection. Studies have reported serious infection like sepsis, pneumocystis jiroveci pneumonia, pulmonary and extra-pulmonary tuberculosis and aspergillosis. Similar interaction as that with isotretinoin and acitretin has been reported in recent studies. The combination with bexarotene may induce hepatotoxicity and may increase the risk of liver injury. Close monitoring is essential as the interaction may appear even when these agents are initiated after discontinuation with teriflunomide because of its prolonged half-life. Treatment should be stopped if there is evidence of serious hepato-toxicity, infection or bone marrow suppression and activated charcoal can be administered for accelerated elimination 59.
See below for an incomplete listing of the other toxins that charcoal is known to bind to. Raid the references of the attached paper below if you want to follow the rabbit holes, otherwise the quoted summary is enough for my taste:
Oral Activated Charcoal in the Treatment of Intoxications.pdf (https://media2-production.mightynetworks.com/asset/15582918/Oral_Activated_Charcoal_in_the_Treatment_of_Intoxications.pdf)
"Activated charcoal has an ability to adsorb a wide variety of substances. This property can be applied to prevent the gastrointestinal absorption of various drugs and toxins and to increase their elimination, even after systemic absorption.
Repeated dosing with oral activated charcoal enhances the elimination of many toxicologically significant agents, e.g. aspirin, carbamazepine, dapsone, dextropropoxyphene, cardiac glycosides, meprobamate, phenobarbitone, phenytoin and theophylline.
Charcoal seems able to accelerate the elimination of many industrial and environmental toxicants like dioxins, polychlorinated biphenyls and possibly also some heavy metals, including their radioactive isotopes."
Here are some other papers of interest regarding charcoal and toxins (including oxalates/oxalic acid, sulfates, and phenols!):
Adsorption of Maleic and Oxalic Acids on Activated Carbons Prepared from Tamarind Seeds (https://www.ijert.org/research/adsorption-of-maleic-and-oxalic-acids-on-activated-carbons-prepared-from-tamarind-seeds-IJERTV3IS040652.pdf)
Adsorption of oxalic acid on activated charcoal (https://fch.upol.cz/skripta/fcc_and_zvem_english/FCH/Adsorption%20of%20oxalic%20acid%20on%20activated%20charcoal.htm)
Removal of Sulfate from Waste Water by Activated Carbon (https://www.iasj.net/iasj?func=fulltext&aId=2357)
Adsorption of phenolic compounds by activated carbon—a critical review (https://www.sciencedirect.com/science/article/abs/pii/S0045653504008641)
Removal of lead(II) by adsorption using treated granular activated carbon: batch and column studies (https://pubmed.ncbi.nlm.nih.gov/16019141/)
Charcoal inhibits (gets in the way of) enterohepatic re-circulation (recycling) of compounds
Look to the second page, first two paragraphs of this paper:
Gastrointestinal Clearance of Drugs with Activated Charcoal.pdf (https://media2-production.mightynetworks.com/asset/15859094/Gastrointestinal_Clearance_of_Drugs_with_Activated_Charcoal.pdf)
Charcoal reduces moxifloxacin (a fluoroquinolone like Cipro/ciprofloxacin) toxicity by reducing recycling and absorption: Influence of activated charcoal on the pharmacokinetics of moxifloxacin following intravenous and oral administration of a 400 mg single dose to healthy males (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884843/)
"The results of this study show that moxifloxacin undergoes pronounced enteric recycling after systemic uptake. In addition, these findings confirm that activated charcoal may be useful in treating moxifloxacin overdose by preventing its absorption."
Toxicity from Vitamin D3 supplements (don't take Vit D supplements!) treated with charcoal: Cholecalciferol (https://pubmed.ncbi.nlm.nih.gov/23796485/)
"Initial treatment relies upon decontamination with emesis induction followed by administration of pulse-dose activated charcoal designed to interfere with the extensive enterohepatic recirculation of toxin."
This paper shows that the effect of activated carbon on bile acid excretion--how much bile is actually being pooped out--is on par with the pharmaceutical cholestyramine:
Effect of activated carbon beads on serum lipid levels and fecal bile acid excretion in rats.pdf (https://media2-production.mightynetworks.com/asset/15582416/Effect_of_activated_carbon_beads_on_serum_lipid_levels_and_fecal_bile_acid_excretion_in_rats.pdf)
"Although little is known about the mechanism by which this is accomplished, it seems to be roughly similar to that of cholestyramine. That is to say, oral administration of activated carbon increases fecal bile acid excretion."
A comparison of known side effects between charcoal and cholestyramine (https://www.drugs.com/sfx/cholestyramine-side-effects.html) should easily show anyone that charcoal is the clear winner.
Here is the YouTube video, with my "transcript" commentary below. All of this is courtesy of Kathy Woodbury (https://members.nutritiondetective.com/members/2546680) :
Below are Kathy's notes that she had taken from the video, with my commentary interspersed:
In July 2011, I saw a patient who had been in my practice for 14 years. At that time, at age 62, she had suffered aggressive psoriasis for 42 years, starting at age 20. Since that time, she had had a moderate to severe level of red, scaly lesions all over her body, from shoulders to toes (notably, not her face). She told me that she was ready to commit suicide because of the unrelenting itching and pain, and resulting sleeplessness.
Four years earlier, she had undergone evaluation of genetic markers, showing that she was unable to clear toxins out of her body because she was missing the CYP450 enzyme. She was unable to clear the toxins arising from mold. She and her husband had spent many years living in substandard housing.
What are fungal toxins made of, you ask? (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591661/) "Volatile organic compounds (VOCs) are carbon-compounds that easily evaporate at room temperature. Toxins are biologically produced poisons; mycotoxins are those toxins produced by microscopic fungi. All fungi emit blends of VOCs; the qualitative and quantitative composition of these volatile blends varies with the species of fungus and the environmental situation in which the fungus is grown. These fungal VOCs, produced as mixtures of alcohols, aldehydes, acids, ethers, esters, ketones, terpenes, thiols and their derivatives, are responsible for the characteristic moldy odors associated with damp indoor spaces. There is increasing experimental evidence that some of these VOCs have toxic properties."
It should not be surprising that if/when people live or work in a moldy environment, that their DH system gets overworked, under-nutriented, and slows down...this then sets them up further for VA and other toxicities.
I told her that use of charcoal, clay, or cholestyramine would help to pull out the toxins. She did this for 4 days and stopped. However, at this time (4 years later), she was so desperate that she said she would do it.
If you choose to experiment with "clay" (see my note on lead contamination previously, and how the lead will come out of clay into you) or cholestyramine (a drug with numerous side effects (https://www.drugs.com/sfx/cholestyramine-side-effects.html)), that is all on you. I'm talking about charcoal here.
She was directed to put 2 t. clay in 1 qt. of her favorite iced tea, and to drink this 90 minutes after her morning meds, and 90 minutes after her evening meds. In 3 weeks, her rash was completely gone.
3 weeks got rid of some (not all) of her more "superficial" toxicity in the skin. There are likely better choices than tea (due to caffeine and polyphenol content), but it still WORKED. There is nothing here about diet changes, and she's taking pharmaceutical meds 2x/day.
I noticed that she was wearing a wig. She had also lost her hair many years prior. I saw her again 9 months later, and this time her hair had begun to fill in on her head.
This is 10 months in, don't forget the math on that part. Again, she has gotten rid of some (not all) of the superficial toxicity in the hair follicles (basically also part of the skin). Also, the word "BEGUN" is important here, it was the early stages, far from done.
The patient told me that for 3 years, she had taken the clay in tea, but only once a day, and nothing happened. This time, taking it twice a day worked.
I don't quite understand what this "3 years...once a day...nothing happened" part. Her rash went away in 3 weeks, and the hair was starting to come back around 10 months. What took 3 years, exactly? I don't know.
My perspective is this: When she took the clay once a day, she would decrease the level of the toxins in the fluid spaces. But, within 24 hours, these levels were certainly coming back up, because they were coming out of the cells of her body, which was the storage site for her toxins. Now that she was doing it twice a day, she kept the levels so low that the immune system could not detect the presence of the toxins. Consequently, the inflammatory processes that were manifesting as these rashes disappeared. The immune system lives in the fluid space, not in the cells. So once she cleared the fluid space, the inflammation disappeared.
This is a big theoretical explanation that isn't really necessary, in my opinion. What we need to do is have over TIME is [ TOXINS OUT > TOXINS IN ]. That's the magick equation. She was not doing anything diet-wise, as far as I can tell (probably still had lots of TOXINS IN). She had to increase her charcoal to speed up the TOXINS OUT, to get ahead of her daily influx. Also, because the liver "stores" VA and other toxins bound to fatty acid esters, it's just going to take some serious time to get rid of the DEEPER toxic storage sites.
At 14 months, she stopped taking the clay. Her symptoms returned, so she resumed the clay, and the symptoms were gone in 2 weeks. At 2 ½ years, she switched to charcoal in the tea, and she continued to be symptom-free.
14 months = superficial (skin) toxin load less, deeper toxin load still very much there, hence 2 weeks of clay calmed down superficial toxicity again
2.5 years, switching from clay to charcoal 2x a day kept her symptom-free.
In May 2017, she came into the office and said she had not taken charcoal in 3 months, yet had no lesions. My thinking is that she had emptied out the storage sites in her cells. It took 6 ½ years to get to that point.
I'm going to say it's more like the massive storage site in her LIVER, but if she's better, who cares? 6.5 years with no apparent dietary intervention. We are shooting for a shorter time than this, obviously!
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-sodium-salt
Salt is easy. You need it. You want clean salt. We have all been lied to about salt for a long time.
1. Sodium ("Salt") Basics
2. What Kind Of Salt To Use?
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-sodium-salt-basics
I don't want this mineral to be a cause of concern for anyone. This is EASY.
First, people who DON'T salt their food, in my experience and opinion, DO NOT GET BETTER, EVER. Here's a free tip: salt your food. If you have avoided salting your food for whatever reason and adapted to not having salt, you're going to want to start slowly re-introducing salt to your food and reconstruct your instinctual salt sensors. Yes, I'm serious.
Next, the hair test sodium level is NOT USEFUL in determining what your sodium intake is, or what it should be. This is basically the same as hair potassium. I discuss these more in my consults, but I definitely do not obsess on sodium, potassium, or the sodium/potassium ratio like other HTMA practitioners. It's a colossal waste of time!
I want you to...SALT YOUR FOOD TO TASTE. That's it. It's that easy. Yes, do the same with the 50/50 salt (it's a little less salty than the sodium salt, so you can use more, because HALF of it is potassium!).
Remember, we give animals salt licks for their NUTRITION, and wild animals look for natural mineral salt licks as well. If we trust farm animals to not overdose on salt when it is freely available to them, I'm going to say that you can trust your taste buds + brain to not overdose you on salt either.
If more salt helps you feel better in some way, then you can do more. Go for it. Realize that your potassium intake should at least somewhat track upward with it, or you may help one issue while causing another one (see potassium articles).
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-what-kind-of-salt-to-use
Because I deal with people worldwide (26 countries was the last count), I simply CANNOT recommend specific brands of salt outside of the US...nor do I have time to research them for you. Please read carefully.
Salts I DO recommend:
Salts I DON'T recommend:
Jacobsen Salt Co. notes:
Reference on microplastics in salt: https://pubmed.ncbi.nlm.nih.gov/?term=microplastics+salt
"ALL THE MINERALS" means ALL the TOXIC MINERALS you don't need ALSO. Salt is easy. Don't make it hard.
The most misunderstood, abundant, and maligned amino acid out there!
1. How to Use MSG, aka Monosodium Glutamate, as a HEALTH BOOSTER, Cravings Reducer, and Food Enjoyment Enhancer!
For the research, propaganda, and mind-blowing connections to health on glutamate & MSG, see the livestream video embedded in this lesson.
Kelsey Kenney and I wanted to add an article here about how to start and use MSG, to expand upon what we say in the livestream.
FIRST, pure MSG is entirely different than junk foods with seasonings or additives that contain glutamate!
DO's:
DON'Ts:
That's it! Everything else is in the livestream linked above!
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-potassium
Getting your potassium intake CORRECT FOR YOU is one of the quickest ways to relieve or reduce many symptoms that cholestasis / vA toxicity / copper toxicity cause us.
If you want to get TESTED for your minerals, instead of GUESSING, contact Julie at admin@nutritionrestored.com for more information.
1. Potassium Video
2. Potassium Basics
3. Potassium Dosing, Foods, Supplements
4. "Potassium Protocol For PMS Study"
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-potassium-video
VIDEO: https://rumble.com/v27zs64-potassium.html
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-potassium-basics
Potassium is something that is very important, yet very hard to test for. It is best assessed by SYMPTOMS and one's response to getting more potassium!
VA toxicity blocks potassium channels, effectively creating an "intracellular potassium deficiency" presentation, even though blood potassium may look fine.
Copper toxicity depletes potassium.
Vitamin D supplements deplete potassium.
Cholestasis, caused and/or aggravated by VA toxicity, copper toxicity, and MANY OTHER THINGS, is commonly (but not always!) associated with hypokalemia (lack of potassium in the blood).
Hair potassium levels are NOT useful for assessing one's intake at all.
Blood potassium levels, if low, pretty much guarantee potassium deficiency.
Normal blood potassium levels do NOT rule out potassium deficiency, and most times, HIGH blood potassium levels indicate excessive LOSSES of potassium from the tissues (unless someone is doing excessively high amounts of potassium in their diet/supplements).
[Updated 4/22/2024 with minimum ratio, potassium citrate, & potassium bicarbonate info]
How much potassium are YOU looking for?
Look, if you don't have potassium deficiency symptoms (see previous article), you don't need to worry about it! Don't add another thing to your "plate" if you don't have to!
THAT SAID, if you have vA toxicity (blocks potassium channels), copper toxicity (depletes potassium), old stored vitamin D supplements in your tissues (depletes potassium), and/or you have STRESS of any type, you'll likely benefit from getting more potassium from foods and/or supplements!
First, if you are going to experiment, the best time to take it first is when you think you are actively having potassium deficiency symptoms, so you can truly see & feel the effects! As an example, if you are having leg/foot cramps at night, and you have a banana and they go away, then you know you need more potassium. Experiment over. Easy.
High potassium, low VA fruits:
Article on the research-demonstrated health benefits of apples, pears, and bananas:
https://nutritionrestored.com/blog-forum/topic/apples-are-an-amazing-food-and-the-research-shows-it/
High potassium, low VA root vegetable:
NOTE: Different people can react ASTONISHINGLY DIFFERENTLY to the different forms of potassium supplements, and to different doses. START SLOW.
This may provide some people with ideas.
IGNORE WITH PREJUDICE anything in this PDF that does not align with what we are doing here (ie. multivitamin, supplementing iron, etc.).
PDF: Potassium Protocol for PMS Study (https://media2-production.mightynetworks.com/asset/33988006/Potassium_Protocol_for_PMS_Study.pdf)
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-magnesium
This section will cover both topical/transdermal and oral forms of magnesium.
1. Topical / Transdermal (AKA Absorbed Through The Skin) Magnesium Approaches
2. LYL Livestream Episode on Topical Magnesium Approaches
Why is magnesium important in this process? Because VA and Vit D supps and calcium supps and all sorts of things SCREW UP OUR CALCIUM METABOLISM, and magnesium is the counterbalance to calcium in the body. You probably need more than you are getting. No, food sources are generally NOT enough during the detox phases while you are trying to regain your health!
If you feel better on any type of magnesium, that automatically implies you are DEFICIENT. [NO, just because you tried some magnesium this one time and didn't feel anything, DOES NOT mean you are OK on magnesium, this is why we "test, don't guess"] If you want to know your magnesium status and if what you are using is working for YOU, that is best assessed through HAIR MINERAL ANALYSIS with someone who knows what they are looking at (*wink*wink*).
This is info that has worked for many of my Testing & Consultation clients in the past. I will eventually update it, but this will do for now.
I believe topical/transdermal magnesium absorption is better than oral for most people for most purposes. Oral magnesium can be used additionally if desired.
Article on topical / transdermal magnesium approaches:
The lesson also contains a video (embedded) and a PDF slide deck on topical/transdermal magnesium approaches:
If you are having any issues with topical/transdermal magnesium, or just want to head off any issue, there is an additional troubleshooting video in this lesson.
This is plenty of information to get anyone started.
VIDEO: https://youtube.com/live/zNGGUHoAmm8
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-selenium
Selenium is important for liver protection, ALDH, antagonizing copper, detoxing heavy metals, and sex hormones.
Our selenium-containing products:
1. Selenium Basics
2. Order of Adding Selenium In
3. Food Sources of Selenium?
4. Selenium Supplement Guidelines
5. Selenium Dosing Guidelines
6. How To Add/Increase Selenium Supplement (Pills)
7. How To Add/Increase Selenium Supplements (Liquids/Drops)
8. Symptoms of Selenium Excess or Intolerance To Watch For
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-selenium-basics
Selenium helps with:
Guidelines for ALL "Big Minerals":
If you don't feel good on a certain dose, TAKE LESS than the dose you have problems at. This might mean ZERO is the right dose for you, especially if you are very toxic or sensitive, in the early stages of your LYL journey.
Most issues with the Big Minerals will show up within the first 3 days of starting or increasing the dose, BUT could take up to a week to show up.
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-order-of-adding-selenium-in
We typically add selenium first of the three "Big Minerals".
Why? Because out of the three "Big Minerals", selenium typically takes the longest time to feel/show benefits, and people are the least likely to have detox/dumping/excess issues with it.
It can be added in anytime. Remember to only change one big mineral variable at a time though!
Guidelines for ALL "Big Minerals" (selenium, molybdenum, and zinc):
If you don't feel good on a certain dose, TAKE LESS than the dose you have problems at. This might mean ZERO is the right dose for you, especially if you are very toxic or sensitive, in the early stages of your LYL journey.
Most issues with the Big Minerals will show up within the first 3 days of starting or increasing the dose, BUT could take up to a week to show up.
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-food-sources-of-selenium
To put it bluntly, if you are not actively trying to restore/improve your selenium situation either by food and/or supplements, you are practically guaranteed to be deficient...and it's extremely difficult to restore selenium with foods alone (you can try, I wouldn't expect success though).
Brazil nuts used to be helpful with restoring selenium, but they are now so much lower that they are not reliable anymore. Brazil nuts are also high in copper and oxalates, either of which can cause or worsen problems. If you want to eat some Brazil nuts because you like them, fine. Don't expect them to raise your selenium like they used to.
Remember that every batch of Brazil nuts has a different amount of selenium...I've seen numbers range from 10 mcg to 100 mcg per nut (so you could effectively underdose or way overdose on 10 nuts/day, see?)
Types of Selenium that we use:
We have moved towards selenium glycinate in ND supplements instead of the old L-selenomethionine because methionine is a sulfur-containing amino acid and glycine is not. Less sulfur from supplements is always preferable. Methylselenocysteine is another sulfur-containing amino acid selenium (via the cysteine), so we'd rather not use that either.
ALL selenium supplements, no matter the type, should be yeast-free. Don't eat yeast, it makes any level of "vitamin" A toxicity worse than it would be otherwise.
Do NOT use sodium selenite, sodium selenate, or "lipid-bound selenium".
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-selenium-dosing-guidelines
ANY dose or frequency that causes negative symptoms should be regarded as too much, and the dose should be reduced to the amount that causes NO negative symptoms!
My suggested "normal" foundational long-term selenium dosing without hair testing is 150 mcg/day.
This is what I consider the foundational long-term dose for ~80% of adults that is enough to improve selenium status (may not be enough to fully replenish levels, yet is much better than nothing) and is unlikely to ever lead to selenium toxicity.
200 mcg pills are the "standard" in the industry and seem to be OK for many people long-term also.
If you choose to take more than 150 mcg/day without hair testing, that is up to you.
I do NOT suggest taking 300 mcg/day or more without experienced guidance.
I would not suggest anyone take 300 mcg/day or more of selenium for longer than 6 months without hair testing to monitor levels.
[See video for detailed information - embedded in this lesson]
ND Selenium Glycinate and ND Keystone Minerals come with 150 mcg selenium per pill. Typical L-selenomethionine pills on the market have 200 mcg per pill.
NOT A SENSITIVE TYPE pill selenium-adding protocol:
SENSITIVE TYPE pill selenium-adding protocol:
Selenium drops come in different forms and potencies.
When ND Liquid Selenium Glycinate and ND Liquid Keystone Minerals come out, they will have 10 mcg selenium glycinate per drop.
GENERAL (Sensitive AND Not Sensitive) liquid selenium-adding protocol:
IMPORTANT - "Anything can cause anything"...if you don't feel good in any way from selenium, even if the symptom is not mentioned here, REDUCE your dose or STOP taking it!
These symptom lists are not meant to scare you, it's to give you all the information so if your body doesn't like the selenium, you know what might have caused it and can find the right dose for YOUR BODY!
We are going up SLOWLY, and not taking STUPID HIGH DOSES, so toxicity should not be an issue. That said, everyone is DIFFERENT, and you should watch for any signs that your body isn't getting along with selenium supplements (and/or any other supplement you might take!)
Selenium is a COPPER ANTAGONIST, so it can "stir up" copper. These symptoms are the "most likely" for our people to possibly see, and is easily fixed by lowering the dose.
A *strange* toxicity symptom of selenium specifically is intrusive sexual thoughts (this appears in the research, it is not a joke - selenium is connected to sex hormones).
COPPER DETOX-DUMPING SYMPTOMS (most common for LYL community):
CONVENTIONAL SELENIUM TOXICITY SYMPTOMS (likely connected to obvious overdosing):
As with ANY supplement, if you have concerns, reduce dose or stop and consult with a knowledgeable practitioner.
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-molybdenum
Molybdenum is important for multiple detox pathways (ethanol, "vitamin" A, aldehydes, uric acid, caffeine, sulfur, etc.), ALDH, antagonizing copper, and balancing iron metabolism.
Our molybdenum-containing products:
Nutrition Detective Molybdenum Glycinate 150 mcg capsules (https://nutritiondetective.com/collections/membership-collection/products/molybdenum-glycinate-150-mcg-100-capsules-vip)
EIDON Ionic Minerals Molybdenum Liquid 2 oz (https://nutritiondetective.com/collections/membership-collection/products/molybdenum-liquid-2-oz)
Keystone Minerals 100 Capsules (https://nutritiondetective.com/collections/membership-collection/products/keystone-minerals-vip)
Keystone Minerals PLUS Niacin 60 capsules (https://nutritiondetective.com/collections/membership-collection/products/keystone-minerals-plus-niacin-60-capsules-vip)
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-molybdenum-basics
Molybdenum is needed (essential) for:
Aldehyde dehydrogenase aka ALDH (very important!)
Aldehyde oxidase (also processes aldehydes to carboxylic acids, including retinaldehyde to retinoic acid)
Xanthine oxidase (detoxes uric acid and caffeine)
Sulfite oxidase (molybdenum is needed for proper sulfur metabolism/detox)
Proper iron metabolism by regulating toxic copper (molybdenum deficiency can lead to iron overload OR iron deficiency)
Signs of molybdenum deficiency (not all of these need to be present):
Hair molybdenum lower than 0.004 on Trace Elements Hair Mineral Test
Sensitivity to alcohol (easily intoxicated, flushing, strong hangovers, etc.)
Wine (sulfites!) causes different or more or worse symptoms than other types of alcohol
Sensitivity to caffeine
History of gout and/or high uric acid
History of yeast and/or fungal issues
Sensitivity to high sulfur foods (garlic, onions, crucifers) or supplements
Sulfur-smelling gas, body odor, or breath
Iron overload (high ferritin)
Chronic low iron/ferritin
We typically add molybdenum second of the three "Big Minerals".
Why? Because it is a microgram dose (like selenium). In my experience it can cause copper-dumping in some people (moreso than selenium), yet not as much as zinc tends to (because zinc is a milligram dose).
It can be added in anytime. Remember to only change one big mineral variable at a time though!
Guidelines for ALL "Big Minerals" (selenium, molybdenum, and zinc):
If you don't feel good on a certain dose, TAKE LESS than the dose you have problems at. This might mean ZERO is the right dose for you, especially if you are very toxic or sensitive, in the early stages of your LYL journey.
Most issues with the Big Minerals will show up within the first 3 days of starting or increasing the dose, BUT could take up to a week to show up.
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-food-sources-of-molybdenum
Can a person get enough molybdenum from foods? Maybe, and probably not.
Beans are the highest source of molybdenum in general.
Black-eyed peas (cowpeas) are the bean highest in molybdenum (yay), yet are also the highest bean in carotenoids (boo).
IMPORTANT: Beans are way LOWER in molybdenum than they used to be, even from 5 years ago, so relying on them for basic molybdenum needs is unlikely to be enough unless you are eating 2 or more cups of (cooked) beans per day. If you're really deficient and/or really copper toxic, beans are probably not going to get you out of deficiency.
Either way, if you don't (hair) test, you're just guessing!
Types of molybdenum that are OK to use:
Molybdenum Glycinate
Sodium Molybdate
If you still have the Biotics Mo-Zyme, that is fine to continue using and/or use up.
Our molybdenum-containing products:
Nutrition Detective Molybdenum Glycinate 150 mcg capsules (https://nutritiondetective.com/collections/membership-collection/products/molybdenum-glycinate-150-mcg-100-capsules-vip)
EIDON Ionic Minerals Molybdenum Liquid 2 oz (https://nutritiondetective.com/collections/membership-collection/products/molybdenum-liquid-2-oz)
Keystone Minerals 100 Capsules (https://nutritiondetective.com/collections/membership-collection/products/keystone-minerals-vip)
Keystone Minerals PLUS Niacin 60 capsules (https://nutritiondetective.com/collections/membership-collection/products/keystone-minerals-plus-niacin-60-capsules-vip)
Do NOT use ammonium molybdate or "lipid-bound molybdenum"
Do NOT mess with molybdenum powders trying to save money or avoid additional ingredients, you'll mess yourself up. Just DON'T do it.
ANY dose or frequency that causes negative symptoms should be regarded as too much, and the dose should be reduced to the amount that causes NO negative symptoms!
My suggested "normal" foundational long-term molybdenum dosing without hair testing/monitoring is 150 mcg/day.
This is what I consider the foundational long-term dose for ~80% of adults that is enough to improve molybdenum status (may not be enough to fully replenish levels, yet is much better than nothing) and is unlikely to ever lead to molybdenum toxicity or the problems I'll discuss in later articles in this series.
150 mcg pills are the "standard" in the industry and seem to be OK for many people long-term also.
If you take a molybdenum pill that is larger than 150 mcg (there are 250, 500, even 1000 mcg pills out there), then skip days taking it as necessary so you average around 150 mcg per day.
If you choose to take more than 150 mcg/day without hair testing, that is up to you. Nutrition Detective, the LYL program, and I take NO responsibility for your megadosing choice. See the following articles for the mechanism of how people can mess themselves up with megadoses!
See this video first for detailed information
All Nutrition Detective molybdenum-containing capsule products (including Keystone Minerals) come with 150 mcg molybdenum per pill.
Molybdenum IS a copper antagonist, which means it can "stir up stored toxic copper", so watch for any of these potential symptoms as you increase your molybdenum dosing:
Fatigue, Brain Fog
Anxiety, Depression, Irritability
Racing Mind
Inner trembling, nerves buzzing (feeling like electricity)
Limb weakness (both arms, or both legs, or both arms & legs)
Headaches
Trouble falling asleep initially
Heart palpitations anytime, but especially before bed
ANYTHING you feel is hormonally-related
NOT A SENSITIVE TYPE pill molybdenum-adding protocol:
Introduce at 1 pill/day for 1 week, watch for ANY negative symptoms
If everything is fine (benefits noted OR no negative effects are both considered "fine") at 150 mcg per day for one week, then you are OK to stay at that dose
If negative symptoms are noted, reduce to a dose you know you tolerate, or stop taking for now (you can try again in the future when you are less toxic), or do the sensitive-type adding protocol below
SENSITIVE TYPE pill molybdenum-adding protocol
Introduce 1 pill on Monday of week 1, no molybdenum on other days
Increase to 1 pill on Mon & Thursday of week 2, no molybdenum on other days
Increase to 1 pill on Mon & Wednesday & Friday of week 3, no molybdenum on other days
Increase to 1 pill on Mon & Tuesday, & Th & Fr of week 4, no molybdenum on other days
Increase to 1 pill on Mon & Tu & Wed, & Fr & Saturday of week 5, no molybdenum on other days
Increase to 1 pill on Mon & Tu & Wed, & Fr & Sat & Sunday of week 6, no molybdenum on other days
Increase to 1 pill every day of week 7
If negative symptoms are noted, reduce to a dose you know you tolerate, or stop taking for now (you can try again in the future when you are less toxic).
Molybdenum drops come in different forms and potencies.
When ND Liquid Molybdenum Glycinate and ND Liquid Keystone Minerals come out, they will have 10 mcg molybdenum glycinate per drop.
EIDON Ionic Minerals Molybdenum Liquid 2 oz (https://nutritiondetective.com/collections/membership-collection/products/molybdenum-liquid-2-oz) contain 6.7 mcg of molybdenum per drop, so it takes ~23 drops to equal 150 mcg.
Molybdenum IS a copper antagonist, which means it can "stir up stored toxic copper", so watch for any of these potential symptoms as you increase your molybdenum dosing:
Fatigue, Brain Fog
Anxiety, Depression, Irritability
Racing Mind
Inner trembling, nerves buzzing (feeling like electricity)
Limb weakness (both arms, or both legs, or both arms & legs)
Headaches
Trouble falling asleep initially
Heart palpitations anytime, but especially before bed
ANYTHING you feel is hormonally-related
GENERAL (Sensitive AND Not Sensitive) EIDON liquid molybdenum-adding protocol:
This approach is automatically slow, it takes 3 weeks to hit the full dose.
Start at 1 drop/day.
Go up by 1 drop/day.
Continue increasing by 1 drop/day until you hit 23 drops (150 mcg) or until you hit copper detox-dumping side effects, then back off by a drop or two to find the dose that works for you.
If negative symptoms are noted, reduce to a dose you know you tolerate, or stop taking for now (you can try again in the future when you are less toxic)
Additional resource: Official Copper Toxicity Resource and Support Site - Empowering Education, Support, and Awareness for Copper Toxicity - Coppertoxic (http://coppertoxic.com/)
There are forum-dwelling anons out on the interwebz, with no health qualifications whatsoever, who are recommending mega-MEGAdosing of molybdenum (milligrams a day, I’ve even heard of 24 mg or more a day, that’s 24,000 mcg plus!!!). This is going to cause MAJOR problems. I have heard of some LYL members wanting to experiment with this. I will say "I told you so" when it ends badly down the line.
Let me make this clear. Megadosing minerals to suppress symptoms (aka "dosing based on symptoms") is NOT in alignment with what we do here at the LYL. Megadosing minerals to suppress symptoms is allopathic (conventional medicine) in nature, it is not fixing any root cause, and it will cause its own problems! (keep reading)
If you choose to do this, as always, you can do whatever you want. I am advising you NOT to, and I take absolutely no responsibility for the outcome and your decision to use a mineral as a drug (because that’s what that is).
Let me tell you the molybdenum overdosing stories I've been privy to. These effects all appear to have backing in the research! DO NOT think some magickal fad protocol by some Peatard forum anon will protect you from these problems (or FAFO, I guess, it’s your life and health). I’m going to do the stories from least bad to worst.
This is NOT to scare you off of SANE dosing of molybdenum. This IS to scare you off of megadosing molybdenum in a DRUG-LIKE manner, particularly if you try to “manage/treat symptoms” with it (note managing symptoms is what DRUGS do).
To set this up, I used to use the Thorne 1 mg (1000 mcg) molybdenum glycinate capsules. Depending on people’s hair test molybdenum, I’d have them use 1 PER WEEK or up to 2/WEEK if they were quite low. That comes out to about 150 mcg and 300 mcg per day, respectively, ON AVERAGE (1000 divided by 7 days equals ~143 mcg per day). Same average daily doses as I still recommend and teach. Thorne stopped selling these, along with many of their other old megadose supplements, probably because they were MESSING PEOPLE UP (this is called foreshadowing, lol). I stopped using them long before Thorne stopped selling them, because the potential for mistakes was way too high, and I watched several overdosings happen. Please read ALL three stories.
First story. A female client of mine misread her treatment plan and started taking 1 PER DAY instead of the stated 1 PER WEEK. So 1 mg or 1000 mcg per day. 7x more than what I wanted her to take. A month later, she emails me asking if it is normal to “feel weird” on the program. I say no, and ask her what she’s taking. She tells me about the molybdenum she was taking. I tell her to STOP. The symptoms fade away over time.
There is a case study in the literature about a man taking 13.5 mg (13500 mcg) over the course of 18 days and causing himself major mental issues:
A case report of acute human molybdenum toxicity from a dietary molybdenum supplement--a new member of the "Lucor metallicum" family.
Let me be clear here. The man in this case study likely had major toxic metal issues underneath it all (note the chelation therapy helping), he was on multiple other (likely toxic) supplements from his chiropractor, and he was told to dose his molybdenum “based on symptoms”. Note that this pattern falls in line with the megadose protocol recommendations out there currently, and “megadosing by symptoms” will come up here later as well.
This can easily cover the "feeling weird", and I also didn't know about molybdenum's potential for copper detox-dumping back then. Both easily explain the symptoms and how it faded away quickly once she stopped. As for that guy in the case study above, like I said, I think he was full of toxic metals or something else, and the medical community saw an opportunity to badmouth molybdenum (and they took it).
Second story. A male client of mine ALSO misread his treatment plan and started taking 2 per DAY instead of the stated 2 per WEEK. So 2 mg or 2000 mcg per day. Again, 7x more than what I wanted him to take. Within several weeks, he emails me admitting that he messed up his molybdenum dosing by taking 2/day. He had given himself GOUT. Yes folks, gout-like symptoms are a known side effect of “molybdenum toxicity”:
From Molybdenum:
“In Armenia, where soil concentrations of molybdenum are unusually high, intakes of 10–15 mg/d have been associated with aching joints, gout-like symptoms, hyperuricosuria, and elevated blood molybdenum.”
Also see Occupational molybdenum exposure and a gouty electrician
So yes, this man caused himself gout with megadosing 2 milligrams a day of molybdenum within several weeks’ time. Pay attention to the milligram dosing causing elevated blood molybdenum, that comes up next.
Third story. A person who is/was extremely familiar with LYL principles was self-administering daily milligram doses (and multi-milligram doses) based on SYMPTOMS, over MULTIPLE YEARS. I want to emphasize that I was NOT managing this person’s supplements long-term.
This person had, at one point, the HIGHEST supplement-induced hair test molybdenum level I have EVER seen, coming in at 0.38 at one point (I want 0.004 - 0.008, so 6.5 times higher than the middle of my range!). I had always made my concerns clear that I had concerns about the megadosing of molybdenum. That said, this person is an adult and I allow people their free will and self-responsibility to do what they want.
One day, this person tells me that their gallbladder “went bad” and that they had to have it surgically removed. This made NO sense to me unless there was some atypical cause outside of “normal LYL stuff”. I had a hunch it was the megadosing molybdenum that did it. So I go and find these papers (recall that milligram doses of molybdenum raise blood levels of molybdenum!):
Serum molybdenum in diseases of the liver, gallbladder, and bile ducts (biliary) system
High blood molybdenum was associated with gallstones, tumors of the gallbladder, elevated liver enzymes, liver cirrhosis, primary biliary cirrhosis, tumors of the extrahepatic bile ducts, acute viral hepatitis, chronic active hepatitis, drug-induced liver injury, alcoholic liver disease, liver metastases, and pancreatic cancer.
Anyone here at LYL should be able to look at the above issues and realize that this is exactly what we DON'T want to do!
A Metallomic Approach to Assess Associations of Serum Metal Levels With Gallstones and Gallbladder Cancer
Higher blood molybdenum levels were associated with gallstones and gallbladder cancer.
Can I say for sure that the molybdenum megadosing caused the gallbladder problem? No. No one can say why this person’s gallbladder tanked, and everything is always multifactorial anyway. We don’t have blood molybdenum levels and we sure don’t have a liver biopsy. That said, a very strong case can be made by the dosing of milligrams per day over years, combined with the massively high hair molybdenum level, combined with the above research, is not something to discard or ignore. Keep reading for the likely mechanism, which isn't what you would expect!
Now I’m going to educate you on the newest wrinkle in the Duration Paradox, in regards to the “good” supplements we use here, like molybdenum. A compound can have one effect in smaller doses, and a COMPLETELY OPPOSITE effect at large doses. This is talked about in the research, mostly under hormesis. Now pay attention, because molybdenum does this!
Molybdenum example.
Molybdenum helps to get copper OUT of the liver at small/”normal” doses
Molybdenum shoves MORE copper (and sulfur!) into the liver at HIGH DOSES
Molybdenum at small/”normal” dosing LOWERING copper levels in the liver of lambs while they were given excess copper during "intensive fattening":
“An experiment was designed to investigate the practical possibility of incorporating small quantities of molybdenum salts into the high copper diets of intensively fattening lambs to prevent or reduce the gradual accumulation of copper from feed. At slaughter (14 weeks of age) lambs which had received Mo supplement (7.7 ppm Mo) showed liver copper levels which were 40.1 per cent lower than those in the control group”
Translated: A small amount of molybdenum helped prevent/reduce copper accumulation in the liver.
The use of molybdenum for the prevention of nutritional copper poisoning in housed sheep
Molybdenum (Mo) at HIGH dosing INCREASING copper (Cu) in the liver in RATS:
“In Cu-excess rats without Mo the liver Cu concentration was higher than in control rats; however, between 0 and 150 mg Mo/kg diet the liver Cu concentration of these rats decreased, whereas between 150 and 500 mg Mo/kg it was raised again, at 500 mg Mo/kg reaching the level of that of the Cu-excess rats without Mo.”
The above, translated into normal terms:
Rats that got excess copper without molybdenum had more copper in their livers than control rats
In excess copper rats that got 50 mg Mo/kg diet and 150 mg Mo/kg diet (the lower doses!), the liver copper went DOWN
In excess copper rats that got MEGA doses of molybdenum, the liver copper went up as high as the rats that got excess copper with ZERO molybdenum! That’s BAD
Look at the image below. There is an obvious trend that as the molybdenum doses get higher, so did the amount of COPPER in the LIVER.
The influence of molybdenum on the copper metabolism of the rat at different Cu levels of the diet.
Molybdenum (Mo) at HIGH dosing INCREASING copper (Cu) in the liver in SHEEP:
“1. Distribution of copper and molybdenum was followed in the body tissues of sheep fed on high levels of Cu (82 mg Cu/sheep per d), sulphur (3.77 g S/sheep per d) and different levels of Mo (0.6 20.8, 38.4 and 58.5 mg Mo/sheep per d). 2. Liver Cu content decreased as Mo intake increased from 0.6 to 38.4 mg/d, but increased again at high intakes of Mo. With an Mo intake of 58.5 mg/d, the Cu content of liver, kidney, lung, spleen and muscle tissue was significantly higher than with an intake of 20.8 mg Mo/d. The trend of increased Cu concentrations in kidneys and plasma was already evident at an Mo intake of 38.4 mg/sheep per d. 3. High positive correlations were observed between Cu and Mo in both the kidney cortex and medulla of the sheep at the two highest Mo treatments."
Effect of different levels of dietary molybdenum on copper and Mo metabolism in sheep fed on high levels of Cu
Look at the table below. Once the molybdenum dosing got high enough, EVERY SINGLE TISSUE had more molybdenum in it (especially note the LIVER and KIDNEYS!). Also note how the "Low-Mo" group was typically the lowest or next-to-lowest group in copper in nearly all the tissues measured!
What is the lesson here? It seems that megadosing molybdenum mega-stores copper in the liver!
What is actually happening though? It is likely that the body is making Copper-Molybdenum-Sulfur compounds and shoving them into the liver!
From the above paper: “It was suggested that in the presence of an abundance of Mo, Cu and S, compounds containing these minerals in metabolically unavailable forms accumulate in the body, first in the kidneys, but eventually also in the other tissues of the sheep.”
“An excess of either copper or molybdenum, by giving rise to a relatively undissociable Cu-Mo-S complex, may produce a deficit of the metal in marginal supply. As dietary excess of copper is known to be common in the United States, and preliminary data suggest that molybdenum intake may not be optimal, it is possible that a conditioned deficit of molybdenum may contribute to abnormalities of iron metabolism and utilization.”
Review: Relationships of copper and molybdenum to iron metabolism
Both of the above translated means that if you already have copper toxicity (excess copper), and you add megadoses of molybdenum, and you’re eating sulfur (which is unavoidable), your body will bind them all together and store them in the liver!
Pay attention here. This next paragraph is SUPER important.
Megadosing molybdenum STORES more COPPER in the liver. This may “reduce symptoms” (ie, they “feel better”) because they are taking the copper out of the BLOOD (where it causes symptoms) and storing it in the LIVER instead. This will look like they are lowering their copper levels on both blood and hair tests, which is the OPPOSITE of what is happening in the liver! They think they’re making progress in the right way, when they’re really setting their liver, gallbladder, bile ducts, and even kidneys up for massive failure sometime in the future. Mark my words.
It may not even be the molybdenum itself that is the toxicity problem. It’s probably the effect it has on shoving/storing even MORE TOXIC COPPER in the LIVER!
Please don't go and prove me right on this. Please don't.
How can you avoid this? What do we do? I’ve already given you the principles.
We take small/”normal” supplement doses of molybdenum as tolerated
We reduce/minimize/eliminate the highest-sulfur foods
We work the LYL approaches on reducing our copper toxicity
We do NOT use DRUG-LEVEL doses of a mineral to SUPPRESS SYMPTOMS (which is what “dosing by symptoms” really is)
This is how we use molybdenum properly and avoid putting fuel on this fire.
Remember, in the previous articles, I told you that:
MAX long-term dosing (aka safe foundational dose) one can do without testing is 150 mcg/day on average)
If a person who is NOT testing decides they want to take more than 150mcg per day, they should STOP doing the higher amount after 6 months if they are not testing
If people are sensitive to the copper detox-dumping of molybdenum and get symptoms from it, they are to go DOWN in dose (not up).
This is how we have avoided all of these problems while helping people to recover their health!
A case report of acute human molybdenum toxicity from a dietary molybdenum supplement--a new member of the "Lucor metallicum" family (https://pubmed.ncbi.nlm.nih.gov/10649845/)
Molybdenum - PMC Article (https://pmc.ncbi.nlm.nih.gov/articles/PMC5952949/)
Occupational molybdenum exposure and a gouty electrician (https://pubmed.ncbi.nlm.nih.gov/15757993/)
Serum molybdenum in diseases of the liver, gallbladder, and bile ducts (biliary) system (https://pubmed.ncbi.nlm.nih.gov/7205061/)
A Metallomic Approach to Assess Associations of Serum Metal Levels With Gallstones and Gallbladder Cancer (https://pubmed.ncbi.nlm.nih.gov/31318976/)
The use of molybdenum for the prevention of nutritional copper poisoning in housed sheep (https://pubmed.ncbi.nlm.nih.gov/982781/)
The influence of molybdenum on the copper metabolism of the rat at different Cu levels of the diet. (https://sci-hub.st/10.1079/bjn19800095)
Effect of different levels of dietary molybdenum on copper and Mo metabolism in sheep fed on high levels of Cu (https://sci-hub.st/10.1079/bjn19810092)
Review: Relationships of copper and molybdenum to iron metabolism (https://www.sciencedirect.com/science/article/abs/pii/S0002916523331216)
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-zinc
Zinc is super important. There are more than 300+ enzymes that require zinc in the body. Don't mess this one up, K? 😉😎
Our zinc-containing products:
Zinc Picolinate 15 mg 100 capsules (https://nutritiondetective.com/collections/membership-collection/products/zinc-picolinate-15-mg-100-capsules-vip)
Zinc Picolinate 30 mg 100 capsules (https://nutritiondetective.com/collections/membership-collection/products/zinc-picolinate-30-mg-100-capsules-vip)
Keystone Minerals 100 Capsules (https://nutritiondetective.com/collections/membership-collection/products/keystone-minerals-vip)
Keystone Minerals PLUS Niacin 60 capsules (https://nutritiondetective.com/collections/membership-collection/products/keystone-minerals-plus-niacin-60-capsules-vip)
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-zinc-basics
Guidelines for ALL "Big Minerals" (selenium, molybdenum, and zinc):
If you don't feel good on a certain dose, TAKE LESS than the dose you have problems at. This might mean ZERO is the right dose for you, especially if you are very toxic or sensitive, in the early stages of your LYL journey.
Most issues with the Big Minerals will show up within the first 3 days of starting or increasing the dose, BUT could take up to a week to show up.
Our zinc-containing products:
Liquid Zinc Picolinate 2mg/drop 1200 drops (https://nutritiondetective.com/collections/membership-collection/products/liquid-zinc-vip?variant=44606958633128)
Zinc Picolinate 15 mg 100 capsules (https://nutritiondetective.com/collections/membership-collection/products/zinc-picolinate-15-mg-100-capsules-vip)
Zinc Picolinate 30 mg 100 capsules (https://nutritiondetective.com/collections/membership-collection/products/zinc-picolinate-30-mg-100-capsules-vip)
Keystone Minerals 100 Capsules (https://nutritiondetective.com/collections/membership-collection/products/keystone-minerals-vip)
Keystone Minerals PLUS Niacin 60 capsules (https://nutritiondetective.com/collections/membership-collection/products/keystone-minerals-plus-niacin-60-capsules-vip)
Let me set the tone here.
Zinc is critical to human life. Zinc is involved in over 200+ enzyme pathways in the human body.
"Zn deficiency in agricultural soils is considered to be the most geographically widespread micronutrient deficiency"...you aren't going to get enough from food alone, in all likelihood.
As I've done this longer and longer, the amounts of zinc I've used with my clients have only gone UP
You need zinc to make Retinol-Binding Protein (RBP), to protect yourself from vA in the blood
You need zinc to displace/"kick" copper out of the liver and to protect you from copper out in your system
Zinc is necessary to run Alcohol Dehydrogenase (ADH), one of the key enzymes in the vA detox pathway
The detox process (see 2 points above for examples) will sometimes use up more zinc than your diet can provide, potentially leaving you with an even worse zinc deficiency than you started with (how could you know this is happening?...testing!). Sometimes the detox uses up even more zinc than diet & supplements provide! I'm not kidding, I see this often. That's why I tell people THIS IS NOT A GAME
I'm re-posting some of my other network posts in this section for those who really want all the info in one place. I'm trying to make this as short and focused as possible.
EVERYONE tests low on zinc, so just because you react badly to it, does not mean you don't NEED it. That said, your reaction means you need a lower dose OR shouldn't take it...YET. If you want to *low dose* or do very *customized* dosing, then the ND Liquid Zinc is what you want (email Julie at admin@nutritiondetective.com (mailto:admin@nutritiondetective.com) for your LYL discounted price). Some people open up capsules and divide them into the amounts they require.
Zinc toxicity is a real thing. That said, all the case studies I have seen show that zinc toxicity happens with doses >100 mg (usually >200 mg) for months and months. Don't do that, k? Otherwise, if you aren't testing and you're going above 30 mg without my guidance, don't blame me if something goes sideways. I personally know a guy who messed himself up with 150 mg zinc a day for an extended period. If you continue taking (too much) zinc when you know it doesn't make you feel good, you are NOT LISTENING to the program!
Getting zinc right is not easy. I give people lots of personalized guidance in zinc dosing & approaches in my Testing & Consultation packages (https://nutritiondetective.com/collections/schedule-a-consultation), which includes the follow-ups in my "Office Hours".
Please see the other zinc articles in this section before posting questions
With the new things I'm figuring out about VA and the liver, zinc becomes more and more important all the time.
If you haven't read this article in the Detox Program yet, please do:
https://members.nutritiondetective.work/posts/basic-vitamin-a-detox-zinc-good-and-copper-bad
Many people insist on trying to fix this problem without supplementing. It's a legit choice, however, that doesn't mean it will be effective. All CHOICES have CONSEQUENCES.
As always, I suggest "testing, not guessing, then addressing" with me, so that I can interpret your blood zinc and hair zinc status, among other values I interpret at the same time, to figure out how much zinc YOU need. Contact Julie at admin@nutritionrestored.com (mailto:admin@nutritionrestored.com) if you need more information.
As I figure out more and more, it seems that it requires EVEN MORE zinc to really get out of our problem than I had previously thought. However, some people are so "sick" (toxic) that they can't take very much zinc at all initially, and some who insist on doing food-alone approaches will take a long time and even struggle to get there.
Note that I reference research (https://pubmed.ncbi.nlm.nih.gov/19291414/) showing:
"Zn deficiency in agricultural soils is considered to be the most geographically widespread micronutrient deficiency"
"In 1945, Beeson [1] published a world-wide review of molybdenum in agricultural soils and plants. Among the conclusions was a statement that zinc was included in his review only for comparative purposes because 'there was very little information on zinc in agriculture at this time'..."
"In 1957, the USA had only about four states with reported zinc deficiency problems in crops. By 1962, the number had grown to 17 states."
"In 1962, deficiency of some of the micronutrients under consideration in this review had been reported in the following countries:
...zinc: 41 countries;
..."
"Zinc (Zn) deficiency in plants is the most widespread micronutrient deficiency disorder affecting crops in the world, occurring in ~50% of arable soils. In the United States, Zn deficiency for one or more crops was reported for 30 states (Berger, 1962)."
"ZINC DEFICIENCY AND CROP DISEASES. – Zinc sufficiency was reported to increase insect pest and disease resistance in crop plants."
This is really NO JOKE, folks! If it's NOT in the soil, it's NOT in the plants, it's NOT in the animals, and it WILL NOT BE IN YOU.
Being that muscle meat (particularly red meat) is the highest source of the most bioavailable zinc, if you are any version of a vegetarian or only eating poultry, you are UNlikely to be getting anywhere near the zinc you need to heal. Sad but true.
So, here's a quick reminder of all the things that zinc is important for, from that same paper:
ROLE OF ZINC IN HUMAN HEALTH. – Zinc is an essential trace element also for human health. Humans require at least 25 elements for their wellbeing. The dietary sources of most of these elements are crop plants. Unfortunately, mineral malnutrition is prevalent world-wide.
Zinc deficiency causes problems in many ways. Zinc is involved in: DNA synthesis, cell division and cell growth, development of bone, teeth, hair and skin, carbohydrate and protein metabolism, regulation of insulin, steroid hormone production, neurological development, immunity, wound healing, and it has antioxidant properties.
It is estimated that 2 billion people in Asia and 400 million people in sub-Saharan Africa could be at the risk of low Zn intake.
The sicker and more COPPER-TOXIC a person is, it is quite likely that their INITIAL tolerance of zinc will be very LOW or even NON-EXISTENT.
As people get better (yet aren't quite all "well"), their TOLERANCE and NEED for zinc actually seems to go way UP.
Eventually, a person may not need supplemental zinc, or will only need a minimal dose to keep them healthy.
How will we know where a person is in the process? Testing, observation, and feedback. That's how.
It is my job to help people determine their best doses of zinc at their phase of this process, and the time I spend on the topic of ZINC in consults is extremely reflective of how important I feel this mineral is to your recovery.
NO, I can't just give everybody an amount of zinc to take. See the last line of the paragraph below.
See referenced research:
Zinc deficiency in soils, crops and humans (https://www.academia.edu/5977489/Zinc_deficiency_in_soils_crops_and_humans_A_Review)
PubMed study on zinc and ethanol liver damage (https://pubmed.ncbi.nlm.nih.gov/19291414/)
Ethanol (what we call alcohol colloquially) is chemically classified as an alcohol. Ethanol is known to cause cholestasis and liver injury. Over time, consumption of ethanol slows down ADH and ALDH in the liver (the main detox pathway of VA as it goes through the liver into the bile).
Retinol is technically an "alcohol" also. Retinol (in the VA family of retinoids) causes cholestasis and liver injury (video coming soon). Retinol goes through the same ADH and ALDH pathways in the liver, and consumption of VA over time will slow these down as well.
When I test people, I test BOTH blood zinc (plasma zinc, to be specific) AND hair zinc levels. I am the only person I know who does this (other than those I've trained ;-) ). This is because getting zinc intake--whether by food alone (typically quite inadequate) or supplements--correct is EXTREMELY IMPORTANT.
So, before I lay out this next study, remember that ethanol (alcohol) and retinol cause the SAME types of damage to the liver, so the zinc deficiency that is talked about here would likely also cause the same PROBLEMS in both. If you have been putting off getting your levels TESTED, this info may cause you to reconsider.
Dietary Zinc Deficiency Exaggerates Ethanol-Induced Liver Injury in Mice: Involvement of Intrahepatic and Extrahepatic Factors (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076522)
Clinical studies have demonstrated that alcoholics have a lower dietary zinc intake compared to health controls. The present study was undertaken to determine the interaction between dietary zinc deficiency and ethanol consumption in the pathogenesis of alcoholic liver disease. C57BL/6N mice were subjected to 8-week feeding of 4 experimental liquid diets: (1) zinc adequate diet, (2) zinc adequate diet plus ethanol, (3) zinc deficient diet, and (4) zinc deficient diet plus ethanol.
Ethanol exposure with adequate dietary zinc resulted in liver damage as indicated by elevated plasma alanine aminotransferase level and increased hepatic lipid accumulation and inflammatory cell infiltration.
--> Even in the presence of enough zinc, ethanol and VA will still cause damage to the liver.
Dietary zinc deficiency alone increased hepatic lipid contents, but did not induce hepatic inflammation.
--> Zinc deficiency by itself will cause FATTY LIVER ("hepatic lipid contents"), which implies cholestasis and LIVER INJURY.
Dietary zinc deficiency showed synergistic effects on ethanol-induced liver damage.
-->So if zinc deficiency and alcohol consumption were synergistic in their "ethanol-induced liver damage", VA toxicity (and probably copper toxicity, which also causes cholestasis and needs zinc to detox) could probably be assumed as well.
Dietary zinc deficiency exaggerated ethanol effects on hepatic genes related to lipid metabolism and inflammatory response.
--> GENETICS loads the gun, but it is ENVIRONMENT (including what we take in our bodies, for better or worse) that PULLS THE TRIGGER. You are not a "victim of your genetics"...you are a victim of your toxicities, deficiencies, and the liver injury they have caused you...and we can fix that.
Dietary zinc deficiency worsened ethanol-induced imbalance between hepatic pro-oxidant and antioxidant enzymes and hepatic expression of cell death receptors.
--> More ungoodness. ;-)
Dietary zinc deficiency exaggerated ethanol-induced reduction of plasma leptin, although it did not affect ethanol-induced reduction of white adipose tissue mass.
--> "Leptin is a hormone predominantly made by adipose cells and enterocytes in the small intestine that helps to regulate energy balance by inhibiting hunger, which in turn diminishes fat storage in adipocytes." Less leptin = more hunger = tendency towards more overeating of fats and sugars = even more cholestasis. BAD COMBO
Dietary zinc deficiency also deteriorated ethanol-induced gut permeability increase and plasma endotoxin elevation.
--> MORE LEAKY GUT with zinc deficiency and excess "alcohols".
These results demonstrate, for the first time, that dietary zinc deficiency is a risk factor in alcoholic liver disease,
--> Test, don't guess, so we can fix the ROOT CAUSE of the problems...one of which for nearly everyone is chronic liver disease, aka cholestasis, aka LIVER INJURY to the bile ducts. Zinc deficiency is involved in nearly all liver disease.
...and multiple intrahepatic and extrahepatic factors may mediate the detrimental effects of zinc deficiency.
--> Know what else has "intrahepatic and extrahepatic factors"? CHOLESTASIS. What "mediates the detrimental effects" in the liver and systemically? TOXIC BILE, coming from the liver itself, being refluxed into the blood.
The moral of the story is that the zinc piece of the health equation is an absolutely CRITICAL mineral to fix, in a properly individualized way, to help correct the cholestasis / LIVER INJURY that is at the ROOT of nearly all modern chronic health issues. A mistake I've seen many times is people assuming that their diet will automatically take care of this for them...sadly, I have not seen this to be true in any case yet where I have seen testing...so don't hold your breath that you'll be the exception.
Do you have an amazing story about what zinc did for your health? Please feel free to share it below!
If you want to get your zinc straightened out, contact Julie at admin@nutritiondetective.com (mailto:admin@nutritiondetective.com) about which testing package is right for you!
This was originally a comment of mine on a network post.
"In certain circumstances, retinoic acid seems to promote inflammatory responses to dietary antigens. Retinoic acid has been linked to inflammatory bowel disease.
Oral isotretinoin does not seem to be associated with celiac disease
However, the main indication for oral isotretinoin, acne, may be more common in patients with celiac disease."
I believe that most autoimmune conditions are built on a foundation of VA toxicity, with other layers of genetics, and/or toxicities, and/or nutrient deficiencies on top of it...this combination determines where the autoimmunity happens.
Ergo, celiac is very linked to VA toxicity combined with a zinc deficiency, IMHO. People who don't have a significant zinc deficiency don't tend to get celiac as much (that's why acne people aka zinc-deficient get more celiac from VA toxicity, while zinc-adequate don't, which is really what they are stating in the above quote).
Rheumatoid arthritis seems to be a combination of VA toxicity and copper toxicity (which also often implies a zinc deficiency, as copper and VA toxicity both deplete/use up more zinc).
In an Inner Circle video, Grant mentioned this cream as providing him some relief from eczema (back when he still had it):
https://supraderm.com/ (https://supraderm.com/)
Ingredients: zinc, lanolin, corn starch and white petrolatum
From their FAQ at https://supraderm.com/faq/ (https://supraderm.com/faq/):
What kinds of rashes can it be used on?
"Supraderm™ can used to relieve painful, itchy and inflamed skin irritations and rashes such as...ECZEMA, HEAT & ALLERGY RASH, INCONTINENCE & DIAPER RASH, BED SORES, PRESSURE SORES, HEMORRHOIDS, CHAFING, COLD SORES, POISON OAK, POISON IVY, POISON SUMAC, INSECT BITES, MINOR CUTS AND SCRAPES, LIGHT BURNS, DRY CRACKED HANDS & HEELS and SHINGLES."
On that note, skin problems that are helped by zinc would imply a systemic zinc deficiency. Zinc is critical for the body to make protective Retinol Binding Protein aka RBP, to run Alcohol (Retinol) Dehydrogenase aka ADH, and to relieve the subclinical cholestasis that VA causes. If one really wants to correct a systemic zinc deficiency, then testing is the BEST option.
Alternate suppliers for Supraderm:
https://olenskincare.com/product/supraderm-2/ (https://olenskincare.com/product/supraderm-2/)
Zinc Oxide Powder alternative:
https://skyorganics.com/products/zinc-oxide-powder (https://skyorganics.com/products/zinc-oxide-powder)
Also available on Amazon (out of stock at time of writing):
https://www.amazon.com/dp/B016V0ST9G (https://www.amazon.com/dp/B016V0ST9G)
"Just wanted to update you on my progress. Zinc has been a miracle. I'm up to 45 mg a day, 15 in morning, 30 at night. I am feeling SOO much better. More flexible, better sleep, so much less pain, calmer, better digestion...everything really is better. I've also been avoiding sulfides and that is DEFINITELY helping my digestion. I had one meal with onions and garlic and got a sour, gassy feeling right away, with a return of nocturia as well. Only lasted that night since I didn't continue.
I just want to thank you especially for catching the zinc. I don't believe anyone had really tested that in a while. It feels like I'm getting aspects of my humanity back that I haven't had for a while...not an exaggeration."
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-lactoferrin
Lactoferrin is a blessing when used correctly.
It will feel like a curse if you overdo it.
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-lactoferrin-faq
What is lactoferrin?
Lactoferrin is a protein found naturally nearly all mammalian bodily fluids (breastmilk, saliva, tears, mucus, and bile). Lactoferrin is found in the highest concentrations in breastmilk, and is purposely put there to protect the newborn from the toxins that the new mother normally detoxes into her breastmilk (breastmilk contains sugar for both energy AND to hide the taste of the toxins within, and it contains lactoferrin to protect the baby's liver and bile ducts from those toxins). If you didn't know already, the placenta is basically a "third liver" (mother, baby, placenta) that is meant to be disposed of (don't eat it, ever!!!) after delivery. Lactoferrin is found in the very highest amounts in colostrum, the breast milk produced for only a short time after a baby is born.
Why might lactoferrin be helpful in our approach?
I go over lots of research on lactoferrin in the video Q&As in the Inner Circle and Advanced course.
Lactoferrin is made by epithelial cells in the body, along with neutrophils (a type of white blood cell).
Vitamin A decreases/destroys epithelial cells (https://pubmed.ncbi.nlm.nih.gov/6198007/). This means less lactoferrin.
Vitamin A also decreases/destroys neutrophils (aka neutropenia) (https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-4362.2003.01657.x?sid=nlm%3Apubmed). This also means less lactoferrin.
Cholangiocytes are also known as "bile duct cells", and are a type of EPITHELIAL CELL (thus damaged/destroyed by VA). It is bile duct damage that is at the ROOT of all cholestasis aka liver injury!
Finally, lactoferrin is critical to repairing and/or renewing the cholangiocytes (https://pubmed.ncbi.nlm.nih.gov/29550924/).
To wrap the above all up, VA damages the cells that make lactoferrin, and it is lactoferrin that actually repairs the damage that VA did to the bile ducts. This means that VA toxic people will likely be low in lactoferrin AND in need of it at the same time!
If our body is still VA toxic and unable to make the lactoferrin it needs to repair the damaged bile ducts, then supplementing with external lactoferrin seems like a reasonable approach.
Where can we get lactoferrin from?
There are several places that one can get therapeutic doses of lactoferrin.
"Human" recombinant lactoferrin derived from genetically modified rice (https://link.springer.com/article/10.1007/s11626-008-9136-7). DON'T EVER USE THIS. I hope I don't need to say more.
Human breastmilk. This is not exactly widely available, seems quite weird to most adults (I'm not pursuing it anytime soon), and would contain all the toxins that the mother was expressing in her breastmilk. If you want to pursue this, I guess one could say that it is the "most natural" source. Don't ever say I told you to go searching for this.
Camel's milk. Note that this has been a "health fad" in recent years, particularly in the autism communities. Most people have no idea that camel's milk contains the highest amount of lactoferrin of any mammalian milk, and that it is 90% similar to human lactoferrin. It is VERY expensive. While camel's milk seems to be fairly low in VA, it's up to you if you want to pursue this option. It is precisely the lactoferrin in camel's milk that I believe is helping the autistic children.
Cow's milk products. Do we really need to talk about all the problems in dairy, and why straight-up dairy products are probably not the best route for a cholestatic person to get their lactoferrin?
Bovine lactoferrin powder. This is what is in most supplemental versions of lactoferrin capsules (including Life Extension and Jarrow). This is lactoferrin PURIFIED and ISOLATED from dairy milk. While I am making no claims around the following statement, others around the internet have stated that people who have issues tolerating normal dairy products do just fine with purified lactoferrin.
Nutrition Detective Lactoferrin (our own is better than the other ones out there, for several very real reasons).
What does lactoferrin do in the body, other than repairing the bile ducts?
Lactoferrin binds to free copper and iron in the body (https://pubmed.ncbi.nlm.nih.gov/3666279/) (this is good!).
Lactoferrin balances the gut biome over time (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801499/).
Lactoferrin transports zinc (https://pubmed.ncbi.nlm.nih.gov/7386420/).
Lactoferrin helps fix iron-deficiency anemias better than iron supplements! (https://pubmed.ncbi.nlm.nih.gov/29059584/)
Lactoferrin helps break down biofilms (https://www.tandfonline.com/doi/full/10.1080/08927014.2013.773317).
Lactoferrin has multiple anti-cancer properties (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175311/).
Due to all the reasons mentioned above, it should be assumed that lactoferrin would be observed to "help the immune system" (https://pubmed.ncbi.nlm.nih.gov/27234407/) in general...mostly by making the system less toxic and less cholestatic!
I cannot begin to tell you how IMPORTANT it is that you read these instructions and LISTEN to them, if you want the MOST BENEFIT and the LEAST SYMPTOM AGGRAVATIONS from this tremendous product!!!
What is lactoferrin? It is a purified, isolated protein typically derived from mammalian milk (although it is found in ALL human body fluids) that does multiple things regarding health that we are interested in:
It helps to repair the bile ducts (aka helps to fix cholestasis aka liver injury)
It binds to free copper and helps to carry it out of the body.
This means that it can also stir up "copper toxicity" symptoms in some people if taken too much, too soon
It helps to balance iron metabolism in the body
It helps to balance the gut biome.
This means that your gut and digestion may have to "adjust" in the early stages, as your gut biome re-orients itself.
Due to the above things, research shows lactoferrin has many positive effects on the overall immune system.
It also seems to, based on our experience in the network here, help to "open up" the bile ducts and get bile moving again. THIS IS THE ISSUE WHEN PEOPLE OVERDO IT. When bile moves, TOXINS in the bile can move TOO FAST, and cause what I call the "lactoferrin cold" or detox/dumping symptoms.
Before I get to the HOW TO USE IT section, let me first talk about the "I FEEL WORSE AFTER STARTING LACTOFERRIN" situation.
Lactoferrin will make bile move. Bile contains TOXINS in cholestatic/liver injured people. When the lactoferrin gets the bile moving TOO FAST--which mostly happens when people take it in too-high of doses in the beginning--you can have LOTS of symptoms that pop up. These I call "the lactoferrin cold" (because people feel like they have a cold, and it includes a stuffy/runny nose) and/or "detox/dumping" symptoms. These symptoms can last for days to weeks if you overdo it badly. They will pass, but again, YOU DO NOT WANT THIS. Just be patient!
Symptoms people often complain of after TOO MUCH LACTOFERRIN:
People who make it worse are the ones who ignore the rule above! If you feel worse in any way after adding the lactoferrin, that is a signal to REDUCE OR STOP THE DOSE IMMEDIATELY, wait until symptoms calm, then restart at a MUCH LOWER dose and go MUCH slower.
Remember that you likely have DECADES worth of toxins to get out of your liver (and a poison on the way in is also a poison on the way OUT), don't be impatient or greedy or a "tough guy/gal" thinking you'll just grit your teeth through the suffering (it will be much longer than you anticipate, you won't last), and you will do fine.
This is where people (e.g. POTENTIALLY YOU) are probably/possibly going to make poor decisions and feel worse, even after reading my advice here.
Here is how to START and PROGRESS.
"If you're going to be DUMB, you better be TOUGH!!!"
People ignoring symptoms that pop up and then continuing to increase their dose, then wondering WHY this/these symptoms that popped up "keep getting worse"--yet never cutting back on lactoferrin even though I have told them over and over in these instructions--is the BIGGEST AND MOST COMMON MISTAKE I SEE! PAY ATTENTION PLEASE. If lactoferrin causes you issues over and over, and you don't cut back, eventually you will swear off lactoferrin and it will be entirely YOUR FAULT, not the lactoferrin's.
This is not absolutely required, but HIGHLY SUGGESTED. Charcoal will help "catch" any bile and toxins that start moving faster and could help prevent or reduce any "lactoferrin cold" or dumping/detox symptoms. It is considered a KEY PART of the LYL protocol. Get on charcoal per the charcoal section BEFORE you start lactoferrin!
This is not absolutely required, but HIGHLY SUGGESTED. Zinc will help protect your liver from the toxic bile that moves faster when you take lactoferrin. It is also the mineral that lactoferrin transports! Copper and zinc are metabolic antagonists, and if lactoferrin stirs up copper in your body (it will likely do this for most people to at least some degree, because copper is typically found in toxic amounts in cholestatic/liver injured people), you want to make sure that you are actively offsetting the copper with zinc.
Note: If you have had bad reactions (nausea, vomiting, sweating, heart palpitations, etc.) to zinc supplementation in the past, then be aware that lactoferrin may cause you similar reactions. This is likely rooted in liver copper toxicity issues.
For many people, in the beginning, lactoferrin is likely to make them feel tired/sleepy. These people should take it at dinner or closer to bed. It is likely to help you sleep.
If lactoferrin negatively affects your sleep, then take it in the morning or at lunchtime!
Take it with food.
Take it with your zinc, if you are taking zinc.
Take it with any probiotics you might be taking (these will likely become unnecessary over time).
Lactoferrin works to open up your fully clogged and partially clogged bile ducts. If you add in lactoferrin too aggressively, much of that toxic bile that is now rushing out of those bile-containing cells can go backwards into your bloodstream (this is called "regurgitation" of bile, and it IS cholestasis by definition). This is what makes you feel bad (toxic bile in your bloodstream, not in your gut where it belongs, where the charcoal can "catch" it).
Think about it like a backed-up sewer system. The pipes are clogged with solidified toxic sludge. You use something (lactoferrin) to soften and dissolve that solidified toxic sludge. Once it softens and dissolves, the sludge can now flow again. If the sludge flows too fast, it can back up into the wrong places (bloodstream) and cause real problems.
You do NOT want to be "pushing through" any symptoms caused by the lactoferrin or "gutting it out" (pun intended). You are NOT helping yourself by doing this (you are literally RE-INJURING THE INJURY by doing this, you are MAKING IT TOO HARD (you are re-injuring the injury by rehabbing it too quickly!). Do not go searching for other things, unless there is a good reason based on your own previously acquired self-knowledge or intuition.
You are to CUT YOUR DOSE OF LACTOFERRIN IN HALF every 3 days until the symptoms calm down again, which they will. This could be days, or in a bad case of ignoring the warning signs, it might be weeks. You will likely notice that once this self-induced aggravation has calmed down, you feel even better than you did before you started the lactoferrin. This means the lactoferrin was doing its job in the background, but the overflow (think toilet backing up) was what was making you feel bad! Your job is to NOT DO THIS TO YOURSELF AGAIN.
You can start ramping back up the lactoferrin once the symptoms have calmed down. Re-start at HALF the dose you were previously doing before you stopped, and GO UP SLOWER THIS TIME.
I do not have any magickal ways of getting you out of this. Just cut the dose way back, be patient, and try to "stay the course" otherwise.
This is an individual journey. There is NO one answer. Some people will feel great at a very low dose, others will need more. Listen to your body!
For reference, amounts seen in various clinical studies:
100 mg / day: Studies in infants and other low-dose research settings.
200 mg / day: Commonly seen in Japanese adult studies.
400 mg / day: (1 NDLF capsule/day) Appears in quite a few adult studies.
800 mg / day: Appears in quite a few adult studies, also the dose used in the "Lactoferrin Helps Reduce Stress" study.
3 g / day: An upper dose used in some research.
7 g / day: Upper doses in serious research settings.
THE PROGRESSION (starting doses):
Week 1 - Drop (approx. 17 mg / 1/64 tsp)
Week 2 - Smidgen (approx. 34 mg / 1/32 tsp)
Week 3 - Pinch (approx. 69 mg / 1/16 tsp)
Week 4 - Dash (approx. 138 mg / 1/8 tsp)
If you're doing well at the end of week 4 (Dash), then...
Month 2 - Tad (approx. 275 mg / 1/4 tsp)
If you're doing well at the end of Month 2 (Tad), then...
Month 3 - 1 Capsule (400 mg)
STAY at each dose increase for AT LEAST 1 FULL MONTH before moving to the next dose increase.
Increases make the jumps along with the fractional teaspoon sizes:
Drop aka 1/64 tsp (approx. 17 mg LF)
Smidgen aka 1/32 tsp (approx. 34 mg LF)
Pinch aka 1/16 tsp (approx.69 mg LF)
Dash aka 1/8 tsp (approx. 138 mg LF)
Tad aka 1/4 tsp (approx. 275 mg LF)
1 CAPSULE (400 mg LF)
I am advising you to stay at each dose increase (which is a doubling of dose each jump) for 1 FULL MONTH before you move up. If you go faster than this, then you risk feeling WORSE for an UNKNOWN PERIOD OF TIME (it will pass over time, and I have NO IDEA how long that might be for your individual situation), and these symptoms will potentially be more severe the more you "push through" without cutting back. This is YOUR RESPONSIBILITY, not mine.
Once you are at 1 capsule/day and doing well, the above schedule can be loosened up. Moving to higher doses beyond 1 capsule/day should still be done with caution, going one more capsule per day maximum, with a minimum of 1 full month at each dose increase. Whether you ever need more than 1 capsule per day is up to your individual situation.
As long as you are STILL BENEFITING from it, you should keep taking it. As long as it is helping and not hurting, keep going! If you have gotten to the place where you feel good, are your healthiest self, and want to try stopping...go for it. If you still benefit from them, then you can keep taking them! Don't make this complicated.
The Nutrition Detective Lactoferrin is 400 mg/capsule. When I say "1 pill/day", this is what I'm referring to. If you buy any other brand, then you will have to adjust your dosing to approximate this as you get close to the "1 pill/day" dose.
If you have questions, first RE-READ this article. Then, if you are not sure of something, ask the question on the network!
This offer is ONLY for Love Your Liver network members, it is NOT in the store yet! Contact Julie at admin@nutritiondetective.com (mailto:admin@nutritiondetective.com) to get instructions on how to place your order!
NOTE: International people should contact Julie directly about shipping feasibility and prices.
Please contact Julie at admin@nutritiondetective.com (mailto:admin@nutritiondetective.com) for LYL members-only prices and specials!
There aren't that many lactoferrin products out there, yet there are definite differences between the products that are available. As I'm sort of a picky guy, I insisted on putting together the best product I could.
No "extra" ingredients. NDLF is just bovine (cow) lactoferrin in a gelatin capsule. That's it. No additives, fillers, binders, flow agents, or anything else.
Comes from FRESH, premium, French milk. Pasteurization and homogenization DENATURE and DESTROY lactoferrin. Our lactoferrin is not involved with either. The "fresh" milk term is used to avoid any legal hassles associated with using another word (that rhymes with "law").
Non-denatured lactoferrin, because it comes from fresh milk and NOT from dairy byproducts. Most lactoferrin out there is derived from whey left over from cheese-making. Studies have shown that LF in whey becomes MUCH less effective (https://pubmed.ncbi.nlm.nih.gov/9220583/).
Our own network experiments (with Inner Circle and Advanced course people) have already shown noticeable differences in effectiveness vs. other brands (both in the ADH/ALDH research area, and also in E. Coli bacterial growth inhibition.
Ingredia ProDiet Proferrin White Paper.pdf (https://media2-production.mightynetworks.com/asset/29805578/Ingredia_ProDiet_Proferrin_White_Paper.pdf)
With all of that said, for anyone who has used LF before, please be aware that the NDLF is likely MUCH MORE POTENT, so it would be wise to start off with less than you were taking before (probably cutting the dose by half).
https://rumble.com/v280j5s-lactoferrin-cold.html (https://rumble.com/v280j5s-lactoferrin-cold.html)
[Video lesson - content available at the Rumble link above]
Cholestasis increases aldehydes in the body:
Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31377417/ (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31377417/)
Cholestasis increases histamine in the body:
Raised histamine concentrations in chronic cholestatic liver disease
https://pubmed.ncbi.nlm.nih.gov/2108078/ (https://pubmed.ncbi.nlm.nih.gov/2108078/)
It is my theory (carefully chosen word there) that lactoferrin helps to reduce cholestasis.
So...
ADH and ALDH (ALDH is the enzyme that breaks down aldehydes):
Effect of oral administration of bovine lactoferrin on alcohol-induced liver injury model rats
https://www.researchgate.net/publication/341160708_Effect_of_oral_administration_of_bovine_lactoferrin_on_alcohol-induced_liver_injury_model_rats (https://www.researchgate.net/publication/341160708_Effect_of_oral_administration_of_bovine_lactoferrin_on_alcohol-induced_liver_injury_model_rats)
Gene expression of IL-11, ADH1, and ALDH2 were significantly higher in the LF and LFH group than in the ethanol group. Conclusion: LF and its pepsin digestion have the potential to induce the production of a hepatocyte growth factor that repairs liver cells.
https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3334 (https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3334)
(Note: the Figure 4D (https://breast-cancer-research.biomedcentral.com/articles/10.1186/bcr3334#Fig4) reference in this study suggests that these cells are primed for milk production)
Modulation of histamine release from human colon mast cells by protease inhibitors
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724932/ (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724932/)
Similarly, inhibitors of tryptase leupeptin, N-tosyl-L-lysine chloromethyl ketone (TLCK), lactoferrin and protamine were also able to inhibit anti-IgE induced histamine release by a maximum of some 48%, 37%, 40% and 34%, respectively.
The inhibition of mast cell activation by neutrophil lactoferrin: uptake by mast cells and interaction with tryptase, chymase and cathepsin G
https://pubmed.ncbi.nlm.nih.gov/12623133/ (https://pubmed.ncbi.nlm.nih.gov/12623133/)
Enzymatically dispersed cells from human skin, lung and tonsil were challenged with anti-IgE or calcium ionophore A23187, following incubation with recombinant human lactoferrin, and histamine release determined. IgE-dependent histamine release from skin mast cells was inhibited by up to 50% following incubation with lactoferrin (50 or 500 nM). Tonsil mast cells were also stabilised. The ability of lactoferrin to inhibit IgE-dependent activation of human mast cells and modulate protease activity suggests that the release of this neutrophil product may have a role in the downregulation of allergic inflammation.
If you find that lactoferrin (any brand) causes you to have heartburn or acid reflux symptoms, this is a simple thing to try that seems to work well.
"Acid" reflux aka heartburn is actually bile going backwards up into your stomach and causing all these problems/symptoms. This is extrahepatic ("outside the liver") cholestasis in action. Because this problem is from bile inside the digestive tract--as opposed to in the bloodstream--we have several means to address it.
This involves "HYDRATED" soluble fiber to soak up the bile that is being released.
APPROACH #1 (thank mitzi Frutiger (https://members.nutritiondetective.com/members/2554462)):
Dissolve your current dose of lactoferrin in water. My preferred method:
1) add a couple ounces of water to a glass,
2) sprinkle lactoferrin on top of water,
3) wait 20-30 minutes, stirring a couple times along the way, until
4) lactoferrin is FULLY dissolved.
Next, you are going to add an amount of psyllium fiber that YOU tolerate to the mixture, AND enough MORE water to fully hydrate the psyllium fiber. Mix well and drink. If you are using Sunfiber/PHGG instead of psyllium, you can follow the same approach. Remember that the goal is HYDRATED soluble fiber here!
Note that the way most people take psyllium ("Metamucil") is to add a little water, stir it up, then drink it as FAST as they can. We are NOT trying to do that here. We need the soluble fiber hydrated and actively adsorbing bile as soon as it touches it in the stomach.
NO, I do not believe the lactoferrin will be adsorbed or neutralized by the psyllium fiber.
Remember when you are first trying this, that you can always add MORE water to the mix, but you can't take water out once it's in.
Less water = thicker, less to "drink"
More water = thinner, more to drink
APPROACH #2 (thank Laura Molluzzo (https://members.nutritiondetective.com/members/8374338)):
Eat a peeled apple right after you take the lactoferrin. Hydrated soluble fiber is in the apple already ready already! :-)
I have had several people tell me this works really well. Why does it work?
Research shows lactoferrin increases bile production and excretion.
People are here because they already have cholestasis problems.
Acid reflux is extrahepatic cholestasis, bile going back into the stomach.
Increased bile + extrahepatic cholestasis = increased acid reflux.
Hydrated soluble fiber in the gut catches the extra bile + carries it out.
Less bile in the stomach = less acid reflux.
To be blunt, I would much more suggest using lactoferrin consistently to help you poop, over trying to force things via any type of magnesium.
Lactoferrin is NOT enteric-coated in breastmilk and it works pretty well, so unless you want to eat shellac (a wood finish), I would ignore that part.
Next, if you decide to add the probiotic that is mentioned below, you are on your own. If you don't feel good, as should be done with any probiotic that doesn't help immediately, stop taking it. It isn't the right one for you. Note they used DEAD probiotics (heat-killed).
Effects of Enteric-coated Lactoferrin Tablets Containing Lactobacillus brevis subsp. coagulans on Fecal Properties, Defecation Frequency and Intestinal Microbiota of Japanese Women with a Tendency for Constipation: a Randomized Placebo-controlled Crossover Study
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24936358/
The effects of oral administration of enteric-coated tablets containing lactoferrin (LF) and Lactobacillus brevis subsp. coagulans (LB) were investigated in 40 Japanese women with a tendency for constipation. Compared with the placebo group, the LF and LB group had a significantly higher defecation frequency (p<0.05) and significantly softer stools (p<0.05). Furthermore, the population of bifidobacteria in feces also significantly increased compared with the placebo group. In an in vitro study, LF and tryptic hydrolysate of LF, but not peptic hydrolysate of LF, upregulated the growth of Bifidobacterium longum ATCC15707 when added to the culture. These results demonstrate the capability of the enteric-coated tablets containing LF and LB in improving intestinal function and suggest that they have a growth promoting function for bifidobacteria.
Oral lactoferrin influences psychological stress in humans: A single-dose administration crossover study (https://www.spandidos-publications.com/br/8/5/426)
This is a SINGLE dose study...decreasing sympathetic & increasing parasympathetic activity...with the equivalent of 2 pills (2 x 400mg) of NDLF.
Lactoferrin is a secretory protein with various physiological functions. Bovine lactoferrin has been demonstrated to alleviate psychological stresses in rats, but this effect in humans has not yet been assessed. The present study aimed to investigate the changes in psychological stress markers following a calculation task, with either lactoferrin or a placebo orally administered prior to the task. A total of 16 healthy female college students visited Juntendo University, Inzai, Japan following an overnight fast. Subjects were quietly seated for 15 min to stabilize the respiratory rate at 0.25 Hz (one breath every 4 sec). Then, subjects provided saliva, ingested either lactoferrin (800 mg of lactoferrin + soy milk) or a placebo (soy milk), remained seated for 30 min, and then performed a mental arithmetic calculation task for 10 min. The calculation set consisted of various multiplications and divisions using pairs of three-digit numbers. Following the calculation task, saliva was collected again. Heart rate was also monitored to identify the frequency domain of heart-rate variability. The calculation task resulted in increased activity of salivary amylase, and decreased concentration of chromogranin A for both lactoferrin (P=0.028 and P<0.001, respectively) and placebo (P=0.003 and P<0.001, respectively) treatments. The degrees of changes in these salivary markers were similar between the two treatments. Heart rate variability exhibited an increase in the high-frequency (HF) component (P=0.022) and a decrease in low-frequency (LF)/HF and LF/(LF+HF) ratios (both P<0.001) following the calculation task under the placebo condition, demonstrating an upregulation of parasympathetic and a downregulation of sympathetic nervous activities. These changes in parasympathetic (HF) and sympathetic (LF/HF) activities, however, were alleviated by lactoferrin compared with the placebo (P=0.007 and P=0.026, respectively). Collectively these results suggest that oral lactoferrin may mitigate psychological stress in humans.
I'm not going to write a lot on this one, I'll let the studies speak for themselves. Remember to watch my video on cholestasis about how fatty liver aka steatosis is the blocking of bile production in the liver, so then the liver starts storing the major building blocks of BILE, those being "retinyl ester, triglyceride, cholesteryl ester, cholesterol, phospholipids and free fatty acids" (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19071229/) in the liver instead of turning them into bile so they can be excreted.
When you understand the theory of what fatty liver is from the cholestasis video (blocked bile production), then this study makes complete sense about how lactoferrin undoes the problem:
Lactoferrin promotes bile acid metabolism and reduces hepatic cholesterol deposition by inhibiting the farnesoid X receptor (FXR)-mediated enterohepatic axis (https://pubs.rsc.org/en/content/articlelanding/2019/FO/C9FO01616C)
[note before starting, high fat diets cause cholestasis, high cholesterol diets aggravate cholestasis, and cholate (think choline) will store more TOXIC stuff in the liver...and don't supplement choline!]
Dietary lactoferrin (LF) significantly decreased hepatic total cholesterol (TC), triglycerides (TG), and total bile acids (BA) as well as serum TC and TG content in mice with a cholesterol-rich diet. Dietary LF significantly inhibited the ileum FXR and FXR-mediated enterohepatic axis, and increased BA synthesis and excretion.
Low lactoferrin levels leads to fatty liver:
Decreased Hepatic Lactotransferrin Induces Hepatic Steatosis in Chronic Non-Alcoholic Fatty Liver Disease Model (https://www.karger.com/Article/FullText/491535)
Results: It was observed that decreased hepatic Ltf expression led to excessive hepatic lipid accumulation in NAFLD mouse. Furthermore, we found that GH [Growth Hormone] was decreased in irradiated mice and functioned as an upstream regulator of Ltf expression. It was observed that GH could stimulate Ltf expression and prevent uptake of dietary lipids in hepatocytes, leading to rescue of NAFLD.[...]Conclusions: Hepatic Ltf prevents hepatic steatosis through inhibition of dietary lipid uptake in radiation-induced NAFLD mouse model.
Lactoferrin helps undo the fatty liver caused by high-FAT diets:
Lactoferrin attenuates high-fat diet-induced hepatic steatosis and lipid metabolic dysfunctions by suppressing hepatic lipogenesis and down-regulating inflammation in C57BL/6J mice (https://pubmed.ncbi.nlm.nih.gov/30040108/)
Lactoferrin dampens high-fructose corn syrup-induced hepatic manifestations of the metabolic syndrome in a murine model (https://pubmed.ncbi.nlm.nih.gov/24816278/)
...investigated the possible protective role of lactoferrin against the onset of hepatic manifestations of the metabolic syndrome by using a murine model administered with high-fructose corn syrup. Our results show that a high-fructose diet stimulates intestinal bacterial overgrowth and increases intestinal permeability, leading to the introduction of endotoxin into blood circulation and liver. Immunohistochemical staining of Toll-like receptor-4 and thymic stromal lymphopoietin indicated that lactoferrin can modulate lipopolysaccharide-mediated inflammatory cascade. The important regulatory roles are played by adipokines including interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, monocyte chemotactic protein-1, and adiponectin, ultimately reducing hepatitis and decreasing serum alanine aminotransferase release. These beneficial effects of lactoferrin related to the downregulation of the lipopolysaccharide-induced inflammatory cascade in the liver. Furthermore, lactoferrin reduced serum and hepatic triglycerides to prevent lipid accumulation in the liver and peripheral adipose tissue. LF supplementation also prevented dyslipidemia and improved insulin resistance in this model of the metabolic syndrome.
Lactoferrin will greatly accelerate your progress on this journey. Contact Julie at admin@nutritiondetective.com (mailto:admin@nutritiondetective.com) to get your Nutrition Detective Lactoferrin at the LYL member prices.
This section contains information from practitioners (and other places) that Dr. Smith and others have utilized and found benefit in. Remember that the mind plays a huge role in health, and that working on it can change health status overnight!
(video below)
Why Well-Being is an Energy Game
Energy cannot be created or destroyed. That means you never lack for life or healing energy — no matter what is going on. So why does it appear and feel to be that way?
Because when you feel like crap, you can't get up, or you can't sleep, or both, and pain, discomfort and worry are draining you, saying you can't actually lack for energy will sound retarded. But in reality life energy, or more accurately, Life Energy, never gets lost.
It just gets tied up.
But if you FEEL to lack energy, and you have the signs and symptoms of that, it is a very important leading indicator that there is a hidden element at play. Hidden means unconscious, what is held "apart" from your direct experience, but is not apart at all.
Recognizable Patterns
We unconsciously organize trapped energy into recognizable patterns of thinking, feeling, and sensing that are highly meaningful (though not helpful), and that at the root level of programs give clear instructions. Though not everyone is ready for it, they are decodable, controllable, and de-programmable. You can learn how to methodically track and decode what roots energy in the unconscious — so it could be returned to the parts of your being that need them to repair, realign, and restore.
That's what I call deprogramming.
Working at Subtle Levels is Easier
It's easier in some ways to work in the more subtle — mental, emotional, and spiritual realms — compared with working on the flesh.
Physical symptoms are much easier to see, but harder to manage. Mental, emotional, and spiritual signs— and the programming that roots them — are harder to see, but easier to manage and detox.
Mental, emotional, and spiritual signs are more subtle, less fixed, and more quickly respond to release and detox than in the physical body.
And in times when the flesh is already expressing the signs of disease, working at the more subtle levels is going to create greater clarity, better moods, increased ability to make decisions, the courage to set and get goals, and the wisdom about how to consciously cooperate with Life, rather than unconsciously cooperate with death programming.
Your Operating System
The operating system of a human being is the combined outcomes and layers of experience in the body, the thinking mind, the feeling emotions, the sensing senses, and the knowing soul.
No one teaches that you are actually the boss of your own operating system. And so it appears, and you experience, that you are at its mercy, and not the other way around.
It's more true physically that humans are victimized with many forms of not limited to chemical, electrical, and psychological warfare. But at the more subtle levels, we victimize ourselves without realizing it. The more remote you are from sensing and being aware of the workings of your operating system, the less attention you pay to them, meaning the more suppressed your signals are, the more they will try to get your attention — first subtly and then increasingly less so — at all cost. The less you read your own signals, the more you will be your own worst enemy.
Precision and Archetypal Patterns
You may have noticed that throwing spaghetti at the wall with your physical health doesn't work. It's the same in the mental, emotional and spiritual realms.
So what might at first seem random and chaotic becomes a much more clear path, literally a map, to not only solving problems, but gaining ultimate freedom.
The power of what you hold in the unconscious is immense because of the force required to keep it there. If you're getting stuck, or if you have greater goals you want to achieve, it's not enough to work with what you already know.
How I survived cancer discovering one archetype on the Hero's Journey
I write about it in detail in my book 'Journey: A Map of Archetypes to Find Lost Purpose in a Sea of Meaninglessness,' seen through the lens of each of the eight archetypes of the Hero's Journey. In short, after three years of fighting for my life with a stage-four lymphoma, a near-death experience, and a second considered terminal diagnosis since I refused a stem cell transplant, I found the exact source of my illness in the Rebel archetype.
It doesn't mean that was my only shadow, but it was big enough that when I woke up to the way I was suppressing the archetype, and faced death to the degree that I let a substantial volume of death programming go, I turned the corner, began to live again, and never had to look back — against the odds and to the shock of my doctors.
It's why I'm committed to helping people find their archetypal patterns and programming before they are in extreme situations, so their lives don't have to come to a full stop like mine did.
Test don't guess…
Sound familiar? The parallels between how Dr. Smith works in the physical and I coach and teach in the subtle energetic realms are numerous.
Once you find the shadow of an archetype, and the program that roots the shadow, you find lost energy that your body can use to heal should you bravely make new decisions to deprogram.
If you find out precisely where you are tying up precious life energy by suppressing unwanted experiences, you've found the "lost" energy needed to heal more easily.
If you haven't already done a King Hero Archetype quiz at my website you can in ten minutes find out where you are on your healing path and learn which archetype you would get the benefit from exploring and awakening right now.
https://www.bethmartens.com/king-hero-archetype-quiz-sign-up (https://www.bethmartens.com/king-hero-archetype-quiz-sign-up)
You can watch the replay of my talk for Love Your Liver members only, "Detoxing the Unconscious Roots" below.
[Video: How Archetype and Deprogramming Work Can Help You Get the Most out of the Love Your Liver Program - embedded via platform video player]
And to get started precisely finding and reclaiming energy from unconscious programming, sign up for a Hero's Journey Archetype reading package with me, or reach out with a DM if you want to meet to talk about other approaches.
See all of the Hero's Journey Archetype Reading details here (https://www.bethmartens.com/products/197342-Heros-Journey-Archetype-Reading-Clear?ref=54953-Dr-%20Garrett-Smith).
Beth's Bio:
For archetype, purpose and business coach, author, coach trainer, podcaster, and founder of the House of Free Will in the Private Domain, Beth Martens, her calling is a life or death thing.
After a decade as a corporate VP in her family's firm, 8 trips to India, and a 3-year battle with cancer 20 years ago, she used archetypes to save her life.
Today she helps truth lovers find their sacred purpose, be valued for their life's work, and survive the ordeals of their Hero's Journey. As a recovering feminist, she helps King Heroes to accomplish their missions, and hosts the King Hero's Journey podcast to highlight important leaders, entrepreneurs, movement makers, law experts, and purveyors of the truth.
To do a free 'King Hero' Archetype Quiz to learn where you are on the path of purpose, find her book, "Journey: A Map of Archetypes to Find Lost Purpose in a Sea of Meaninglessness", and to apply to become a member in the House of Free Will Ministry visit her website at https://www.bethmartens.com (https://www.bethmartens.com).
NOTE: It is EXTREMELY important to READ ALL THE ARTICLES in this section, both BEFORE you do HDT and DURING the HDT process.
If you have been sent here to read or re-read these articles, PLEASE DO SO
The VIDEO below is basically an FAQ, it is NOT all of the instructions!
You will be ordering from Julie for your first 8-week HDT cycle, either the:
Camphora 200C and Poly Bowel Plus remedy series, OR
Camphora 200C and Poly Bowel Plus remedy series and your chosen medication/vaccine/toxin remedy series
Please read or re-read all of the HDT articles so you fully understand the above.
Please DO NOT ask any questions UNTIL you have WATCHED this video AND read all the articles first!
https://rumble.com/v4vl9l3-cut-rumble-video-5-13-2024.html (https://rumble.com/v4vl9l3-cut-rumble-video-5-13-2024.html)
NOTE: It is EXTREMELY important to READ ALL THE ARTICLES in this section, both BEFORE you do HDT and DURING the HDT process.
If you have been sent here to read or re-read these articles, PLEASE DO SO
The VIDEO below is basically an FAQ, it is NOT all of the instructions!
You will be ordering from Julie for your first 8-week HDT cycle, either the:
Camphora 200C and Poly Bowel Plus remedy series, OR
Camphora 200C and Poly Bowel Plus remedy series and your chosen medication/vaccine/toxin remedy series
Please read or re-read all of the HDT articles so you fully understand the above.
Please DO NOT ask any questions UNTIL you have WATCHED this video AND read all the articles first!
https://rumble.com/v4vl9l3-cut-rumble-video-5-13-2024.html (https://rumble.com/v4vl9l3-cut-rumble-video-5-13-2024.html)
Please refer back to this video (and help others to do so) if they are asking these same questions
Timestamps:
0:00 Intro
1:30 Consult Information
3:00 How it fits in the framework/Overview
11:40 Explanation of Do It Yourself
12:47 Which remedies you should order
14:45 Discussion of remedies per cycle
19:26 Read all information in articles
20:00 How do you take the remedies
21:30 Only can order two remedies at a time
23:15 Fighting Fire with Fire Book
24:15 Scheduling of remedies
24:44 Handling Detox Reactions
29:17 Remedies available
This is an article from the creator of modern HDT, Ton Jansen (note: he still thinks cod liver oil is a good thing and "vitamin" A is essential, and his individual client approaches are way more detailed than just HDT and WILL include vA, so keep that in mind if you try to work with him directly)
Extract-Fighting-Fire-with-Fire-Ton-Jansen.pdf (https://media2-production.mightynetworks.com/asset/ab6e4245-047d-4f76-ac91-9fe789ff2c93/Extract-Fighting-Fire-with-Fire-Ton-Jansen.pdf)
Based on the writings of the man (Ton Jansen) who first came up with Homeopathic Detox Therapy (https://amzn.to/3ef9Ew6) (centered around undoing the specific damage of pharmaceuticals, drugs, chemicals, poisons, etc. using an isopathic approach).
Here's the simple way to figure out what remedies to start with. There isn't really a "wrong" choice. Choosing better will simply get you more positive results sooner.
How to pick the "most helpful" remedies for your personal health situation:
NOTE: You may have a bunch of medications you think you want to do...try to do them in order from #1 to #4, at least as far as you can tell:
Is there a pharmaceutical/vaccine/drug/chemical/poison that you took or were exposed to, that you can honestly say, "my life was NEVER the same after I took that" or "that RUINED my health". THIS is your #1 remedy.
Is there a pharmaceutical/vaccine/drug/chemical/poison that you took or were exposed to, that you know you got side effects from, and those side effects have never gone away? THIS is your #2 remedy.
Is there a pharmaceutical/vaccine/drug/chemical/poison that you took or were exposed to, that you know you had a bad reaction to but the side effects eventually went away? THIS is your #3 remedy.
Is there a pharmaceutical/vaccine/drug/chemical/poison that you know you have taken a lot of over your lifetime (or were exposed to quite a bit), but had no noticeable side effects? THIS is your #4 remedy.
Note: homeopathy also has and this effect is in the research (https://pubmed.ncbi.nlm.nih.gov/6151171/) the concept of the "similar" remedy causing a reaction AND the proving (which is taking the remedy when you DON'T have the disease). It is similar to an allergy test, in that the "skin reaction" of a positive proves that you have the allergy. In HDT, this concept of the "proving" suggests that if you have a somewhat strong reaction to a remedy, that is actually evidence that you NEED that remedy.
EVERYONE starts with the POLY BOWEL PLUS sequence, either by itself (SUPER-SENSITIVE people) OR in combination with a second remedy. YOU pick the second remedy, UNLESS you want to pay for 30-minute consult with me (Dr. Smith) to help you pick it (email Julie at admin@nutritionrestored.com (mailto:admin@nutritionrestored.com) to schedule).
Think of POLY BOWEL PLUS as a homeopathic "helpful re-balancer" of your gut biome. No, this doesn't replace "real probiotics", nor do probiotics replace what this can do. They act on different levels/mechanisms.
If you are SUPER-SENSITIVE and want to start SUPER-SLOW, you're going to start with ONLY the POLY BOWEL PLUS remedy sequence by itself for 8 weeks. After this is done, you can do your first MEDICATION/DRUG/CHEMICAL sequence for 8 weeks. It would likely be best that SUPER-SENSITIVE people only do one remedy at a time, instead of two.
If you want to start with the "standard" approach, then you will start with POLY BOWEL PLUS sequence PLUS one other MEDICATION/DRUG/CHEMICAL sequence for 8 weeks.
I did the Ketoconazole and POLY BOWEL PLUS remedy sequences together first. I am fairly sensitive to things, but I do not consider myself super-sensitive.
Later rounds of HDT:
YOU will pick one OR two other remedies and do it/them for an 8-week sequence. MAX of 2 remedy sequences used together at one time. This process can be repeated as many times as necessary.
Later, I did the Poly Child Vaccination A - USA Schedule and Poly Antibiotics remedy sequences together.
This is not very complicated, but many people will over-complicate it.
Here is the basic dosing schedule I give people:
[IMAGE: HDT Dosing Schedule Template - https://media1-production-mightynetworks.imgix.net/asset/a60f320c-68cf-4bc3-b246-d6a6d9e235ae/170958]
I realize that's a little confusing, so here is that template filled in with the POLY BOWEL PLUS and Accutane remedy sequences (any two remedy sequences, or just one remedy sequence could be used, the set-up is the same):
[IMAGE: HDT Dosing Schedule Example (POLY BOWEL PLUS + Accutane) - https://media1-production-mightynetworks.imgix.net/asset/795c12a6-1f13-432b-904d-f0458e5cd355/170958]
So, here's the gist.
You do NOT take two different remedies on the SAME DAY at any point in this process.
ONE DOSE (when I say "dose", I mean 2 pellets) of Camphora 200c is taken BEFORE starting ANY of the other remedies. It can be on the Sunday before you start, but the day of the week or how long before you start the other 2 remedies doesn't really matter as long as it is done PRIOR TO starting the other 2 remedies, OK? You put your pants on BEFORE leaving the house...how long before doesn't really matter, as long as you put them on BEFORE you leave, see?
Weeks 1 and 2: Use the 30c strength remedies. One remedy is taken Mon and Thurs, the other remedy is taken Tues and Fri.
Weeks 3 and 4: Use the 200c strength remedies. Same pattern.
Weeks 5 and 6: Use the 1M strength remedies. Same pattern.
Weeks 7 and 8: Use the 10M strength remedies. Same pattern.
Then you are done with that/those sequence(s).
Do Camphora 200c one dose
4 total doses of 30c remedy(s)
4 total doses of 200c remedy(s)
4 total doses of 1M remedy(s)
4 total doses of 10M remedy(s)
Finish "first grade" completely (4 doses of 30c), before moving up to "second grade" (200c).
At some point, you are going to MISS/FORGET taking a dose. We're going to talk about what you do when that happens.
Are the days of the week for the remedies set in stone? No. Not at all.
Does this sequence have to be completed in 8 weeks? NO, it does not! In fact, I don't care how long it takes you to finish it, ***as long as you don't SKIP taking any of the 4 total doses of each remedy strength, taken in the proper order/sequence!***
EXAMPLES of correcting missed dose events:
Example 1.
Let's say Johnny took his Remedy 1 on Monday, then took Remedy 2 on Tuesday, then FORGOT to take his Remedy 1 on Thursday. He remembered on Saturday. Can he just take his Remedy 1 on Saturday? YES HE CAN, because he is NOT taking two different remedies on the same day. Saturday he takes Remedy 1 (the missed dose), and then Sunday he takes Remedy 2 (also a missed/late dose). He can then take Monday off, and resume the normal Mon/Thurs and Tues/Fri pattern the following Monday.
Example 2.
Now, let's say Johnny forgot to take any/all of his remedies from Monday-Friday, and there is only the weekend left...he cannot get all 4 doses in 2 days, because we DON'T take 2 different remedies on the same day! Well, just to get back on track, Johnny might want to simply wait until the following Monday to start the week fresh. So he misses a week...it doesn't matter ***as long as he doesn't SKIP taking any of the 4 total doses of each remedy strength, taken in the proper order/sequence!***
Example 3.
Johnny was 3 weeks into doing his HDT program. Then this weird new thing called "COVID" hit the world. Johnny was really stressed and stopped taking his remedies in the middle of week 3. It's now 2 months later, and Johnny wants to get back on his HDT program. What should he do? Should he start over? NO! He simply resumes the program at the exact spot where he left off...***as long as he doesn't SKIP taking any of the 4 total doses of each remedy, taken in the proper order/sequence!***
You're probably going to miss a dose here and there, and maybe even fall off track completely at some point (life is a bitch, and shit happens). With the above examples, you should have enough info to get yourself back on track.
We are going to cover several approaches here.
FIRST, you may be doing HDT and you get some sort of reaction during the 8-week sequence. Let's be smart and realize that it MAY OR MAY NOT BE THE HDT. It could be something else entirely (like SPACE WEATHER, or you changed one of your other SUPPLEMENTS, or you added a new FOOD!). It is absolutely fine to use the methods below to try and see if it is actually the HDT...but if the problem remains after both the "Water Method" and stopping the remedy(s) entirely, then you should start searching ELSEWHERE.
ALSO, it would be VERY WISE to have your diet and supplement regimen QUITE STABLE before you embark on an 8-week HDT sequence, so you are not changing variables mid-sequence (life happens regardless, and minimizing variables makes things easier to figure out).
IF you were to get symptoms/reactions from a remedy, and you were to CONTINUE doing the remedy without taking steps to deal with the reaction, then you would be "pushing through" what is essentially a "healing crisis" or "detox reaction". If you keep pushing through, you risk making the reaction WORSE THAN IT WOULD OTHERWISE BE. Can you live through it? YES. Did you need to make it that bad? NO. You are smarter than that, right? Right!
Here is the process:
1. STOP ALL HOMEOPATHIC REMEDIES. DO NOT RE-START ANY OF THEM UNTIL THIS PROCESS IS OVER. I REPEAT, STOP ALL HOMEOPATHIC REMEDIES DURING THE "Water Method" phase.
2. Watch and wait for 24 hours (1st 24-hour period) to see if the symptoms subside on their own. If they do, then you can resume HDT exactly where you left off. If they DON'T, then go to step 3.
3. Now begins the 2nd 24-hour period, and this is where the "Water Method" really begins. Pick the remedy that you think is the "primary suspect" causing the issues. If you have no idea, then simply pick one of them.
4. Using ONE PELLET of "primary suspect" remedy, add it to a "made of glass" glass of water (a "glass-glass" if you will). Amount of water really doesn't matter. Wait for pellet to fully dissolve.
5. Pay attention. You will then take ONE SPOONFUL (just a normal spoon you have around your kitchen, exact size doesn't really matter) of that water. Watch and see if your symptoms reduce or resolve.
6. During this 2nd 24-hour period, you can take ONE SPOONFUL of the "remedy water" up to 4 SEPARATE TIMES, each dose separated by at least ONE HOUR. If the symptoms completely resolve after any "remedy water" dose, then you are OK to resume the HDT exactly where you left off. If, after this 2nd 24-hour period and 4 spoonfuls of the "remedy water", you are still having symptoms/reactions, then go to step 7.
7. If you are taking 2 HDT remedies, then go to step 8. If you are only taking one remedy, then go to step 9.
8. This is now into the 3rd 24-hour period. You repeat the "Water Method" for the "other remedy", using the exact same process described in steps 4-6.
9. If you are finding that the "Water Method" for your chosen remedy(s) did not work, you should STOP the HDT sequence and start searching ELSEWHERE for the cause of your issues.
Note: For example, if you are doing a Mercury remedy and you have a mouth full of mercury amalgam fillings...the mercury problem will come up again and again, and it has NOTHING to do with the HDT.
For the people who end up needing the "Water Method", it typically resolves the issue and they only have to use it once (maybe twice) in the entire sequence.
If you are continually finding that the HDT remedy(s) are requiring you to use the "Water Method" over and over, then you are ***NOT READY YET*** for one or both of the remedies. There are either other remedies or nutrient deficiencies that you likely need to address BEFORE the ones that are causing you issues.
The remedies at the high potencies used in these protocols are only sold to practitioners, so you'll need to contact Julie at admin@nutritiondetective.com (mailto:admin@nutritiondetective.com) to order them through my office (NO, they are not on the online store!). I am making these available to you here because I believe in the safety and effectiveness of this approach, AND that since you are here in this network, YOU are INTELLIGENT and WILL CAREFULLY FOLLOW MY DIRECTIONS in the following articles, OK? I'm also doing this to make these more affordable to you, because many of you have multiple medications that you need to "detox" from!
NOTE: Julie will only sell remedies to members of this network, a MAX of 2 remedy sequences within an 8-week period.
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-list-of-remedies
Please understand that I'm not going to put EVERY SINGLE REMEDY sequence that my supplier carries here. That's a giant spreadsheet and is unnecessary.
Below are the remedies that I have used with clients to this point, as most people's remedies will fall within this list. To order, contact Julie at admin@nutritiondetective.com (mailto:admin@nutritiondetective.com).
That said, if you have a SPECIFIC pharmaceutical/vaccine/drug/chemical/poison that you want to use that ISN'T on this list, simply email Julie and she will check with our supplier. For really rare things, special orders can be made. PLEASE take the time to look through the list below before emailing her.
For those of you outside the US, please let Julie know first so that she can advise you about currently known shipping/Customs situations.
The List:
POLY BOWEL PLUS [for the gut biome balancing, the FIRST REMEDY that should be done by everyone]
ACC-CLEAR [Accutane, isotretinoin]
POLY BC [birth control, covers Eugynon '30', Levonorgestrel, Loestrin (Norethisterone Acetate 1mg / Ethinylestradiol 10mcg), Microgynon '30' (Levonorgestrel 150mcg / Ethinylestradiol 30mcg), Microvlar '30' (Levonorgestrel 150mcg / Ethinylestradiol 30mcg), Microval (Norgestrel 30mcg), Minulet (Gestodene 75mcg / Ethinylestradiol 30mcg), Norgestimate (Cyclen / Cilest - Norgestimate 250mcg / Ethinylestradiol 35mcg), Norimin (Norethisterone 1mg / Ethinylestradiol 35mcg), Norinyl-1 (Norethisterone 1mg / Ethinylestradiol 50mcg), Noriday (Norethisterone 350mcg), Noristerat (Norethisterone Enanthate 200mg), Norgeston (Levonorgestrel 30mcg), Norgestral (Prempak), Normin (Norethisterone 1mg / Ethinylestradiol 35mcg), Schering PC4 (Morning after pill - Norgestrel 500 micrograms (same as Levonorgestral)), Yasmin (Drospirenone/Ethinylestradiol), Co-Cyprindiol (Dianette), Medroxyprogesterone]
POLY ANTIBIOTICS [covers Amoxicillin, Co-Amoxiclav, Ampicillin, Azithromycin, Benzylpenicillin, Cefaclor, Cefazolin, Cefotaxin, Cefradinum, Ceftazidin, Ceftriaxon, Ceuroxin, Clarithromycin, Clindamycin, Doxycicline, Erythromycin, Flucloxacillin, Gentamicin, Minocycline, Spiramycin, Tetracycline, Co-Trimoxazola, Nitrolurantoin, Cephalexin, Phenoxymethylpenicillin, Metronidazole, Oxytetracycline, Chloramphenicol, Levofloxacin, Ofloxacin, Ciprofloxacin]
POLY CHILD VACCINATION A - USA [most vaccines in one combo, covers DPT/Polio/HIB, Polio Vaccine, Pneumococcal, Meningitis C, Menitorix, MMR Vaccine, D.P.T. / Polio (Salk) / HIB, Repevax (D.P.T. / Polio), D.P.T. + Polio Booster, D.P.T. Vaccine, Influenza-08, Influenza-09, Influenza-10, Varic-v, Rotarix, Hepatitis-A, Hepatitis-B]
POLY PAM [benzodiazepines, covers Clonazepam, Diazepam, Flurazepam, Lorazepam, Nitrazepam, Oxazepam, Temazepam, Clobazam, Midazolam, Alprazolam]
POLY SSRI [selective serotonin reuptake inhibitors, a type of antidepressant, covers Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Venlafaxine HCL]
POLY TCA [tricyclic antidepressants, covers Amitriptyline, Clomipramine, Imiprmaine, Mianserine, Mirtazapine, Nortriptyline]
POLY STEROIDS [corticosteroids, covers Betamethasone, Dexamethasone, Flixotide (Fluticasone), Hydrocortisone, Methylpredisolone, Mometasone Furoate, Prednisolone, Synacthen (tetracosactide), Triamcinolone]
POLY NARC [street drugs, covers Opium, Cannabis sativa aka marijuana, Cocaine, Heroin, Ecstasy/MDMA]
KETCNZ-CLR [ketoconazole]
POLY AUTO TOX [covers Toluene, Xylene, Ketones, Glycol ethers, Chlorinated Hydrocarbons, Benzene, Titanium Dioxide, Petroleum solvents, Asbestos]
POLY ANESTHETICS [IV anesthesia meds, covers Isoflurane, Ethrane, Alcuronium, Hypnomidate, Tracrium, Droleptan, Scolone, Pavulon]
CHOP-CLEAR [chemotherapy, covers Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulfate, Prednisone]
ABVD-CLEAR [chemotherapy, covers adriamycin, bleomycin, vinblastine, dacarbazine]
MOLD CLEAR [NOTE: YOU need to GET RID OF or GET AWAY from the mold before using this remedy!]
DIPH-CLR [benadryl]
STAM-CLEAR [Yellow Fever vaccine]
MTNZ-CLEAR [metronidazole/Flagyl]
BCTR-CLEAR [Bactrim, SMP-TMZ]
See below video for more information.
https://rumble.com/v273soi-arsenic-video-rice-water-hair-test-information.html (https://rumble.com/v273soi-arsenic-video-rice-water-hair-test-information.html)
I'm going to suggest that you combine 2, or even 3, of the methods described in the studies below, to help reduce the toxic metal content (including, but not limited to arsenic) of the rice you consume.
The more often you consume rice OR rice-based products, the more important this becomes!
Study #1 (PDF below) shows that washing (aka rinsing, they did it TWICE and used deionized water, very similar to distilled water) the rice beforehand does remove some of the toxic mineral content:
"Washing significantly reduced concentrations of Cd, As, and Pb, and all three types of cooking reduced bioaccessibilities of these elements."
Effects of washing, soaking and domestic cooking on cadmium, arsenic and lead bioaccessibilities in rice.pdf (https://media2-production.mightynetworks.com/asset/33783781/Effects_of_washing__soaking_and_domestic_cooking_on_cadmium__arsenic_and_lead_bioaccessibilities_in_rice.pdf?_gl=1*1eeydg6*_ga*NTk3MzQ1ODguMTYzMzQ0OTkxNg..*_ga_T49FMYQ9FZ*MTY0MjUyMjU1Ni40OTIuMS4xNjQyNTI0MTg5LjA.)
Study #2, found by Maria Meiners (https://members.nutritiondetective.com/members/3589631)
Improved rice cooking approach to maximise arsenic removal while preserving nutrient elements
https://www.sciencedirect.com/science/article/pii/S0048969720368728?via%3Dihub (https://www.sciencedirect.com/science/article/pii/S0048969720368728?via%3Dihub)
"Parboiled and absorbed (PBA) method removed 54% & 73% iAs from brown & white rice."
Study #3, the "excess water" aka pasta method of rice cooking:
Cooking rice in excess water reduces both arsenic and enriched vitamins in the cooked grain
https://pubmed.ncbi.nlm.nih.gov/26515534/ (https://pubmed.ncbi.nlm.nih.gov/26515534/)
"We prepared multiple rice varietals both rinsed and unrinsed and with varying amounts of cooking water. Rinsing rice before cooking has a minimal effect on the arsenic (As) content of the cooked grain, but washes enriched iron, folate, thiamin and niacin from polished and parboiled rice. Cooking rice in excess water efficiently reduces the amount of As in the cooked grain. Excess water cooking reduces average inorganic As by 40% from long grain polished, 60% from parboiled and 50% from brown rice. Iron, folate, niacin and thiamin are reduced by 50-70% for enriched polished and parboiled rice, but significantly less so for brown rice, which is not enriched."
The information I will be posting here will be *from my own experience*.
If you choose to not get involved with this, then DON'T. You don't HAVE to do anything.
I will not be giving anyone who is not an active client of mine in Testing & Consultation direct advice on how to use these products.
I personally think that UNactivated MMS, aka sodium chlorite in water, when used properly, has taken me significantly further than my previous improvements with correcting my mineral deficiencies, reducing toxicities, and lactoferrin.
Take it for what you will. The mainstream HATES this stuff for a good reason, IMO.
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-quick-faq-to-begin
What is "Unactivated MMS" aka Sodium Chlorite in water aka one of many methods to use chlorine dioxide?
It's a weak oxidizing compound that will help your body to break down vA, bile acids, and other toxins. IT IS NOT "DRINKING INDUSTRIAL BLEACH".
BE AWARE: In some people, it does increase the production and excretion of bile SIGNIFICANTLY. If I were using it and I felt anything I didn't like, I would immediately REDUCE MY DOSE as I read to do in the "Simple Molecular Medicines" pdf.
Here is a safety study in humans (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569027/):
However, by the absence of detrimental physiological responses within the limits of the study, the relative safety of oral ingestion of chlorine dioxide and its metabolites, chlorite and chlorate, was demonstrated.
Here is a safety study in animals (https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/28327506/):
A 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test revealed that the cell viability of mouse lung fibroblast L929 cells was 93.7% at a 200 ppm UC-1 concentration that is over that anticipated in routine disinfection use and there is no cytotoxicity above the level for safety. Results from this cell viability test, the bacteria elimination test, the animal exposure test, and the human use test suggest that UC-1 is safe for use as a disinfectant at appropriate concentrations.
Sodium chlorite was approved as an "orphan drug" for the treatment of Amyotrophic Lateral Sclerosis in the EU (https://www.ema.europa.eu/en/medicines/human/orphan-designations/eu3131139) (see also: orphan designation (https://www.ema.europa.eu/en/glossary/orphan-designation)).
Six months of inhaling chlorine dioxide gas caused no damage or toxicity in rats (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298712/):
No CD gas-related toxicity sign was observed during the whole study period. No significant difference was observed in body weight gain, food and water consumptions, and relative organ weight. In biochemistry and hematology examinations, changes did not appear to be related to CD gas toxicity. In necropsy and histopathology, no CD gas-related toxicity was observed even in expected target respiratory organs.
Conclusions: CD gas up to 0.1 ppm, exceeding the level effective against microbes, exposed to whole body in rats continuously for six months was not toxic, under a condition simulating the conventional lifestyle in human.
Sodium chlorite in the drinking water of mice showed no problems at any of the concentrations they tried (https://pubmed.ncbi.nlm.nih.gov/4078693/):
Examination by light and transmission electron microscopes did not reveal any evidence of renal pathologies. In addition, no evidence of significant mortality, water consumption differences, body weight change differences, kidney weight differences, or histopathological abnormalities was found in the study groups compared to the control groups.
Is it safe?
PROPERLY USED, In my opinion and in my experience, yes. Other people have accumulated this data already. I've been using it 6 months as of August 2022.
How can I screw this up? I really want to screw this up!
[sarcasm]
Then make sure to NOT read the following information carefully. Definitely don't read it twice through. Make up new approaches. Don't do what people have found works, be a unique snowflake!!!
[/sarcasm]
First...
DO NOT ASK ME CHLORINE DIOXIDE (CD) QUESTIONS OUTSIDE OF THIS NETWORK...EVER. I will only answer *general* questions, if that much, on the LYL main network, and those will be presented from *my personal experience*.
Much of the info I'm going to share is going to come from PAGES 1-59 of the "Simple Molecular Medicines" (https://drive.google.com/file/d/1n87jWO8m0_3wTzcPazNa3-9jIA_OmRa9/view) book that is available for FREE at https://chlorinedioxidetruth.weebly.com/ (https://chlorinedioxidetruth.weebly.com/) along with other free e-books (I have NOT looked at any of the other ones, so NO endorsement is being offered).
Also, here is Jim Humble's "Health Recovery Guidebook" e-book on how to use MMS/CD for various conditions:
MMS_Health_Recovery_Guidebook_Ebook_2016b.pdf (https://media2-production.mightynetworks.com/asset/e933df79-0eca-44c8-afe9-14bb9e185d61/MMS_Health_Recovery_Guidebook_Ebook_2016b.pdf)
What do I believe CD does, in regards to detox and diseases?
It is a "weak oxidizer". This means it can move vA, bile acids, and other toxins along their detox pathways by oxidizing them. It is doing the "same general things" in our context, through a DIFFERENT MECHANISM (oxidation vs. binding/adsorption) as many other things we do on the LYL program. NONE OF THEM ARE WRONG TO USE TOGETHER.
Here's what some of you are going to do right off the bat, guaranteed. You're not going to read the rest of the articles. You're going to take the rope I gave you with the links above, and you're going to go hang yourself with it (for the non-English speakers here, it's an expression about people taking a small bit of knowledge and hurting themselves with it).
I will be talking here about how I use CD, and how I think it is best used in the context of this program. If you venture from that path, do not ask me what to do, why you feel bad, why are these things going wrong, etc. I can't fix problems I've never seen before with a compound that seems to have hundreds of different application approaches.
First question people ask me is, "Dr. Smith, where did you put this in your approach, relative to the other supplements?" In short, this is the order I would use:
Minerals (molybdenum, zinc, selenium, magnesium, potassium, sodium)
Sunfiber + Charcoal
Niacin
Lactoferrin
Chlorine Dioxide
Lactoferrin
Then return to adjusting minerals, like a loop I can keep going through
If you want to read the rest of the e-book, I think that's going to be helpful. I'm not going to re-write details about CD's proven safety record, the history of CD, etc. etc. etc. here, when there are many good resources elsewhere (like the e-book I linked above).
I highly suggest reading ONLY pages 1-59 (and any appendices that are mentioned directly) in the "Simple Molecular Medicines" pdf (thanks to Betty Stahl (https://members.nutritiondetective.com/members/7712722) for bringing this to my attention in the past)
https://drive.google.com/file/d/1n87jWO8m0_3wTzcPazNa3-9jIA_OmRa9/view (https://drive.google.com/file/d/1n87jWO8m0_3wTzcPazNa3-9jIA_OmRa9/view)
Below is an excerpt about how to do "Unactivated MMS". If you want to see all the images, look to the book, pages 48-59.
Chapter 5: BASIC MMS - Sodium Chlorite + Water (Protocol 1)
Easy Start, No Flavor, No Mixing Acid Activator
The term "MMS" is one that has been given by those who add Sodium Chlorite with water to drink for medicinal purposes. It is also sometimes referred to as "Unactivated MMS" because there is no acid mixed with it when you use it. However, this mix of those two ingredients is not new to the health-supplement industry. It is also called "stabilized oxygen" and has been marketed as a liquid form of chemically-packaged oxygen for decades in their stores. It can also be used alone as a water purifier for your drinking water as well. Additionally, it has been used as a food additive since the 1940's and has been allowed for use in food manufacturing for decades.
How Protocol 1 Works
The secret to this protocol is that the chlorite (NaClo2) in the Sodium Chlorite solution reacts to the hydrochloric acid (HCL) in your stomach. Think about your stomach as a "test tube" that sits between your esophagus and small intestine. In here, the HCL acid naturally generated by your body is released during digestion. As long as you have adequate amount of HCL in your stomach and are not taking products that neutralize your stomach acids (such as products with sodium bicarbonate and other antacids), the chemical reaction will occur once the NaClo2 hits the stomach.
How much HCL is in your stomach? On average a human stomach generates anywhere from 500-700 ml of stomach acid per day and it can regenerate at a rate of 800 drops an hour. If you compare this 800 drops of this HCL to the 1-5 drops of Unactivated MMS (Sodium Chlorite) that you would be drinking with this protocol 1, you can easily see that the chemical reaction will make Chlorine Dioxide (Clo2) within the stomach chamber. Some initial research that I have done with this shows that each drop of Unactivated MMS in drinking water produces about 7 mg of Clo2 as it is processed in the body. This is a little more than if you were to Activate a drop of MMS and it is more than double of what a milliliter of CDS gives you. This means that 1 drop of Unactivated MMS does NOT equal 1 drop of Activated MMS. It also means that a drop of Activated MMS does NOT equal 1 ml of CDS.
Not the Same Potency
1 drop of Unactivated MMS does NOT equal 1 drop of Activated MMS
1 drop of Activated MMS does NOT equal 1 ml of CDS
This version of Clo2 in the stomach is most potent and pure because it does not "gas off" into the open air like any of the methods of making it. For this reason, it is only recommended to use it in lower quantities. Where the other protocols call for 3-6+ drops of Activated MMS at a time, with Protocol 1, it is recommended to start with 1-2 drops.
The Chemical Reaction Inside Your Stomach
The equation that happens inside the stomach looks like this:
NaClo2 + HCL = ?
Answer:
1. Chlorine Dioxide (Clo2)
2. Salt (NaCl) 1-2 grains per drop
3. Hydrogen (H)
[*disregard the hydrogen stuff below, DO NOT use Brown's Gas or Molecular Hydrogen*]
It is worth noting here that I explain a lot of the benefits of Hydrogen as a medicine in a later chapters of this book. This includes information on producing it in the home for drinking, putting it on the skin and inhaling the gas (called "Browns Gas"). In fact, I share links to over 600 studies and other articles that show the benefits of this gas as it is ingested in the body. This means that when you drink the Protocol 1, you are also taking Hydrogen in your body which can contribute to your health as well. This hydrogen-based benefit does not occur with Activated MMS nor with CDS because the Hydrogen goes into the air and upward very quickly. However, when the chemical reaction takes place in the stomach, the Hydrogen is contained and absorbed by the body.
[*disregard the hydrogen stuff above, DO NOT use Brown's Gas or Molecular Hydrogen*]
Why did the author add Protocol 1 to the available protocols?
It would seem that taking Sodium Chlorite and just adding it to water (without acid), that would mean that it would NOT create Chlorine Dioxide until it got to the stomach (where the HCL is). What I realized was that drinking the Chlorine Dioxide from CDS or Activated MMS was not going to produce as much in the bloodstream because it was creating the reaction much too quickly to get into the bloodstream. This means that it would only affect the gut flora at the initial mixing stage. However, with Protocol 1, it would naturally pass thru the stomach and then begin to produce the Chlorine Dioxide in the actual bloodstream as the HCL passes through the body's digestive system.
[EDIT 1: I (Dr. Smith) am going to note here that SOME PEOPLE have "low stomach acid" (technically called hypochlorhydria) and may not produce enough HCL to "activate" the Unactivated MMS in the stomach. For those people, it would be wise to add 1-2 teaspoons of apple cider vinegar in water, to put some acids down into the stomach with the Unactivated MMS to replace the HCL that is missing]
[EDIT 2: I also took out all his info on "low stomach acid", because there are many things in it that will only confuse people and is probably counterproductive]
Protocol 1 Startup Suggestions: Easing into the MMS/Sodium Chlorite
In doing the Protocol 1, you can begin in small amounts and ease up in the number of drops overtime. However, remember that even a single drop or two a day may have an impact on a person's health as a maintenance dosage (In my case, I noticed a positive difference with just 2 drops of mms a day). There is no reason to rush the increase in drops any faster than your body will accept them. Here is a suggested amount for starting up quickly with Protocol 1:
Day 1 - put 1 drop in each of the 2 liters/quarts of water. Drink this during the day as you would normally drink water.
Day 2 - 2 drops in each of 2 liters/quarts of water. Drink during day.
Day 3 - 3 drops in each of 2 liters/quarts of water. Drink during day.
If at any time your body does not feel comfortable or like it wants more, then stop increasing or back down to a lower level. At some point, 1-5 drops in 2 liters per day is going to be the goal most people strive for.
Continuing the Protocol 1
If you are tolerating the protocol well, you can gradually increase over time. Remember to always start with less if you are a beginner or if you had problems with higher doses in the past. It is ok to be drinking the water with a 1-2 drops per liter dosage and gradually increase as your body can handle it. If your symptoms worsen after increasing, then don't increase anymore (or even reduce) until things are back to normal.
Do Foods or Supplements Neutralize the Potency of Protocol 1?
The short answer is YES. As explained earlier in the book, there are foods that will neutralize the potency of Unactivated MMS, because of the Chlorine Dioxide that will be entering the bloodstream. The same things, like chocolate, milk, and other foods high in antioxidants will cause the water to be temporarily neutralized for an hour or two. However, keep in mind that this water is in a lower dosage and it is more consistently taken throughout the full day compared to the other methods and formulas of Chlorine Dioxide. Where Activated MMS and CDS are taken for 8-10 hours a day for 21 days, you would be taking a Protocol 1 all day for months on end or longer (See future chapters for more information on these protocols).
How I Do Protocol 1 [this is the author, not me]
I have used different variations of the Protocol 1 for over 7 years myself and with hundreds of patients. I began by recommending most people use 1 drop per liter of water and then slowly increase the dose over time. I saw that people were tolerating it very well to begin with and could handle 1-5 drops per liter without too much discomfort. I take the protocol 1 all day by filling up a 2-liter or 64 oz. bottle with filtered water. Then, I add 2-4 drops of Sodium Chlorite to the bottle for the day. I sip this throughout the day, and drink most of the bottle by evening. On days when my body feels a little cramp, I may sip only 1 or 2 from the bottle and then get a drink of normal water for any extra thirst. That way, I am lowering my intake of Protocol 1 but still getting water, as needed.
So, what is the solution to taking Protocol 1 around foods or supplements that might weaken or neutralize the Chlorine Dioxide? It is to space these items apart from your drinks within reason. Don't worry too much about it but try as best as you can to steer clear of things. For instance, if you know that you are going to have some chocolate cake with milk after dinner (or before, hehe!), then you may try to have a protocol 1 drink of about 100-200 ml's (or about 2-6 sips, for me) at least 15 minutes before having the cake. This will get at least some of the supplement in your bloodstream before the chocolate neutralizes it. Additionally, if you are going to have a meal that may have some antioxidants in it, try to space at least 10-15 minutes or more between a drink of the Protocol 1 water before or after the meal. The Protocol 1 may NOT be as well-known but it IS extremely convenient. Remember that 1 drop of Naclo2 in water is NOT the same as a 1-drop mix of Activated MMS. It IS probably more potent. Additionally, 1-Drop Activated MMS IS also probably more potent than a milliliter of CDS. For me, Protocol 1 IS the most practical way to take chlorine dioxide on a daily basis.
SOURCE: https://members.nutritiondetective.com/posts/love-your-liver-the-program-how-not-to-mess-oneself-up
Quotes will be taken from "Simple Molecular Medicines":
https://drive.google.com/file/d/1n87jWO8m0_3wTzcPazNa3-9jIA_OmRa9/view (https://drive.google.com/file/d/1n87jWO8m0_3wTzcPazNa3-9jIA_OmRa9/view)
First, a WARNING about how not to be STUPID when using this powerful stuff, and basically speaking towards using the "minimal effective dose" (you may have heard someone speak of this previously):
Starting with Chlorine Dioxide: Guidance from Experienced Users & Experts
Sometimes, people starting out with dosages just jump right in and start taking 3-drop dosages. They might think that "More is better" or just be impatient to take this new fad medicine. So they push it by taking 5 or more drops at a time. We all know people like this and there are several accounts from people on the website https://mmstestimonials.co/ (https://mmstestimonials.co/). This website is setup so that people can set up an account and post their own experience for the world to read about. There are hundreds of accounts at this site for all types of diseases treated with Chlorine Dioxide. It is good to know that some people might not respond well to higher doses at first, and this is ok. Here are some of the things that have been said by experts and in accounts at this website. Many people have seen significant results using 1-3 drops per day in 2 liters of water. Sometimes the dosage can also be higher than average amounts in special situations, but for our purposes, WE WILL BE KEEPING THE DOSE AS LOW AS POSSIBLE WHILE STILL GETTING IMPROVEMENT.
Why? Because in our specific situation, the CD seems to greatly increase bile production/excretion. That bile in cholestatic conditions contains TOXINS. Getting too much too fast out is the same problem we have with too much lactoferrin, too much niacin, too much charcoal being processed through the gut at once, etc.
So keep it low, keep it slow.
Now, here's some MORE advice from the book on this subject:
The 3 Golden Rules: What I created and called a "decision tree" about CD dosing decisions before I read this book, the author called his "The 3 Golden Rules".
1. No Change, 2. Reduce or 3. Increase Dosage Amounts
The three golden rules are a way to understand if you should adjust your dosage amounts up or down while using CD. It applies to most circumstances where you are taking it. It includes rules for MMS, Activated MMS, CDS and even another molecule called Hypochlorous Acid which will be described in a future chapter. These rules are so important that I made a whole tab on my spreadsheet dedicated to what they are. If you understand how these rules work, you will see that it is more a way of thinking instead of a set of strict rules. Here are the rules that you need to think about while drinking doses of Chlorine Dioxide:
Rule #1 (No Change Rule)
If your Symptoms are improving? Do not change anything. Continue with what you are doing.
Rule #2: (Reduce Rule)
If your Symptoms are staying the same or getting worse? Reduce to 50% of what you were doing, and continue at that 50% reduction amount for at least a few days before thinking about increasing again. Keep reducing by 50% until you find an amount where you feel improvement.
Rule #3: (Increase Rule)
If your Symptoms seem to be improving and they have remained stable for 1+ week without change? Increase your dosage by a small increment. Keep increasing in small increments until you find a place that causes a worsening of your symptoms, and then return to rule #2 to reduce.
Is there anything I should avoid or watch out for during Protocol 1?
From the book, with his editorial comments in brackets and mine in these brackets [Dr. Smith]:
Do not take any antioxidants within 1-2 hours of taking any form of CD. That means avoid vitamin A, vitamin D, or vitamin E supplements.
If one was on vitamin C supplements, they should be figuring out their "minimal effective dose" and then creating a plan to wean off it over time. Vit C would definitely undo the activity of the CD in the system.
Regarding B-vitamins, I would only take specific, individual B-vitamins I felt distinct benefit from, and stop all others.
I do NOT think anyone should use Molecular Hydrogen aka Brown's Gas, please IGNORE that entire section of the book!
Do NOT do a keto diet (this is in Kerri Rivera's book about CD & autism)
I would already be avoiding/minimizing dairy, chocolate, alcohol, coffee, teas, and time-release supplements.
Basically, ALMOST everything someone might be doing that is in alignment with the LYL program basics is OK, except for the several things in the article linked above. The list of things I would suggest separating from CD by 1-2 hours are in this article (https://members.nutritiondetective.com/posts/love-your-liver-dont-take-chlorine-dioxide-too-close-to-these-things-25991750).
There are a couple things that are OK'd to use in the LYL program that it would be best to space out from UNactivated MMS (or any other CD you end up using). If I were using any of these things, I would not take them within 1-2 hours--both before and after--taking the sodium chlorite in water:
Colloidal silver
Activated charcoal
Any other "oxidative" approach (hydrogen peroxide, IV ozone, etc., don't push too hard all in one direction at once)
DO NOT use alkaline water (not recommended on this program, just noting this here), it will neutralize stomach acid and make it so that one cannot/will not "activate" the Unactivated MMS!
Testimonials/anecdotes, look up different conditions here:
https://mmstestimonials.co/ (https://mmstestimonials.co/)
Link to a Google Drive folder containing research related to chlorine dioxide:
https://drive.google.com/drive/folders/1W2L0HTeDarQE3XgqYsQLbcOaVFKRnvJW?usp=sharing (https://drive.google.com/drive/folders/1W2L0HTeDarQE3XgqYsQLbcOaVFKRnvJW?usp=sharing)
Kerri Rivera with autistic children
Note, I absolutely do not support the ketogenic diet she uses, I think some of the rapid improvements her people see are from the increased fat intake simply storing more toxins in the liver.
She does cover how to use Activated MMS and/or CDS in enemas to help autistic children with their CONSTIPATION, so some may find that of great interest.
CD specifically oxidizes and moves ALDEHYDES through the detox pathways...what do you know, here's a whole paper on The Pivotal Role of Aldehyde Toxicity in Autism Spectrum Disorder (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910734/). Such a weird coincidence, right?!?!
Link to PDF:
http://enabled.in/wp/wp-content/uploads/2015/03/Healing_the_Symptoms_Known_as_Autism_SECOND_EDITION_9780989289023s.pdf (http://enabled.in/wp/wp-content/uploads/2015/03/Healing_the_Symptoms_Known_as_Autism_SECOND_EDITION_9780989289023s.pdf)
Here is where I got mine from:
https://topsellerbestsellers.com/collections/nacs/products/water-purification-no-activator (https://topsellerbestsellers.com/collections/nacs/products/water-purification-no-activator)
There are other places, but I've been reading about sketchy Chinese products out there, so I'm sticking with this place for now. The book talks about how to make your own, should you be a DIYer.
It was estimated that a person might go through 1-3 bottles a YEAR, depending on their dosing, so it is a relatively minor expense.
SECTION HEADER PAGE: TOXINS/POISONS - Reduce, Minimize, Eliminate Exposures
This is a catch-all section for things I've found we've been poisoned with, that we were all-too-often told were "good for us".
I don't want to be a bummer, but it seems that things that give a SWEET TASTE cause liver injury, aka cholestasis. This seems to be the reality.
How did this realization come about?
I went over this paper on ***FDA-approved food additives*** that cause liver injury, and Neotame was in it (Neotame aka NutraSweet aka aspartame aka Equal).
https://www.sciencedirect.com/science/article/pii/S0160412019334610?via%3Dihub#t0005 It was the very-short-duration migraines that aspartame gave me as a teenager that was part of sending me on my life's mission to this day. Guess what? I took out aspartame, and MY HEADACHES DISAPPEARED. Aspartame breaks down to methanol (toxic) and then to formaldehyde (also toxic).
Then I thought, let's see if the newer kid on the block, sucralose, causes liver injury? Well that didn't take long: https://pubmed.ncbi.nlm.nih.gov/30078469/
Then I thought, let's look up sugar alcohols (xylitol, sorbitol, etc.). That didn't take long either! https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32092943/
But, but, but, what about stevia???
https://www.sciencedirect.com/science/article/pii/S1319016420301997
"Histopathological examination in sucralose and stevia administrated groups confirmed the biochemical results; where it revealed a severe damage in liver and kidney sections."
There seems to be a pattern here...SWEET THINGS HURT YOUR LIVER (which then hurts your kidneys).
Quitting sugar and the SWEET TASTE is not easy, as they behave EXACTLY LIKE ADDICTIVE DRUGS. If you need to get over your sugar and/or SWEET TASTE addiction, I HIGHLY suggest Allen Carr's work on this subject, called "Good Sugar, Bad Sugar". ONLY use the first 8-12 chapters, before it dives too much into encouraging basically veganism, but don't let this dissuade you from the first part, it really works! You can find his books on iTunes, Google Play store, Amazon, and AllenCarr.com (https://allencarr.com/). I DO NOT RECOMMEND his weight loss books!!!
The combination of using Allen Carr's work to "unbrainwash" yourself, along with getting rid of most or even ALL of the sugar and/or SWEET TASTE in your diet, WILL HELP YOUR HEALTH MORE THAN YOU EVER IMAGINED.
I do not trust anything "nano-".
This is not God's/Nature's design.
These particles are able to get DEEPER into places that they were never supposed to be.
This even includes "nano-" versions of supplements you might see me recommend here on this program.
Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models
https://link.springer.com/article/10.1007/s00204-020-02940-x
The unique physicochemical properties of materials at nanoscale have opened a plethora of opportunities for applications in the pharmaceutical and medical field, but also in consumer products from food and cosmetics industries. As a consequence, daily human exposure to nanomaterials through distinct routes is considerable and, therefore, may raise health concerns. Many nanomaterials have been described to accumulate and induce adversity in the liver. Among these, silica and some types of metallic nanoparticles are the most broadly used in consumer products and, therefore, the most studied and reported. The reviewed literature was collected from PubMed.gov during the month of March 2020 using the search words “nanomaterials induced hepatotoxicity”, which yielded 181 papers. This present paper reviews the hepatotoxic effects of nanomaterials described in in vitro and in vivo studies, with emphasis on the underlying mechanisms. The induction of oxidative stress and inflammation are the manifestations of toxicity most frequently reported following exposure of cells or animal models to different nanomaterials. Furthermore, the available in vitro models for the evaluation of the hepatotoxic effects of nanomaterials are discussed, highlighting the continuous interest in the development of more advanced and reliable in vitro models for nanotoxicology.
Humans will not improve upon God's design(s). Stop anything/everything "nano-".
Lugol's, Iodoral, SSKI, and under many other names...high-dose POTASSIUM IODIDE ruins thyroids, and this is well documented in the literature.
I am NOT saying iodINE is bad, I am saying that POTASSIUM IODIDE IS BAD. See for yourself below. This is not some crazy conspiracy, it's in the literature. Just because something may be helpful during nuclear fallout (ie. not dying from radiation toxicity damage to the thyroid), DOES NOT mean that it is something that is healthy to take in high doses on a daily basis!
Thyroid failure after potassium iodide treatment of diffuse toxic goiter (https://www.ncbi.nlm.nih.gov/pubmed/1243786)
"1. The treatment of Graves' Disease by Potassium Iodide (like thyroidectomy, radioiodine, and antithyroid drugs) is followed by rate failure of thyroid function. [...] 4. In certain patients, Potassium Iodide appears to be an effective means of controlling the hyperthyroidism of Graves' Disease."
Translation: Potassium iodide directly ruins (chemically damages) the thyroid.
Feel free to look at the documented toxicity of potassium iodide here (see link for references):
POTASSIUM IODIDE - https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+5040 (this link is now gone)
/SIGNS AND SYMPTOMS/ In a small proportion of individuals given large doses of iodide for long periods ... thyroid gland shows hyperplasia & is depleted of stores of iodine. Thyroid hormone corrects hypothyroidism and causes goiter to subside ... /Iodide preparation/ [Note above that iodIDE depleted the thyroid's iodINE stores]
/SIGNS AND SYMPTOMS/ Sudden withdrawal may precipitate thyroid storm.
Since some individuals are markedly sensitive to iodides, potassium iodide should be used with caution when initially administered. Patients at risk for iodine-induced adverse effects include those with hypocomplementemic vasculitis and those with goiter or autoimmune thyroid disease.
Potassium iodide may cause skin rash and thyroid suppression in infants.
Potassium iodide is distributed into breast milk; use by nursing mothers may cause skin rash and thyroid suppression in the infant.
Prolonged use may result in hypothyroidism, parotitis, iodism, and, particularly in postpubescent patients, acneiform skin lesions.
Iodides readily cross the placenta [fetus] and may result in abnormal thyroid function and/or goiter in the neonate. [newborn]
...repeat administration of potassium iodide should be avoided in neonates (birth to 1 month of age) to minimize the risk of hypothyroidism during a period of critical brain development...
USES: Iodides have been utilized to treat iodine disorders, hyperthyroidism, bacterial, fungal or protozoal infections, and also were traditionally as expectorants because of their stimulatory effects on bronchial secretions. Potassium iodide is indicated for use as a thyroid blocking agent following exposure to radioisotopes of iodine from a nuclear reactor accident. [does it not make sense that something used to suppress hyperthyroidism is also a thyroid "blocking" agent, and long-term use would cause HYPOthyroidism?]
COMMON: POTASSIUM IODIDE can cause stomach upset, diarrhea, nausea, vomiting, stomach pain, skin rash and salivary gland swelling or tenderness.
LESS COMMON: POTASSIUM IODIDE can cause gastrointestinal bleeding, confusion, dysrhythmias, numbness, pain or weakness in hands or feet, unusual fatigue, weakness or heaviness of legs, fever, and edema of neck or throat. Thyroid adenoma, goiter, and myxedema are also possible side effects.
RARE: Iodism is a rare occurrence with iodides; however, it may develop during prolonged treatment or with the use of high doses. Symptoms include burning of mouth, severe headache, metallic taste, soreness of teeth and gums, symptoms of head cold, irritation of the eyes with swelling of the eyelids, unusual increase in salivation, acneform skin lesions in the seborrheic areas, and rarely, severe skin eruptions.
Chronic iodide therapy has produced goiters, hypothyroidism, and rarely hyperthyroidism.
Monitor thyroid function in cases of severe overdose for decreased serum T4 levels and increased serum TSH levels.
Discontinuation of the iodide source will usually result in restoration of normal thyroid function within several weeks.
Mechanism of Action: In hyperthyroid patients, potassium iodide produces rapid remission of symptoms by inhibiting the release of thyroid hormone into the circulation. The effects of potassium iodide on the thyroid gland include reduction of vascularity, a firming of the glandular tissue, shrinkage of the size of individual cells, reaccumulation of colloid in the follicles, and increases in bound iodine.
When administered prior to and following administration of radioactive isotopes and in radiation emergencies involving the release of radioactive iodine, potassium iodide protects the thyroid gland by blocking the thyroidal uptake of radioactive isotopes of iodine.[KEY CONCEPT already noted above...potassium iodide BLOCKS normal thyroid uptake of ALL iodINE, not just the radioactive stuff!!!]
Potassium iodide is indicated in the treatment of hyperthyroidism.
Potassium iodide is used concurrently with an antithyroid agent to induce thyroid involution prior to thyroidectomy. [involution means degeneration]
Interactions: Potassium iodide increased the toxic effect in selenium poisoning. [whoa...if you are doing high-dose potassium iodide AND selenium supplementation for your thyroid, you might want to reconsider]
In treatment of hyperthyroidism /Lugol's solution/
Potassium Iodide - Safety & Hazards (https://pubchem.ncbi.nlm.nih.gov/compound/Potassium-iodide#section=Safety-and-Hazards&fullscreen=true) (looks pretty dang toxic to me!
StatPearls - Potassium Iodide (https://www.ncbi.nlm.nih.gov/books/NBK542320/)
Adverse Effects
Adverse effects are unlikely when KI is used at low doses and for a short time (less than two weeks). The most common side effects are on the digestive system, predominantly gastrointestinal intolerance and its bitter (metallic) taste; thus, the recommendation is to take it with juice or milk to protect against gastrointestinal irritation.[9] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#) However, significant side effects may occur when high doses are administered, especially for treating infectious skin disorders.
The acute side effects include diarrhea, nausea, vomiting, and stomach pain that can be ameliorated with gastrointestinal protection and by avoiding rapid dosage increases. Nevertheless, prolonged use can cause Iodism or potassium toxicity. Iodism is an iodide poisoning syndrome characterized by soreness of the teeth and gums, severe headache, conjunctival hyperemia, lacrimation, blurred vision, rhinorrhea, and sialorrhea. Concurrent use of KI with impaired renal function or other potassium-containing medications, potassium-sparing diuretics, and angiotensin-converting enzyme inhibitors (ACE inhibitors) may result in hyperkalemia.[8] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#)[9] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#)
Because the patients receive large amounts of iodine in the drug, it could affect the metabolism of the thyroid gland. It can produce a Wolff-Chaikoff effect and produce hypothyroidism. However, there are autoregulation mechanisms that help maintain the normal function of the gland in euthyroid patients. The imbalance of thyroid hormones occurs when autoregulation is defective or absent. If it is just defective, the resulting Wolff-Chaikoff effect is inevitable, TSH increases, and hypothyroidism and goiter ensue. Failure to escape this condition, with resulting hypothyroidism, can result from the administration of KI in patients with Hashimoto's thyroiditis, euthyroid patients previously treated by thyroid surgery or radioactive iodine for Graves' disease, patients taking certain drugs that inhibit thyroid function (e.g., lithium, phenazone, and, possibly, sulfonamides), patients previously treated with interferon alfa for chronic viral hepatitis,[20] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#) and patients with a history of amiodarone-induced thyrotoxicosis, subacute thyroiditis, or Graves disease. When autoregulation is absent, Jod-Basedow disease occurs. The absence of autoregulation is typically only seen in areas where iodine deficiency with long-standing goiters occurs. This alteration produces an excess of thyroid hormone resulting in thyrotoxicosis.[9] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#)
Allergic reactions such as angioedema and urticaria should be considered during the administration of KI, like any drug. KI use can also cause an uncommon lesion in the skin called Ioderma, which is characterized by severe acneiform, vesicular pustular, hemorrhagic, or urticarial lesions. Other systemic side effects of SSKI include urticaria, fever, eosinophilia, jaundice, pruritus, angioedema, and bronchospasm. In this case, the treatment is high-dose corticosteroid therapy.[21] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#)
Contraindications
KI is contraindicated in patients who have thyroid disease or are using any drug that could alter thyroid function.[22] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#) Contraindications also include patients with an allergy to iodine. Clinicians should avoid giving it to patients with chronic renal failure because of the presence of potassium. Furthermore, it should be avoided in patients using potassium-sparing diuretics or angiotensin-converting-enzyme inhibitors to prevent hyperkalemia.[23] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#) Immunocompromised patients such as patients with cancer, cirrhosis, AIDS, autoimmune diseases, or poorly managed diabetics, transplant patients, and those using corticosteroids should not use KI as it affects the immune system.[23] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#) It should not be indicated in pregnant or nursing women because it causes neonatal hypothyroidism, thyromegaly, fetal airway obstruction, and prolonged labor. Also, it is a pregnancy category D drug.[9] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#)
Monitoring
For all who prescribe KI, previous knowledge of the Wolff-Chaikoff effect, of the patients’ potassium levels, and their renal function is imperative. Recommendations include inquiring about any history of thyroid disease, autoimmune disease, or drugs that the patient is using. Unless there is a suspicion of thyroid disease, the baseline thyroid function test is not indicated. If KI use is for more than one month, it is recommended to do a screening test of TSH to ensure that the patients are not in hypothyroidism. If iodide-induced hypothyroidism is detected, these changes are reversible by discontinuing the administration of KI.[9] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#) Furthermore, according to the FDA's guidance, thyroid function should be monitored in pregnant or breastfeeding women, neonates, and young infants if repeat doses are necessary following radioactive iodine exposure. The FDA strongly recommends monitoring neonates and infants for potential hypothyroidism, particularly when:
Nursing mothers who receive greater than one dose of KI
Infants under one month of age receiving any KI
Neonates who receive more than one dose of KI
Neonates or infants whose at-risk mothers do not switch from breast milk to formula or other foods
Toxicity
If iodide-induced hypothyroidism is detected, these changes are reversible by discontinuing the administration of KI. A study of 7 patients with iodide-induced hypothyroidism showed serum T4, T3, and TSH concentrations returned to normal within one month of iodide withdrawal.[22] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#)
Drug-induced hyperkalemia is a medical urgency of which the physician should be aware. Prompt management is necessary with immediate (under 3 minutes) treatment: ECG monitoring is advisable. Changes suggest a potassium level greater than 7 mmol/L. Therefore, calcium gluconate administration is the recommended intervention in that case. Within minutes (under 30 minutes), the treatment combines insulin-dextrose and beta-2 receptor agonists. Within hours (subacute), the management is sodium bicarbonate if the patient has acidosis, loop diuretics, and/or dialysis in patients with advanced Stage 5 kidney disease (eGFR less than 15 mL/min/1.73 m^2) or patients with very high potassium values (i.e., greater than 6.0 mmol/L).[24] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#)
In the case of iodism or ioderma, it is treatable with withdrawal and high doses of corticosteroids.[21] (https://www.ncbi.nlm.nih.gov/books/NBK542320/#)
When there is iodINE easily available, and the toxicity research seems quite overwhelmingly BAD on potassium iodIDE, why would anyone continue taking this stuff? Saying "somebody wrote a book on it" is not an acceptable answer to defend poisoning yourself or others.
Hanging on to potassium iodIDE because "that's what they did in the past" is a pure example of the "Appeal to Tradition" fallacy.
http://changingminds.org/disciplines/argument/fallacies/appeal_tradition.htm
"Tradition, once established, becomes a cultural thing, where people do it without thinking and defend it simply because it now is a part of the woodwork. Familiarity breeds both ignorance of the true value of something and a reluctance to give up the 'tried and true'."
It's time to stop poisoning your thyroid, folks. Simple changes can have amazing results.
“There is nothing more deceptive than an obvious fact.” ― Arthur Conan Doyle, The Boscombe Valley Mystery
In short, I do not recommend using curcumin supplements or high doses of turmeric. Here is the reasoning that brought me to this decision.
We cannot ignore the fact that curcumin is very, very yellow. Like other carotenoids.
Xanthophylls are yellow plant pigments (beta-carotene is actually an orangish-red color, not yellow), and curcumin is a xanthophyll.
Note the ending of the word "curcumin". The "-in". Note how it is exactly the same as the other xanthophylls:
zeaxanthin
lutein
astaxanthin
beta-cryptoxanthin
As with so many other terms in the VA world that seem almost intended to obscure and confuse, a xanthophyll is an oxygenated carotenoid (so many places in the literature never refer to it as a carotenoid, they refer to it only as a xanthophyll).
Curcumin is also referred to as a polyphenol (https://pubmed.ncbi.nlm.nih.gov/20484172/). Note that link shows that curcumin slows one of the liver cytochrome systems (not a good thing in general). Polyphenols deplete thiamine B1, as is described elsewhere.
There is a lot of seemingly positive research on turmeric / curcumin, however, I do not feel comfortable with giving the OK to these types of supplements any longer.
My theory is that the supposed "benefits" of turmeric are quite possibly from it displacing more harmful retinoids from their binding sites, thus reducing the VA damage at that time...and over time, the problems will arise again (like with so many things that seem to help VA problems only temporarily). There are also many discussions in the literature of the "amazing" research on turmeric/curcumin having lots of financial conflicts of interest.
These are some important articles to read, that no one in the mainstream will bring up:
Turmeric Induced Liver Injury: A Report of Two Cases (https://www.hindawi.com/journals/crihep/2019/6741213/)
and
Take turmeric with a grain of salt (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205834/)
Perhaps you’ve heard that turmeric, the golden curry spice, is the new wonder supplement. Turmeric contains curcumin, which Google — without my needing to click through to any website — tells me can help prevent heart disease, Alzheimer disease and cancer, as well as relieve symptoms of depression and arthritis. Curcumin has exciting, powerful anti-inflammatory properties, apparently. And this wonder supplement of the age has been marketed so well that we can now buy turmeric lattes in ordinary chain coffee shops and turmeric smoothies just about everywhere. There is some evidence to support curcumin’s anti-inflammatory effects, which is why the authors of a linked research study sought to examine its effectiveness in preventing organ damage following major vascular surgery.1 Unsurprisingly, the findings of this large multicentre randomized controlled trial don’t support the widespread claims of powerful anti-inflammatory properties of curcumin, highlighting the importance of studying natural health products like this.
Garg and colleagues randomized more than 600 patients, scheduled for elective abdominal aortic aneurysm repair at 1 of 10 Canadian hospitals, to either high-dose perioperative oral curcumin or placebo. They looked at levels of four biomarkers of tissue inflammation in the hours and days after surgery. At a dose of 2000 mg twice a day over four days — a dose much higher than usual dietary consumption — oral curcumin was no more effective than placebo in ameliorating the inflammatory complications of aortic aneurysm repair. Examination of secondary outcomes showed a higher risk of postoperative kidney injury in the curcumin supplementation group, but no differences in adverse-effect profiles.1
The authors carried out this study because a small single-centre randomized trial of patients scheduled for elective coronary artery bypass grafting found a reduction in three inflammatory biomarkers among those who took oral curcumin peri operatively,2 and animal studies had indicated an effect before that. They did the right thing. Building on promising pre-clinical and preliminary work by undertaking a larger and more rigorous trial is what pharmaceutical companies do all the time when testing new drugs. The dumpsters of these companies are filled with compounds that should have worked (based on preclinical work), but then sadly weren’t found to be effective in large-scale human trials. No one should be shocked by the findings of the study by Garg and colleagues. This is how science works. It’s deeply disappointing when a promising compound is shown to be no better than nothing. But it happens every day.
Except it doesn’t happen every day for natural health products touted as having wondrous medicinal properties. Health Canada does not hold “natural” health products to the same high standard as it does pharmaceutical products. As CMAJ editors have previously pointed out, manufacturers of natural health products can sell a product and claim health benefits without having to obtain the same supporting evidence that would be needed if it were sold as a drug.3,4 With natural health products, the marketing most often comes first — usually based on few small, nonrandomized and unblinded studies at best — and the good science usually fails to follow. “But it’s natural; it can’t cause harm,” shout the purveyors of natural health products. Yet natural doesn’t mean safe or even good. Caffeine is natural. Many people enjoy its effects and may find them to enhance well-being, but excess consumption can harm. Tobacco is natural. So is arsenic.
We need lots more studies like the linked trial by Garg and colleagues. We need to know when a substance that offers much hope and, through poor regulation, benefits from premature hype is actually useless or harmful. Although not every natural health product may be studied, priority-setting for research may include its breadth of use and likelihood of benefit or harm.
Consumers may still prefer a turmeric to a pumpkin spice latte, but at least they will now be able to hand over their money knowing that a proven health benefit is lacking. Natural health products should be subject to a high standard of scientific testing, journals should publish and promote these high-quality studies for the public good, and purveyors of natural health products need to be as willing — or should be regulated to be as willing — to admit that their health claims are wrong when good science demonstrates them to be so.
If you choose to continue using turmeric in food/seasoning doses, that call is up to you.
TL;DR version: Don't use any ***supplements of Vitamin E*** (I don't care if they are high gamma-tocopherol or not). Don't purposely eat foods high in Vitamin E to try to get more. I have my doubts about Vitamin E as an actual "vitamin" now, but I do not see it as even 1/10 of the problem of VA. I'm not purposely avoiding it in foods, but I'm also personally not eating that many high Vitamin E foods either (nuts, seeds, avocados, and extracted oils are pretty minimal/rare for me these days).
For those worried about "Vitamin E deficiency", I'm going to stand behind the concept that we can get enough from the basic dietary principles we follow here that would include muscle meats, beans/legumes/pulses, grains, and maybe some nuts and seeds (if you so choose on those last ones). Grant has eaten nearly only beef or bison, brown or white rice, and pinto beans in 6 years. Nuts, seeds, and avocados are NOT part of his diet, yet he is showing no signs of Vitamin E deficiency (OR he is getting enough from the foods he is eating, if it is actually a vitamin). Either way, he's the early demonstration that we likely don't need much or any of that so-called "fat-soluble" vitamin either!
I had previously thought, based on mounds of research I had accumulated, that Vitamin E was both depleted by VA, and that it was also helpful in protecting the body from VA toxicity. Some of you may have seen my large posts on the Research Forum (which I have since taken down). I don't believe that any longer.
Based on what I have figured out to this point in all of the VA metabolism and storage pathways, and after taking another LONG and hard look at Vitamin E research, it seems that the supposed "benefits" to Vitamin E come from its ability to shove VA into the liver (thus reducing the blood levels and reducing the symptoms/diseases for a while, until the liver becomes full and the original disease returns and more problems appear over time, because the blood is now over-full of VA without the liver storage available to "more safely" store it away).
First, let's go into how Vitamin E is actually a fat-soluble ALCOHOL:
Tocopherol (https://medical-dictionary.thefreedictionary.com/tocopherol): "Any of a group of closely related, fat-soluble alcohols constituting vitamin E and similar compounds."
Is this sounding familiar to anyone already? No, I can't find any tocopherAL or tocopherALDEHYDE though...but one is theorized to exist, as I cover below.
The alcohol angle is interesting, but not an indictment in itself. If you are the person who sent me the email pointing this alcohol fact out, please let me know and I'll give you a tag here, thank you! ;-) )
Now we move on to the really problematic stuff (I also couldn't find the email to tag who sent me this next one, so please let me know if you want the shout-out). It seems that Vitamin E stores way more VA in the liver (from a 1940 paper, emphasis mine, my comments are in brackets):
156. THE EFFECT OF VITAMIN E DEFICIENCY ON THE VITAMIN A RESERVES OF THE RAT (https://sci-hub.tw/10.1042/bj0341321)
"In early work in this laboratory on vitamin E deficiency in the rat a basal diet was used in which vitamin A was supplied as cod liver oil (ca. 1000 IU. per g.). [...] They indicate that in deficiency of vitamin E the vitamin A reserves of the liver may be much reduced.
[following text refers to Table 1 above] The vitamin A reserves of the rats given vitamin E were invariably much higher than those of the rats deficient in vitamin E. The positive control group had a mean total vitamin A reserve more than twice as great as that of the deficient group. The reserve per g. of liver for the control group was almost twice as much as the corresponding value for the deficient group.
[following text refers to Table 2 above] The mean vitamin A reserves, both total and per g., were about 10 times greater in the groups given vitamin E concentrate than in the deficient groups. Casein deficiency had a relatively small effect of doubtful significance. The group given a normal allowance of casein without vitamin E had total reserves about twice as great as those given a low allowance of casein without vitamin E. When the reserves are calculated per g. of liver this difference disappears.
[there is VA hiding in the casein (https://nutritionrestored.com/blog-forum/topic/the-perfect-storm-of-poison-vitamin-a-problems-from-dairy-products/), this is why there is 2X as much VA in the livers of the rats who got more casein!]
[following text refers to Table 4 above] ...the vitamin A reserves for these groups were only 1/4 to 1/2 of those found in the groups receiving adequate allowances of vitamin E.
[following text refers to Table 5 above] The vitamin A reserves determined at autopsy were found to be graded between the groups receiving different levels of carotene without a single instance of overlapping. This applied equally to groups with and without tocopherol. The differences in the vitamin A reserves ascribable to the administration of tocopherol were much less marked than in the previous experiments on the storage of preformed vitamin. Although slight, however, the differences were always in favour of the groups which had received tocopherol. The most marked difference between vitamin A reserves was found in the paired groups receiving 0.5 mg. of carotene daily. The mean total reserve for the group receiving tocopherol was 62 % greater than the corresponding value for the untreated group.
In all the above experiments in which halibut liver oil was given the vitamin A reserves were always much lower in rats deprived of vitamin E than in animals subjected to exactly the same treatment except for the addition of vitamin E. In Exp. 1 the reserves of rats given vitamin E were about twice as high as those of deficient animals; in Exps. 2 and 3 about ten times, and in Exp. 4 about three times as high. No explanation of these differences in the degrees of disparity can at present be offered. In work by Bacharach [1940] confirming this effect of vitamin E deficiency in lowering the vitamin A reserves the differences noted between the treated and untreated groups were much smaller, amounting to only some 50% difference between means in favour of the treated group. In his work however the rats were kept on the deficient diet for a shorter period.
The efficiency of storage of the ingested vitamin A, neglecting the small contribution of carotene in the groups receiving wheat germ oil concentrate, may be calculated as follows:
In the groups given vitamin E the rate of storage of 40-50 % points to high efficiency, particularly in view of the prolonged periods during which the earlier doses of vitamin A must have been kept in the livers before they were examined. Without vitamin E the efficiency of storage in Exps. 2 and 3 was very poor. It must be pointed out that both in the present work and in that of Bacharach [1940] the dietary intake of vitamin A was large, and that even in the groups deficient in vitamin E the reserves of vitamin A were not very low in an absolute sense. Experiments at lower levels of dietary intake of vitamin A are obviously needed.
[haha, how about NONE]
1. The vitamin A reserves of rats kept for prolonged periods on a diet deficient in vitamin E in which vitamin A was supplied as halibut liver oil were always much lower than those of control animals receiving supplements of vitamin E."
(https://sci-hub.tw/10.1042/bj0341321) (https://sci-hub.tw/10.1042/bj0341321)
If that weren't enough, then let's go over the MANY other similarities between Vitamin E and VA I've found!
Vitamin E is stored in the liver, particularly in fatty liver (https://ggenereux.blog/2020/02/19/100-million-americans-now-have-nafld/), and it is bound to lipoproteins in the blood (cholesterol is a lipoprotein, VA is part of LDL and VLDL cholesterol, lutein is part of HDL, coincidences are unlikely!):
Vitamin E sequestration by liver fat in humans (https://pubmed.ncbi.nlm.nih.gov/31821172/)
In healthy subjects, 85% of intravenous d6-α-tocopherol disappeared from the circulation within 20 minutes but reappeared within minutes and peaked at 3–4 hours; d3- and d6-α-tocopherols localized to lipoproteins. Lipoprotein redistribution occurred only in vivo within 1 hour, indicating a key role of the liver in uptake and re-release.
CONCLUSIONS: The unique role of the liver in vitamin E physiology is dysregulated by excess liver fat. Obesity-associated hepatosteatosis may produce unrecognized hepatic vitamin E sequestration, which might subsequently drive liver disease. Our findings raise the possibility that hepatosteatosis may similarly alter hepatic physiology of other fat-soluble vitamins.
Vitamin E slows down ADH:
Putrescine treatment reverses α-tocopherol-induced desynchronization of polyamine and retinoid metabolism during rat liver regeneration (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080801/)
"The proliferating liver after PH is highly sensible to small dosing of α-tocopherol, which alters the pattern of signal transducer and activator of transcription (STAT) protein activation, and blunts retinoic acid formation by decreasing alcohol dehydrogenase (ADH) activity [11 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080801/#CR11), 12 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080801/#CR12)]."
Vitamin E slows down ALDH:
α-Tocopherol Is Ineffective in Preventing the Decomposition of Preformed Lipid Peroxides and May Promote the Accumulation of Toxic Aldehydes: A Potential Explanation for the Failure of Antioxidants to Affect Human Atherosclerosis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842134/)
"Moreover, the inclusion of α-tocopherol during the decomposition of 13-HPODE resulted in an accumulation of aldehydes. Further oxidation of aldehydes to carboxylic acids by a number of oxidases was prevented by α-tocopherol.
Chemical oxidation of aldehydes is arrested by antioxidants."
Apparently an aldehyde of Vitamin E hasn't been found yet, but it is theorized to exist in the metabolism ("detox"?) of Vitamin E in the body:
COMPOUND SUMMARY 13'-Hydroxy-alpha-tocopherol (https://pubchem.ncbi.nlm.nih.gov/compound/13_-Hydroxy-alpha-tocopherol)
"13'-hydroxy-alpha-tocopherol is the precursor in dehydrogenation to 13'-carboxy-alpha-tocopherol (https://pubchem.ncbi.nlm.nih.gov/compound/13%27-carboxy-alpha-tocopherol) by an unidentified microsomal enzyme(s) probably via an aldehyde intermediate."
Vitamin E apparently inhibits rat liver regeneration (well, if it stores more VA in the liver, and even stores itself in the liver, this might be expected!):
High dosing of α-tocopherol inhibits rat liver regeneration by modifying signal transducer and activator of transcription protein expression and its correlation with cell redox state and retinoid metabolism (https://pubmed.ncbi.nlm.nih.gov/22826360/)
"In conclusion, altered activation and translocation of STAT-1 and -3 proteins and inhibited retinoid metabolism seem to be involved in the VE-induced inhibition of rat liver regeneration."
A bit of review. Vitamin A as retinoic acid has been studied as an adjuvant for vaccines. Here is a big article of mine on that: https://nutritionrestored.com/blog-forum/topic/poison-vitamin-a-is-an-adjuvant-think-vaccines-and-adjuvants-cause-autoimmunity/ .. Worth the read IMHO :-)
So then, what do we think when Vitamin E also increases antibody response to vaccines, and is said to have "an adjuvant effect"? Not good, right?:
Vitamin E in Viral Inactivated Vaccines (https://www.researchgate.net/publication/15407444_Vitamin_E_in_Viral_Inactivated_Vaccines)
"Results show that vaccines with vitamin E, especially when it replaces 20 or 30% of mineral oil, induces a more rapid and higher antibody response than control vaccines. An adjuvant effect of vitamin E was also present in viral vaccine lacking bacterial antigens."
Make sure to read that last sentence again. Antibodies are a sign of the body reacting against a POISON or TOXIN. The body had a poison/toxin response to the Vitamin E in a "vaccine" that didn't even have the "vaccine" antigens in it!!! Mind-boggling.
Here is my video all about how VA depletes Vitamin K:
It has ALSO been shown that Vitamin E depletes Vitamin K! See multiple studies below:
Deuterium-labeled Phylloquinone Fed to α-Tocopherol Injected Rats Demonstrates Sensitivity of Low Phylloquinone-Containing Tissues to Menaquinone-4 Depletion (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183557/)
"The influence of excess α-tocopherol (α-T) on tissue depletion of phylloquinone (PK) and menaquinone-4 (MK-4) was evaluated by feeding rats (n=5/group) deuterium-labeled-PK (d4-PK, 2 µmol/kg) for 17 d, thereby labeling the conversion from d4-PK to d4-MK-4. Then they were injected subcutaneously daily for the last seven days with saline, vehicle, or α-T (100 mg/kg BW). α-T injections 1) increased α-T concentrations by 10-fold in liver, doubled them in plasma and most tissues, but they were unchanged in brain; 2) increased the α-T metabolite, carboxyethyl hydroxychromanol (α-CEHC) concentrations: >25-fold in liver and kidney, 10-fold in plasma and lung, and 50-fold in heart; brain contained detectable α-CEHC (0.26 ± 0.03 nmol/g) only in α-T injected animals and 3) depleted most tissues’ vitamin K. Compared with vehicle-injected rats, brains from α-T rats contained half the total vitamin K (10.3 ± 0.5 vs. 21 ± 2 pmol/g, P=0.0002) and one third the d4-MK-4 (5.8 ± 0.5 vs. 14.6 ± 1.7 pmol/g, P=0.0002). Tissues with high PK concentrations (liver, 21–30 pmol/g and heart, 28–50 pmol/g) were resistant to K depletion. We propose that α-T dependent vitamin K depletion is likely mediated at an intermediate step in MK-4 production; thus, tissues with high PK are unaffected."
Excess α-tocopherol decreases extrahepatic phylloquinone in phylloquinone-fed rats but not menaquinone-4 in menaquinone-4-fed rats (https://pubmed.ncbi.nlm.nih.gov/24737747/)
α-Tocopherol Intake Decreases Phylloquinone Concentration in Bone but Does Not Affect Bone Metabolism in Rats (https://pubmed.ncbi.nlm.nih.gov/30175786/)
Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione or phylloquinone (https://pubmed.ncbi.nlm.nih.gov/22707266/)
Vitamin E is "metabolized" aka detoxified on the same pathways as pharmaceuticals and xenobiotics (a chemical compound foreign to a given biological system ), and is excreted in the bile!:
Adverse effects of vitamin E by induction of drug metabolism (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474942/)
"Metabolism of vitamin E follows the metabolism of xenobiotics. Drugs are mainly taken up in the liver by the organic anion transporting peptide (OATP) or the organic cation transporters (OCT) at the sinusoidal membrane. All forms of chylomicron-remnant-bound vitamin E enter the hepatocyte via the LDL-receptor, HDL-bound α-tocopherol via the scavenger receptor BI (SR-BI). Within the cell the mainly lipophilic drugs become “activated” by phase I enzymes which oxidize, reduce or hydrolyze drugs before they are subjected to phase II metabolism. Oxidation/hydroxylation is catalyzed by cytochrome P450 enzymes, mainly by CYP3A4 in humans, Cyp3a11 in mice and CYP3A1 in rats. Tocopherols and tocotrienols are hydroxylated in human cells by CYP3A4 or CYP4F2. The hydroxy group is oxidized by ω-oxidation to the carboxy group, then the side chain is degraded by β-oxidation ending up in carboxyethyl hydroxychromans (CEHC), see Fig. 1 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474942/figure/Fig1/). Metabolites of drugs and vitamin E are sulphated or glucuronidated during phase II metabolism to make them more hydrophilic for the excretion via the biliary or the renal route. Efflux into the bile occurs via the ABC transporters MDR1 or MRP2. Intact vitamin E appears to take this route, too. MRP1 and MRP3 are located at the sinusoidal membrane and pump drugs and their metabolites into the circulation for renal excretion."
There are quite a few studies noting negative effects of Vitamin E supplementation, including negative impacts on mortality (ie. earlier death than should have happened). Please read this article, as it's just too much to quote from:
Should Anyone Take Vitamin E? (https://www.berkeleywellness.com/supplements/vitamins/article/should-anyone-still-take-vitamin-e)
Finally, if Vitamin E is something of a problem like VA, then things that help reduce VA toxicity should also reduce Vitamin E levels in the body also, correct? This also seems to be true! Pectin, a soluble fiber, grabs onto Vitamin E just like it grabs onto VA.
Here are those connections:
In rats, pectin dietary content of 6% decreased Vitamin E levels (https://www.ncbi.nlm.nih.gov/pubmed/3968591).
In women. 8-10.4 grams of pectin taken with a carotenoid-supplemented meal reduced the next day’s blood levels of beta-carotene (42% lower), lutein (~40% lower), and lycopene (~40% lower). (https://sci-hub.tw/10.1093/jn/129.12.2170) Over 6 grams of pectin inhibited Vitamin E (alpha-tocopherol) absorption.
Pectin at 10% of the rat diet reduced tissue Vitamin E concentrations. (https://www.sciencedirect.com/science/article/pii/S0271531782800286)
More pectin, less Vitamin E.
Do you believe all of these parallels are just coincidences?
Vitamin A is a POISON.
Vitamin D is a HORMONE.
Vitamin E, well, now you've seen the evidence above. I'm going to guess that the early "Vitamin E deficiency studies" were probably screwed up in similar ways to the early "VA deficiency studies".
As for Vitamin K, I haven't found anything negative at all on it yet, and no one has sent me anything.
First, if you are reading this and I put you on a boron supplement in the past, I would highly suggest you STOP and toss it.
Why? Because I have seen boron rise to "normal levels" on hair testing ON ITS OWN--without needing supplements or high-boron foods or especially BORAX--better by following the principles I lay out here than with anything else I have ever seen. Having "low boron" on a hair test (below 0.10) is not anything to try to "fix", because it will fix ITSELF over time if you simply do what is laid out here.
NOTE: The hair mineral analysis lab I use (Trace Elements Inc, "TEI") has added a significant additional charge to analyze for boron, and because I do not believe it to be an "essential" mineral, and boron problems solve themselves when people follow my recommendations, I have STOPPED TESTING IT. The "N/A" on your test does not mean you have zero boron, it means it wasn't analyzed.
Remember kids, the not-so-secret-anymore goal of the elites is to sterilize you, and they will use conventional AND ALTERNATIVE MEDICINE SHILLS to convince you to do it to yourself.
What's the lie we've been told? Boron is good for bone health and TESTOSTERONE PRODUCTION in men. Oh, really? Is that so? Is it possible that this is a short-term effect, only to ruin our fertility later, as the boron damage accumulates? I call that sort of thing the "Duration Paradox". Let's see if there is any evidence to this theory, shall we?
Chemical Disposition of Boron in Animals and Humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1566637/pdf/envhper00403-0110.pdf
Chemical Disposition of Boron in Animals.pdf (https://media2-production.mightynetworks.com/asset/27071597/Chemical_Disposition_of_Boron_in_Animals.pdf)
"Boric acid has been shown to adversely affect the reproductive organs of male rats causing testicular atrophy and cellular dystrophy.
For both the 7- and 28- day studies, the soft tissues did not appear to accumulate boron at levels substantially above that found in blood. Fat tissue contained significantly less boron that other tissues. This is not surprising since boron is probably in the very polar form of boric acid in the body and thus not likely to accumulate in the nonpolar fat tissue.
***The adverse reproductive effects in male rats, and the visible testicular lesions***, do not appear to be the result of accumulation of very high concentrations of boron in the testis or other reproductive organs. The levels of boron in these tissues are no higher than the boron found in blood and the other soft tissues of the exposed animals."
Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2776007/
Borax [sodium borate] is the chemical substance which is toxic to human and animal. In human, borax is toxic to cells and has a slow excretion rate through the kidney. Kidney toxicity is the greatest, with liver fatty degenerations, cerebral edema and gastroenteritis. In animal, the testicular effects of borax were observed in rat, mouse and dog [14 (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2776007/#B14)]. In rats, a single dose of 175 mg borax/kg bw was found to cause reversible disruption of tubular spermiation [15 (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2776007/#B15)]. There were the reports about borax toxicity that it caused testicular atrophy, degeneration of seminiferous tubules, reduced sperm count, reduction in fertility in rats [16 (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2776007/#B16)] and reduced fertility [17 (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2776007/#B17)]. For the developmental toxicity of borax, the foetal body weight was decreased [18 (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2776007/#B18)], minor skeleton variation with the exception of short rib XIII in rats [19 (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2776007/#B19)].
Conclusion
Borax is used as a food additive in some countries. This study suggests that borax may effect on immune cell (lymphocyte) cytotoxicity and genetic damage. The consumer should be careful about eating the preserved food for their health.
The big study on boron that all the meatheads like to quote, that boosted testosterone by taking a high dose of boron, ONLY LASTED 10 DAYS. Weird, almost like they knew if it went too long, they'd see bad effects maybe???
I have now started seeing MASSIVE boron dumps on hair testing that only can align with the body wanting to get rid of it.
Sea Buckthorn Oil as a Valuable Source of Bioaccessible Xanthophylls
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020026/
"Sea buckthorn oil has a unique chemical composition, combining high concentrations of carotenoids with a very particular fatty acid profile and a high content of tocopherols. The most important carotenoid in the Romanian sea buckthorn oil is zeaxanthin, mostly in esterified forms."
This is SO HORRIBLE.
I'm not going to spend a lot of time on this one.
Copper toxicity in general causes cholestasis.
Manganese (*NOT magnesium!*) toxicity in general causes cholestasis.
DO NOT take any of either of these minerals in ANY supplement!
Micronutrients in Liver Disease: Roles, Risk Factors for Deficiency, and Recommendations for Supplementation
https://aspenjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/ncp.10451
Micronutrients in Liver Disease Roles Risk Factors for Deficiency and Recommendations for Supplementation.pdf (https://media2-production.mightynetworks.com/asset/27286402/Micronutrients_in_Liver_Disease_Roles_Risk_Factors_for_Deficiency_and_Recommendations_for_Supplementation.pdf)
Potential Micronutrient Toxicities
Although micronutrient deficiency is far more common amongst patients with liver disease, clinicians should also be aware of risk factors for toxicity. Copper and manganese are almost exclusively eliminated via the hepatobiliary system, leading to increased likelihood of toxicity with cholestatic liver disease and/or biliary obstructions. This risk is exacerbated with use of parenteral trace elements. Copper toxicity signs include metallic taste, blood in urine, kidney failure, liver damage, coma, and death. Clinical and neurological signs and symptoms of manganese toxicity include neurotoxicity, Parkinson-like motor dysfunction, hyperirritability, violent tendencies, hallucinations, disturbances of libido, ataxia, immune and reproductive dysfunction, nephritis, pancreatitis, hepatic damage, and testicular damage. For patients receiving parenteral nutrition, dose reduction or removal of copper and manganese from parenteral nutrition has been suggested when conjugated (direct) bilirubin is >2 mg/dL...
If you are here, and you have chronic health issues, you have cholestasis. Having cholestasis means you likely have an excess of copper and manganese in your liver. Using blood tests and hair tests can begin to suggest how much is in there...but ONLY A LIVER BIOPSY can tell us the exact amount.
Don't take copper or manganese in any supplemental form. Period.
SECTION HEADER PAGE: Soluble Fiber
It is VERY important to watch the video on soluble fiber, so YOU will know how to best make soluble fiber work for you (and not against you!)
The information in this video takes precedence over any other information that you have heard from Dr. Smith about soluble fiber previously.
https://rumble.com/v280hp0-soluble-fiber.html
Fiber in grains (link mentioned in video): https://wholegrainscouncil.org/whole-grains-101/identifying-whole-grain-products/fiber-whole-grains
There are likely many useful bits to be found in these older articles about soluble fiber. Remember that any information that conflicts with the video, the VIDEO information takes precedence!
Helpful Soluble Fiber Food Amounts Documents (https://members.nutritiondetective.com/posts/vitamin-a-detox-archive-helpful-soluble-fiber-food-amounts-documents) (from old VA Detox course, still relevant)
Fiber In Whole Grains (https://wholegrainscouncil.org/whole-grains-101/identifying-whole-grain-products/fiber-whole-grains) (you may want more or less, watch video again if you don't understand why)
OLD articles on soluble fiber from previous VA Detox course (https://members.nutritiondetective.com/posts/vitamin-a-detox-archive-soluble-fiberstart-working-on-this-after-you-have-gone-organic), with disclaimer:
SOME INFORMATION IN THOSE ARTICLES IS NOT UP-TO-DATE. PLEASE WATCH THE SOLUBLE FIBER VIDEO (https://members.nutritiondetective.com/posts/love-your-liver-soluble-fiber-video), AND KNOW THAT THE VIDEO TAKES COMPLETE PRECEDENCE IN TERMS OF ANY CONFLICTING INFORMATION YOU MAY FIND THERE.
SECTION PAGE: OPTIONAL - Bile Binders
These generally ONLY work on bile that has actually made it into the GUT.
SECTION PAGE: Probiotics & Gut Biome
If you haven't read the lactoferrin articles, start there first! Links below video
https://rumble.com/v2805mu-probiotics.html
Articles mentioned (and screen shared) in video can be found in the "old" VA Detox program here:
Inulin as a cause of cholestasis and liver cancer studies mentioned:
Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/33092056/
Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232850/
Lactoferrin correcting the gut biome studies mentioned:
The Impact of Lactoferrin on the Growth of Intestinal Inhabitant Bacteria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801499/
Bioavailability of a Novel Form of Microencapsulated Bovine Lactoferrin and Its Effect on Inflammatory Markers and the Gut Microbiome: A Pilot Study
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/30126153/
Growth-promoting effects of lactoferrin on L. acidophilus and Bifidobacterium spp
https://pubmed.ncbi.nlm.nih.gov/15222478/
SECTION PAGE: AGITATORS Video
These are things that often INCREASE bile dumping, which is MOST TIMES the cause of any increases in current symptoms, return of old symptoms, or even the arrival of new symptoms. Take things slow, one step at a time.
https://rumble.com/v27z3vo-agitators-things-that-cause-bile-dumping-original.html
SECTION PAGE: SUNLIGHT & UV-B Videos & Articles
LYL Livestream on Sunlight & UV-B for detox:
(https://www.youtube.com/embed/live)
https://youtube.com/live/exzFAtYr9UE
My Twitter thread on sunlight, UV-A, & UV-B (please read):
https://twitter.com/NutriDetect/status/1625178007294951455
Direct link to video:
https://rumble.com/v273q7m-sunlight-and-uv-b-video.html
DIY UV-B/A light:
https://optimizeyourbiology.com/diy-vitamin-d-sun-lamp/
Links mentioned:
https://vitamindwiki.com/Vitamin+D+from+low-cost+UVB+lamps
https://www.toxinless.com/vitamin-d-uvb-lamps
SECTION PAGE: Space Weather Video + Article
https://rumble.com/v282the-space-weather-original.html
(article below)
Original article here: https://nutritionrestored.com/blog-forum/topic/factors-beyond-human-control-that-affect-human-health-moon-cycles-space-weather-schumann-resonance-etc/
There are multiple things beyond human control that have been shown in the scientific literature to affect human health. These include weather changes, moon (lunar) cycles, space weather (several types), and spikes in the Schumann resonance.
Pain has been shown to change in concert with weather changes. Do you think that the strange weather patterns, hitting high and low records all over the place, can affect how you feel? If you said yes, you are correct:
Fluctuation of pain by weather change in musculoskeletal disorders. (https://www.ncbi.nlm.nih.gov/pubmed/22081184)
In order to find out the fluctuation of pain by weather change, a descriptive cross-sectional study was conducted among 138 individuals having musculoskeletal disorders (MSDs) attending the out patient department (OPD) of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University (BSMMU) Hospital, Dhaka, during March 2004 to June 2004. Data were collected by face to face interview employing a pre-tested interview schedule containing structured questions. Among 138 respondents, male were predominant (52.2%). Mean age of the respondents was 39.42±10.79 years, while the most common age group was found as '31 to 40 years'. By occupation, majority were housewives (40.58%), followed by businessmen (29.71%), service holder (15.22%), laborer (7.97%), and students (6.52%). The primary sites of pain were back and low back (38.4%), knee (24.6%), leg (8.7%), ankle and heel (8.0%), hand and wrist (6.5%), neck (5.8%), shoulder (5.8%), and elbow (2.2%). Highest number (47.8%) patients reported aching pain, while one fifth (20.3%) of them experienced burning pain. About 36.2 percent respondents mentioned 'prolonged standing' as the main cause of pain aggravation, while almost half (48.6%) of the patients perceived that 'application of heat' was the key relieving factor of their pain. About two third (63%) of the respondents were sensitive to weather change; among them 56.3 percent reported that their pain increased during cold weather. Moreover, more than two third (67.4%) study-patients experienced deterioration of pain due to seasonal variation; of them 59.1 percent reported that their pain was exacerbated in winter season. Of all respondents, less than one third (30.4%) experienced aggravation of pain due to lunar change; of them majority (85.7%) experienced increased pain during dark fortnights. Our study concluded that weather change might have an important role in fluctuation of pain among individuals having musculoskeletal disorders.
Lunar (moon) cycles are next, these affect nearly everything:
Effects of different phases of the lunar month on humans (https://www.researchgate.net/publication/278098473_Effects_of_different_phases_of_the_lunar_month_on_humans) (full study pdf attached)
This one should be fairly easy to understand. If the moon's effects on Earth are enough to move the ocean (tides), then the moon is easily capable of influencing our physiology & biochemistry.
The four prominent phases of the lunar month are new moon, first quarter, full moon, and third quarter. According to the position of the moon in its orbit, the gravitational pull of the moon on earth changes and the amplitude of ocean tides also vary. A large number of investigations have shown the association of different lunar phases with the mental health or physical health and diseases, physical activity pattern, and reproduction of humans. The changes occurred may be due to either the disturbance of electromagnetic field of the earth or the changes of lunar gravitational force on earth and changes of "human tidal wave" or "biological tide" during different lunar phases. The altered autonomic neural activity and cardiovascular activity during different lunar phases is probably one of the fundamental causes of the changes of human physiology.
This paper discusses the following health issues as related to lunar cycles: sleep issues, fatigue, seizures, Sudden Unexpected Death in Epilepsy (SUDEP), gout attacks, asthma, paroxysmal tacharrhythmia (fast, irregular heartbeat that starts and stop abruptly), atrial fibrillation, visual acuity, abdominal aortic aneurysm ruptures, intracranial aneurysm rupture, gastrointestinal hemorrhage (gut bleeding), angina (heart-related chest pain), heart attacks, thyroid issues, spontaneous pneumothorax (collapsed lung without apparent cause), stroke symptoms without apparent cause, and urinary retention issues.
Few reports found that there is no relationship between lunar phases and human health and diseases.
The connection between mental health issues and the lunar cycle is strongly present:
For identifying peoples' opinion about lunar effects in New Orleans, Italy, a questionnaire was sent to 325 people, out of which 140 individuals (43%) held the opinion that lunar phenomena alter personal behavior. Specifically, it came out that mental health professionals (social workers, clinical psychologists, nurses' aides) held this belief more strongly than other occupational groups (Vance 1995; Zanchin 2001).
Mental health issues connected to the lunar cycle included (from the paper): aggressive behaviors, agitation, crimes of violence (homicides, aggravated assaults), suicides, fatal traffic accidents, aggravated assaults, psychiatric emergency room visits, psychological crises, and schizophrenia.
Other interesting connections to the lunar cycle (also from the paper): amount of food consumed, amount of alcohol consumed, increase in "misbehaviors" (not described further), menstrual cycle, fertility, onset of labor, spontaneous rupture of membranes in pregnancy, spontaneous human abortion (miscarriage), and autonomic nervous system tone.
4. Conclusion
As the gravitational pull of the moon on earth varies in different phases of the lunar month, the ocean tides change according to the relative position of the moon. There are different types of effects of lunar phases in the human body reflected in different physiological, psychological or behavioral and reproductive changes. These changes occurred may be due to the disturbance of the electromagnetic field of the earth or may be due to the changes of lunar gravitational force on earth as well as changes of "human tidal wave" or "biological tide" during different phases of the lunar month. The altered autonomic activity during different lunar phases is probably one of the fundamental causes of the changes of human physiology.
These are two planets in a gravitational tug-of-war. Our physiology suffers some collateral damage (friendly fire) because of it. No one is immune to these effects. The sicker a person is, the more it will affect them. Before we go deeper, it should be noted that Traditional Chinese Medicine (TCM) noted that the moon affected biological rhythms two thousand years ago. This is not a new concept.
Human biological rhythm in traditional Chinese medicine (https://www.sciencedirect.com/science/article/pii/S2095754816301028)
Human syzygial rhythm is embodied in prosperity-decline variation of qi and blood. It is stated in Bazhengshenming Article of Plain Questions that accumulation of blood qi and circulation of Wei Qi start from crescent; at the full moon, blood qi are substantiated and muscles strengthened; at the wane, muscles and meridians are weakened, Wei Qi is gone and figure exists alone without essence. It is stated in Suilu Article of Spiritual Pivot that at the full moon sea water flushes to the west and human qi and blood are accumulated with strengthened muscles, tight skin, strong hair and compact texture, but at the wane sea water flushes to the east and human qi and blood are weak, with Wei Qi gone, figure alone (without essence), shrunk muscles, flabby skin, open texture, sparse hair and thin muscle texture. So phase of the moon is synchronized with the prosperity-decline of human blood and qi.
Now, on to space weather.
This article by David Hyde and Ben Davidson is a good intro on space weather's effects on human health for those who want to read and have reference links (https://www.newdawnmagazine.com/articles/space-weather-its-effect-on-human-health-behaviour), while the following videos are from Ben Davidson as well, through his YouTube channel Suspicious0bservers. He makes a Disaster Prediction App (http://spaceweathernews.com/) for smartphones that gives alerts when the space weather of any type kicks up, I believe it costs $6. Following are some of the videos that he has made discussing this subject:
(https://www.youtube.com/embed/ush_54S8aLU)
(https://www.youtube.com/embed/ZFLYj_SVX0M)
(https://www.youtube.com/embed/SyibQpj79Bk)
(https://www.youtube.com/embed/mo62uOT4TS8)
Finally, there is the connection between Schumann resonance and health (and the recent massive uptick in major spikes in this area). Note the frequency range below, specifically as it relates to the spikes discussed afterwards.
Schumann Resonances, a plausible biophysical mechanism for the human health effects of Solar (https://link.springer.com/article/10.1023/A:1015637127504)
A large number of studies have identified significant physical, biological and health effects associated with changes in Solar and Geomagnetic Activity (S-GMA). Variations in solar activity, geomagnetic activity and ionospheric ion/electron concentrations are all mutually highly correlated and strongly linked by geophysical processes. A key scientific question is, what factor is it in the natural environment that causes the observed biological and physical effects? The effects include altered blood pressure and melatonin, increased cancer, reproductive, cardiac and neurological disease and death. Many occupational studies have found that exposure to ELF [Extremely Low Frequency] fields between 16.7 Hz and 50/60 Hz significantly reduces melatonin levels.
This provides strong support for identifying the Schumann Resonance signals as the S-GMA biophysical mechanism, primarily through a melatonin mechanism. It strongly supports the classification of S-GMA as a natural hazard.
I'm going to make this simple. There is a growing body of research on the health effects of grounding/Earthing (https://www.earthinginstitute.net/research/), which is connecting to the earth through physical contact.
If we were to assume that grounding/Earthing was connecting us to the "hum" of the Earth--the Schumann resonance--and that the normal "hum" of 7.83 Hx was having major spikes interspersed, that this could affect how we feel (https://drjoedispenza.net/blog/consciousness/what-does-the-spike-in-the-schumann-resonance-mean/).
On January 31, 2017, for the first time in recorded history, the Schumann resonance reached frequencies of 36+ Hz. It was considered an anomaly when in 2014 this frequency rose from its usual 7.83 Hz to somewhere in the 15-25 Hz levels—so a jump from 7.83 Hz to 36+ Hz is a big deal. That's more than a five-fold increase in resonant frequency levels. What does this mean to us as inhabitants of Mother Earth? According to neuroscience, frequency recordings of 36+ Hz in the human brain are more associated with a stressed nervous system than a relaxed and healthy one.
After the above article was written, there were articles mentioning the Schumann resonance spiking up to record levels of 110-120 Hz in May 2017!
This is a link to the current data on the Schumann resonance (http://sosrff.tsu.ru/new/shm.jpg). Note it comes downwards from the top of the graph rather than going upwards, so the further down the green/yellow/white spikes go, the stronger the Schumann resonance is at that moment. It is important to know that up until 2017 it stayed EXTREMELY STEADY at 7.83 Hz, so all those obvious "spikes" on an almost daily basis are extremely ABNORMAL.
I collected four studies showing that extremely low frequency magnetic fields (ELF-MF) interact with Poison/"Vitamin A" at the cellular level. (https://nutritionrestored.com/blog-forum/topic/extremely-low-frequency-elf-magnetic-fields-synergize-in-a-bad-way-with-poison-vitamin-a-in-cancer-cell-lines/#postid-386)
Here is what I can say. Note the mention of a melatonin mechanism in the scientific paper linked two quotations above. I used to feel that Earthing products (using them in my bed while sleeping) were helpful. At some point, both my wife and I felt that they were making our sleep worse and we stopped using them. I heard this exact same observation from several clients as well. If we are connecting to the "electrical circuit" of the Earth through grounding/Earthing, and there are distinct surges/spikes in that system that decrease the production of melatonin, then it only makes sense that the previous calming and sleep-assisting effects that some people noticed could change too.
To sum up, we are part of the solar system. If the forces out there can affect entire planets across amazing distances, it would be ludicrous to assume that those same forces couldn't affect us internally. Logic and research bears this out as well.
SECTION HEADER PAGE: All About Reducing Your LIVER POISON Called "Vitamin A"
This is not a place to justify eating low VA, this is the place for learning how to do it.
You'll also see that I'm not as neurotic and paranoid about every molecule of VA as many others on the internet (I am not saying Grant is like that, he agrees with me here).
These are principles. Don't ask me for fine details about every single situation, please.
This list may never be finalized. Additions will be noted in comments as they are added.
If you eat foods that are very low in VA to begin with, the following things will not matter as much!
Sprouting / "germinating" plant foods. As seeds start sprouting and creating their chemical warfare defense systems, this is when they really pick up their production of carotenoids. I do NOT believe that overnight soaking of grains and beans in the REFRIGERATOR is going to do any actual sprouting or germinating, in that amount of time or in that temperature. If you see a sprout poking out, you decide.
"Disruption of the food matrix". This should make sense. The more that a food is "processed" or "ground up", the easier it is for one to digest and absorb WHATEVER is in it, for better or WORSE. Note the recent juicing fads. This has been shown to increase the absorption of carotenoids from plant foods.
Fats and oils. If you are going to eat VA, the best thing you can do to minimize your absorption of any/all of the VA in it is to NOT eat fatty foods or add oils with that meal. Also see the OVER & UNDER types article.
Vitamin E, in foods and/or supplements. The so-called "Vitamin" E greatly increases the amount of VA that gets stored in your liver. Vitamin E tends to come in higher-fat foods like nuts and seeds, see #3 above. Also see Vitamin E article.
Eating your grains hot. STOP YOUR FREAKING-OUT BRAIN RIGHT NOW AND LISTEN. I did NOT just say to stop cooking grains. What I'm saying is that cooking grains (another way of "processing" food), increases your absorption of VA from said grains, if there is any there anyway. Yes, some grains have enough VA (mostly lutein/zeaxanthin) to bother some people. Something you CAN do to minimize this, say from rolled oats, is to make them "overnight oats" style...you add the rolled oats (they've already been steamed MULTIPLE TIMES, they have been cooked and cooled, but NOT turned into typical oat mush/porridge/gruel consistency) to some room temp filtered water and let them sit 15-30 minutes to soak up that water, then eat. I can say, and I believe other people here will back me up on this, that I feel MUCH BETTER eating oats this way than if I were to freshly cook them up on the stove.
If you need the basics on these things, the internet has tons of info for you to get the basics with.
Added sugar of any type is generally BAD and should be reduced/minimized/avoided.
I will not debate which sugar source (honey, maple syrup, etc.) is better or worse. The fructose is the foundational issue, everything else is window-dressing, for better or worse.
The higher the fructose content of any sugar source, the LESS you should use it, if ever.
Fructose is really what makes "natural" foods sweet, so you can be fairly safe in assuming that the sweeter a "natural" food is, the more fructose is in it.
Fruit contains fructose. I will give you guidelines on fructose intake and sugar below. If you choose to eat fruit regularly (I do not any longer), then you can likely manage it within the guidelines fairly easily.
I'm not going to debate "natural" fructose versus "processed" fructose, just as I don't debate "natural vs. synthetic VA".
Fructose generally SLOWS DOWN the ALDH (Aldehyde Dehydrogenase) detox pathway in your liver, and this is NOT GOOD for your VA detox process.
Here is one of Lustig's (Mr. Anti-Fructose) papers on fructose, with choice parts taken out and highlighted:
Fructose: it's "alcohol without the buzz"
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23493539/
What do the Atkins Diet and the traditional Japanese diet have in common? The Atkins Diet is low in carbohydrate and usually high in fat; the Japanese diet is high in carbohydrate and usually low in fat. Yet both work to promote weight loss. One commonality of both diets is that they both eliminate the monosaccharide fructose. Sucrose (table sugar) and its synthetic sister high fructose corn syrup consist of 2 molecules, glucose and fructose. Glucose is the molecule that when polymerized forms starch, which has a high glycemic index, generates an insulin response, and is not particularly sweet. Fructose is found in fruit, does not generate an insulin response, and is very sweet. Fructose consumption has increased worldwide, paralleling the obesity and chronic metabolic disease pandemic. Sugar (i.e., fructose-containing mixtures) has been vilified by nutritionists for ages as a source of "empty calories," no different from any other empty calorie. However, fructose is unlike glucose. In the hypercaloric glycogen-replete state, intermediary metabolites from fructose metabolism overwhelm hepatic mitochondrial capacity, which promotes de novo lipogenesis and leads to hepatic insulin resistance, which drives chronic metabolic disease. Fructose also promotes reactive oxygen species formation, which leads to cellular dysfunction and aging, and promotes changes in the brain's reward system, which drives excessive consumption. Thus, fructose can exert detrimental health effects beyond its calories and in ways that mimic those of ethanol, its metabolic cousin. Indeed, the only distinction is that because fructose is not metabolized in the central nervous system, it does not exert the acute neuronal depression experienced by those imbibing ethanol. These metabolic and hedonic analogies argue that fructose should be thought of as "alcohol without the buzz."
Conclusions
Most people consider sugar (i.e., fructose-containing compounds) to be just “empty calories.” However, this paper reports 3 separate ways that fructose exerts negative effects beyond its caloric equivalent. First, in the hypercaloric state, fructose drives DNL, resulting in dyslipidemia, hepatic steatosis, and insulin resistance, akin to that seen with ethanol. This should not be surprising because fructose and ethanol are congruent evolutionarily and biochemically. Ethanol is manufactured by the fermentation of fructose — the big difference is that for ethanol, the yeast performs the glycolysis, whereas for fructose, we humans perform our own glycolysis. Second, through production of reactive carbonyl moieties, both fructose and ethanol generate excess ROS, which increases the risk of hepatocellular damage if not quenched by antioxidants. Last, by downregulation of D2 receptors in the reward pathway, chronic fructose exposure contributes to a paradigm of continuous food intake independent of energy need and exerts symptoms of tolerance and withdrawal, similar to chronic ethanol abuse. Therefore, it should not be surprising that the disease profile of fructose and ethanol overconsumption would also be similar (Table 2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649103/table/tbl2/)).
[image from https://nashaware.com/2019/02/15/our-sugar-addiction-is-slowly-killing-us/ ]
Fructose also exhibits notable social and market similarities with ethanol. Both have been “fetishized” by various cultures in times past. Of course, today both sugar and alcohol are legal commodities and are traded freely. The problems of overuse and related health harm tend to occur in lower socioeconomic groups. Those who overconsume either substance are stigmatized. Finally, within public health circles, alcohol clearly evinces the 4 criteria of unavoidability, toxicity, abuse, and negative impact on society, which warrant consideration for personal intervention (e.g., “rehab”) and societal intervention (e.g., “laws”). Sucrose/HFCS satisfies those same 4 criteria as well (6 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649103/#bib6)).
Although fructose does not exhibit the same acute toxic effects of ethanol (i.e., central nervous system depression and resultant auto accidents), it recapitulates all the chronic toxic effects on long-term health. It is time for a paradigm shift in our societal treatment of fructose, recognizing that fructose is “alcohol without the buzz.”
There is really very little difference between fructose and alcohol, and I'm going to suggest you'll do better without them both than you would with them.
You all know me...I don't like big organizations...however, I think they put out some useful guidelines in this area ("a broken clock is right twice a day" sort of thing).
Before you look at the below guidelines, Google lists an "apple" as having 19 grams of sugar, for reference.
Here is the daily "added" sugar limit recommendation from the American Heart Association (https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/sugar/added-sugars), AND I would suggest this is one good guideline for MAX TOTAL daily sugar intake from ALL sources:
Next, we have the World Health Organization:
WHO calls on countries to reduce sugars intake among adults and children (https://www.who.int/news/item/04-03-2015-who-calls-on-countries-to-reduce-sugars-intake-among-adults-and-children)
"A new WHO guideline recommends adults and children reduce their daily intake of free sugars to less than 10% of their total energy intake. A further reduction to below 5% or roughly 25 grams (6 teaspoons) per day would provide additional health benefits."
In a 2000 Calorie-per-day adult diet, the above 10% means a max of 200 Calories from sugar, which is 50 grams of sugar. 5% would then be a max of 100 Calories from sugar. Again, I would use those limits for TOTAL SUGAR FROM ALL SOURCES, not just for "added sugars".
The final paper I'll present here:
Health implications of fructose consumption: A review of recent data (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991323/)
"The issue of dietary fructose and health is linked to the quantity consumed, which is the same issue for any macro- or micro nutrients. It has been considered that moderate fructose consumption of ≤50g/day or ~10% of energy has no deleterious effect on lipid and glucose control and of ≤100g/day does not influence body weight."\
Quitting sugar is not easy, as it acts EXACTLY LIKE AN ADDICTIVE DRUG. If you need to get over your sugar addiction, I HIGHLY suggest Allen Carr's work on this subject, called "Good Sugar, Bad Sugar". ONLY use the first 8-12 chapters, before it dives too much into encouraging basically veganism, but don't let this dissuade you from the first part, it really works! You can find his books on iTunes, Google Play store, Amazon, and AllenCarr.com (https://allencarr.com/). I DO NOT RECOMMEND his weight loss books!!!
The combination of using Allen Carr's work to "unbrainwash" yourself, along with getting rid of most or even ALL of the sugars in your diet, WILL HELP YOUR HEALTH MORE THAN YOU EVER IMAGINED.
https://rumble.com/v27zpt4-fat-and-oils.html